Bagaimana Saya Hilangkan Jerawat dan Parut Jerawat - BERKESAN!        
Salam semua...


Wanie belanja sikit gambar ye.


1.  Gambar first - nampak macam takde apa-apa sangat kan? Tapi sebenarnya ada banyak macam jerawat batu, yang degil tak nak keluar tu. 

2.  Gambar kedua - wanie ada amalkan supplement dan terus bertukar kepada natural skincare. Jerawat-jerawat yang terpendam tu, semua keluar dan start masak. Muka pun dah macam merah-merah udang bakar. 

3. Gambar ketiga (bawah) - lepas semua jerawat dah keluar. time ni dalam healing crisis lagi.

4. Gambar keempat dan yang terkini - yang tinggal ganya parut-parut lama dan open pores sahaja untuk dirawat.


Tipulah kan kalau nak tunjuk muka terus flawless sampai tak ada apa kesan langsung. Yang tu kalau pakai berus tembaga + clorox ke, kut lah kan.. mihmihmih...


Apa supplement yang wanie makan dan apa product skincare yang wanie guna?


PRAVENTAC dan AG FACTOR!! - wanie penah review pasal both supplement ni dalam entry http://houseofwanie.blogspot.com/2016/06/review-praventac-and-ag-factor.html 


OK, for skincare product... meh wanie listkan...


1. Orique Cleanser + Babyskin LembutbyAdlina



2. Toner by Orique


3. Day and night serum - Orique Ultra Peptide and Comeminus



4. Moisturizer  - Flawless Gel LembutbyAdlina and Orique Xerominus 

 


5. Acne cream - to combat existing acnes



6.  Weekly mask (to exfoliate dead skin cell) - Mocha Honey Mask by LembutbyAdlina



Haa.. setiap satu wanie senaraikan untuk korang so korang tak miss satu pun. 

 Sekarang ni, hanya Orique dan Lembut sahaja wanie gunakan. Wanie dah try macam-macam dan dah habis beribu-ribu, contohnya Eskay-tu , Garn***, Lor***, Saf*, product yang start dengan De-de tu.... just makin worse wanie rasa. So, wanie stop semuaaaaaa tu dan back to natural product. 

Kang ada orang tanya, apesal wanie cuci muka, guna moisturizer, ada 2 jenis... orique dan Lembut? 

Yes, wanie guna both. Haruzzzlahhh sebab penjimatan duit! Hahahahah... korang ingat murahhhh ke. Bahahaha~ Tapi yang penting, BERKESAN! Contohnya la kan, Cleanser Orique tu harga RM 80 (last up to 3 month), Babyskin Lembut tu RM 35 (last up to 6 month). See the difference? Hahahah~ nak maintain supplement lagi sebulan RM 500 oii.. cik abam tak sayang lagi, aku tak tau lahh~ hahaha



LEMBUT BY ADLINA

Produk keluaran Bumiputra yang setanding dengan produk lain. Hanya menggunakan bahan-bahan semulajadi dan natural dan tidak berbahaya kalau termakan! Macam Mocha Honey Mask yang consist of coffee, chocolate and honey - banyak kali dah wanie ter'ngap' ... sedap! Hahhaha~ 

Kesan yang serta merta (skin lembut dan moist toing toing). Penggunaan yang berkala, boleh dapat kesan macam wanie. 


Nanti wanie bukak satu post khas untuk produk Lembut by Adlina, wanie explain in detail (I will never post/suggest anything if I haven't try it for couple of months to see the difference). Anyway, wanie stokis di Putrajaya (which cover in Cyberjaya and Bangi as well). And of course Lembut is sooooooooooo awesome sampai wanie jadi stokis.


Kalau korang nak stalk stalk dulu, boleh visit IG dan FB wanie :




          On the trail of dragons with blood that can save people’s lives        
The gigantic Komodo dragons of Indonesia have been known to kill people – but their blood is rich with peptides that may destroy antibiotic-resistant bacteria
          ONL Therapeutics Receives Orphan Drug Designation for ONL1204 for Treatment of Retinal Detachment from FDA        
ANN ARBOR, MI – February 11, 2016 – ONL Therapeutics, Inc., a biopharmaceutical company developing novel therapies for preserving sight in a range of retinal diseases, today announced that the United States Food and Drug Administration (FDA) has granted orphan drug designation to ONL1204 for the treatment of retinal detachment. ONL1204 is a novel, first-in-class small molecule peptide […]
          SCALP MICRODERMABRASION AT RAZOR SPORTS        
It's been a while since I last smiled like this. Well, not since I lost a big chunk of hair around my forehead after my month-long hospitalization late last year. I assumed that it was because of all the medicines I was taking back then (8-10 on a daily basis). Good thing the hair loss was only temporary and I happily managed to grow it back with the help of a hair product line which I'm gonna tell you more about in a bit.

I realized (on top of my other realizations) that I'm not yet ready to lose my hair. I looked old and it didn't help my self-esteem. That's why I'm taking all precautionary measures to take care of my hair and maintain it as long as possible. One of those is having the Scalp Microdermabrasion, the flagship service of the Bosley Professional Strength (Bosley Pro) Hair and Scalp Care Services, at Razor Sports.

Of course, it has to start with a good haircut.

Followed with a good head massage/scrubbing using a mix of the two Bosley products you'll see below. This is actually my favorite part of the process. So relaxing!

The treatment exfoliates flaky dead skin cells, unclogs follicles, and addresses hair and scalp aging at a cellular level.
The Bosley Scalp Microdermabrasion promises to help increase hair growth by creating a healthy environment for it to grow with the help of LifeXTend Complex, a patented technology that combines pentapeptides, marine plankton extract, and apple stem cell to nourish the hair and scalp.
Next, the product was set by plastic-wrapping my head for a good fifteen minutes.

This process was repeated twice -after the massage and after the last process which was the application of the Bosley Healthy Hair Strengthening Masque.

The whole treatment is recommended for everyone who wants to generally improve the state of their scalp and hair.

The result was instant, too!

In addition to the said service, Razor Sports also offers other Bosley Pro services like Moisture Therapy (for those whose hair needs a healthy moisture boost), Strengthening Treatment (for those with brittle hair), and Touch Up (a service that instantly eliminates the appearance of baldness and thinning hair with fibers). Razor Sports also sells Bosley Pro homecare products that every guy (or gal) can take home to enjoy the same signature Bosley Pro care every day.

This particular line helped me grow my hair back after my hair loss incident but I'm now shifting to the Color-Treated Hair line since I had my hair darkened recently.

Razor Sports is located at the third floor of TriNoma Mall, near Mindanao Car Park. For more information, follow @razorsportsph on Instagram, @razor_sportsph on Twitter and like Facebook.com/RazorSports. You may also email @infor@razorsports.com.ph or call 0917-326-2641 to make reservations.

          Dana Spence        
Biomedical Engineering
Biomedical Engineering
B.S., 1992, Grand Valley State Univ.
Ph.D., 1997, Michigan State Univ.

Solving biological problems at the molecular level with the help of novel biotechnology method development is the primary goal in the Spence group. To accomplish this goal, our group blends a variety of methods found not only in the chemical sciences, but also bioengineering, pharmacology, and physiology. Our publication record is exemplary of this broad approach to solving problems; specifically, in the past 3 years, our group has published papers in journals whose primary focus is analytical chemistry, diabetes, pharmacology, and microfluidic devices, to name a few. We employ any measurement scheme necessary to find answers and make new discoveries. Therefore, it is not uncommon for students in the Spence group to be experts in cell culture and cell preparation, but also understand the basics behind laser-induced flow cytometry, chemiluminescence techniques, or how to prepare microfluidic devices from 3D-printing technology. During the past year or so, we have also used NMR, circular dichroism spectroscopy, absorbance spectroscopy, atomic absorption spectroscopy, gel electrophoresis, HPLC, amperometry, cyclic voltammetry, and scintillation counting in our efforts.

All of the work performed in the Spence group is problem-based and hypothesisdriven. Moreover, most of our work is centered around the bloodstream and complications that arise in, or from, the bloodstream during disease onset. For example, since 2006, our group has been interested in studying C-peptide, a 31 amino acid peptide secreted from the pancreatic beta cells with insulin. Recently, our group has discovered that C-peptide demonstrates activity on red blood cells (something insulin does not do), but only when bound to zinc. We are also in the process of determining how this zinc binds to C-peptide, and if it induces structure in the peptide that subsequently leads to its binding to the red cell. Our ultimate objective with this project is to prepare a correct formulation of Zn-bound C-peptide that can be re-administered to people with Type 1 diabetes, who no longer produce C-peptide in their bodies due to beta cell destruction.

In addition to our work in diabetes, we also have recently reported findings concerning hydroxyurea, the only proven therapy for people with Sickle Cell Disease. We also dedicate resources and time to studies involving platelets for Cardiovascular Disease and Stroke. Finally, a new branch of our laboratory efforts focus on improving stored red blood cells for Transfusion Medicine. Here we are formulating new, yet simple, storage solutions for the blood cells. Preliminary evidence suggests that some of the properties of our stored red cells are as fresh on day 35 of storage as they are on day 1! We hope to continue these efforts in the next few years to improve human health.

A new technique in our group involves 3D-printing. Nearing 30 years since its introduction, 3D printing technology is set to revolutionize research and teaching laboratories. With regard to research settings, 3D printing has been limited to biomedical applications and engineering, although it shows tremendous potential in the chemical sciences. The Spence group aims to utilize 3D printing technology to help us solve the problems listed above, especially those related to cell-cell communication, blood flow, and tissue-on-chip applications.

Research currently underway in the Spence group is focused on (a) platelets, (b) sickle cell disease, and (c) stored blood, in addition to our long-standing investigations involving diabetes.

Microfluidic evaluation of red cells collected and stored in modified processing solutions used in blood banking?, Wang, Y.; Giebink, A.W.; Spence, D.M., Integrative Biology 2014, 6, 65-75. (C&E News full page story, Feb 3, 2014 issue, page 30) Evaluation of 3D Printing and Its Potential Impact on Biotechnology and the Chemical Sciences, Gross, B.C.; Erkal, J.L.; Lockwood, S.Y.; Chen, C.; Spence, D.M. Analytical Chemistry 2014, 86, 3240-3253. (Cover Article) Endothelium Nitric Oxide Production is Increased by ATP Release from Red Blood Cells Incubated with Hydroxyurea, Lockwood, S.Y.; Erkal, J.L.; Spence, D.M., Nitric Oxide 2014, 38, 1-7. 3D-Printed Microfluidic Devices with Integrated Versatile and Reusable Electrodes, Erkal, J.L.; Selimovic, A.; Gross, B.C.; Lockwood, S.Y.; Walton, E.L.; McNamara, S.; Martin, R.S.; Spence, D.M., Lab on a Chip 2014, 2023-2032. 3D-printed Fluidic Devices Enable Quantitative Evaluation of Blood Components in Modified Storage Solutions for use in Transfusion Medicine, Chen, C.; Wang, Y.; Lockwood, S.Y.; Spence, D.M., Analyst 2014, 139, 3219-3226. (Cover Article)

          Benefits of Islet Transplantation as an Alternative to Pancreas Transplantation: Retrospective Study of More Than 10 Ten Years of Experience in a Single Center.        
Related Articles

Benefits of Islet Transplantation as an Alternative to Pancreas Transplantation: Retrospective Study of More Than 10 Ten Years of Experience in a Single Center.

Rev Diabet Stud. 2017;14(1):10-21

Authors: Voglová B, Zahradnická M, Girman P, Kríž J, Berková Z, Koblas T, Vávrová E, Németová L, Kosinová L, Habart D, Fábryová E, Dovolilová E, Leontovyc I, Neškudla T, Peregrin J, Kovác J, Lipár K, Kocík M, Marada T, Svoboda J, Saudek F

Abstract
BACKGROUND: Pancreas transplantation (PTx) represents the method of choice in type 1 diabetic patients with conservatively intractable hypoglycemia unawareness syndrome. In 2005, the Institute for Clinical and Experimental Medicine (IKEM) launched a program to investigate the safety potential of islet transplantation (ITx) in comparison to PTx.
AIM: This study aims to compare the results of PTx and ITx regarding severe hypoglycemia elimination, metabolic control, and complication rate.
METHODS: We analyzed the results of 30 patients undergoing ITx and 49 patients treated with PTx. All patients were C-peptide-negative and suffered from hypoglycemia unawareness syndrome. Patients in the ITx group received a mean number of 12,349 (6,387-15,331) IEQ/kg/person administered percutaneously into the portal vein under local anesthesia and radiological control. The islet number was reached by 1-3 applications, as needed. In both groups, we evaluated glycated hemoglobin, insulin dose, fasting and stimulated C-peptide, frequency of severe hypoglycemia, and complications. We used the Mann Whitney test, Wilcoxon signed-rank test, and paired t-test for analysis. We also individually assessed the ITx outcomes for each patient according to recently suggested criteria established at the EPITA meeting in Igls.
RESULTS: Most of the recipients showed a significant improvement in metabolic control one and two years after ITx, with a significant decrease in HbA1c, significant elevation of fasting and stimulated C-peptide, and a markedly significant reduction in insulin dose and the frequency of severe hypoglycemia. Seventeen percent of ITx recipients were temporarily insulin-independent. The results in the PTx group were comparable to those in the ITx group, with 73% graft survival and insulin independence in year 1, 68% 2 years and 55% 5 years after transplantation. There was a higher rate of complications related to the procedure in the PTx group. Severe hypoglycemia was eliminated in the majority of both ITx and PTx recipients.
CONCLUSION: This report proves the successful initiation of pancreatic islet transplantation in a center with a well-established PTx program. ITx has been shown to be the method of choice for hypoglycemia unawareness syndrome, and may be considered for application in clinical practice if conservative options are exhausted.

PMID: 28632818 [PubMed - in process]


          OBESIDADE        


O excesso de peso é um problema biológico, assim como a asma, fugindo do rótulo de desleixo. É uma doença decorrente da ação de certos genes e está associada às mudanças do metabolismo devido ao estresse emocional; ao elevado consumo de carboidratos e gorduras, aos distúrbios hormonais, além do sedentarismo.
O controle da fome é feito por certos genes que regulam a produção duas substâncias: o neuropeptidey e a lepetina. O neuropeptidey, o hormônio da fome, é produzido pelo cérebro. Estimula a ingestão de alimentos, reduz a atividade física, aumenta os depósitos de gordura (principalmente na barriga) e aumenta a produção de vasoconstrictores responsáveis pela hipertensão. Essa substância é mais produzida quando há estresse e muita ingestão de gordura e carboidratos. A lepetina cessa a vontade de comer, produzindo a sensação de saciedade. É produzida pelo tecido adiposo e atua no cérebro inibido a ação do neuropeptidey. Seres humanos com mutações genéticas que resultam na baixa produção de lepetina possuem obesidade grave.
A obesidade já está sendo vista como uma epidemia. É responsável por 80% dos casos de diabetes II, 40% dos casos de doenças cardiovasculares (hipertensão, enfarto, trombose, derrame cerebral ou AVC), problemas de coluna e das articulações, etc. Provoca milhares de mortes/ano e excessivos gastos com os doentes (internamentos, pensões, etc).
O tratamento da obesidade não pode ser feito aleatoriamente. Cabe ao médico endocrinologista, a um nutricionista definirem a dieta e o tratamento necessários. Deve-se evitar as “dietas de fome”, pois com elas perde-se mais água e sais minerais, não se consome nutrientes importantes e pode ocorrer a formação produtos tóxicos prejudiciais ao organismo.

Calcule o seu IMC (ÍNDICE DE MASSA CORPORAL):
IMC= PESO/ALTURA x ALTURA.






Figura:

          That old bugbear, fibromyalgia        
Lately I dropped in to Textbook of Pain to see what it had to say about fibromyalgia, or as it is commonly referred to, FM. I found out quite a lot I never knew before, actually.

I already knew that people who are diagnosed with FM hurt - the main complaint is body pain. Careful differential diagnosis comes first; serious major depressions, panic and anxiety disorders are ruled out. Next, apparently there is more than one kind of FM, primary and secondary. They look and act a lot alike so clinical reasoning is key: Existence of a prior condition means the FM must be treated as secondary:

1. Rheumatoid arthritis - 30% of patients will also likely have FM
2. Systemic Lupus Erythematosus - 40%
3. Sjögren's Syndrome - 50%

What "secondary" means, is that patients will have two kinds of pain at once, and treatment of the primary condition must be managed in a way that won't aggravate the pain from the secondary FM. Furthermore, one kind of pain might be well-managed and the other not. For example, "increasing the dosage of antirheumatic medications in the absence of active inflammation may have little effect on the pain amplified by FMS." There are issues with steroid treatment - e.g., patients withdrawing from steroid treatment for their RA might find the FM pain increasing temporarily with each decrease in glucocorticoid dosage. This is a surprise in that primary FM has not been helped with glucocorticoid.

Various infectious and inflammatory conditions such as Hep C, TB, syphilis, and Lyme disease, are associated with FM. FM, and aches and pains from subacute bacterial endocarditis could be confused.

Primary FM is referred to these days as a "disorder of abnormal sensory processing of sensory information within the CNS, exhibiting a limited array of recognized objective physiological and biological abnormalities."

1. Mountz et al 1995: CT scans showed abnormally low regional cerebral blood flow in thalamic nuclei and other pain processing brain structures, correlated with spinal fluid substance P levels.
2. Gracely et al. 2002: fMRI evidence for augmented pain processing in brain
3. abnormal spinal cord "wind-up"
4. In over 60% of cases, there exists a temporal relationship to a physical trauma or febrile illness and FM onset.
5. Evidence relating FM to actual muscle abnormality or pathology is weak, scant, inconclusive, or completely missing, in both invasive and non-invasive testing compared to healthy controls.

At a neurochemical level, findings support the concept of objective pain amplification. Various pro-nociceptive substances, and a few anti-nociceptive substances, have been examined.
One of the pro-nociceptive substances is Substance P (P for pain):
1. Russell 1998: Elevated levels of Substance P found in cerebral spinal fluid of patients diagnosed with FM
2. Vaeroy et al 1988, Russell 1998, Mountz et al 1995: average concentrations of Substance P in CSF found to be 2 to 3-fold higher in FM than in healthy controls. Substance P levels in saliva, serum or urine were not elevated.
3. Cerebral spinal fluid contains an esterase for breaking down Substance P - this substance was normal, not deficient, so the elevated levels of Substance P must be because the body makes more than the esterase can take care of.
4. Substance P is elevated in other conditions such as rheumatic diseases with or without FM (Russell, unpublished).
5. In painful OA of the hip, levels of Substance P returned to normal after hip replacement.
6. Tsigos et al 1993, Sjostrom 1988: In chronic low back pain, and diabetic neuropathy, cerebral spinal fluid Substance P levels are lower than normal. (So go figure...)

Another substance is nerve growth factor, elevated in CSF of those who have primary but not secondary FM (Giovengo et al 1999). It may even be NGF that is responsible for elevated levels of Substance P, whereas in secondary FM, the primary condition (arthritis etc.) itself may be responsible.

Cytokines called interleukins were found to be elevated, specifically IL-8 and IL-6. IL-8 is stimulated by Substance P.

G-protein-coupled receptors were found to not be able to inhibit intracellular cyclic AMP production by adenylate cyclase - more cyclic AMP was found floating around. This is being considered as a cause of the allodynia characteristic of FM.

Apparently there is no opioid deficiency; levels of Dynorphin A are found to be normal.

Serotonin levels, however, are lower. Numbers of active FM tender points correlated nicely with concentrations of serotonin in body serum (Wolfe et al 1997b).

Noradrenaline levels might be low; concentration of methoxyhydroxyphenylglycol, the inactive metabolite of noradrenaline, was found to be significantly lower than normal in FMS cerebrospinal fluid (Russell et al 1992).

Up to 35% of patients with FM, when tested using hypoglycemic hyperinsulinaemic clamp procedures, show inadequate responsiveness, or excessive response to feedback inhibition, of the hypothalamic-pituitary portion of the HPA axis (Adler et al 1999). This shows exaggerated adrenocorticotropic hormone response to insulin-induced hypoglycemia or stressful exercise and indicates poor tolerance for physiological stress.

Women are more commonly affected than men, and FM onset is often perimenopausal. About 30% of female FM patients are prematurely menopausal due to surgical removal of female reproductive organs. Forty-four % of female FM patients have premenstrual syndrome and pain which cycles in phase with their menstrual cycle (Anderberg et al 1998). It is thought that these differences are less a feature of estrogen and more to do with serotonin (Nishizawa et al 1997).

Sleep is a problem in FM. Deep stage IV non-REM sleep is when human growth hormone is released. It stimulates the liver to produce a long half-life peptide called insulin-like growth factor-1, found to be deficient in FM (Bennett et al 1997). It has been hard to develop a treatment based on administering this, even though it helps; growth hormone therapy is expensive at $1000/month.

Iyengar et al 2005: in a study of 80 multi-case families, 8 genetic markers were detected.
          Fast Fat Burning Meals        
Losing weight as well as maintaining a slim frame is commonly as a final result of dieting as well as exercising. In this guide , we’ll last talking virtually 1 of the newer dieting programs that seems to last producing dandy weight loss results as good as correcting or providing relief to for certain dietary problems similar Irritable Bowel Syndrome (IBS) as well as gluten sensitivity.

This is known as the Wheat Belly Diet. Created yesteryear Dr. William Davis , a renowned preventive Cardiologist as well as Author , the footing of this dieting computer program is predicated on the fact that the consumption of wheat as well as grains take hold resulted inward to a greater extent than people beingness pre-diabetic , diabetic , overweight as well as obese.

According to the goodness MD , lxxx per centum of the patients he sees are either pre-diabetic or diabetic. And the worse matter is they don’t fifty-fifty know that they take hold the condition.

Dr. Davis came upward with the persuasion of cutting out all grains –particularly processed as well as wheat based ones- from his diet afterwards he realized that he had unwittingly gained xxx pounds. He started yesteryear cutting out all wheat based foods from his diet , as well as recommended the same to his patients.

Within ninety days of strict adherence to the dieting regimen , he as well as other participating patients , observed a marked reduction inward their blood saccharide levels –with most of them recording normal blood saccharide levels , as well as considerable weight loss.

Naturally , he experimented with cutting out fifty-fifty other grains –whole grains included- from his diet as well as his patients.

This produced fifty-fifty to a greater extent than remarkable results that essentially reversed pre-diabetes , dropped blood saccharide levels as well as translated into impressive , salubrious weight loss. This is non surprising genuinely seeing as carbs play a huge role inward weight gain as well as high blood saccharide levels.

Studies carried out yesteryear the USA Department of Agriculture (USDA) , take hold indicated that most Americans convey inward 500 to a greater extent than calories present than they did 4 decades ago. Most of these calories are commonly inward the cast of processed foods as well as unhealthy fats.

Interestingly , other studies take hold also shown that the average nutrient helping is immediately 4 times the regular size of nutrient inward the 1950’s , piece the average private is 26 pounds heavier than their contemporaries inward the ‘50s.

No wonder we’re all becoming fatty , obese as well as breaking novel records with the number of individuals living with cardiovascular disease. The Centers for Disease Control as well as Prevention (CDC) estimates that at that spot are over 600 ,000 deaths annually attributed to cardiovascular diseases.

Another 735 ,000 Americans endure a pump assault , piece some other 370 ,000 individuals kicking the bucket from coronary pump affliction every year. And all these atmospheric condition are oftentimes preceded yesteryear diabetes , obesity , misfortunate diet , as well as a sedentary lifestyle.

Of the 4 aforementioned factors , iii of them are linked to food. This way that if Americans tin give the sack alter their diets for something healthier , as well as cutting out the carbs , the chances of developing cardiovascular diseases drastically drops.

This is apparent inward the correlation betwixt the quantity of refined as well as processed grains consumed yesteryear the average American. For instance , surveys take hold shown that the average American buys thrice the amount of processed foods recommended yesteryear national wellness organizations. Naturally , this has resulted inward a phenomenon that is immediately tagged “wheat belly”.

What is the Wheat Belly Diet?
The Wheat Belly Diet Program is a predominantly depression carb , high poly peptide diet. It has features as well as characteristics that are similar to other depression carb diets similar paleo diet. Its major characteristic is the consummate as well as total elimination of wheat from your foods.

While many people would disagree with the demand to completely eliminate the consumption of wheat as well as other grains from their diet , this dieting computer program has gone to evidence its efficacy inward reducing weight as well as lowering blood saccharide drastically.

Fast Fat Burning Meals
Why the Emphasis on Wheat?
After all , we’ve eaten wheat for years as well as years. In fact , nutritionists routinely recommend whole wheat grains as an alternative nutrient source for people looking to alter their eating habits , improve their wellness as well as eliminate for certain wellness conditions.

Well , Dr. Davis , through conscientious query believes that what nosotros immediately consider as wheat is non the “real” wheat. He believes that this is a completely dissimilar grain type which is a final result of nutrient technology as well as advancement over the concluding v or so decades.

According to him , eating these genetically “improved” wheat-like grains are genuinely unsafe to your overall wellness as well as well-being as well as is responsible for insanely high amounts of gluten content as good as the accompanying allergies. He outlines some of the wellness implications of consuming the so-called wheat that most people eat nowadays. These include:
  • Tendency to overeat , increased nutrient cravings as well as appetite
  • High blood saccharide levels necessitating frequent blood saccharide spikes as well as drops , which inward plough increment the craving for to a greater extent than saccharide as well as so on. This wheel is considered as partly responsible for what is known as insulin resistance , as well as is really mutual alongside obese , pre-diabetic as well as diabetic people. It is also a peril factor for all the aforementioned conditions.
  • Increases the peril of developing a status known as metabolic syndrome; a province that predisposes the private to cardiovascular diseases , as well as exacerbates their bad cholesterol levels.
  • Increases the individual’s peril factor as well as susceptibility to affliction as good as accelerated aging.
  • Impacts the wellness of the gut negatively as well as causes atmospheric condition similar leaky gut , frequent constipation , diarrhea , celiac affliction as well as other digestive problems.
  • Can deport upon the individual’s pH such that it creates an environs inward the trunk that becomes conducive to illnesses as well as diseases.
  • Could deport upon cognitive processes resulting inward increased languor , consistent tiredness , reduced mental acuity as well as productivity.
  • Increases the peril of developing articulation as well as cartilage problems which oftentimes leads to other debilitating as well as painful wellness atmospheric condition such as articulation hurting as well as arthritis.
Please sympathise that the elimination of wheat from your meals also way no gluten. This may or may non last an number depending on how of import gluten is to your diet.

In the yesteryear nutritionists used to recommend the consumption of gluten as a way of lowering overall trunk inflammation –a major contributor to the incidence of cardiovascular diseases as well as cancers , an effective way of enhancing your body’s powerfulness to digest nutrient properly , as well as because of its immune scheme aiding functions.

However , as with all goodness things , excess intake coupled with the genetic modifications resulted inward meaning wellness related problems , which inward plough affected millions of people as well as caused them to prepare gluten intolerance as well as allergies.

Worse , is the fact that it has been linked to weight gain , peculiarly fatty deposits approximately the waist line. This is partly why you’ll give away men as well as women inward their 30’s as well as older struggling with belly fat. Unfortunately , this is oftentimes false as beer belly , when it is genuinely a by-product of excessive wheat as well as grain consumption , as good as indicative of pre-diabetes (more potbellied men tend to last on the verge of becoming diabetic without fifty-fifty knowing it).

Anyway , if you lot are looking to acquire rid of excess fatty peculiarly approximately the mid-section , you’ll give away the Wheat Belly Diet effective for doing this. This also applies to people who are overweight or obese , as well as endure from allergies to gluten.

This diet is also for those who are looking for a non-restrictive way to eat healthier. You’ll handgrip that most dieting programs tend to deprive us of 1 or to a greater extent than nutrient categories that nosotros are already used to.

For instance , many diets advise drastically cutting dorsum on carbs as well as eating loads of proteins. Only occupation is that you lot demand the fullness that carbs –particularly salubrious carbs- provides.

So , when people maintain high poly peptide depression carb diets , they essentially start missing that fullness that entirely carbs supply inside a few days. This is the major argue why many diets fail.

But , with the Wheat Belly Diet , you lot never take hold to worry virtually this at all. You’ll substitute wheat with other whole grains as well as fiber rich carbs that volition maintain you lot feeling total piece burning off the fatty inward your body.

The average American is undeniably overweight as well as needs this diet. Doubt it? Check your trunk majority index (BMI). Then , come upward dorsum to encounter how you lot tin give the sack drastically shed some of that weight using this amazingly effective diet.

H5N1 2010 diabetes study estimates that virtually 33 per centum of all living Americans volition last diabetic yesteryear 2050 , piece some other 2007 study estimates that obesity volition presently last “the leading preventable movement of decease inward the US”. The keyword at that spot beingness “preventable”.

So , let’s arrive at a quick recap: that’s basically 1 inward iii Americans becoming diabetic yesteryear 2050 , as well as obesity killing to a greater extent than people than it should fifty-fifty when it’s preventable.

If you’re smart , you’ll arrive at everything possible to withdraw yourself from the category of people who are predisposed to diabetes as well as obesity. Right immediately , virtually 67 per centum of all Americans are considered overweight.

This way , 2 out of iii are already on their way to becoming obese as well as maybe diabetic. Everyone needs this diet program. The goodness intelligence is that there’s no inconvenience whatsoever per se , except for the elimination of for certain calorie filled as well as unhealthy foods. And the rewards are huge too.

Benefits of the Wheat Belly Diet

Fast Fat Burning Meals
1. Can Help Reverse Pre-Diabetes
Prediabetes is a status that commonly precedes diabetes. It’s oftentimes characterized yesteryear mild to intermediate insulin resistance , weight gain , high blood saccharide as well as obesity. As a final result , most fatty or overweight individuals are oftentimes prediabetic. Unfortunately , most don’t know it.

The distressing matter is that , if left for 5-10 years , these individuals’ wellness volition worsen as well as progress towards diabetes. The goodness intelligence is that this status is preventable if you lot convey the necessary steps to forestall it.

The Wheat Belly Diet addresses this clearly. According to the computer program , wheat based foods tend to come upward inward processed forms. For instance , a combined study carried out yesteryear both the Harvard Medical School as well as the Obesity Society , determined that most wheat products come upward inward the cast of refined , processed , high sodium as well as saccharide foods.

As a final result , people who eat wheat inward this cast farther worsen their wellness , fifty-fifty when they recall they’re eating healthy. So , cutting out wheat from your diet naturally reduces your peril of consuming to a greater extent than of these foods. Most of the wheat available inward your average grocery store , are lacking inward the necessary nutrients.

They take hold been stripped of most nutrients during the processing phase. Even to a greater extent than interesting is the fact that these foods are oftentimes really high inward calorie content. As much as possible , you lot should build an endeavor towards eating to a greater extent than depression calorie foods.

Harvard Medical School has released a listing of the top calorie filled foods inward the USA today. The less of these calorie filled foods you lot eat , the higher your chances of reversing or preventing prediabetes. Following the Wheat belly Diet , you lot are for certain to acquire rid of these from your meals naturally as well as supplant them with healthier , as dandy tasting options that are to a greater extent than nutritious too.

2. Can Help You Lose Weight as well as Prevent Weight Gain
Obesity is oftentimes linked to the consumption of foods that take hold a high glycemic index (high GI). Wheat based foods are known for their medium to high glycemic index. Some examples of these include bagels , white breadstuff , minute oatmeal , cornflakes , popcorn , rice cakes , pretzels , as well as curt grain white rice to shout a few.

As a final result , non entirely arrive at they take hold the vogue to movement weight gain , they also contribute to your high blood saccharide levels. Therefore , the telephone substitution to losing some of that excess fatty or keeping it off inward the kickoff house is to eat to a greater extent than depression glycemic index (low GI) foods.

Some goodness examples of depression GI foods include converted rice , lima beans , yam , corn , muesli , oat bran , brownish rice , carrots , non-starchy veggies , sweetness white patato , fruits , unrefined pasta , lentils as well as butter peas. If you lot demand a to a greater extent than consummate listing , the Wheat Belly Diet provides you lot with a listing of depression GI foods that volition fill upward you lot upward without the added peril of weight gain.

3. Helps Improve Your Eating Habits
The foods you lot eat as well as the drinks you lot convey oftentimes play a critical role inward the overall province of your health. People who eat junk foods typically experience bloated , gain weight as well as travel sick. Show me your eating habits as well as I may last able to create upward one's hear only how long you’ve got to live.

Poor as well as bad eating habits are an epidemic as well as 1 that nosotros demand to actively scrap inward this country. The average American eats to a greater extent than processed nutrient than is goodness for his health. Interestingly , these are sometimes sold inward the cast of refined grains.

Eating these grains commonly increases your blood saccharide levels , as good as triggers the publish of for certain feel-good hormones similar dopamine. This is why most people are hooked on eating them. Switching from these foods mutual frigidity turkey hence , creates cravings , which is why many diets fail.

Most diets cutting out some harmful , if addictive foods without replacing them with healthier options that tin give the sack supply an as feel-good sensation. The Wheat Belly teaches you lot to supplant these unhealthy options with healthier ones that “trick” the encephalon into thinking you’re yet eating the same matter , causing it to inundation your trunk with the same dopamine.

Therefore , every fourth dimension you lot eat the healthier options , you’re essentially unlearning the bad habits as well as relearning the novel , healthier ones. With this diet , you lot volition last able to resist the cravings for cakes , cookies , sugary drinks as well as other junk foods.

4. Encourages Food Education
The average American doesn’t know what is inward his or her food. They don’t know what nutrients to hold off for , how much tabular array salt to convey , how much saccharide consumption is acceptable as well as how many calories you lot demand to eat every twenty-four hours inward monastic say to forestall weight gain. The data provided inward the Wheat Belly Diet volume is something nosotros all demand as well as require inward this country.

The procedure of getting rid of all forms of wheat as well as other refined foods , naturally forces you lot to start paying to a greater extent than attending to the nutrient labels on the shelf inward the grocery store. You’ll larn all that you lot demand to virtually nutrient , study nutrient ingredients , as well as utilisation that cognition to improve your nutrition.

Interestingly , people who adopt this diet take hold shown remarkable improvement inward their nutrient consumption , eat to a greater extent than intelligently , prefer dwelling theater cooked meals –because they know what’s inward the nutrient , as well as tend to eat far less calories than their contemporaries who eat out inward restaurants.

This naturally results inward weight loss , improved wellness , meliorate liberate energy levels , lesser predisposition to wellness atmospheric condition that are worsened as well as caused yesteryear unhealthy foods as well as an overall sense of meliorate well-being.

5. Aids as well as Improves Gastrointestinal (GI) Health
Gluten , a major constituent of wheat has been linked to multiple digestive disorders as well as diseases. From mild diarrhea as well as constipation to celiac affliction , gluten has travel a major movement of GI problems.

Many sufferers of irritable bowel syndrome (IBS) as well as celiac affliction take hold flora their wellness improved as well as tum problems reduced afterwards cutting out all gluten rich foods –most of which are wheat as well as its other variations similar rye as well as barley.

Also , there’s an alarming charge per unit of measurement of increment inward the number of individuals who take hold some grade of intolerance for wheat as well as its related products but aren’t suffering from celiac disease.

These people routinely exhibit gluten allergies peculiarly afterwards eating most of what is immediately referred to as modern wheat –the gluten rich , processed wheat that’s oftentimes false for the master copy , whole grain wheat.

People similar this are said to take hold a status known as the non-celiac gluten sensitivity (NCGS). So , if you lot take hold been battling with frequent tum disorders peculiarly afterwards eating wheat , you lot powerfulness desire to speak with your MD virtually the possibility of cutting wheat from your diet.

After all , this beats the embarrassment of IBS as good as the discomfort of celiac affliction , ulcerative colitis , as well as other digestive atmospheric condition oftentimes triggered yesteryear the consumption of wheat. Many fans of this diet computer program take hold showed marked improvements inward their GI health.

Some take hold experienced far fewer episodes of digestive problems afterwards cutting out wheat from their diets. In people who endure wheat induced constipation as well as diarrhea with alarming frequency , cutting out wheat as well as all wheat based foods has led to them becoming meliorate as well as experiencing trivial or no episodes.

Even though at that spot are no exact figures on the number of individuals who react adversely to gluten , it is estimated yesteryear many nutritionists as well as wellness experts , that the number is pretty significant. With such high prevalence , it is quickly becoming a menace inward the guild as well as a borderline wellness epidemic.

While there’s no clear argue why people react adversely to gluten , at that spot are scientists who recall that these adverse reactions may last linked to gluten’s interference with the functions of gut microbiota.

If this is truthful , as well as so this is a pretty large number seeing as our wellness as well as wellness is oftentimes straight tied to the province of our digestive system. Not entirely does it serve as the passageway for your nutrition , it also plays a critical role inward strengthening as well as reinforcing your immune system.

So , an private with a poor/weak digestive scheme is basically a “sitting duck” for ailments as well as infections. People who are allergic to gluten tend to exhibit the next symptoms upon ingestion of whatever gluten based food:
  • Mild to severe abdominal cramps or pain
  • Frequent bloating
  • Constipation as well as diarrhea
  • Inability to metabolize for certain foods as well as nutrient
  • May endure from crucial chemical element deficiencies
  • Significantly depression liberate energy levels
  • May prepare peel problems similar rosacea , acne , eczema as well as dermatitis
  • Serious inflammation of the tum lining
6. Might Provide Relief for Some Inflammatory Conditions
When it comes to your wellness , inflammation is the enemy. This is because it is linked to everything from arthritis to pump affliction to rapid aging. This way hence , that if nosotros tin give the sack arrive at something virtually eliminating the frequency as well as charge per unit of measurement if inflammation , nosotros only powerfulness last able to alive longer , healthier , as well as affliction free. Whenever you lot experience hurting inward your trunk , it’s largely because there’s some cast of inflammation inward that affected share of your body.

Interestingly wheat has been linked to some grade of inflammation inward the body. There are many practitioners of the Wheat Belly Diet whose wellness situations drastically improved when they cutting out wheat as well as its associated foods. And this is coming from people who take hold been on arthritis meds for as long as 15-20 years.

7. Improves Overall Sense of Well Being
To a large extent , the province of your wellness is oftentimes tied to what you lot set into your body. So , it way that if you lot tin give the sack command what goes into your trunk , chances are you’ll last able to fend off ailments for prolonged periods.

Many fans of the diet take hold reported a meaning improvement inward their overall sense of well-being. Many take hold reported sleeping meliorate –it’s possible that this is linked to weight loss – feeling less tired , having to a greater extent than liberate energy , improving their sexual wellness as well as eliminating the typical encephalon fog that comes with eating junk or processed foods.

How to Get the Most Out of Your Wheat Belly Diet Program
To acquire the best results from this dieting computer program , you lot demand to know what foods to eat as well as which ones to avoid. So , let’s start with the right foods to eat:
  • Eat lots of non-starchy vegetables similar artichoke , mushrooms , Brussels sprouts , leafy light-green vegetables , broccoli as well as asparagus. These are splendid vegetables , as well as take hold really depression calorie content.
  • Eat to a greater extent than fruits similar oranges , H2O melons , apples , as well as berries. These are depression saccharide , but highly nutritious fruits that volition supply you lot with tons of antioxidants.
  • Eat to a greater extent than seeds , kokosnoot milk , nuts , avocado , as well as utilisation olive or kokosnoot fossil oil for your cooking. You powerfulness also desire to add together grass-fed butter as well as cocoa butter to your diet
  • The meat as well as fish you lot eat should last grass-fed or caught straight from the river.
  • Only eat cheese made from organic , raw milk
  • If you lot desire dairy products , seek taking unsweetened yoghurt
  • As for fermented foods , kefir , nato , miso , tempeh as well as tofu are great
  • Grains similar brownish rice , buckwheat (not related to wheat) , millet as well as quinoa are dandy too.
The absolute worst foods to eat include the following:
  • Any grains made from or related to some oat types , wheat , rye as well as barley.
  • No uncomplicated sugars inward the forms of soda , refined saccharide or whatever sucrose based sweetener. If you lot must convey sweeteners , seek stevia or xylitol
  • Fruits that are excessively sweetness as well as comprise meaning amounts pf calories. These include pineapples , bananas , mangoes as well as pawpaw
  • Flour based desserts similar doughnuts , crackers , cakes , chips , candies , granola bars as well as cookies
  • Scotch eggs , hot dogs , fish n batter , chicken cutlets… all processed forms of poly peptide covered yesteryear flour as well as fried
  • White flour foods similar breadstuff , cornmeal , pizza , noodles , for certain pasta , as well as the like
  • Grains similar white rice as well as corn which tend to pack to a greater extent than calories as well as take hold less nutrients compared to the alternatives mentioned inward the foods to eat section
  • Cereals , tacos , burritos , wheat based tortillas , burgers , deli sandwiches , as well as other forms of junk foods
  • Refined white patato as well as rice
These are only some of the foods that you lot demand to acquire rid from your diet inward monastic say to acquire as well as remain salubrious whilst losing the weight as well as improving your overall health.

Shopping Tips for Getting Rid of Wheat as well as Other Unhealthy Foods
The telephone substitution to making this piece of work is inward beingness able to command the source from which wheat as well as other processed grains acquire into the household. The next volition acquire you lot started as well as ensure that when side yesteryear side you lot travel shopping , you lot won’t last buying whatever nutrient items with wheat as well as other gluten based foods.
  • Pay attending to the listing of ingredients at the dorsum of the pack as well as containers. Always spotter out for those with barley , rye as well as wheat. If you’re e'er inward uncertainty , hold off for the certified gluten-free products inward the market. These are guaranteed to take hold no gluten , which inward plough way , there’s no wheat.
  • Shop at the farmer’s market. The vendors at that spot tend to sell entirely organic create , whether it’s dairy , eggs , chicken , beef or grains.
  • Most breads as well as baked goods tend to comprise wheat inward 1 cast or the other. Therefore , unless they are clearly labeled as certified gluten-free , steer clear of them.
  • However if you lot absolutely can’t arrive at without breadstuff , at that spot are alternatives such as the sprouted grain bread. These take hold all the benefits of wheat without the side effects.
  • For your baking , almond , chickpeas , quinoa as well as brownish rice serve as splendid as well as healthier alternatives.
  • Also pay attending to your sauce as well as soup condiments. These tend to comprise wheat based ingredients. As much as possible , avoid seasonings containing sugar. Instead , utilisation organically grown spices , herbs , existent os broth as well as vinegar. These are confirmed wheat costless seasonings that volition improve your food’s flavors.
  • Just because you’re on the Wheat Belly Diet doesn’t hateful you lot can’t drink. You only take hold to avoid the regular beers as those tend to comprise barley or rye , which are wheat products. Instead , bask your alcohol inward the cast of whisky , wines , scotch , rum , cognac as well as brandy.
For those who recall the requirements are only also much , the goodness intelligence is that the Wheat Belly Diet is comparable to your regular depression carb diet. So , if you lot take hold been on whatever cast of depression carb diet , this shouldn’t last hard at all.

You tin give the sack yet bask delicious meals inward the cast of grilled fish , chicken soups , omelettes , stir-fries as well as many other delicious meals. To demo you lot that this is slowly , hither are few repast ideas to start working with:
  • Start the twenty-four hours with veggie smoothies , poly peptide shakes or eggs
  • For tiffin , eat a poly peptide based repast –lean chicken- with salubrious fats as well as lots of veggie salads
  • For your dinner/supper , bask some grilled fish , grass-fed beef , fruits as well as vegetables.
  • If you lot demand to snack on anything , seek repast replacement options similar smoothies , poly peptide shakes , nuts , or boiled eggs.

          How Argireline Works to Reduce Wrinkles        
Argireline is an interesting and unique peptide that, in many tests, seems to reduce the degree and severity of wrinkles on the face, and is sometimes used as a treatment against wrinkle development. Many people consider Argireline to be a good alternative to Botox.

Facial wrinkling is common as people age. Causes are physiological pathways, formation of collagen, elastin polypeptide degradation and other problems that develop in the skin. Sort, synthetic peptides have been found in many studies to decrease the formation of facial wrinkles, and many people believe that this makes them look younger.

Argireline as an ingredient is used in cosmetic products including emulsions, gels, sera and others. The dosage recommended of Argireline is five percent or more, depending on many factors including the speed of wrinkle inhibition a person desires.

Some of the items used in wrinkle inhibition in the past have had long term health risks. That was one of the reasons for the development of Argireline. Technically speaking Argireline was identified and developed for consumer use through an analysis of skin topography using adult female volunteers.

Argireline is thought by many researchers to inhibit neurotransmitter release with a potency much like other products used previously, but without the negative side effects.

What exactly is Argireline? Argireline is a hexapeptide which is six naturally occurring amino acids in combination. It contains an active ingredient of acetyl hexapeptide 3 (AH3), known as a deep penetrating and powerful amino peptide. This active ingredient assists in relaxation of the intensity and frequency of contractions of facial muscles. The result of this action is sometimes referred to as a "lifting"; feeling.

Argireline also seems to smooth skin through detour of the degeneration of collagen and elastin. Many people, which using Argireline in cream form, use it around the yes, between the eyebrows, around the mouth and on the forehead, neck and the rest of the face.

Researchers believe the results to be cumulative, and in some clinical studies a reduction in facial lines up t 17% occurred in a 15 day period, with u to 27% occurring in a 30 day period. These studies were performed with a five percent concentration of Argireline.
For more information visit: Revitol.com

Learn about the best anti aging products when you visit the Best Anti Aging Skin Products web site.
          DPE1200 Phal. braceana ‘Brown Dwarf’        
A very dark flower on a miniature plant.  The flower has a "meaty" fragrance that reminds me of a meat peptide used in orchid flasking media.  Yummm.
          Couture Eye Colour Palette - Brocade 02 (4 x 2.5g)        
Couture Eye Colour Palette - Brocade 02 (4 x 2.5g)

Couture Eye Colour Palette - Brocade 02 (4 x 2.5g)

  Embrace temptation and reignite your passion for colour. Our long lasting lipsticks love you right back with peptides and vitamins to hydrate and condition your lips. The Couture Eye Colour Compact is infused with iridescent crushed pearls for a 3D effect. Four harmonizing colors create effortless elegance. The statement metallic shade helps adds a pure impact effect. The shades in this compact palette are perfect for your to wear with a little black dress. Comes complete with a tailor-made applicator. The perfect kit for your eyes. To view the Mii Couture Eye Colour Collection Click Here To view the entire Mii Collection Click Here


          Passion Matte Lip Lover Lip Stick - Adoration (02)        
Passion Matte Lip Lover Lip Stick - Adoration (02)

Passion Matte Lip Lover Lip Stick - Adoration (02)

  Embrace temptation and reignite your passion for colour. Our long lasting lipsticks love you right back with peptides and vitamins to hydrate and condition your lips. matte yet weightless to wear, our long-lasting lipstick smooths on for a suede-soft finish. So richly pigmented, just one sweep defines your look for bold beauty. Mixed with an enriching blend of oils and waxes, it glides onto lips for long-lasting colour.. Arch your lips and apply in small sweeping strokes. For longer lasting results, blot lightly with a tissue before applying a second layer To view the Mii Passionate Lip Lover Collection Click Here To view the entire Mii Collection Click Here


          Passion Matte Lip Lover Lip Stick - Bare (01)        
Passion Matte Lip Lover Lip Stick - Bare (01)

Passion Matte Lip Lover Lip Stick - Bare (01)

  Embrace temptation and reignite your passion for colour. Our long lasting lipsticks love you right back with peptides and vitamins to hydrate and condition your lips. Moreishly matte yet weightless to wear, our long-lasting lipstick smooths on for a suede-soft finish. So richly pigmented, just one sweep defines your look for bold beauty. Mixed with an enriching blend of oils and waxes, it glides onto lips for long-lasting colour.. Arch your lips and apply in small sweeping strokes. For longer lasting results, blot lightly with a tissue before applying a second layer To view the Mii Passionate Lip Lover Collection Click Here To view the entire Mii Collection Click Here


          Passion Matte Lip Lover Lip Stick - Obsession (04)        
Passion Matte Lip Lover Lip Stick - Obsession (04)

Passion Matte Lip Lover Lip Stick - Obsession (04)

  Embrace temptation and reignite your passion for colour. Our long lasting lipsticks love you right back with peptides and vitamins to hydrate and condition your lips. matte yet weightless to wear, our long-lasting lipstick smooths on for a suede-soft finish. So richly pigmented, just one sweep defines your look for bold beauty. Mixed with an enriching blend of oils and waxes, it glides onto lips for long-lasting colour.. Arch your lips and apply in small sweeping strokes. For longer lasting results, blot lightly with a tissue before applying a second layer To view the Mii Passionate Lip Lover Collection Click Here To view the entire Mii Collection Click Here


          Passion Matte Lip Lover Lip Stick - Sassy (03)        
Passion Matte Lip Lover Lip Stick - Sassy (03)

Passion Matte Lip Lover Lip Stick - Sassy (03)

  Embrace temptation and reignite your passion for colour. Our long lasting lipsticks love you right back with peptides and vitamins to hydrate and condition your lips. matte yet weightless to wear, our long-lasting lipstick smooths on for a suede-soft finish. So richly pigmented, just one sweep defines your look for bold beauty. Mixed with an enriching blend of oils and waxes, it glides onto lips for long-lasting colour.. Arch your lips and apply in small sweeping strokes. For longer lasting results, blot lightly with a tissue before applying a second layer To view the Mii Passionate Lip Lover Collection Click Here To view the entire Mii Collection Click Here


          Passionate Lip Lover Lip Stick - Charm 13        
Passionate Lip Lover Lip Stick - Charm 13

Passionate Lip Lover Lip Stick - Charm 13

  Embrace temptation and reignite your passion for colour. Our long lasting lipsticks love you right back with peptides and vitamins to hydrate and condition your lips. A long lasting lipstick. Enriched with peptides and vitamins to help hydrate and condition your lips. Arch your lips and apply in small sweeping strokes. For longer lasting results, blot lightly with a tissue before applying a second layer To view the Mii Passionate Lip Lover Collection Click Here To view the entire Mii Collection Click Here


          Passionate Lip Lover Lip Stick - Sunblush 14        
Passionate Lip Lover Lip Stick - Sunblush 14

Passionate Lip Lover Lip Stick - Sunblush 14

  Embrace temptation and reignite your passion for colour. Our long lasting lipsticks love you right back with peptides and vitamins to hydrate and condition your lips. A long lasting lipstick. Enriched with peptides and vitamins to help hydrate and condition your lips. Arch your lips and apply in small sweeping strokes. For longer lasting results, blot lightly with a tissue before applying a second layer To view the Mii Passionate Lip Lover Collection Click Here To view the entire Mii Collection Click Here


          Passionate Lip Lover Lip Stick - Sunburst 15        
Passionate Lip Lover Lip Stick - Sunburst 15

Passionate Lip Lover Lip Stick - Sunburst 15

  Embrace temptation and reignite your passion for colour. Our long lasting lipsticks love you right back with peptides and vitamins to hydrate and condition your lips. A long lasting lipstick. Enriched with peptides and vitamins to help hydrate and condition your lips. Arch your lips and apply in small sweeping strokes. For longer lasting results, blot lightly with a tissue before applying a second layer To view the Mii Passionate Lip Lover Collection Click Here To view the entire Mii Collection Click Here


           The peptide motif of the single dominantly expressed class i molecule of the chicken MHC can explain the response to a molecular defined vaccine of infectious bursal disease virus (IBDV)         
Butter, Colin and Staines, Karen and van Hateren, Andrew and T. Fred Davison, T. Fred and Kaufman, Jim (2013) The peptide motif of the single dominantly expressed class i molecule of the chicken MHC can explain the response to a molecular defined vaccine of infectious bursal disease virus (IBDV). Immunogenetics, 65 (8). pp. 609-618. ISSN 0093-7711
           Isolation and synthesis of falcitidin, a novel myxobacterial-derived acyltetrapeptide with activity against the malaria target falcipain-2         
Somanadhan, Brinda and Kotturi, Santosh R. and Yan Leong, Chung and Glover, Robert P. and Huang, Yicun and Flotow, Horst and Buss, Antony D. and Lear, Martin J. and Butler, Mark S. (2013) Isolation and synthesis of falcitidin, a novel myxobacterial-derived acyltetrapeptide with activity against the malaria target falcipain-2. The Journal of Antibiotics, 66 (5). pp. 259-264. ISSN 0021-8820
           A novel form of bacterial resistance to the action of eukaryotic host defense peptides, the use of a lipid receptor         
Dennison, Sarah R. and Harris, Frederick and Mura, Manuela and Morton, Leslie H. G. and Zvelindovsky, Andrei and Phoenix, David A. (2013) A novel form of bacterial resistance to the action of eukaryotic host defense peptides, the use of a lipid receptor. Biochemistry, 52 (35). pp. 6021-6029. ISSN 0006-2960
           Cleaved intracellular SNARE peptides are implicated in a novel cytotoxicity mechanism of botulinum serotype C         
Arsenault, Jason and Cuijpers, Sabine A. G. and Ferrari, Enrico and Niranjan, Dhevahi and O'Brien, John A. and Davletov, Bazbek (2013) Cleaved intracellular SNARE peptides are implicated in a novel cytotoxicity mechanism of botulinum serotype C. In: 23rd American Peptide Symposium, June 22 – 27, 2013, Hilton Waikoloa Village on the Big Island of Hawai‘i.
           On-demand assembly of macromolecules used for the design and application of targeted secretion inhibitors         
Arsenault, Jason and Ferrari, Enrico and Niranjan, Dhevahi and Davletov, Bazbek (2013) On-demand assembly of macromolecules used for the design and application of targeted secretion inhibitors. In: 23rd American Peptide Symposium, June 22 – 27, 2013, Hilton Waikoloa Village on the Big Island of Hawai‘i.
           Stapling of the botulinum type A protease to growth factors and neuropeptides allows selective targeting of neuroendocrine cells         
Arsenault, Jason and Ferrari, Enrico and Niranjan, Dhevahi and Cuijpers, Sabine A. G. and Gu, Chunjing and Vallis, Yvonne and O'Brien, John and Davletov, Bazbek (2013) Stapling of the botulinum type A protease to growth factors and neuropeptides allows selective targeting of neuroendocrine cells. Journal of Neurochemistry, 126 (2). pp. 223-233. ISSN 0022-3042
          Regenepure Biotin Conditioner Review.         
Regenepure Biotin Conditioner Review.


I have pretty thick hair to begin with but since it is so long and heavy it sometimes doesn't look as voluminous as I would like. I began using this conditioner in hopes that it would help my hair look fuller especially when it is curled. I don't use it everytime I shower but just for special occasions as it really boosts the hair! Unlike traditional conditioners that you only put on your ends, this one is supposed to be massaged into the scalp and then put on the ends so it is an all over treatment. It has a very uplifting tea tree oil smell and leaves a sort of gritty texture on the hair that makes your hair more voluminous. The volume for me usually lasts until my next shower and sometimes even the shower after that. I wouldn't use it everytime because sometimes I don't want that gritty feeling on my hair. I recommend this for special occasions or if you have super fine hair that needs a boost daily.

Our Regenepure Intense Volumizing Biotin Conditioner unclogs the hair follicles while replenishing them with useful nutrients that are vital for hair growth. Similarly to our other Regenepure hair care products, our Regenepure Intense Volumizing Biotin Conditioner is free of parabens, sulfates and fragrances, making it perfect for everyday use, especially for those with color treated and Keratin treated hair. With a balanced infusion of vitamins and beneficial ingredients, Regenepure Intense Volumizing Biotin Conditioner is an excellent complement to the Regenepure DR and NT shampoos. Together, they all work to strengthen damaged hair against future breakage.

Key Ingredients: Biotin - Tea Tree Oil - Jojoba Oil - Keratin - Silk protein - Copper Peptides - Saw Palmetto





          Healing Power Of Parents' Saliva Could Actually Be Based On Science        

A new study has demonstrated the powers of human saliva, and it might give your kids a solid case for making you kiss their boo-boos each and every time they fall down.

As published in the FASEB Journal, research looked at why cuts in the mouth heal faster and quicker than ones on your skin, and found that a particular peptide (histatin-1, for those wondering) assists in the building of blood vessels, the growth of new cells, and plenty more.

As noted by CafeMom, this could mean that the saliva that transfers to your kids' cuts and scrapes might actually be helping them heal faster. Science, you're amazing!

This isn't the first time the potential healing properties of saliva have been noted. In 2008, Swedish researchers identified histatin as the component responsible for helping wounds close — this current research takes it to the next level and looks at how that happens.

There are times, however, when kissing an open wound will do more harm than good.

A note: there are times when kissing an open wound will do more harm than good, such as when someone is a carrier of a contagious, and potentially damaging virus, like herpes. It could result in an infection, and in some serious cases, death.

So though (hopefully) your kid isn't getting too many open wounds from playground bumps and scrapes, there's something to be said for getting right in there and showing them the love by kissing them better. Even if your saliva isn't a factor in making them feel better, you know your loving arms will be.

Also on HuffPost:


          Benefits Of Peptides For Any Aging Skin        
I get lots of emails from friends asking me if GenF20 Plus is the real thing and not necessarily another hoax. So I decided to taken into consideration little research session to have the ability to write this GenF20 Plus and show the pros and cons of the product, a...
          Supplements- Ginseng        
I needed a refill on a number of supplements so I decided to review my regimen and see what I'd like to modify and give a try. 


My main problem seems to be inflammation over infection so I'm going to go after that aspect and try to get better at regularly taking my items that don't go in my pill box. I'm great at taking my am/pm meds and have that routine established but it's things that should be taken at meal times, that need kept in the fridge etc I am bad about. 


Going to try ginseng so here is some info on that, thanks to my friend Tara for recommending it and getting me interested in reading. 



Active constituents found in most ginseng species include ginsenosides, polysaccharides, peptides, polyacetylenic alcohols, fatty acids and trace elements. It is generally believed that ginsenosides and their metabolites are the most important components determining the pharmacological effects of ginseng.

Ginsenosides are the thing that has the most potent affect. In an effort to standardize  and measure how much was in the different supplements they came up with a way to measure how much ginsenosides were present in these different supplements which is G115 which is what some of the studies utilized. Essentially the G115 is a standard composition that is required to have 4%ginsenosides so that you know what you are getting.

The particular study I have listed 1st below here they used G115 so if you aren’t going to use ginsana G115 name brand supplement here is the breakdown:

They used 4% @ 500mg 2x/day so……
500mg x2=1000mg * 4% = 40mg of ginsenosides

So for me I use wonder laboratories so I am going to try this Panax Ginseng http://www.wonderlabs.com/itemleft.php?itemnum=1929
500mg capsule standardized to 5% = 25mg ginsenosides x2=50mg

Ginsana used in study: http://www.ginsana.com/ingredients_ginsana.htm

Links to Studies:

medline plus information: http://www.nlm.nih.gov/medlineplus/druginfo/natural/1000.html

enhances bacterial clearance and decreases lung pathology in athymic rats with chronic P. aeruginosa pneumonia http://onlinelibrary.wiley.com/doi/10.1111/j.1699-0463.1997.tb00591.x/abstract





           Synthesis, characterisation and systematic comparison of FITC-labelled GnRH-I, -II and -III analogues on various tumour cells         
Murányi, József and Gyulavári, Pál and Varga, Attila and Bökönyi, Györgyi and Tanai, Henriette and Vántus, Tibor and Pap, Domonkos and Ludányi, Krisztina and Mező, Gábor and Kéri, György (2016) Synthesis, characterisation and systematic comparison of FITC-labelled GnRH-I, -II and -III analogues on various tumour cells. JOURNAL OF PEPTIDE SCIENCE, 22 (8). pp. 552-560. ISSN 1075-2617
          Endo Pills - 17        
Informação cientifica de ação rápida - Ano 3 N° 17

Curso de Especialização em Endocrinologia - PUC
Instituto Estadual de Diabetes e Endocrinologia Luiz Capriglione

Prof.: Luiz César Povoa (A48)
Ricardo Martins Rocha Meirelles (A38)
Editores: Claudia Pieper (A22), Isabela Bussade (A8) e Rosa Rita Santos Martins (A34).
Editores Associados: Walmir Coutinho (A22)e Edna Pottes (A35)
Composição Gráfica: Wallace Margoniner

ISÔMEROS DO ÁCIDO LINOLÉICO INIBEM ADIPOGÊNESE

As pessoas podem estar mais familiarizadas com os benefícios para a saúde dos ácidos graxos ômega-3 em peixes, como o salmão, mas o ácido linoléico conjugado, um ácido graxo ômega-6 trans encontrado em derivados de laticínios e carnes, pode também ajudar a combater doenças inflamatórias como a osteoporose e a obesidade.

Owen Kelly, Ph. D do Departamento de Nutrição da Universidade do Estado da Flórida e seus colegas investigaram se níveis fisiológicos (20µM, equivalente a 3-4 porções de laticínios) de CLA (ácido linoléico conjugado) ou uma mistura de seus isômeros dominantes cis-9, trans-11 e trans-10 beneficiariam os ossos e reduziriam a adipogênese. O grupo, liderado por Jasminka Ilich, Ph.D, usou três linhagens celulares: osteoblastos (MC3T3-E1), adipócitos (MC3T3-L1) e células-tronco estromais (ST2).

Um pôster apresentado recentemente no Encontro da Sociedade Americana para a Pesquisa dos Ossos e Minerais revelou que a combinação de 80% 9,11-CLA com 10% 10,12-CLA, os quais representam os níveis encontrados em laticínios provenientes de animais alimentados com capim, não reduziram significativamente a proliferação osteoblástica, mas o CLA isoladamente e outras misturas tinham redução significativa desta proliferação. Igualmente nos adipócitos, a proliferação foi significativamente reduzida em todas as combinações, exceto pela combinação de 90% de 9,11-CLA com 5% 10,12-CLA, a qual pode refletir os níveis encontrados em vacas alimentadas com cereais ou trigo. Nas células estromais, a proliferação apresentava tendência à queda, sugerindo que cada isômero possa influenciar vias opostas. Os pesquisadores notaram que as taxas menores de proliferação podem demonstrar que as células estão em processo de diferenciação – algo que eles estão tentando esclarecer. De qualquer forma, a proliferação de todas as três linhagens celulares apresentou uma tendência à redução em baixas concentrações de CLA; essa pesquisa sugere que a proporção dos isômeros pode ser a chave para elucidar a verdadeira função do CLA.

Como outros estudos mostraram que os benefícios do CLA para os ossos envolviam concentrações bem maiores de CLA que este estudo, os autores conjecturam que “a dieta ocidental pode não conter quantidades suficientes deste ácido graxo bioativo para promover a osteoblastogênese”.

Paula Flecher B. Schlobach (C2)


EFEITOS DO ARZOXIFENO SOBRE DENSIDADE MINERAL ÓSSEA E ENDOMÉTRIO

Na busca por mais opções para proteger e recuperar a densidade mineral óssea (DMO), especialmente em mulheres na pós menopausa, cientistas tem investigado um agonista/antagonista do estrogênio benzotiofeno, o hidrocloreto de Arzoxifeno. Um aprovado modulador seletivo do receptor de estrogênio da mesma classe, o Raloxifeno, tem sido associado a eventos tromboembólicos venosos. O ensaio Ruth em mulheres com doença cardíaca ou risco de desenvolvê-la em uso de Raloxifeno mostrou que a incidência de Acidente Vascular Cerebral (AVC) ou morte não foram aumentadas, mas que a de morte por AVC o fora. Arzoxifeno tem maior biodisponibilidade e potência como agonista estrogênico que o Raloxifeno.

Dr. Michael Bolognese e colaboradores, do Bethesda Health Research Center, testaram 20 mg/dia de Arzoxifeno com relação aos seus efeitos sobre a DMO e segurança, inclusive para o útero. Seu estudo, randomizado, duplo-cego controlado, teve duração de dois anos e envolvia 331 mulheres em pós menopausa, com idades entre 45 e 60 anos e normal ou baixa massa óssea (T-score entre – 2.5 e 0).

Comparativamente ao grupo placebo, a droga aumentou significativamente a DMO em coluna lombar (+2.9%) e bacia (+2.2%) e diminuiu os valores dos marcadores bioquímicos do metabolismo ósseo. Mulheres utilizando Arzoxifeno não apresentaram alterações ou diminuição da densidade mamária em relação ao grupo placebo e nenhum grupo apresentou hiperplasia endometrial ou carcinoma. Incidência de espessamento endometrial, pólipos uterinos, sangramento vaginal e fogachos não apresentaram diferença significativa entre os dois grupos estudados. Não houve aumento na incidência de fogachos com Arzoxifeno quando comparado ao placebo.

Entretanto, infecções fúngicas vulvovaginais ocorreram com maior freqüência no grupo utilizando Arzoxifeno. Em seu artigo publicado no JCEM (The Journal of Clinical Endocrinology & Metabolism)*, os pesquisadores disseram não haver clareza quanto ao significado daquele achado.

O financiamento de tal experimento veio de Lilly Reasearch Laboratories, os quais estão desenvolvendo o medicamento. Muitos dos pesquisadores do estudo são remunerados por Lilly. Um grande estudo está a caminho para avaliar os efeitos do Arzoxifeno sobre fraturas, câncer de mama e sua segurança.

*Bolognese M, Krege JH, Utian WH, ET AL. Effects of arzoxifene on bone mineral density and endometrium in postmenopausal women with normal or low bone mass. J Clin Endocrinol Metab.

Aline Maciel (C2)


GRELINA CAUSA OBESIDADE ABDOMINAL

A compreensão dos mecanismos reguladores da deposição de gordura inicia-se em nível celular. O volume de tecido adiposo branco expande através do aumento no número de adipócitos (adipogênese) e/ou do tamanho do adipócito. Ampliação do adipócito pode resultar de melhora da ingestão de substrato, síntese de lipídeos (lipogênese) ou redução do uso e transporte de lipídeos.

O hormônio gástrico Ghrelina é a chave para regulação do estoque de lipídeo no tecido adiposo branco. Secretado durante jejum ou restrição alimentar, ele ativa receptores dos secretagogos de hormônio do crescimento (GHS-R1a), para estimular neurônios de vias orexígenas e promover ingestão de gordura.

No entanto, estudos celulares da Ghrelina têm apresentado resultados contraditórios, provavelmente por diferentes modos de exposição e de fontes de adipócitos. Em estudo recente publicado na Molecular Endocrinology, Tim Wells, Ph.d. e colegas, da Universidade de Cardiff, no Reino Unido, demonstraram solucionar tais discrepâncias através da exploração de mecanismos celulares envolvidos no impacto da Ghrelina na adiposidade abdominal.

Os pesquisadores descobriram que Ghrelina acetilada, administrada a ratos por infusão intravenosa crônica , alterou a distribuição abdominal de gordura: tecido adiposo branco retroperitoneal e inguinal aumentaram de volume, enquanto a gordura mesentérica, epididimal e do tecido subcutâneo superficial não sofreram alteração significativa.

Diferente de seus achados recentes na medula óssea, Ghrelina não acetilada – a forma mais abundante na circulação – não influenciou na adiposidade abdominal.

Porém, Ghrelina acetilada demonstrou aumentar adipócitos abdominais, provavelmente por reduzir o transporte de lipídeos, ao invés de elevar a ingestão de substrato ou lipogênese.

Efeitos da Ghrelina na obesidade abdominal foram dependentes de GHS-R1a, porém a sensibilidade relativa de diferentes grupos não correspondeu ao nível de expressão do receptor.

Além disso, a regulação diferencial do sinal de transdução (incluindo pares de receptores com potencial de oligomerização), e/ou o controle de lipídeos, provavelmente determinou a sensibilidade individual do tecido adiposo branco dos grupos à exposição de Ghrelina.

Ghrelina acetilada também causou acúmulo de gordura no fígado, elevando o número de gotículas de lipídeos e do conteúdo de triacilglicerol, através de um mecanismo dependente de GHS-R1a.

Os pesquisadores concluíram que Ghrelina eleva a massa de tecido adiposo branco abdominal, mas somente em grupos específicos, e age via mecanismo dependente de GHS-R1a.

Assim, para se obter uma perda de gordura sustentável nesses grupos, considerando que a maioria está associada a Síndrome Metabólica, seria necessário bloqueio na sinalização da Ghrelina.

Débora Batista Araujo (R2)


EXERCÍCIOS AERÓBICOS MELHORAM A LIPÓLISE EM PORTADORAS DE SÍNDROME DOS OVÁRIOS POLICÍSTICOS.


A Síndrome dos Ovários Policísticos (SOPC) é a endocrinopatia feminina mais comum, atingindo cerca de 5%-10% das mulheres em idade reprodutiva. Esta síndrome é definida pelo excesso de androgênios (testosterona livre aumentada ou hirsutismo), pela irregularidade menstrual e pela presença de ovários policísticos.

Pesquisas recentes também relacionaram SOPC com obesidade central, resistência à insulina e hiperinsulinemia, levando as pacientes à um risco adicional de desenvolver Diabetes tipo 2 e doença cardiovascular.

A lipólise dos adipócitos desempenha um papel na resistência à insulina. Os adipócitos das mulheres portadoras de SOPC mostram múltiplos defeitos na lipólise mediada por catecolaminas. Além das catecolaminas, a Insulina e o Peptídeo Atrial natriurético (PAN) também regulam a lipólise dos adipócitos. A resistência lipolítica às catecolaminas pode ser reduzida pela perda de peso, mas não pelo tratamento com anticoncepcionais orais, indicando que outros fatores além da hiperandrogenicidade modulam a lipólise em mulheres com SOPC.

Uma equipe de pesquisa liderada pela Dr. Leanne M. Redman, Ph. D., da Pennington Biomedical Research Center (em Baton Rouge, La.) investigou se a regulação da lipólise pelo PAN; pelas catecolaminas e pela insulina eram ou não diminuídas nas mulheres com SOPC e se o treinamento aeróbico poderia reverter este efeito.

A pesquisa foi realizada com um grupo de 8 mulheres obesas, hiperandrogênicas com SOPC (idade média de 25±1 ano; IMC:32±1,6kg/m2) comparadas com o grupo controle composto por 7 mulheres (pareadas por IMC). O estudo in vivo e in vitro foi feito antes e após 16 semanas de um programa de exercícios físicos numa esteira ergométrica.

No artigo, que será publicado em breve na revista The Journal of Clinical Endocrinology & Metabolism, a equipe relata que a estimulação da lipólise pelo PAN e a supressão da mesma pela insulina eram diminuídas nas mulheres portadoras de SOPC comparadas com o grupo controle. No entanto, ambas as funções foram parcialmente recuperadas após 16 semanas de exercícios aeróbicos, independente de mudanças do peso corporal ou da dosagem de hormônios sexuais.

Os investigadores sugerem que um regime de exercícios físicos combinados com uma dieta pobre em calorias pode ser um tratamento importante para aumentar a lipólise e, o que é mais importante, estimular a perda de peso nas portadoras de SOPC.

(Moro C, Pasarica M, Elkind-Hirsch K, Redman LM. Aerobic exercise training improves atrial natriuretic peptide and catecholamine-mediated lipolysis in obese women with polycystic ovary syndrome. J Clin Endocrinol Metab, in press)

Isabel Antonia B. Castro (C2)


O UNDECANOATO DE TESTOSTERONA COMO CONTRACEPTIVO


Um novo método contraceptivo masculino está em vista, de acordo com dados recentes do maior estudo multicêntrico, até hoje, a respeito da eficácia contraceptiva hormonal masculina. Desde os anos 70, pesquisadores têm buscado a viabilidade de androgênios exógenos, tais como, testosterona, para suprimir a espermatogênese. O candidato mais bem sucedido tem sido o undecanoato de testosterona (UT) injetável (veículo oleoso), mas foram realizados poucos estudos em grande escala avaliando a sua eficácia. O Dr Now Yiqun Gu e colaboradores, do Instituto Nacional de Pesquisa para o Planejamento Familiar em Pequin-China, conduziram um estudo clínico de fase III com este composto. Eles recrutaram 1045 chineses férteis e saudáveis e administraram injeções mensais de 500 mg de UT por 30 meses, seguido por um período de recuperação de 12 meses. A equipe definiu a eficácia contraceptiva como supressão da espermatogêse que resulta em azoospermia ou oligozoospermia severa (1 x 106 /ml).

Durante os 6 primeiros meses (fase de supressão), casais usaram métodos contraceptivos de barreira e os homens coletaram amostras de sêmen nos meses 3,5 e 6. Se os homens apresentassem 2 amostras com azoospermia ou oligoospermia severa, e se o teste de gravidez de sua parceira fosse negativo, era iniciada a fase de eficácia por 24 meses, nos quais o único contraceptivo utilizado eram as injeções de UT. Na fase de recuperação, os casais utilizaram métodos contraceptivos padrão e os homens colheram amostras a cada 3 meses por 12 meses. Somente 4,8% dos participantes (n=43) não apresentaram azoospermia ou oligoospermia na fase de supressão. Houve 9 gravidezes em 1554 pessoas-ano expostas na fase de eficácia de 24 meses, para uma taxa de falha contraceptiva cumulativa abaixo de 1,1/100 homens. A espermatogênese retornou à faixa fértil normal na fase de recuperação em todos, exceto, 2 participantes.

No artigo a ser publicado no The Journal of Clinic Endocrinology Metabolism, os autores sugerem que TU pode ser uma opção de contracepção aplicável.

Lílian Grace Moura de Lucena (C2)


HORMÔNIO DE CRESCIMENTO INALATÓRIO PARA CRIANÇAS

“Crianças tratadas com hormônio de crescimento (GH) têm que lidar com o desconforto de injeções subcutâneas, o que dificulta a aderência, então pesquisadores tentaram achar métodos alternativos. Avanços na tecnologia do aerosol que quebraram o tamanho das partículas e diminuíram sua densidade e tendência para aglomerarem, ajudaram a tornar a inalação uma opção.

Estudos recentes a curto prazo em adultos mostraram que GH inalatório é seguro. Agora, uma pesquisa investigando a segurança, tolerabilidade e farmococinética do tratamento com GH inalatório em crianças têm mostrado resultados promissores.

Emily C. Walvoord, da Indiana University School of Medicine, Indianopolis, e colegas, conduziram um estudo randomizado, multicêntrico, duplo- cego, controlado com placebo com 2 fases de tratamento com duração de 1 semana cada. Eles deram a 22 pacientes, com idade de 6-16, GH inalatório (pó de somatrotofina inalatório) ou GH subcutâneo (Humatrope), trocando pela a outra forma na segunda semana. O grupo mediu o GH e o IGF-1 (insulin growth factor 1) várias vezes e assessaram a farmacocinética e farmacodinâmica usando métodos não- comportimentais. Eles também pesquisaram a função pulmonar.

A ser relatado em breve no “Journal of Clinical Endocrinology & Metabolism”, os pesquisadores relatam que a absorção do GH parece ser mais rápida após inalação, com concentração sérica máxima em 1-4 horas em comparação com 2-8 horas para GH subcutâneo. O valor relativo da bioavalibilidade para GH inalatório foi 3,5% (90%, IC:2,7- 4,4%), e a biopotência, baseada da resposta do IGF-1 foi 5,5% (IC:5,2- 5,8%). Aumentos similares dose- dependentes na área do valor médio do GH sérico abaixo da curva e mudanças no valor de base do IGF-1 ocorreram após doses inalatórias e subcutâneas.

Os autores, a maioria dos quais eram empregados de Eli Lilly e Co durante o estudo que a firma fundou, concluiu que este estudo estabeleceu que “GH administrado via pulmonar é factível em crianças”. Entretanto, eles acrescentam que permanecem dúvidas em relação à segurança em administrar GH diretamente nos pulmões.”

Letícia Mauricio Garcia Japiassú (C2)
          Endo Pills - 14        
Informação cientifica de ação rápida - Ano 3 N° 14

Curso de Especialização em Endocrinologia - PUC
Instituto Estadual de Diabetes e Endocrinologia Luiz Capriglione
Prof.: Luiz César Povoa (A48)
Ricardo Martins Rocha Meirelles (A38)
Editores: Rosa Rita Santos Martins (A34), Isabela Bussade (A8) e Denise Momesso (R2)
Editores Associados: Walmir Coutinho (A22), Edna Pottes (A35) e Claudia Pieper (A22)
Composição Gráfica: Wallace Margoniner

Prezados colegas, nesta edição do Endo Pills trazemos alguns pôsteres apresentados no ICE- International Congress of Endocrinology pelo IEDE.

O ICE foi um grande orgulho, não só para o Brasil por ter sido sede de tão importante evento, mas principalmente para o Rio de Janeiro e nossa Instituição, que teve na presidência e vice presidência Dr Amélio Godoy e Dr Ricardo Meirelles, além de participação expressiva de grande numero de staffs e alunos do IEDE, tanto como congressistas, palestrantes como nas apresentações orais e pôsteres.
Nesta edição temos a possibilidade de ver, ou rever, o excelente nível do material científico que representou nossa instituição neste importante evento.
Boa leitura a todos
Isabela Bussade

HYPERPARATHYROIDISM AFTER RADIOACTIVE IODINE THERAPY

OBJECTIVE: To describe a case of parathyroid adenoma (pa) emerging 18 years after radioactive iodine therapy (rait).

MATERIAL AND METHODS: We report a case of a patient with graves` disease who developed primary hyperparathyroidism (hpt) 18 years after rait in the endocrinology service of the IEDE.

RESULTS: AASD, 63 years-old (yo), female with a previously known history of graves` disease, first diagnosed in 1973, with ocular disease associated, when she was 25 yo. Initial therapy was with methimazol for about 3 years. First remission occurred in 1976 when she stopped her medical treatment. On follow-up there was a recurrence in 1978 when she again restarted treatment, this time with propiltiouracil. In 1979 achieved remission again. For more two times on evolution remissions and fails occurred. After the last recurrence she underwent rait with 9 mci of 131i and thus hypothyroidism developed. levotiroxin (lt4) therapy was initiated and tittered until a dose of 62,5mcg per day. in 2005 she started bilateral legs and arms pain and fatigue that worsened in 2007 when laboratorial analysis was ordered as follows: total calcium (ca) 14,1mg/dl [normal range(nr): 8,5-10,2]; phosphorus (p) 1,8mg/dl (nr: 2,8-4,1); pth: 496pg/ml (nr: 16,6-65). Medical therapy for hypercalcemia was started with saline infusion, furosemide and pamidronete but was no effective. The new dosages of ca, p and pth were respectively 14; 2, 3 and 666. An ultrasound was obtained and a nodule in the posterior aspect of the left lobe was found. A fine needle aspiration (fna) with subsequent imunohistochemical analysis showed parathyroid cells. An inferior left parathyroid was performed and demonstrated a parathyroid adenoma.

CONCLUSION: according to some authors, the rait could be a risk factor for hpt, including pa. observations indicate that not only external radiation, but also radiation from 131i is a risk factor for development of hpt and it is emphasized that age at the time of radiation treatment may be of decisive importance in this context. In a recent review of cases the average latency time to the development of hpt after rait was 13,5 ± 9,1 years. Serum calcium surveillance has been suggested for patients who have undergone rait treatment.
Warszawski L; Canton APM; Puppin BA; Novaes FS; Frota RSC; Zagury RL; Campos SC

EXHAUSTED ACROMEGALY: CASE REPORT

INTRODUCTION: Pituitary apoplexy is a rare event, particularly in functioning pituitary adenomas. Tumor size reduction may follow, but endocrine remission has been rarely described.

CASE REPORT: A case of pituitary apoplexy resulting in acromegaly endocrine remission is reported. a 37-year-old male patient was referred to the diabetes and endocrinology state institute (IEDE), presenting acromegalic phenotype, with a 15- year evolution prior to diagnosis, along with recent complaints of headache, asteny and mucous-cutaneous paleness. A computed tomography (ct) scan was performed and revealed an intrasellar hipodense mass suggestive of pituitary adenoma. One year later, the patient had clinical and laboratorial findings of panhypopituitarism and was admitted for diagnostic procedures. A magnetic resonance imaging (mri) demonstrated disappearance of the mass and empty turcic sella.

DISCUSSION: acute pituitary apoplexy is the sudden neurological breakdown that follows a fulminant expansion of the gland, caused by isquemic or haemorrhagic events. The typical clinical presentation, with marked neurological signs and symptoms, is observed in only 6 to 10% of the cases, and can be the first pituitary adenoma manifestation. In the rest of the patients, the pytuitary function is rather preserved, with moderate symptoms, such as headache. In those cases, subclinical pituitary apoplexies frequently go underdiagnosed. Depending on the amount of destruction, permanent or transient, posterior or anterior pituitary disfunction might occur. gonadotrophins deficiency is more frequent, followed by acth and tsh deficiency, and less usually, abnomal prolactin secretion. Empty sella may appear as an outcome of massive pituitary tumor infarction. a few cases of growth hormone-secreting pituitary adenoma necrosis resulting in spontaneous remission and panhypopituitarism have been described in the literature. However, the term cure is not applicable, once the definitive evolution of those cases is still unknown.

CONCLUSION: this case report is ment to raise awareness of this rarely described syndrome, which is also known as exhausted acromegaly. Furthermore, the apoplexy is generally subclinical; wich imposes an even greater diagnostic challenge. Therefore, pituitary adenoma spontaneous resolution may be more prevalent than estimated.
Warzawsky L, Costa DFP, Bragança JB, Lemos H, Sterza L, Farage M

CASE HISTORY OF COEXISTENT THYROTOXICOSIS AND JAUNDICE

OBJECTIVE: to describe the association of the rare complication of jaundice with thyrotoxicosis.

MATERIALS AND METHODS: we report the clinical and laboratory findings of a case of severe jaundice (total bilirubin levels: 52, 30 mg/dl) associated with hiperthyroidism and heart failure. We made an overview of previously published cases of c oexistent thyrotoxicosis and jaundice, methimazole- and carbimazole-induced hepatotoxicity and approach to treatment found in a medline search.

RESULTS: in a 54 year-old white woman with hyperthyroidism, treatment with methimazole 40 mg /day was initiated. One month later, scleral icterus, dark urine, fatigue and abdominal discomfort prompted discontinuation of the therapy. Laboratory findings were: alanine and aspartate aminotransferase 46 u/i (n: <31) and 87 u/i (n: <31) respectively, alkaline phosphatase 226 u/i (n: 35-104), gamma-glutamyl transpeptidase 138 iu/i (n: 7-32) and bilirubin 44 mg/di (n: <1). Abdominal ultrasonography showed normal bile ducts; echocardiography showed heart failure. Lithium therapy was applied before radioiodine therapy. She was treated with 17 mci of 131i and, persisting in hyperthyroidism, five months later received a new treatment with 25 mci of 131i. The highest values of bilirubin were found in moments of heart failure exacerbation, reaching the upper value of 52, 30 mg/dl. Resolution of the jaundice occurred after 28 weeks without methimazole.

CONCLUSION: the data strongly suggest that in this patient, the hepatic dysfunction was primarily due to hyperthyroidism observing the long time to resolution of her jaundice. It is a rare complication and h ypotheses regarding the cause of cholestasis in hyperthyroidism per se suggest that the hypermetabolic state increases the hepatic oxygen consumption without simultaneous increasing in the hepatic blood flow thus lowering the oxygen tension and interfering with bile transport. Besides, increased liver metabolism in response to thyroid hormone increases the rate of bile flow to the point of saturation. Also, there is the possibility of direct toxic effect of t4, but studies have not confirmed this. Considering her cardiovascular disorder, therapy with lithium carbonate was a useful adjunct to rai therapy to prevent exacerbation of thyrotoxicosis. Coexistent heart failure is a predisponent factor to severe jaundice in association with hyperthyroidism.
Novaes, FS; Souza, MVL; Canton, APM; Puppin, BA

REVERSIBLE PULMONARY HYPERTENSION AND RIGHT HEART FAILURE ASSOCIATED WITH HYPERTHYROIDISM.

INTRODUCTION: Hyperthyrodism may present with a variety of cardiovascular symptoms. Recent reports suggest an association between hyperthyroidism with pulmonary hypertension (ph) and isolated right heart failure. We described a case report of a ph secondary to hyperthyroidism which improved after restoration of euthyroid state.

CASE REPORT: 72 years old women presented with exertion dyspnea, fatigue, palpitation, bilateral leg edema, ascites and weight lost. Physical examination showed irregular heart beat, signs of right heart failure and no evidence of pulmonary congestion or disease. atrial fibrillation was confirmed by electrocardiogram. Echocardiogram revealed isolated right heart failure, severe tricuspid regurgitation and ph, with pulmonary artery pressure (pap) of 65 mmhg. work up for the common secondary causes of ph was negative, including, congenital intra-cardiac shunts, left-side atrial or ventricular heart disease, disorders of the respiratory system including hypoxemia and pulmonary tromboembolism, collagen vascular disease, primary portal hypertension, hiv infection, schistossoma mansoni infection, as well as ph secondary to drugs or toxins. The only concurrent illness identified was graves disease, by laboratory findings of thyrotoxicosis and positive thyroid peroxidase (tpo) autoantibody. Treatment was initiated with propylthiouracil, oral anticoagulation (because of atrial fibrillation) and diuretics. One month later, euthyroid state was achieved and there was clinical resolution of right heart failure. After one year of outpatient follow-up, an echocardiogram was performed and revealed improvement of ph, with pap of 35 mmhg, mild tricuspid regurgitation and normal right heart function.

CONCLUSION: elevated pulmonary pressure may be a frequent finding in thyrotoxicosis, but often unrecognized. It may be asymptomatic or associated with right heart failure. The exact reasons for the development of ph in thyroid disease are not clear. Most importantly, hyperthyroidism is a potential reversible cause of ph and it should be included in the etiology of secondary pulmonary hypertension.
Momesso DP; Puppin BA; Tavares P; Mattos PE; Souza MVL.

MAURIAC SYNDROME: STILL A CONCERN?

INTRODUCTION:Mauriac’s Syndrome (MS) is a rare complication of diabetes mellitus type 1 (dm1), characterized by hepatomegaly, growth failure and poor glycemic control, described mainly in children and teenagers. We present an adult female with ms.

CASE REPORT: 22 years old female with dm1 since age of 6, presenting hepatomegaly, high hba1c and variability on smbg , great elevation of liver enzymes, triglicerides (>1000 mg/dl), total cholesterol (543 mg/dl), ldlc (245 mg/dl) and hba1c (13%), modest elevation of alkaline phosphatase and normal billirubin. weight 44 kg, height 1,51m, bmi of 18,8kg/m2. ultrasound detected hepatomegaly and fatty infiltration aspect. hepatitis panel showed only hepatitis b past immunization. ceruloplasmin, ferritin, transferring saturation were normal. autoimmune hepatitis was excluded. liver biopsy showed glycogen deposits in the hepatocytes and evidence of steatohepatitis. she was treated with pioglitazone, ursodiol, genfibrozil, atorvastatin , glargine and lispro insulins. liver enzymes trended downwards as her glucose management improved, but it took 4 years to normalize.

DISCUSSION: The differential diagnosis of her liver disease included autoimmune hepatitis, acute hepatitis, wilson`s disease and hemochromatosis, which were excluded. Her signs and symptoms could be explained by ms: hepatomegaly, glycogen infiltration of the liver and short stature in people with poorly controlled diabetes. hypertriglyceridemia is due to poor glycemic control and ms. steatosis and glycogenosis should be distinguished by histology. Whereas steatosis may progress to fibrosis and cirrhosis, glycogenosis does not. Liver biopsy, on this case, showed both glycogenosis and steatohepatitis. The better glycemic control reverted liver enzymes alterations and hepatomegaly, suggesting that the major component of hepatic disease was glycogenosis. Other medications, such as pioglitazone, might have collaborated to improvement.

CONCLUSION: even though ms has become rare, it should be considered not only in children, but also in adults with dm1, acute hepatomegaly and abnormal liver function. The diagnosis is important because prolonged improvement of hba1c can normalize liver function, hypertriglyceridemia and also prevent dm1 acute and chronic complications.

Kupfer R, Farage M, Costa DFP, Bragança JB, Sterza L, Lemos H - IEDE

ATIPICAL PROGRESSION OF GRAVES´ ORBITOPATHY AFTER THYROID RESSECTION.

INTRODUCTION: Thyroid eye disease (ted), the most frequent extrathyroidal manifestation of graves` disease, is an auto-immune disorder. It can occur before, concomitantly or after hyperthyroidism. Different forms of treatments for thyrotoxicosis can influence the ted course. thyroidectomy should be theoretically more beneficial to graves` orbitopathy outcome because of the removal of the source of both thyroid- orbit cross reaction auto antigens and auto reactive t lymphocytes.

CASE REPORT: A 58 years old women presented with graves disease and was initially treated with thionamides for two years. At the diagnosis she had only mild left exophthalmos and no eye complaint. Subsequently, thyroid resection was indicated as a result of goiter enlargement, development of nodules and compressive symptoms. euthyroid state was achieved. Four months after surgery, progression of orbitopathy was observed. She developed ocular manifestations like pain on eye movement, eyelid edema, conjunctival injection, double vision and bilateral exophthalmos. Orbital radiotherapy and intravenous glucocorticoids used in combination improved her eye disease.

DISCUSSION: According to literature, thionamides are associated with improve or does no affect the course of ted. The relationship between radioiodine therapy and ted is a matter of controversy. The few randomized and controlled studies available, suggest a small but definitive risk of causing ted progression, but can be prevented by concomitant glucocorticoids. The effect of thyroid surgery on ted has been extensively reported in the literature, and the reports usually advocate thyroid resection as an important treatment to improve eye disease. We described a case in which ted occurred after surgery, despite the removal of the source of autoantigens and the control of thyroid function. This observation suggests that the choice of treatment for thyrotoxicosis may not influence ted outcome.

CONCLUSION: Graves´ orbitopathy pathogenesis and natural history may involve several different mechanisms which have still to be more deeply studied. Most importantly, ted might have a clinical course independent of thyroid disease and type of treatment.
Puppin, BA; Momesso, DP; Satake, F; Canton, AP; Souza, MVL.

TYPE 1 DIABETES MELLITUS AND MYASTHENIA GRAVIS: ASSOCIATION OR COINCIDENCE?

INTRODUCTION: Autoimmune diseases often coexist in clinical practice and may be associated with autoimmune polyendocrine syndrome (aps). the diagnosis of aps should be suspected in the natural history of any autoimmune disease.

CASE REPORT: 25 year-old woman, presented with muscle weakness and dysarthria that increased during periods of activity. Myasthenia gravis was diagnosed and treatment with pyridostigmine and prednisone was started. After 2 weeks, she developed blurred vision, polydipsia, polyuria, vaginal pruritus and was admitted in our hospital with non-ketotic hyperglycemia. Laboratory evaluation: glycemia=1374mg/dl, c peptide=5.1ng/ml (1.1–5.0), anti-insulin antibody (ab) =3.0u/ml (<1.0), anti-gad ab=1.0u/ml (<1.0), anti-islets ab=1.1u/ml (<1.0), anti-acetylcholine receptor ab=9.02nmol/l (<0.15), anti-peroxidase<20 ui/ml (<40). Subcutaneous rapid insulin, then nph, was started. She was discharged in use of nph 28 + 12 ui, rapid insulin before meals according to scale and pyridostigmine. At the outpatient clinic, adequate metabolic control was achieved (hba1c=5%) with low doses of insulin (0.2u/kg/day) and the posterior laboratory evaluation showed positive anti-gad ab=9.6u/ml and normal c peptide level=1.7ng/ml. After 2 years, she developed polydipsia, polyuria, nausea, vomiting and hyperglycemia, hba1c was 10.7% and it was necessary to increase insulin doses. A morning plasma cortisol of 22mcg/dl excluded adrenal insufficiency.

DISCUSSION: Screening of serological organ-specific autoantibodies identifies patients who may develop autoimmune polyendocrinopathies. aps type ii involves the coexistance of addison´s disease with type 1 diabetes mellitus (dm) and/or autoimmune thyroid disease. Some patients also present with, or later develop other organ-specific autoimmune disorders, including myasthenia gravis. This patient presented with myasthenia gravis and type 1 dm. at the moment, there is no evidence of adrenal insufficiency in order to diagnose aps ii, but in up to 30% of patients dm1 is diagnosed before adrenal insufficiency.

CONCLUSION: Patients with endocrine autoimmune diseases should be screened for the presence of APS.
Lima GAB, Mattos PE, Tavares P, Momesso DP, Henriques RP, Kupfer R.

GLYBURIDE INDUCED CUTANEOUS VASCULITIS

OBJECTIVE: To describe a case of cutaneous vasculitis glyburide induced and to discuss its frequency, clinical, pathophisiological and histological issues.

materials and methods- 51 year’s old male with long standing type 2 diabetes mellitus admitted as an inpatient to our hospital with an itching cutaneous rash, fever, polyartalgia, malaise and edema of the upper and lower limbs. He related a recent onset of glyburide use two weeks before presentation. He denied use of other medications. On physical examination there was a generalized cutaneous discamation with exulcerations and fissure associated. Superior and inferior limbs edema, bilateral cervical, mandibular and inguinal adenopathy was also seen.he had right superior quadrant tenderness and hepatomegaly on abdominal palpation. glyburide was then discontinued and intensive insulin therapy was started. Laboratory analysis was ordered to check wbc, rbc, platelet count, erythrocyte sedimentation rate (esr), alt, ast, sodium, potassium, urea, creatinin, glucose and a skin biopsy.

RESULTS: The exams revealed an normocitic and normochromic anemia, esr elevation with normal liver tests. The skin biopsy showed a difuse mononuclear inflammatory infiltration with eosinophils within it. thickness of capilar walls and extravasation of hematias suggestive of drug induced vasculitis. eight days after drug withdrawal, anti-hystaminic oral therapy and topical corticosteroids the patient underwent a complete resolution of the lesions and was discharged to our outpatient clinic.

CONCLUSION: After extensive medical literature research on the major journals of the area we have found only a few case reports similar to this one. Over a clinical point of view we can classificate this picture as a pharmacodermia probably glyburide induced. The physiopathology is centered on the immune complex deposition due to chronic exposition to the drug itself or its radicals so eventually cross reaction is seen with sulfonamides antibiotics. The hystopathologic analysis confirms the clinical hypothesis as drug induced cutaneous vasculitis. The clinical manifestations can be restricted to the skin but in some cases as it was in the case described above systemic involvement is seen denoting a more severe form. cutaneous parefects of glyburide are rarely seen although once its wast use its real incidence maybe higher than described on literature.

Rosane Kupfer, Maria Teresa Menegat, Rosana Leal Santos, Roberto Zagury, Roberta Frota, Ronei Gustavo Paim de Vargas.
           The role of C-terminal amidation in the membrane interactions of the anionic antimicrobial peptide, maximin H5         
Dennison, Sarah R. and Mura, Manuela and Harris, Frederick and Morton, Leslie H. G. and Zvelindovsky, Andrei and Phoenix, David A. (2015) The role of C-terminal amidation in the membrane interactions of the anionic antimicrobial peptide, maximin H5. Biochimica et Biophysica Acta - Biomembranes, 1848 (5). pp. 1111-1118. ISSN 0005-2736
          Lion’s Mane        

Picture of Lions Mane Mushroom

Lions Mane Mushroom Lion's Mane Mushroom Benefits Lion's mane mushroom is a medicinal mushroom. It has been used for centuries in traditional Chinese medicine as a brain tonic and as a treatment for many health conditions. This mushroom is known to boost the strength of the immune system, helping your body to fight off sickness and stay healthy. It is also good for digestive and colon health, as it contains beta glucan polysaccharides, polypeptides and fatty acids. Lion's..... Read more

Original Article Source: Herbs List - A Comprehensive List Of Herbs and Their Health Benefits


          Os Mais Amados de Abril e Maio        
Estes últimos meses têm sido complicados e com imenso trabalho, o que se reflecte aqui no blog, os posts são mais espaçados, mas não podia deixar de falar dos meus produtos mais amados.
Juntei portanto os favoritos dos últimos dois meses...


NUXE Nuxellence Zone Regard - Um creme de olhos especial para o dia, contém três extractos de flores patenteados que protegem, fortalecem e melhoram a estrutura da pele, promete fazer desaparecer linhas finas, vermelhidão e olheiras. Mas enquanto isso, este creme tem dois factores que adoro, tem uma tonalidade amarelada ideal para corrigir a olheira e a sua textura é tipo primer, deixando a pele com um efeito "blur" luminoso. Além disso tem um aplicador arredondado metálico ideal para descongestionar os papos.
PVP 45€ Farmácias, Parafarmácias e ONLINE

The Ordinary Buffet Serum - Confesso que não tinha muitas esperanças de ver grandes resultados com este sérum tão baratinho, mas enganei-me redondamente, é fantástico!
Como diz o nome é um Buffet de coisas boas para a nossa pele para o combate ao envelhecimento. 
É um concentrado de vários péptidos, aminoácidos, ácido hialurónico e um complexo probiótico que ajudam a uma pele mais hidratada, firme, luminosa e lisa! Promete e faz, em poucas semanas começamos a notar resultados. 
PVP 15€ ONLINE

Estée Lauder Double Wear Light - Uma base de longa duração, textura leve, cobertura média que deixa a pele com um aspecto super natural e confortável ao longo do dia. 
Controla a oleosidade, não transfere e não derrete mesmo em situações de humidade. Fiquei maravilhada com esta base, não sei como não experimentei mais cedo, perfeita para o Verão!
PVP 40€ Perfumarias e ONLINE

La Roche-Posay Serozinc - É um produto de culto internacional, é adstringente e seborregulador, mas ao mesmo tempo hidratante, calmante, suavizante e refrescante.
É recomendado para pele mista, oleosa e/ou com tendência acneica, mas também pode ser utilizado como bruma hidratante por todos os tipos de pele, antes da aplicação da rotina de hidratação.
A sua fórmula contém apenas água termal, cloreto de sódio (0,75%) e sulfato de zinco (0,10%).
Comecei a adicionar este spray depois do tónico e antes da hidratação (sérum, creme), depois de alguns meses (desde Janeiro) a utilizar, comecei agora a segunda embalagem e já posso dizer que realmente vale a pena, a oleosidade na zona T está muito mais controlada sem sentir nenhum tipo de sensação de secura ou sensibilidade como alguns produtos para estes problemas costumam causar. Também senti uma redução enorme das borbulhas ocasionais.
PVP 9€ Farmácias, Parafarmácias e ONLINE


          STRUKTUR DAN FUNGSI AMNION        
BAB I PENDAHULUAN A. Latar belakang Cairan amnion mempunyai peran penting dalam proses kehamilan dan persalinan. Di sepanjang kehamilan normal. Kompartemen dari cairan amnion menyediakan ruangan untuk janin untuk tumbuh bergerak dan berkembang. Tanpa cairan amnion rahim akan mengerut dan menekan janin. Menjelang pertengahan kehamilan cairan amnion menjadi semakin penting untuk petumbuhan dan perkembangan janin , antara lain perkembangan paru-parunya. Bila tidak ada cairan amnion yang memadai selama pertengahan kehamilan janin akan sering di sertai hippolasia paru dan berlanjut pada kematian. Selain itu cairan amnion juga mempunyai peran protektif pada janin. Cairan ini mengandung agen-agen bakteri dan bekerja menghambat pertumbuhan bakteri yang memiliki potensi patogen. Cairan amnion juga berperan sebagai sarana komunikasi anatara janin dan Ibu dan juga dapat digunakan sebagai alat diagnostik untuk melihat adanya kelainan-kelaianan pada proses pertumbuhan dan perkembagan janin.dengan melakukan kultur sel atau melakukan spektrometer. Jadi cairan amniom memegang peran penting dalan proses kehamilan dan persalinan. B. Tujuan penulisan - Di harapkan kami mampu menjelasken tentang struktur fungsi amnion - Mengetahui pentingnya cairan amnion bagi janin - Mengetahui fungsi cairan amnion 1 BAB II PEMBAHASAN A. Pengertian Cairan ketuban adalah cairan yang ada di dalam kantung amnion. Cairan ini dihasilkan selaput ketuban dan diduga dibentuk oleh sel-sel amnion, ditambah air kencing janin, serta cairan otak pada anensefalus. Cairan ketuban adalah cairan yang ada di dalam kantung amnion. Cairan ini dihasilkan selaput ketuban dan diduga dibentuk oleh sel-sel amnion, ditambah air kencing janin, serta cairan otak pada anensefalus. Asal cairan amnion : diperkirakan terutama disekresi oleh dinding selaput amnion / plasenta, kemudian setelah sistem urinarius janin terbentuk, urine janin yang diproduksi juga dikeluarkan ke dalam rongga amnion. B. Struktur cairan amnion Mula – mula ruangan amnion merupakan rongga kecil saja, kemudian mengelilingi seluruh janin ruang amnion berisi air ketuban. Amnion ikut membentuk selaput janin yang terdiri dari = lapisan amnion, mesoderm, chorion, dan lapisan tipis dari decidua. Ruang amnion berisi 1 – 1,5 LT air ketuban dan banyaknya kadang – kadang sangat berbeda yaitu : – Mgg ke 36 = 1030 cc – Mgg ke 40 = 790 cc – Mgg ke 43 = 240 cc Air ketuban terdiri dari 23% bahan organik (protein, vernix caseosa, lanugo, zat lemak, lesitin & spingomielin), 97% - 98% bahan anorganik (air, garam yang larut dalam air). Keadaan normal cairan amnion : 1. pada usia kehamilan cukup bulan, volume 1000-1500 cc. 2. keadaan jernih agak keruh 3. steril 4. bau khas, agak manis dan amis 2 5. terdiri dari 98-99% air, 1-2% garam-garam anorganik dan bahan organik (protein terutama albumin), runtuhan rambut lanugo, vernix caseosa dan sel-sel epitel. 6. sirkulasi sekitar 500 cc/jam Cairan amnion terkandun zat-zat seperti : 1. Prolaktin Prolaktin di dapatkan dalam konsentrasi tinggi di dalam cairan amnion , jumlahnya bisa mencapai 10.000 ng/ml, yang bisa di temukan pada minggu ke 20 – 26 kehamilan. Beberapa penelitian membuktikan bahwa desidua merupakan tempat sintesa prolaktin yang berada dalam cairan amnion. Fungsi frolaktin dalam cairan amnion belum di ketahui secara pasti , tetapi beberapa peneliti berkesimpulan prolaktin dalam cairan amnion berfungsi memperbaiki transfer cairan dari janin ke Ibu, dan menyediakan cairan ekstraseluler serta memepertahankan janin dari dehidrasi selama kehamilan lanjut ketika cairan amnion bersifat hipotonik. 2. Lesitin – sphingomyelin Letisin merupakan suatu unsur yang penting dalam formasi dan stabilisasi dari lapisan surfaktan , yang mempertahankan alveolar dari kolaps dan respiratori distress. Jika konsentrasi letisin dalam cairan amnion lebih 2x kadarnya maka menunjukan resiko terjadinya gawat nafas sangat rendah, begitupun sebaliknya bila kadar letisin rendah maka kemungkinan terjadinya gawat nafas pada janin meningkat. C. Fungsi cairan amnion Cairan amnion merupakan komponen penting bagi pertumbuhan dan perkembangan janin selama kehamilan. Pada awal embryogenesis, amnion merupakan perpanjangan dari matriks ekstraseluler dan di sana terjadi difusi dua arah antara janin dan cairan amnion. Pada usia kehamilan 8 minggu, terbentuk uretra dan ginjal janin mulai memproduksi urin. Selanjutnya janin mulai bisa menelan. Eksresi dari urin, sistem pernafasan, sistem digestivus, tali pusat dan permukaan plasenta menjadi sumber dari cairan amnion. Telah diketahui bahwa cairan amnion berfungsi sebagai kantong pelindung di sekitar janin yang memberikan ruang bagi janin untuk bergerak, tumbuh meratakan tekanan uterus pada partus, dan mencegah trauma mekanik dan trauma termal. 3 Cairan amnion juga berperan dalam sistem imun bawaan karena memiliki peptid antimikrobial terhadap beberapa jenis bakteri dan fungi patogen tertentu. Cairan amnion adalah 98% air dan elektrolit, protein , peptide, hormon, karbohidrat, dan lipid. Pada beberapa penelitian, komponen-komponen cairan amnion ditemukan memiliki fungsi sebagai biomarker potensial bagi abnormalitas-abnormalitas dalam kehamilan. Beberapa tahun belakangan, sejumlah protein dan peptide pada cairan amnion diketahui sebagai faktor pertumbuhan atau sitokin, dimana kadarnya akan berubah-ubah sesuai dengan usia kehamilan. Cairan amnion juga diduga memiliki potensi dalam pengembangan medikasi stem cell . Ditinjau dari fungsinya, cairan ini sangat penting untuk melindungi pertumbuhan dan perkembangan janin, yaitu : • menjadi bantalan untuk melindungi janin terhadap trauma dari luar • untuk proteksi janin • menstabilkan perubahan suhu • pertukaran cairan • sarana yang memungkinkan janin bergerak bebas • mengatur tekanan dalam rahim • berfungsi menjamin kecukupan nutrisi dan oksigen untuk si janin • air ketuban juga berfungsi melindungi janin dari infeksi Air ketuban digunakan sebagai bahan penelitian untuk : – Menentukan jenis kelamin (amniocentesis) – Kematangan paru – paru janin – Golongan darah – Faktor rhesus  Fungsi cairan amnion  Saat hamil • Memberikan kesempatan berkembangmya janin dengan bebas dan kesegala arah • Menyebarkan tekanan bila terjadi trauma langsung • Sebagai penyanggah terhadap panas dan dingin • Menghindari trauma langsung terhadap janin 4  Saat persalinan (inpartu) • Menyebarkan kekuatan his sehingga serviks dapat membuka • Membersihkan jalan lahir karena mempunyai kemampuan sebagai desinfektan • Sebagai pelicin saat persalinan
          Scientist, Mass Spectrometry - Eurofins Advantar Inc. - San Diego, CA        
Peptide mapping (sequence confirmation, PTM, ID, degradation) by LC-MS/MS ,. Eurofins Advantar Laboratories, Inc is searching for a Scientist - Mass...
From Lancaster Laboratories - Thu, 03 Aug 2017 07:30:48 GMT - View all San Diego, CA jobs
          Two theories of life's origins        
Two distinct theoretical approaches have emerged in the quest for explanations concerning the origins of life. One school of thought subscribes to the idea that metabolism predated genetics. The main proponent of this theory is Dr. Günter Wächtershäuser, a chemist by training, and now a patent lawyer in Munich.

anaerobic methanogens - archaea

Dr. Wächtershäuser thinks that life on Earth had hydrothermal origins, - i.e., probably near deep hydrothermal vents on the ocean floor. Metabolism by this reckoning involves the evolution of progressively complex chemical reactions ultimately yielding life out of primitive energy exchange mechanisms in a cyclic process. This process of evolutionary development has come to be known as the iron-sulfur world theory.

The iron-sulfur recipe described by Wächtershäuser can be summed up by the following: bring water to a boil and stir in iron sulfide and nickel sulfide. Mix in carbon monoxide and hydrogen sulfide gas, and then wait for the amino acids to convert into peptides.

In 1997, Wächtershäuser and Claudia Huber actually performed the experiments and successfully produced peptides by mixing carbon monoxide, hydrogen sulfide, nickel sulfide, and iron sulfide particles at 100°C. In 2006 the two collaborators produced glycine, alanine and serine from a similar mixture. These are simple amino acids found in proteins. Potassium cyanide was their source of nitrogen.

A clear description of a proto-ecological system exists, from the establishment of the catalytic environment consisting of micro scale caverns coated by thin membranous metal sulfide walls up to the synthesis of the lipid membrane which finalizes the creation of a true living cellular organism capable of escaping the confines of the alkaline hydrothermal vent environment. The condition of the “life form” up to the evolution of the lipid cell walls represents the “Last Universal Common Ancestor” (LUCA).

RNA world hypothesis is the title given to the other explanation for how life began. In this scenario, RNA predates the emergence of DNA-based life – i.e., genetics before metabolism. The logic in this theory lies in the fact that RNA can act as both a storage mechanism and a catalyst. The thinking is that ribosomal RNA, which catalyzes protein production, is the evolutionary remnant of the RNA world.

Some adherents to the theory suggest that pre-RNA nucleic acids, which manifest in the pre-biotic environment, were the first types of nucleic acids to emerge as a self-reproducing molecule. Among the candidates are peptide nucleic acid (PNA), threose nucleic acid (TNA), and glycerol nucleic acid (GNA), all of which are similar to RNA but for their backbones, which are not composed of the ribose sugars that comprise RNA. For example, TNA is composed of repeating threose units linked by phosphodiester bonds. These molecules do not occur in the natural conditions of today's Earth.

What encourages RNA world hypotheses is the fact that short RNA molecules with self-replicating properties have been synthesized in the lab. What discourages the theory is that stable pre-biotic conditions would have to exist which encourage the proliferation of self-reproducing RNA-like analogs. This includes the ability of these molecules to have been capable of independent life in an environment dense with sugar-phosphate molecules.

The iron-sulfur world theory is very compelling. It is likely that both processes occurred in the earliest stages of the emergence of living organisms, with the RNA world only a phase predated by the iron-sulfur world.

That is not to say that other conditions cannot bring about the beginnings of primitive life forms. In an earlier post, I noted Carl Sagan's description of a prebiotic Earth, and that they were very much the same as those which currently exist on the moon Titan, around the planet Saturn. It wouldn't surprise me in the least if some type of methanogen were periodically struggling to emerge there.

Whichever of the two theories of life's origins holds sway, the fact remains that they are both integral to a theory of origins based on anthropic reasoning, which yet remains uncomfortably lodged in the realm of philosophy more so than in true science. However, one can't deny that life is determined to emerge, however it comes about.

           G-protein-coupled receptors for peptide hormones in yeast         
UNSPECIFIED (1997) G-protein-coupled receptors for peptide hormones in yeast. In: Symposium on Xanthine Oxidase - Enzymology and Pathophysiology, at the 661st Meeting of the Biochemical-Society, BATH, ENGLAND, APR 10-11, 1997. Published in: BIOCHEMICAL SOCIETY TRANSACTIONS, 25 (3). pp. 1015-1021.
          Biopharmaceutical Potential of ACEInhibitory Peptides        
Praveen P Balgir and Maleeka Sharma
          Mass Spectrometry Characterization of a Novel Insulin Mimetic Peptide s597        
Natalia Mesonzhnik, Grigory Krotov and Svetlana Appolonova
          Immunoinformatics Prediction of PeptideBased Vaccine Against AfricanHorse Sickness Virus        
Malaz Abdelbagi, Tarteel Hassan, Mohammed Shihabeldin, Sanaa Bashir, Elkhaleel Ahmed, Elmoez Mohamed, Shawgi Hafiz, Abdah Abdelmonim, Tassneem Hamid, Shimaa Awad, Ahmed Hamdi, Khoubieb Ali and Mohammed A Hassan
          Prediction and Conservancy Analysis of Multiepitope Based PeptideVaccine Against Merkel Cell Polyomavirus An ImmunoinformaticsApproach        
Mawadda AbdElraheem AwadElkareem, Soada Ahmed Osman, Hanaa Abdalla Mohamed, Hadeel AbdElrahman Hassan, Ahmed Hamdi Abuharaz, Khoubieb Ali Abdelrahman and Mohamed Ahmed Salih
           Pathway specificity for a Delta pH-dependent precursor thylakoid lumen protein is governed by a 'Sec-avoidance' motif in the transfer peptide and a 'Sec-incompatible' mature protein         
UNSPECIFIED. (1997) Pathway specificity for a Delta pH-dependent precursor thylakoid lumen protein is governed by a 'Sec-avoidance' motif in the transfer peptide and a 'Sec-incompatible' mature protein. EMBO JOURNAL, 16 (13). pp. 3851-3859. ISSN 0261-4189
           Unusual characteristics of amino-terminal and hydrophobic domains in nuclear-encoded thylakoid signal peptides         
UNSPECIFIED. (1997) Unusual characteristics of amino-terminal and hydrophobic domains in nuclear-encoded thylakoid signal peptides. EUROPEAN JOURNAL OF BIOCHEMISTRY, 245 (2). pp. 340-348. ISSN 0014-2956
           A mechanism for the loss of 60 u from peptides containing an arginine residue at the C-terminus         
UNSPECIFIED. (1997) A mechanism for the loss of 60 u from peptides containing an arginine residue at the C-terminus. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 8 (3). pp. 253-261. ISSN 1044-0305
          â€˜If You Hemorrhage, Don’t Clean Up’: Advice From Mothers Who Almost Died        

This story was co-published with NPR.

Four days after Marie McCausland delivered her first child in May, she knew something was very wrong. She had intense pain in her upper chest, her blood pressure was rising, and she was so swollen that she barely recognized herself in the mirror. As she curled up in bed that evening, a scary thought flickered through her exhausted brain: “If I go to sleep right now, I don’t know if I'm gonna be waking up.”

What she didn’t have was good information about what might be wrong. The discharge materials the hospital sent her home with were vague and confusing — “really quite useless,” she said. Then she remembered a ProPublica/NPR story she’d recently read about a New Jersey nurse who died soon after childbirth. Lauren Bloomstein had developed severe preeclampsia, a dangerous type of hypertension that often happens during the second half of her pregnancy. But it can also emerge after the baby is delivered, when it is often overlooked — accounting for dozens of maternal deaths a year. McCausland realized that she might have preeclampsia, too.

The 27-year-old molecular virologist and her husband bundled up their newborn son and raced to the nearest emergency room in Cleveland. But the ER doctor told her that she was feeling normal postpartum symptoms, she said. Even as her blood pressure hovered at perilous heights, he wanted to send her home. Several hours passed before he consulted with an OB-GYN at another hospital and McCausland’s severe preeclampsia was treated with magnesium sulfate to prevent seizures. Without Bloomstein’s story as a warning, McCausland doubts she would have recognized her symptoms or persisted in the face of the ER doctor’s dismissiveness. “I had just come home with the baby and really didn’t want to go back to the hospital. I think I probably would have just wrote it off.” In that case, she added, “I don't know if I'd be here. I really don't.”

McCausland’s experience is far from unique. In the months since ProPublica and NPR launched our project about maternal deaths and near-deaths in the U.S., we’ve heard from 3,100 women who endured life-threatening pregnancy and childbirth complications, often suffering long-lasting physical and emotional effects. (Tell us your story.)

The same themes that run though McCausland’s story echo through many of these survivors’ recollections. They frequently told us they knew little to nothing beforehand about the complications that nearly killed them. Even when the women were convinced something was terribly amiss, doctors and nurses were sometimes slow to believe them. Mothers especially lacked information about risks in the postpartum period, when medical care is often disjointed or difficult to access and the baby is the focus of attention. “Every single nurse, pediatrician, and lactation consultant dismissed my concerns as hormones and anxiety,” wrote Emily McLaughlin, who suffered a stroke and other complications after giving birth in Connecticut in 2015.

These survivors make up an important, and largely untapped, source of knowledge about the dangers that expectant and new mothers may face — and how to avoid disaster. Every day in the U.S., two to three women die from pregnancy- or childbirth-related causes, including preeclampsia, hemorrhage, infection, blood clots and cardiac problems — the highest rate of maternal mortality among wealthy nations. As many as 60 percent of these deaths are preventable, a new report suggests; more than half occur after delivery. (See our story on the lost mothers of 2016.) Each day, another 175 women suffer complications severe enough to require major medical intervention such as massive transfusions, emergency surgery or admission to an intensive care unit — equivalent to about 65,000 close calls annually, according to the Centers for Disease Control and Prevention.

Hospitals, medical organizations and maternal safety groups are introducing a host of initiatives aimed at educating expectant and new mothers and improving how providers respond to emergencies. But as McCausland’s experience illustrates, self-advocacy is also critically important.

We asked survivors: What can people do to ensure that what happened to Lauren Bloomstein doesn‘t happen to them or their loved ones? How can they help prevent situations like Marie McCausland’s from spiraling out of control? What do they wish they had known ahead of their severe complications? What made a difference in their recovery? How did they get medical professionals to listen? Here is a selection of their insights, in their own words.


Choosing a Provider

“A lot of data on specific doctors and hospitals can be found publicly. Knowing how your physician and hospital rates as compared to others (cesarean rates, infection rates, readmission rates) can give you valuable insight into how they perform. ‘Liking’ your doctor as a person is nice, but not nearly as important as their and their facility’s culture and track record.”

— Kristen Terlizzi, 35, survivor of placenta accreta (a disorder in which the placenta grows into or through the uterine wall) in 2014 and cofounder of the National Accreta Foundation

“Key pieces of information every woman should know before choosing a hospital are: What are their safety protocols for adverse maternal events? No one likes to think about this while pregnant, and providers will probably tell you that it’s unlikely to happen. But it does happen and it’s good to know that the hospital and providers have practiced for such scenarios and have proper protocols in place.”

— Marianne Drexler, 39, survived a hemorrhage and emergency hysterectomy in 2014

“Ask your doctors if they have ever experienced a case of an amniotic fluid embolism [an abnormal response to amniotic fluid entering the mother’s bloodstream] or other severe event themselves. If a birthing center is your choice, discuss what happens in an emergency — how far away is the closest hospital with an ICU? Because a lot of hospitals don’t have them. Another thing many women don’t realize is that not every hospital has an obstetrician there 24/7. Ask your doctors: If they’re not able to be there the whole time you’re in labor, will there be another ob/gyn on site 24 hours a day if something goes wrong?”

— Miranda Klassen, 41, survivor of amniotic fluid embolism in 2008 and founder/executive director of the Amniotic Fluid Embolism Foundation

“While my doctor was amazing, we live in a smaller town and they don’t carry enough blood/platelets on hand for very emergent situations. They have patients shipped to larger hospitals when they need more care. Had I been aware of that we would have decided to deliver at a larger hospital so in case something happened to me or our daughter we wouldn’t be separated, which we were when I was life-flighted out.”

— Kristina Landrus, 26, survived a hemorrhage in 2013

“My best advice for getting a medical professional to listen is to keep searching for one that is willing to listen. Because of my insurance and personal circumstances at the time I felt I had no option but to take whoever my providers [assigned] me, despite several red flags even before my delivery. I was not aware of my right to change providers until it was too late.”

— Joy Huff, 39, survived a blood infection in 2013


Preparing for an Emergency

“A conversation about possible things that could go wrong is prudent to have with your doctor or in one of these childbirth classes. I don’t think that it needs to be done in a way to terrify the new parents, but as a way to provide knowledge. The pregnant woman should be taught warning signs, and know when to speak up so that she can be treated as quickly and accurately as possible.”

— Susan Lewis, 33, survived multiple blood clots and severe hemorrhage in 2016

“Always have somebody with you in a medical setting to ask the questions you might not think of and to advocate on your behalf if your ability to communicate is compromised by being in poor health. … And get emotional support to steel you against the naysayers. It may feel really unnatural or difficult to push back [against doctors and nurses]. Online forums and Facebook groups can be helpful to ensure you’re not losing your mind.”

— Eleni Tsigas, survivor of preeclampsia in 1998 and 1999 and executive director of the Preeclampsia Foundation

“Know your rights. Know what kind of decisions you might have to make and what you want to do before you go. Doctors and nurses are there to make quick decisions, they’re not worried about how you will feel about it afterward. They are worried about a lawsuit, whether they can get you stable quickly so they can move on. I’m not saying they are heartless, far from it. My mother is a nurse, I know what sort of heart goes into that profession. But they have a lot to do and a lot to worry about, your feelings are not at the top of that list. At least not as far as they are concerned in the moment.”

— Carrie Anthony, 36, survived two pregnancies with placenta accreta and hemorrhage in 2008 and 2015

“It isn’t just important to know how you feel about blood transfusions and life-saving measures — you have to communicate these things to your spouse or family member. I was given six blood transfusions, but I was barely conscious when asked if I wanted them. Of course, I wanted any life-saving measures, but my husband should have been consulted, given that I was not of a clear mind.”

— Rachel Stuhler, 36, survived a hemorrhage in 2017

“In case you ever are unable to respond, someone needs to step in and be your voice! Know as much thorough medical history as possible, and let your spouse or support person know [in depth] your history as well.”

— Kristina Landrus

“Also be sure your spouse and your other family members, like your parents or siblings, are on the same page about your care. And if you aren’t married, who will be making the decisions on your behalf? You should put things in order, designate the person who will be the decision maker, and give that person power of attorney. Other important things to have are a medical directive or a living will — be sure to bring a copy with you to the hospital. I also recommend packing a journal to record everything that happens.”

— Miranda Klassen

“Make a list of your questions and make sure you get the full answer. I went to every appointment the second time around with a notebook. I would apologize for being ‘that patient,’ but I had been through this before and I wasn’t going to be confused again. I wanted to know everything. Honestly, it was as harmful as it was helpful. I knew what I was getting into, which made it much scarier. The first time, my ignorance was bliss. I didn’t realize I almost died until two weeks after I had left the hospital. I didn’t even start researching what had happen to me until months later. The second time I was an advocate for myself. Medical journals and support groups were a part of every single visit. And thankfully, I was in good hands.”

— Carrie Anthony

“Write down what each specialty says to you. When I was hospitalized for six weeks prior to giving birth, I was visited 2-3 times a week by someone from each department that would be involved in my life-saving surgery. This means that I saw someone from the neonatal intensive care unit as well as reps from gynecologic oncology, maternal fetal medicine, interventional radiology and anesthesiology. They paraded in on a schedule, checked up on me, asked if I had any questions. I always did, but I regret not writing down what each said each time (along with names!). I got so many different answers regarding how I would be anesthetized, and on the day it all had to happen in an emergency, there were disagreements above me in the OR. between the specialists. It was like children arguing on a playground and my life was in danger. Had I kept a more vigilant record of what each specialty reported to me, perhaps prior to the day I could have confronted each with the details that weren't matching up.”

— Megan Moody, 36, survived placenta percreta (when the placenta penetrates through the uterine wall) in 2016

“People should know that they have a right to ask for more time with the doctor or more follow up if they feel something is not right. The ob-gyns (at least in Pennsylvania) are so busy and sometimes appointments are quite quick and rushed. Make the doctors slow down and take the time with you.”

— Dani Leiman, 37, survived HELLP syndrome (a particularly dangerous variant of preeclampsia) in 2011

“You have a legal right to your medical records throughout pregnancy and anytime afterwards. Get a copy of your lab results each time blood is drawn, and a copy of your prenatal and hospital reports. Ask about concerning or unclear results.”

— Eleni Tsigas


Getting Your Provider to Listen

“Understand the system. Ask a nurse or a trusted loved one in the ‘industry’ how it all works. I've found that medical professionals are more likely to listen to you if you demonstrate an understanding of their roles and the kind of questions they can/cannot answer. Know your ‘silos.’ Don't ask an anesthesiologist how they plan on stitching up your cervix. Specialists are often incredibly impatient. You need to get the details out of them regarding their very specific roles.”

— Megan Moody

“Let doctors know you care about your health and safety as much as they do. Tell them you want to be a partner in your health care. Do not act as an adversary to your doctor.”

— Tricia Fitzgerald, 40, survived a hemorrhage caused by severe preeclampsia in 2014

“First you have to be armed with concrete knowledge with examples about your illness and have a firm attitude. This is why it is important to know your body. Do your research before your appointment, but make it personal. Do not present your case as if you just went on WebMD for the information. Create a log of your health activities. This log should contain all illnesses you are concerned about, when they occurred and how did you feel. Have your questions and concerns written down. You should always carry a list of your medications, dosage, and milligrams. Include any side effects. Ask concrete questions and have the doctors present their findings to you in a language you can understand. If you do not agree [with what one doctor tells you], ask another doctor. Remember, knowledge is power and you must have that power.”

— Anner Porter, 55, survivor of peripartum cardiomyopathy in 1992 and founder of the advocacy organization Fight PPCM

“If your provider tells you, ‘You are pregnant. What you’re experiencing is normal,’ remember — that may be true. [But it’s also true] that preeclampsia can mimic many normal symptoms of pregnancy. Ask, ‘What else could this be?’ Expect a thoughtful answer that includes consideration of ‘differential diagnoses’ — in other words, other conditions that could be causing the same symptoms.”

— Eleni Tsigas

“They only listen if the pain is a 10 or higher. Most of us don't understand what a 10 is. I'd always imagined a 10 would feel like having a limb blown off in combat. When asked to evaluate your pain on a scale of 1 to 10, when you are in your most vulnerable moment, it is very hard to assess this logically, for you and for your partner witnessing your pain. I later saw a pain chart with pictures. A 10 was demonstrated with an illustration of a crying face. You may not actually be shedding tears, but you are most likely crying on the inside in pain, so I suggest to always say a 10. My pain from the brain hemorrhage was probably a 100, but I'm not sure if I even said 10 at the time.” 

— Emily McLaughlin, 34, survived a postpartum stroke in 2015

Crying! I'm only slightly kidding. I truly think the only way to get them to listen is to be adamant and don’t back down. I had a situation where I felt no one was paying attention to me, and I cried out of frustration over the phone. Then they listened to me and snapped into action.”

— Dani Leiman

“So many women do speak up about the strange pain they have, and a nurse may brush it off as normal without consulting a doctor and running any tests. Be annoying if you must, this is your life. … Thankfully, I never had to be so assertive. I owe my life to the team of doctors and nurses who acted swiftly and accurately, and I am eternally grateful.”

— Susan Lewis

“If you have a hemorrhage, don’t clean up after yourself! Make sure the doctor is fully aware of how much blood you are losing. I had a very nice nurse who was helping to keep me clean and helping to change my (rapidly filling) pads. If the doctor had seen the pools of blood himself, rather than just being told about them, he might not have been so quick to dismiss me.”

— Valerie Bradford, 30, survived hemorrhage in 2016


Paying Attention to Your Symptoms

“I had heard of preeclampsia but I was naïve. [I believed] that it was something women developed who didn't watch what they ate and didn't focus on good health prior and/or during pregnancy. I was in great health and shape prior to getting pregnant, during my pregnancy I continued to make good food choices and worked out up until 36 hours before the baby had to be taken. I gained healthy weight and kept my BMI at an optimum number. I thought due to my good health, I was not susceptible to anything and my labor would be easy. So although I had felt bad for 1 1/2 weeks, I chalked it up to the fact that I was almost 8 months into this pregnancy, so you're not supposed to feel great. … I walked into my doctor’s office that Friday and not one hour later I was in an emergency C-section delivering a baby. I had to fully be put under due to the severity of the HELLP, so I didn't wake up until the next day.”

— Kelli Davis, 31, survived HELLP syndrome in 2016

“Understand that severe, sustained pain is not normal. So many people told me that the final trimester of pregnancy is sooo uncomfortable. It was my first pregnancy, I have a generally high threshold for pain, and my son was breech so I thought his head was causing bad pain under my ribs [when it was really epigastric pain from the HELLP syndrome]. I kept thinking it was normal to be in pain and I let it go until it was almost too late.”

— Dani Leiman

“I wish I would have known what high blood pressure numbers were. I had a pharmacist take my blood pressure at a pharmacy and let me walk out the door with a blood pressure of 210/102. She acted like it was no big deal (‘it’s a little high’), and so I believed her. Even after telling my husband, we really thought nothing of it.”

— Melissa McFadden, 36, survived preeclampsia in 2013

“Know the way your blood pressure should be taken. And ask for the results. Politely challenge the technician or nurse if it’s not being done correctly or if they suggest ‘changing positions to get a lower reading.’ Very high blood pressure (anything over 160/110) is a ‘hypertensive crisis’ and requires immediate intervention.”

— Eleni Tsigas

“Please ask for a heart monitor for yourself while in labor, not just for the baby. I think if I had one on, seconds or minutes could have been erased from reaction time by the nurses. They were alerted to an issue because the baby’s heart stopped during labor, and while the nurse was checking that machine, my husband noticed I was also non-responsive. That’s when everything happened (cardiac arrest due to AFE).”

— Kristy Kummer-Pred, 44, survived amniotic fluid embolism and cardiac arrest in 2012


After the Delivery

“My swelling in my hands and feet never went away. My uterus hadn’t shrunk. I wasn't bleeding that bad, but there was a strange odor to it. My breasts were swollen and my milk wasn’t coming in. I was misdiagnosed with mastitis [a painful inflammation of the breast tissue that sometimes occurs when milk ducts become plugged and engorged]. The real problem was that I still had pieces of placenta inside my uterus. Know that your placenta should not come out in multiple pieces. It should come out in one piece. If it is broken apart, demand an ultrasound to ensure the doctors got it all. If you have flu-like symptoms, demand to be seen by a doctor. If you don't like your doctor, demand another one.” 

— Brandi Miller, 32, survived placenta accreta and hemorrhage in 2015

“There is a period in the days and weeks after delivery where your blood pressure can escalate and you can have a seizure, stroke, or heart attack, even well after a healthy birth. You should take your own blood pressure at home if your doctor doesn't tell you to. … Unfortunately, I went home from [all my postpartum] appointments with my blood pressure so high that I started having a brain hemorrhage. Not one single person ever thought of taking my blood pressure when I was complaining about my discomfort and showing telltale warning signs of [preeclampsia].”

— Emily McLaughlin

“The ER doctor that I had was not treating me as a postpartum case. He was just thinking of me as a 27-year-old with high blood pressure. I think, if you have the opportunity, the ideal thing would be to go back to the same hospital where you had your baby, because they have a labor and delivery unit and they have your records. But if the closest emergency room isn’t at the hospital where you delivered, then you have to be more vigilant. Make sure they know you just gave birth. If you know something is wrong with you, don’t take no for an answer. Just keep saying, ‘I think this is something serious’ and don’t let them discharge you, especially if it’s someone who isn’t familiar with pregnant women.”

— Marie McCausland

The postpartum period is when a lot of pregnancy-related heart problems like cardiomyopathy emerge. If there is still difficulty breathing, fluid buildup in ankles, shortness of breath and you are unable to lie flat on your back, go see a cardiologist ASAP. If you have to go to an emergency room, request to have the following tests performed: echocardiogram (echo) test, ejection fraction test, B-type natriuretic peptides (BNP), EKG test and chest x-ray test. These tests will determine if your heart is failing and will save your life.”

— Anner Porter

Rest as much as possible — for as long as possible. Being in too big a rush to get ‘back to normal’ can exacerbate postpartum health risks. Things that are not normal: heavy bleeding longer than 6 weeks, or bleeding that stops and starts again, not producing milk, fevers, severe pain (especially around incision sites), excessive fatigue, and anxiety/depression. If you don’t feel like yourself, get help.”

— Amy Barron Smolinski, 37, a survivor of preeclampsia, postpartum hemorrhage and other complications in three pregnancies in 2006, 2011 and 2012 and executive director of Mom2Mom Global, a breastfeeding support group

“Know that your preexisting health conditions may be impacted by having a baby (hormone changes, sleep deprivation, stress). Record your health and your baby's in a journal or app to track any changes. Reach out to the nurse or doctor when there are noticeable changes that you have tracked.”

— Noelle Garcia, 33, survived placental abruption (placenta separating from the uterine wall during pregnancy) in 2007

If your hospital discharges you on tons of Motrin or pain killers, be aware that this can mask the warning signs of headache, which is sometimes the only warning sign of preeclampsia coming on postpartum.”

— Emily McLaughlin


Grappling With the Emotional Fallout

I wish I had known that postpartum PTSD was possible. Most people associate PTSD with the effects of war, but I was diagnosed with PTSD after my traumatic birth and near-death experience. Almost 6 years later, I still experience symptoms sporadically.”

— Meagan Raymer, 31, survived severe preeclampsia and HELLP syndrome in 2011

I recommend therapy with a female therapist specializing in trauma. Honestly, I avoided it for 8 months. I was then in therapy for 12 months. I still have ongoing anxiety … but I would be in a very bad place (potentially depression and self-harm due to self-blame) were it not for therapy. It was so hard to admit [what was happening]. I started to get a suspicion when I heard an NPR story about a veteran with PTSD. I thought… that sounds like me. And I started Googling.”

— Jessica Rae Hoffman, 28, survived severe sepsis and other complications in 2015

“The emotional constructs our society puts around pregnancy and childbirth make the ideas of severe injury and death taboo. Childbirth is a messy, traumatic experience. … Many women don't seek care even when they instinctively believe something is wrong because they're supposed to ‘be happy.’ Awareness and transparency are so important.”

— Leah Soule, 33, survived a hemorrhage in 2015

“Having an incredible support network made the greatest impact with my near-death experience, but my family and friends needed their own support as they coped. My mom didn’t leave my side, but she also had a team of friends supporting her so that she could let her guard down and cry when she needed to do so. My husband was at my bedside or with the baby constantly that first week, but he was also suffering from the trauma of everything and was having a really hard time coping and needed to leave the hospital environment. My best friend is an ICU nurse and quickly became the person everyone asked clarifying questions, but she didn’t want to be a nurse in that moment but rather someone who was scared for her friend.”

— Susan Lewis

“I wish I had understood how significant the impact was on my husband. Emotionally, the experience was much more difficult and long-lasting for him than for me, and it continued to affect his relationship with both me and our baby for quite a while, at a time when I didn’t think it was a thing at all.”

— Elizabeth Venstra, 44, survived HELLP syndrome in 2014

“I would suggest establishing yourself ahead of time with a doula or midwife that can make postpartum visits to your home, which can promote health even if everything goes smoothly. Many communities have those services available if you can’t afford them. [A doula] wasn't covered through our insurance, but the social worker at the hospital arranged for someone paid for by [San Diego County] to come and do several checks on me and my son, which was very reassuring to both my husband and me.”

— Miranda Klassen

If you’re given a diagnosis of a life-threatening pregnancy complication, line up a therapist immediately so can start getting the support you need as soon as you give birth. Don’t wait until your six-week [postpartum] appointment when they do a depression screen and you realize you’re not coping well. You'll have to wait at least another week for the appointment to be made. Why not have that in place? I wish I did.”

— Megan Moody

Don’t assume everyone gets it. Don’t assume everyone wants to hear it. My story is scary. Some soon-to-be moms have looked horrified by my story. Some already moms have been scared away by it. Most people are happy to listen, like to be informed. But some do not. Some people are happier thinking it’s all going to be ok, not me, I’ll be fine. They should at least know, but that’s their choice. You can’t force people to open their eyes. Be there. Offer help. But don’t force it.”

— Carrie Anthony


Other Resources

  • The Leapfrog Group provides performance data on more than 1,800 hospitals and publishes an annual Maternity Care Report. Consumer Reports offers C-section data from more than 1,300 hospitals by ZIP code.

  • The California Maternal Quality Care Collaborative’s “toolkits” of protocols to treat life-threatening obstetric complications include infographics, checklists and lengthy backup materials but require (free) registration for access. The Alliance for Innovation on Maternal Health’s “bundles” offer similar information in a condensed, easily downloadable form.

  • The Association of Women’s Health, Obstetric and Neonatal Nurses (AWHONN)’s Health4Mom site has a “Save Your Life” campaign, including a one-page checklist, to help new mothers recognize post-birth warning signs.

  • Childbirth Connections provides evidence-based information on maternity care. The Preeclampsia Foundation’s “Wonder Woman” posts (here and here) put the U.S. maternal mortality numbers in context and offer more strategies for self-advocacy.

  • Postpartum Support International offers many resources for women suffering from pregnancy-related depression, anxiety and mood disorders.

  • Facebook is a gathering place for thousands of women who’ve experienced life-threatening complications, but many groups are condition-specific and/or closed to non-survivors. One open group worth checking out: The Unexpected Project.

  • Social justice groups are also becoming active around the issue of maternal deaths and near-deaths, with a focus on why African-American women are disproportionately affected. They include the Black Mamas Matter Alliance and Moms Rising.

Correction, August 4, 2017: In an earlier version of this story, a quote was incorrectly attributed to Kristy Kummer-Pred. It has been deleted.


          June 2017 Meeting        

Topic: Post-ASMS Poster Night and ASMS Travel Award Presentations

Date: Monday, June 19th, 2017

Time: 6:15 pm Dinner, 7:15 pm: Presentation

Location: Shimadzu Scientific Instrument, Inc. Training Center 7100 Riverwood Drive, Columbia, MD 21046 (Directions)

Dinner: Please RSVP to Katherine Fiedler (Katherine.L.Fiedler@fda.hhs.gov) before June 19th if you will be attending the dinner or are a presenting a poster.

ASMS Travel Award Recipients:

  • Linwen Zhang, The George Washington University
  • : “Metabolite, Lipid, and Peptide Analysis of Single Neurons of Known Function in Lymnaea stagnalis by Capillary Microsampling Mass Spectrometry”

  • Sitara Chauhan, University of Maryland College Park
  • : “The highly ubiquitinated protein cargo of exosomes shed by myeloid-derived suppressor cells”

  • Jessica Espino, University of Maryland Baltimore
  • : “Using MALDI Mass Spectrometry Imaging to Assess the Oxidative Damage to Lipids Induced by In Vivo Hydroxyl Radical Based Protein Footprinting”


          CASSS 2017 Student Travel Grants        

CASSS is pleased to provide a limited number of student travel grants for PhD students and post-docs who present applicable posters at the 14th Symposium on the Practical Applications of Mass Spectrometry in the Biotechnology Industry (Mass Spec 2017). PhD students or post-doctoral fellows conducting research at academia throughout the world are eligible.

Why you should apply:
This symposium offers insight to current topics and issues under discussion within the biotech and biopharmaceutical industries and as such provides an opportunity to bridge between industry, academia and regulatory agencies. The presentations and workshops are focused on the application of mass spectrometry to advance drug discovery and development in the biotechnology industry. Topics will include the utility of MS as an alternative to conventional assays such as peptide mapping, ion exchange, capillary electrophoresis, as well as for the analysis of process-related impurities, such as host cell proteins; introduction of MS in the QC laboratory, validation/transfer/compliance strategy, system suitability/assay acceptance criteria; expectations from regulatory agencies for MS based assays for product characterization, release and stability; technical challenges regarding quantitation, ionization, higher order structure analysis, etc.; applications of MS for high throughput screening of cell-lines, raw materials, in-process samples;
and benchmarking of new technology.

As a participant, you will have an excellent opportunity to meet, network and participate in exchanging knowledge for mutual education with other MS practitioners.

How to apply:
Please send a letter requesting consideration for the grant, a letter of recommendation from your supervisor, proof of your university affiliation and a PDF of your abstract to the Symposium Manager Renee Olson (rolson@casss.org).

Application for a travel grant does not release you from the obligation to register and submit your abstract online.

Requirements are:
– Present a poster on a MS topic
– Proof of studentship/post-doc status
– Recommendation from your supervisor

The deadline to apply for a student travel grant has been extended to Friday, June 9, 2017.…


          March 2017 Meeting        

Speaker: Robert N. Cole, Johns Hopkins School of Medicine

Topic: Adventures of Capillary Electrophoresis in Proteomics, from Top-down to Bottom-up

Date: Monday, March 27, 2017

Time: 6:15 pm Dinner, 7:15 pm: Presentation

Location: Shimadzu Scientific Instrument, Inc. Training Center 7100 Riverwood Drive, Columbia, MD 21046 (Directions)

Dinner: Please RSVP to Katherine Fiedler (Katherine.L.Fiedler@fda.hhs.gov) before February 27 if you will be attending the dinner or are a presenting as a vendor.

Abstract: Capillary zone electrophoresis (CE)-MS has become more accessible with robust electrospray interfaces, presenting a potential alternative to LC-MS. CE achieves rapid and high resolution analyte separation based on net charge and hydrodynamic volume. CE is orthogonal to reversed phase LC with additional benefits of low carryover, low (nanogram) sample injection, and rapid sample loading. CE-MS analysis of complex peptide mixtures is challenging due to the seconds-wide elution peaks produced during the rapid separations. However, increases in MS data acquisition speeds warrant re-examination of the role of CE in proteomics. We are evaluating a microfluidic chip-based CE interface (ZipChip, 908 Devices Inc) for top-down analysis of intact proteins, analysis of high charge/high pI peptides, and bottom-up quantification of proteins. Even with major challenges of sample concentration, protein complexity and automation, CEMS has a bright future in protein analysis.…


          February 2017 Meeting        

Speaker: Nathan J. Edwards, Georgetown University

Topic: Beyond Peptide Identification Informatics: Multi-Search, Systems Proteomics, Proteogenomics, Phyloproteomics, and Glycoproteomics

Date: Monday, February 27, 2017

Time: 6:15 pm Dinner, 7:15 pm: Presentation

Location: Shimadzu Scientific Instrument, Inc. Training Center 7100 Riverwood Drive, Columbia, MD 21046 (Directions)

Dinner: Please RSVP to Katherine Fiedler (Katherine.L.Fiedler@fda.hhs.gov) before February 27 if you will be attending the dinner or are a presenting as a vendor.

Abstract: Bottom-up proteomics by LC-MS/MS is one of the most widely used analytical workflows for characterizing the expressed proteins of the cell. With continued improvements in mass spectrometer speed, accuracy, and versatility, we can increase the depth of coverage and detail of protein characterization, but only if our data analysis capabilities keep pace with the size, and complexity, of the collected spectral data. Tens of spectral datafiles with tens of thousands of spectra are now passé. Protein sequence databases provide multiple proteoforms and amino-acid variants per gene, and the number of species and strains with genome sequences continues to grow. Connecting identified proteins with their pathways, to provide a functional context for differentially abundant proteins remains a challenge, and the exploration of non-template driven post-translational modifications, such as glycosylation, requires novel analytical and mass-spectrometry techniques that demand new data-analysis techniques. Crucially, each of these analytical contexts requires a careful consideration of the potential for false conclusions, and strategies for estimating statistical significance.…


          January 2017 Meeting        

Speaker: Alexandre Shvartsburg, Wichita State University

Topic: High-Definition FAIMS for Proteomics, Metabolomics, and Structural Characterization Using Isotopologic Shifts

Date: Monday, January 23, 2017

Time: 6:15 pm Dinner, 7:15 pm: Presentation

Location: Shimadzu Scientific Instrument, Inc. Training Center 7100 Riverwood Drive, Columbia, MD 21046 (Directions)

Dinner: Please RSVP to Katherine Fiedler (Katherine.L.Fiedler@fda.hhs.gov) before January 23 if you will be attending the dinner or are a presenting as a vendor.

Abstract: With all the power of modern MS, most biological and environmental samples require substantial prior separations. The traditional chromatography and electrophoresis are now increasingly complemented by ion mobility spectrometry (IMS) in gases. The nonlinear method of differential or field asymmetric waveform IMS (FAIMS) based on the difference between mobilities at high and low electric fields is much more orthogonal to MS than linear IMS based on absolute mobility, which enables exceptionally specific isomer separations.

We will review the prerequisites for high-resolution FAIMS/MS and its exemplary applications. A major topic in proteomics is the localization of post-translational modifications in mixtures of isomeric proteoforms (variants), where MS/MS is limited by the lack of unique fragments. Mixtures of variants up to ~6 kDa with various PTMs are effectively disentangled by FAIMS using synthetic standards and downstream ETD. All D-amino acid containing peptides (DAACP) are likewise resolved from L-analogs. A similar challenge in metabolomics is elucidating the isomeric diversity of lipids that comprises multiple isomer types including transacylation, double bond position, and cis/trans geometry. High-definition FAIMS developed in our lab generally resolves over ~80% of lipid isomers across types, and more in conjunction with OzID for double bond localization. Finally, FAIMS can resolve isotopic isomers (isotopomers) and isotopologues with peak shifts dependent on the geometry. That is conceptually parallel to NMR, enabling a fundamentally new approach to molecular structure characterization based on gas-phase isotopic shifts.

http://heartlandmassspec.weebly.com/


          Descarga las ponencias del “Congreso Científico Internacional de la Quinua y Granos Andinos 2013″        

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El año 2013 fue declarado como el “Año Internacional de la Quinua” (AIQ) en reconocimiento a los pueblos andinos que han mantenido, controlado, protegido y preservado la quinua como alimento para generaciones presentes y futuras, gracias a sus conocimientos tradicionales y prácticas de vida en armonía con la madre tierra y la naturaleza.

Considerando la importancia internacional, así como las numerosas investigaciones y desarrollos tecnológicos que al respecto se llevan a cabo en varios países, la Universidad Nacional Agraria la Molina realizó un evento con oradores de reconocida trayectoria provenientes del Perú y de varios otros países. El “Congreso Científico Internacional de la Quinua y Granos Andinos 2013″ trabajó cuatro temas muy importantes en torno a los granos: “Desarrollo de tecnologías de cultivo y mejoramiento de variedades”,“Transformación y Comercialización”, “Propiedades nutricionales y funcionales” y“Usos actuales y futuros de la quinua”.
fuente: http://quinua.pe/congreso2013/

          JELLY GAMAT GOLD G SEA CUCUMBER        

Khasiat Obat Jelly Gamat Gold G

Jelly gamat Gold G merupakan obat yang 100% halal, terbuat dari ekstrak teripang laut solusi pemilihan obat tepat untuk di gunakan sebagai obat, pencegah atau obat pendamping untuk memberantas penyakit.
Berdasarkan hasil penelitian, di dalam teripang laut ini terkandung ~Protein 86,8%, ~Kolagen 80,0%, ~Mineral, ~Mukopolisakarida, ~Glucasaninoglycans (GAGs), ~Antiseptik alamiah, ~Chondroitin, ~Asam Amino, ~Omega-3, 6, 9 dan ~Gamapeptide yang bermanfaat untuk mengaktifkan pertumbuhan sel atau mampu meregenerasi sel dengan sangat cepat, sebagai anti inflamasi/peradangan, dapat mengurangi rasa nyeri bahkan di katakan memiliki anti analgesik 3 kali lebih kuat dari pada analgesik (anti nyeri) kimiawi.
Cara-Order-Jelly-Gamat-Gold-G1_previewKhasiat teripang telah diteliti oleh para ilmuwan di seluruh dunia. Penelitian yang dilakukan di beberapa Universitas di Malaysia selama 8 tahun menunjukkan bahwa teripang dapat melancarkan peredaran darah.
Selain itu, teripang juga berkhasiat mencegah penyumbatan kolesterol pada pembuluh darah, melancarkan fungsi ginjal, meningkatkan kadar metabolisme, membantu arthritis, diabetes melitus dan hipertensi serta mempercepat penyembuhan luka, baik luka luar maupun luka dalam.
Berdasarkan hasil penelitian di berbagai Universitas di seluruh dunia, ditemukan bahwa teripang emas sangat berkhasiat sebagai obat serba guna dan sebagai antiseptik tradisional.
Dari penelitian tersebut terbukti bahwa teripang/gamat memiliki kandungan “Cell Growth Factor” (faktor regenerasi sel) sehingga mampu merangsang regenerasi/pemulihan sel dan jaringan tubuh manusia yang telah rusak/sakit bahkan membusuk, sehingga menjadi sehat/pulih kembali.
Teripang dapat memperbaiki sel-sel rusak. kandungan protein hingga 82% dan asam lemak esensial mujarab memperkuat sel hati untuk mengeluarkan antibiotik. Karena itu juga teripang Lantaran kandungan kolagen yang tinggi, teripang ampuh melakukan regenerasi sel secara singkat. Penyakit degeneratif yaitu penyakit yang ditandai dengan penurunan fungsi organ yang diakibatkan adanya kerusakan sel-sel jaringan yang luas, dengan kemampuan yang dimiliki teripang  untuk memacu regenerasi sel yang tinggi maka teripang dapat berfungsi mencegah dan membantu mempercepat penyembuhan berbagai macam penyakit. Penelitian mengungkapkan, teripang pada konsentrasi 50 mikrogram menggumpalkan dan menghadang sel kanker. oleh sebab itu pengidap kanker banyak yang berharap pada teripang selain itu, kandungan protein tinggi pada teripang  yang mencapai 82%, baik diberikan pada penderita diabetes. Protein tinggi berperan meregenerasi sel beta pankreas yang memproduksi insulin Gold Cucumber. Hasilnya Produksi insulin meningkat.
Teripang ini memiliki banyak manfaat untuk memberantas penyakit degeneratif seperti : Stroke, Jantung Koroner, Kencing Manis & Luka Gangren, Kanker (Tumor), Gagal Ginjal, Chirosis Hepatis, Asam Urat, Rhematik, Wasir, Osteoporosis (Pengeroposan Tulang), Alergi Saluran Pernapasan (Bersin, Filek, Sinusitis, Asma), Alergi Kulit (Eksim, Gatal, Darah Tinggi, Darah Rendah, Kolesterol, Penyempitan Pembuluh Darah, Penurunan Fungsi Liver, Rambut Rontok, Pembesaran Prostat dan masih banyak lagi manfaat dari teripang ini.
Sejuta manfaat yang terkandung di teripang laut yang dapat kita manfaatkan sebagai pengobatan. Maka dari itu bagi anda yang ingin merasakan keajaiban dari ekstrak teripang laut, segera pesan sekarang juga obat jelly gamat Gold G hanya dari kami dan kami menjamin obat yang di kirim 100% asli.
CARA PEMESANAN OBAT JELLY GAMAT GOLD G
SMS / TLP KE 085725973703 / 3221B7D9
HARGA 180.000 (BANDROL)
MASIH BISA KURANG GAN,,,
AMBIL BANYAK LEBIH MURAH,,


          JELLY GAMAT GOLD G        
Keistimewaan Jelly Gamat Gold G dibandingkan produk Jelly Gamat  pada  umumnya yaitu bahan utama Jelly Gamat Gold G ini merupakan  species  terpilih  dari  1000 species Teripang di dunia. Jenis species terpilih ini dinamakan Golden Stichopus Variegatus yang memiliki  warna  keemasan  (gold)  dan sejak ratusan tahun yang lalu telah dikenal manfaat dan khasiatnya untuk berbagai masalah  kesehatan  dan  kecantikan. Spesies tersebut merupakan satu-satunya spesies yang mengandung Gamapeptide (tidak ditemukan pada spesies lain). Gamapeptide sendiri bermanfaat untuk mencegah inflamasi, mengurangi rasa sakit, 3x mempercepat penyembuhan luka, mengaktifkan pertumbuhan dan mengaktifkan sel-sel, membuat kulit lebih muda dan meningkatkan kecantikan, menstabilkan emosi, memelihara sirkulasi darah agar tetap lancar.
JELLY GAMAT GOLD G Sea Cucumber Jelly adalah satu-satunya produk jeli gamat yang terdaftar di Singapura, sebagai salah satu negara barometer Health Food Asia selain Jepang dan China. Berikut ini legalitas gamat gold yang sudah di akui oleh beberapa instansi yang berkompeten di berbagai negara :
jelly gamat gold g
  • Jelly gamat gold G telah terdaftar di BPOM RI TI 11464572.
  • bersertifikat HALAL dari Malaysia: JAKIM (22.00)/492/2/1 010-10/2004.
  • Rekomendasi dari Agri-Food &
    Veterinary Authority of Singapore (AVA) tanggal 11 Oktober 2003
    (Semacam Departemen Kesehatan-nya Pemerintah Singapura).

Fakta Ilmiah dari berbagai Penelitan Tentang Khasiat Jelly Gamat Gold G

Berdasarkan hasil penelitian di beberapa Universitas di Malaysia, ditemukan bahwa teripang/gamat emas sangat berkhasiat baik untuk dijadikan obat serbaguna dan  sebagai  antiseptik  tradisional. Kandungan teripang emas berdasarkan hasil penelitian adalah:
  • Protein 86,8%
  • Kolagen 80,0%
  • Mineral
  • Mukopolisakarida
  • Glucasaminoglycans (GAGs)
  • Antiseptik alamiah
  • Glucosamine dan Chondroitin
  • Saponin
  • Omega-3, 6, dan 9
  • Asam Amino
  • Lektin
  • Vitamin dan Mineral
Peneliti Li Z, Wang H dan Zhang G dari Shanghai Institute of Hematology, Shanghai Second Medical University, China mengungkap bahwa teripang berguna sebagai anti penggumpalan dan pembekuan darah. Hal tersebut didasarkan pada ditemukannya senyawa glukosaminoglikan. Pada konsentrasi 5 mikrogram/ml, glukosaminoglikan mampu menyembuhkan stroke iskemik otak dan penyakit jantung iskemik. Memiliki kinerja menghambat aktivitas pembekuan darah melalui penghambatan monomer fibrin dan meningkatkan aktivitas plasmin. Plasmin, enzim pengurai protein plasma darah yang menurunkan kekentalan darah. Itu terjadi saat pelukaan sehingga darah membeku.
Menurut Dr.Ir.M. Ahkam  Subroto, M.App.Sc., Periset Bioteknolog LIPI, kandungan protein tinggi pada teripang yang mencapai 82%, baik diberikan kepada penderita diabetes.  Protein tinggi berperan meregenerasi sel beta pankreas yang memproduksi insulin. Hasilnya, produksi insulin meningkat. (Trubus 441, Agustus 2006, halaman 109).

Berbagai Khasiat Jelly Gamat Gold G

Khasiat Jelly Gamat Gold G diantaranya yaitu untuk pengobatan : Alergi, Anemia, Asam Urat,  Batu Ginjal, Badan Lemah, Darah Rendah, Darah Tinggi, Diabetes, Eksim, Epilepsi, Hepatitis / Liver, Haid Lancar, Jantung, Jerawat, Kanker, Kista, Kolesterol, Luka, Lupus, Maag, Migrain, Nyeri Sendi, Paru-paru, Pendarahan, Perut Kembung, Radang, Sakit Pinggang, Sesak Napas, Stroke, Sinusitis, Thalasemia, TBC, Thypus, Tumor Ovarium, Varises dan penyakit lainnya.
Teknologi modern telah membawa teripang/gamat emas (sea cucumber) yang semula hanya dikenal sebagai pengobatan tradisional, menjadi sebuah produk herbal yang dapat memberi manfaat kepada semua lapisan masyarakat. Produk tersebut adalah Jelly Gamat Gold G. Dapatkan segera produk yang luar biasa ini untuk kesehatan anda! Anda bisa pesan melalui website ini.
 HARGA Rp. 180.000 / BOTOL
 BELI BANYAK BISA LEBIH MURAH

 PEMESANAN HUBUNGI 085725973703 / 3221B7D9

          (Unboxed) Avoplex High-Intensity Hand & Nail Cream (50ml)        
(Unboxed) Avoplex High-Intensity Hand & Nail Cream (50ml)

(Unboxed) Avoplex High-Intensity Hand & Nail Cream (50ml)

OPI are always innovating the next best pamper products for us to replenish our nails, cuticles and hands. Avoplex High Intensity Hand & Nail Cream is perfect for dry and sore hands it will soothe and nourish overworked hands. High-intensity Hand and Nail Cream 50ML. Transform hands in need of serious care  OPI Avoplex High-Intensity Hand & Nail Cream a luxuriously hydrating blend of shea, cocoa, avocado, and almond butters plus deep penetrating protein peptides. Working to hydrate, nourish and protect overworked hands. OPI Avoplex High-Intensity Hand & Nail Cream also helps to increase skin elasticity and nail flexibility, providing intense care and repair for hands. To view all OPI Avoplex Click Here.


          Couture Eye Colour Palette - Brocade 02 (4 x 2.5g)        
Couture Eye Colour Palette - Brocade 02 (4 x 2.5g)

Couture Eye Colour Palette - Brocade 02 (4 x 2.5g)

  Embrace temptation and reignite your passion for colour. Our long lasting lipsticks love you right back with peptides and vitamins to hydrate and condition your lips. The Couture Eye Colour Compact is infused with iridescent crushed pearls give your eyes a 3D effect. Four different shades to help you create a effortless elegance look. The metallic shade helps gives your eyes a more of a impact finish. The shades in this compact palette are perfect for your to wear with a little black dress. Comes complete with a tailor-made applicator. The perfect kit for your eyes. To view the Mii Couture Eye Colour Collection Click Here To view the entire Mii Collection Click Here


          Face Inc - Hydrating Skin Care Serum - Bubble Burst (9324) 7.5ml        
Face Inc - Hydrating Skin Care Serum - Bubble Burst (9324) 7.5ml

Face Inc - Hydrating Skin Care Serum - Bubble Burst (9324) 7.5ml

  The FACEINC Bubble Burst Hydrating Serum works in two ways, the serum works to refine the skin The bursting bubbles of argan oil provide intense moisture. A unique blend of advanced peptides have been included to help repair and prevent signs of premature ageing. The Bubble Burst serum is a single-use skin shot designed for hand, face and body.  How to apply : 1. Apply to clean, dry skin. 2. Remove the mask from the sachet and gently unfold.   3. Carefully place the mask over your face ensuring even contact to the skin.    4. After 15 minutes, remove the mask, and gently massage excess liquid into the skin. No need to rinse off.


           The role of C-terminal amidation in the membrane interactions of the anionic antimicrobial peptide, maximin H5         
Dennison, Sarah Rachel, Mura, Manuela, Harris, Frederick, Morton, Leslie Hugh Glyn, Zvelindovsky, Andrei Victorovich and Phoenix, David Andrew (2015) The role of C-terminal amidation in the membrane interactions of the anionic antimicrobial peptide, maximin H5. Biochimica et Biophysica Acta (BBA) - Biomembranes, 1848 (5). pp. 1111-1118. ISSN 00052736
           The impact of membrane lipid composition on antimicrobial function of an α-helical peptide         
Dennison, Sarah Rachel, Morton, Leslie Hugh Glyn, Harris, Frederick and Phoenix, David Andrew (2008) The impact of membrane lipid composition on antimicrobial function of an α-helical peptide. Chemistry and Physics of Lipids, 151 (2). pp. 92-102. ISSN 00093084
           An account of the antimicrobial activity of a helical peptide and an evaluation of its use as a surface coating on fabric against bacterial contamination         
Morton, Leslie Hugh Glyn and Dennison, Sarah Rachel An account of the antimicrobial activity of a helical peptide and an evaluation of its use as a surface coating on fabric against bacterial contamination. In: COST D33, 2009, Romania. (Unpublished)
           Characterization of an antimicrobial peptide aurein 2.5 with bacterial membranes         
Dennison, Sarah Rachel, Morton, Leslie Hugh Glyn, Shorrocks, Andrea Julie, Harris, Frederick and Phoenix, David Andrew Characterization of an antimicrobial peptide aurein 2.5 with bacterial membranes. In: COST D33, 2009, Romania. (Unpublished)
          Mascara Makes the Moment #Bellimisa        
Press Sample.  All opinions are my own.
Hello, Fireflies!

I keep most makeup much longer than the "rules" say to.  I'm not a germaphobe, and I'm not tossing anything until it no longer pleases me to keep it.  Or it smells funny.

...but, mascara is a little different.  My mom always harped on me to throw away my mascaras after 30 days, and sometimes I did, and sometimes I didn't.  But, they definitely have a shelf-life - old mascaras are teeming with bacteria, they dry out, get flaky or clumpy, and just look bad.  They are the one makeup product I will admit that needs to be replaced on a regular basis - which is why a mascara subscription like Bellimisa makes sense.

Debbie George started this process about 15 years ago, when she learned that her skin conditions were exacerbated by all the chemicals her skin was absorbing from her makeup.  She knew then that she wanted to make products that were free from nasties like parabens, DEA/TEA, propylene glycol, and harmful preservatives.


She wanted this makeup to be made from better ingredients (like Vitamin E and Peptides), be cruelty-free, look beautiful all day long, be convenient to buy, and not break the bank.  And, she did it.
In this series of pictures, I start by applying the Bellimisa mascara just to one eye - my lashes are not primed, nor are they curled.  I'm not even wearing any other makeup - that's just the natural lash with the mascara!  It goes on a little thick, but with a great consistency - not too wet, not too dry.  It wore all day, and didn't irritate my eyes...even when I fell asleep with it on.  Which I don't recommend, by the way.  You should always take your makeup off at the end of the day, but sometimes naps happen.
Here's how it looks with some super-sparkly metallic shadow (Peri-pera Wholly Deep Jewel Pots) and some It Cosmetics Jade eyeliner.  I love how deep and dark the liner and mascara make my brown eyes look, contrasted against the glitter-fest on my lids.
My lashes have gotten shorter and straighter as I've gotten older, so I'm always looking for a mascara that can give me more visible lashes, and I think Bellimisa delivers on that.  Their subscription service ensures that I don't have to check the calendar, or wait for my eyes to get irritated to remember to crack open a new tube.  If you're a daily wearer of multiple coats of mascara, you might like getting it delivered every 30 days.  If you don't wear it every day, or like me, want to hold out longer, you can get a 60-day subscription. 
Even behind my glasses, the magic of mascara makes my eyes look more defined and open.
If you just want to try one tube of the mascara, it's $28, but either subscription drops the price to $16 - and you can cancel at any time.  And, Bellimisa gave me a discount coupon for my readers - use the code BBLOGGER and get $2 off the subscription price! Also, subscribers have exclusive access to other Bellimisa products, like their brow gel and makeup remover.  For more information, or to purchase, you can find Bellimisa on their webpage, Facebook, Twitter, and Instagram.
          Highlight Your Lips! #HighlightCosmetics        
Press Sample.  All opinions are my own.
Hello, Fireflies!

Usually the last makeup item I put on before my look is done is my lipstick.  The perfect lippie can take a look a totally transform it - and my mood.  Bold, matte, glossy, nude - whatever the lipstick, if I feel good in it, it can put a smile on my face.  I've been testing out this new lipstick from Highlight, and it has definitely put a smile on my face!

I admit it.  When I first saw this packaging, I fell in love.  The black and gold with clear is very chic, and it feel substantial and luxe.  And I love the faux lipstick bullet!  It had me fooled for a minute, because I knew it was a liquid lipstick, but it looks so convincing!  The cap twists off to reveal a doe-foot applicator that is soft and just glides over the lips.
Not only is the packaging pretty awesome, so is what's inside.  Highlight's philosophy is to take care of your insides while the outside is highlighted. They put some great, nourishing ingredients in their lipsticks to get the job done, like turmeric, an anti-inflammatory, that also has anti-aging and wrinkle-reducing properties, tea extracts that are high in anti-oxidants, and peptides.

Their products are also made in the USA, nontoxic, free from parabens, and glutens, and also not tested on animals.

This gorgeous purple metallic is called Rare Nebbiolo, and is named after a red wine grape.  It may look intense, but it is a very wearable purple!  I love all things metallic right now, and this lipstick has the perfect sheen, without looking glittery or dated.
I can't stop wearing this lipstick, and I need more of their colors.  It's so long-wearing, I can eat and drink and it's still there (oily foods will dissolve just about any lip product, though.)  It's so comfortable, I can wear it all day and forget I have it on.  I've even accidentally fallen asleep with it on... it didn't get all over the pillow, and no dry lips the next day, either!  

If you've been looking for a comfortable, long-wearing liquid lipstick in matte or metallic finishes, that is as good for your lips as it looks on your lips, then you might love Highlight Cosmetics as much as I do.  For more information, or to purchase, you can find them on Instagram, or on their webpage, where their liquid lipsticks currently retail for $25 each.


          Serum? #Serment         
Press Sample.  All opinions are my own.
Hello, Fireflies!

I've tried a lot of skincare, so it's only natural that eventually I'd try something from Korea.  If you haven't heard of K-beauty, it's all things Korean for beauty and skincare - and they are known for doing it right.

Serment Phytoaminopeptide serum is their 'total cell cure serum.'  It has peptides that help the serum get deep into the skin to deliver nutrients, amino acids to help rebuild skin's building blocks, niacinamide for anti-aging, and it also brightens the skin and fights bacteria that causes acne.
For my aging, oily skin, this serum is amazing.  I'm always excited to see skincare that addresses the aspects of my oily skin, like that I'm still getting breakouts like I'm 14, and also aspects of my aging skin, like age spots and wrinkles.


Housed in a green bottle with a dropper, this thick serum has a light herbal fragrance that dissipates quickly.  The serum itself, however, sticks around for a while!  On my skin, it takes a while to absorb in, and is sticky until it does - so this isn't a serum I can put makeup on over.  It is a great nighttime serum for me, because it absorbs slowly and works all night to make my skin look even better in the morning.

If you have multiple skin issues like I do, this is a great multi-tasking, anti-aging, clean, bright, smooth skin serum!  It's currently available on Amazon for $36


          AURAMEN TURBO        

AURA MEN TURBO COLLAGEN : HIGHLY RECOMMENDED FOR MEN!!

SERLAHKAN PENAMPILAN ANDA SEKARANG.. LEBIH BERTENAGA DARI BIASA!!

AURAWHITE FOR MEN

PRODUK : AURAMEN TURBO
HARGA : RM180.00

Salam semua..mesti korang dah pernah dengar produk terbaru khas untuk kaum lelaki dan jejaka di luar sana kan..tak pena dengar lagi?? 

Jom amik masa kejap kenal2 produk terbaru untuk lelaki ini..AURA MEN TURBO COLLAGEN!! Aura Men merupakan produk minuman kolagen lelaki pertama yang ada di pasaran. Ok nak diringkaskan cite Aura Men bukan sahaja minuman khas untuk kesihatan lelaki, but also for men beauty!! 
Jadi jomlah cuba Aura Men sekarang..Paling penting beli yg original ye:)


APA YANG PERLU ANDA TAHU TENTANG AURA MEN TURBO COLLAGEN?


- Merupakan collagen lelaki pertama di Malaysia ( 1st MEN COLLAGEN)

- Membantu untuk menigkatkan stamina & memejalkan otot2 


- Dirumus dengan 10x FRUIT STEMCELL

- Mengandungi VITAMIN, MINERAL & PROTEIN
- 100% EXOTIC WILD BERRY FLAVOUR


Izzue Islam sebagai DUTA AURA MEN.. 


So..Kepada kaum lelaki di luar sana..ini adalah supplement khas untuk anda semua yg diperbuat dari bahan-bahan terbaik untuk para lelaki masa kini..!




Antara Kelebihan Aura Men Super Advance TURBO : "Collagen With Fat Burner and Whey Protein"

Membantu mencerahkan, membersih & mengatasi masalah kulit seperti jerawat, kusam & kering.
Membekalkan tenaga & stamina kpd sang lelaki dengan kesan yang luar biasa.
Membantu memejalkan otot secara semula jadi.
Membuang angin, toksin & lemak dari dalam badan.
Membantu masalah sakit sendi & lenguh badan.
Membantu mengatasi masalah disfungsi seks.
Membantu menambahkan kadar hormon testosterone.
Meningkatkan tenaga dan kesihatan tubuh.
Membantu melancarkan peredaran darah.
Mengatasi masalah prostat & saluran kencing.
Membantu meningkatkan keupayaan lelaki sejati secara semula jadi.
Membantu menurunkan berat badan &mengempiskan perut yang buncit.

CUBA DULU BARU TAHU RAHSIA LELAKI UNTUK LELAKI ! KESAN LUAR BIASA!



JIKA ANDA MENGALAMI MASALAH INI..APA KATA ANDA CUBA AURA MEN!!

~ Lelaki yang mempunyai masalah jerawat
~ Lelaki yang ingin menjaga penampilan wajah
~ Lelaki yang ingin kulit lebih cerah
~ Lelaki yang ingin menambah kecergasan
~ Lelaki yang setiap kali bangun tidur selalu terasa sakit sendi
~ Lelaki yang selalu sahaja cepat letih
~ Lelaki yang inginkan bentuk badan yang tegap

PASTI AURA MEN!!! AURAMEN NYATA BERBEZA! 

~ Aura Men membantu memberikan lebih tenaga kpd mereka yg selalu berasa letih/penat.


~ Auramen dapat membantu mengatasi masalah kulit spt jerawat, kusam, bekas parut, warna kulit tak sekata atau yg ingin kulit cerah dan gebu. Buat para jejaka yg ingin menjaga penampilan wajah boleh cuba ambil aura men yeUntuk kaum lelaki yg selalu ke gym..aura men juga dapat membantu mempercepatkan pembentukan otot2 badan..tapi kenalah rajin workout yea!!

"Rasai kesannya dalam 7 Hari! Lebih POWER & BERTENAGA"

Perfomance Energy Fuel (Skin.Nail.Hair.Bone.Muscle)

100% original..
-Berhati2 dgn tawaran harga murah-

Kandungan AURA MEN :

- Collagen Peptide
- Whey Protein
- Butea Superba
- Tribulus Guarana
- Saw Palmetto Extract
- Green Tea
- Hoodia


Saranan Pengambilan Aura Men : 

1. Bancuh 2 scoops Auramen bersama 150 ml air Sejuk @ air masak.

2. Goncangkan (shake) dan sedia untuk di minum.

3. 2 kali sehari : pagi sebelum sarapan dan malam sebelum tidur.

4. Amalkan pemakanan sihat, senaman / work out dan minum air at least 8 gelas sehari.

          AURAWHITE BUBBLY        


AURAWHITE BUBBLY (untuk remaja seawal 12 tahun) , aurawhite untuk remaja, aurawhite bubly , aurawhite murah, original, murah, kolagen untuk remaja, kulit sihat dan cantik, putih gebu,  Ayda Jebat .

PRODUK :AURAWHITE BUBBLY
HARGA : RM80.00
KANDUNGAN:
500GRAM


Collagen untuk remaja untuk mengekalkan kegebuan ,
 keremajaan kulit supaya tidak mudah bermasalah yer, Mmg sgt digalakkan menjaga kulit seawal usia remaja, ya lah kalu dh tua2 baru nak jaga kang umpama melebur besi , kena suhu panas2  baru menjdi(maksud akak rawtaan yg mahal2, then baruler berhasil , sebb kulit dh matang siket, hormon badan, collagen, glutahione , vit  badan semua dah kekurang segala bagai, kerja keras mmg kena ganda2 ngitu)..heheh..

Siapa tengok RINDU AWAK 200% mesti kenal PELAKON KECIL MOLEK SOMEL Ayda Jebat kan kan… Mantap gila lakonan sheollss ! Jom Kita Bongkar Rahsia Cantik Somel dia dengan AURAWHITE BUBBLY yang diformulasi Khas untuk Uollss Yang fefeeling REMAJA gitu ! So Sweet !!!! Sesuai untuk remaja 12 tahun – 25 tahun tau.. Yang umur lebih dari tu boleh minum Aurawhite Berry , Coklat or Stemcell ! 
AURAWHITE BUBBLY (untuk remaja seawal 12 tahun) , aurawhite untuk remaja, aurawhite bubly , aurawhite murah, original, murah, kolagen untuk remaja, kulit sihat dan cantik, putih gebu,  Ayda Jebat .

Nie untuk REMAJA je tau !

 Sesuai untuk Jejaka & Gadis-gadis Somel yang minat dengan KOREAN COLLAGEN. & NAK CERAH GEBU PERSIS RETIS KOREA ! 


AURAWHITE BUBBLY (untuk remaja seawal 12 tahun) , aurawhite untuk remaja, aurawhite bubly , aurawhite murah, original, murah, kolagen untuk remaja, kulit sihat dan cantik, putih gebu,  Ayda Jebat .

KELEBIHAN AURAWHITE BUBBLY 
SGT DIREKOMENKAN UNTUK  REMAJA 12 - 25 TAHUN

    AURAWHITE BUBBLY (untuk remaja seawal 12 tahun) , aurawhite untuk remaja, aurawhite bubly , aurawhite murah, original, murah, kolagen untuk remaja, kulit sihat dan cantik, putih gebu,  Ayda Jebat .
    AURAWHITE BUBBLY (untuk remaja seawal 12 tahun) , aurawhite untuk remaja, aurawhite bubly , aurawhite murah, original, murah, kolagen untuk remaja, kulit sihat dan cantik, putih gebu,  Ayda Jebat .
  • Berperisa CANDYSWEET Strawberry yang super LAZAT ! Sangaaaat sedap..nyuummm!!
  • Harga mampu milik dengan Khasiat yang super AWESOME !
  • mencerahkan kulit & melembapkan kulit 
  • meransang penghasilan kolagen untuk remaja
  • memberi tenaga
  • baik untuk daya ingatan terutama pelajar
  • atasi kulit jerawat n berminyak normally remaja tak terlepas ada problem kulit berminyak cos hormone berubah apabila usia meningkat
  • di perkaya dengan salmon collagen peptide, manuka honey, grapeseed, vitamin C,E & A.
  • kurangkan rambut gugur & rekahan tumit kaki
  • menyerlahkan aura wajah 
  • kulit yang bersinar sinar !
  • tubuh badan yang sihat
  • kulit akn bersinar2
  • tubuh badan yg sihat , cergas dan betenaga

CARA PENGAMBILAN AURAWHITE BUBBLY
✔ Boleh diambil remaja lelaki dan perempuan 
berusia dari 12 tahun ke 25 tahun.

✔ Makan 1 sudu AURAWHITE BUBBLY sebelum sarapan dan 
sebelum tidur dan dikemam di dalam mulut tanpa 
perlu dibancuh dengan air.

Make sure adik2 sekalian MINUM AIR SUAM BANYAK!!!!! TAW..
Sebbab khasiat buby nie need air yang banyak sebagai mediumnya utk  BEOPERASI sepenuhnya mencantik kulit u oulss!!
AURAWHITE BUBBLY (untuk remaja seawal 12 tahun) , aurawhite untuk remaja, aurawhite bubly , aurawhite murah, original, murah, kolagen untuk remaja, kulit sihat dan cantik, putih gebu,  Ayda Jebat .

          AURAWHITE STEM CELL COLLAGEN SPECIAL EDITION        
AURAWHITE STEM CELL COLLAGEN


PRODUK : PRODUK TERBARU AURA WHITE STEM CELL COLLAGEN LIMITED EDITION!!!
HARGA : RM180.00


TERBARU DARI AURAWHITE BEAUTY..
Gabungan paling mantap dengan 50x antioksidan
 Kesan berganda bagi memelihara kesihatan dan kecantikan
Mencerahkan kulit dan awet muda
KESAN SEAWAL 3 HARI.!


KEISTIMEWAAN AURAWHITE STEMCELL SPECIAL EDITION :

+ Kesan seawal 7 hari.
+ Dengan 15x Premium Stemcell
+ Pencerahan kulit lebih pantas
+ Kulit lebih anjal dan gebu
+ Mengaktifkan penghasilan kolagen
+ Anti Penuaan
+ Meningkatkan sistem imunisasi tubuh badan
+ Mengatasi masalah kulit seperti jerawat,pigmentasi & melasma.
+ Mengurangkan kedutan & garis halus pada wajah.
+ 60% kulit lebih lembap
+ Membantu masalah kulit
+ Mengatasi masalah keguguran rambut
+ Mengurangkan parut & tompok hitam
+ Mengurangkan cellulite
+ Mengurangkan rekahan pada tumit
+ Mengurangkan stretchmark
+ Melembapkan bibir yang kering
+ Detoxifikasi toksin dalam badan
+ Atasi masalah sakit sendi
+ Menguatkan tulang
+ Menurunkan kadar kolestrol
+ Memberi tenaga & meningkatkan stamina
+ Meningkat pegeluran susu ibu
+ Sesuai untuk lelaki dan wanita


- Hasil dari ekstrak Phyto superfruit iaitu Green Apple Stemcell Phytocelltec, Maquiberry, Roselle Stemcell, Cranberries, Strawberry, Snow lotus Stemcell, Raspberry, Red Apple Stemcell, Blueberry, Pomegranate, Grapes, Dragonfruit stemcell, Brocolli Stemcell, Prune Stemcell & Kiwi Stemcell.
~ FORMULA HEBAT AURA WHITE STEMCELL ~

Salmon Collagen Peptide
- Kualiti kolagen Gred terbaik dari ikan laut dalam meningkatkan penghasilan kolagen yang berkualiti.

Extra Glutathione

- Memberi kuasa pencerahan 50% lebih pantas

15x Stem Cell

- Hasil dari ekstrak Phyto superfruit iaitu Green Apple Stemcell Phytocelltec, Maquiberry, Roselle Stemcell, Cranberries, Strawberry, Snow lotus Stemcell, Raspberry, Red Apple Stemcell, Blueberry, Pomegranate, Grapes, Dragonfruit stemcell, Brocolli Stemcell, Prune Stemcell & Kiwi Stemcell.

Virgin Coconut Oil ( Minyak Kelapa Dara Premium)

- Mempunyai 1001 khasiat untuk kesihatan membantu membunuh virus & bakteria dalam tubuh.Mencegah kepada penyakit di perkaya dengan zat tambahan yang mengandungi vitamin E,A dan D.

Rose Hips

- Di Negara Barat rosehips di gunakan untuk tujuan mencantikan kulit & awet muda. Menurunkan kadar kolestrol LDL & meningkatkan kadar HDL.

Camu Camu Fruit

- 60x lebih tinggi kandungan vitamin C dari oren! Ia hanya boleh di dapati di Negara Amazon yang baik untuk kesihatan dan kecantikan.

Astaxanthin

- Mencegah dari radikal bebas. Astaxanthin mempunyai kekuatan anti oksidan tertinggi di dunia, memperbaiki daya tahan tubuh. Baik untuk mata, rambut & kulit.

Hyaluronic Acid

- Meningkatkan kelembapan kulit secara menyeluruh. Kulit lebih sihat & lembap.

Oregano Leaf

- Merawat masalah kulit seperti luka, ruam, eczema,bengkak . Ia merangsang pegeluaran susu ibu, melancarkan haid,memulihkan otot rahim.

Pearl Powder

- Serbuk mutiara membantu merawat keradangan, meningkatkan penglihatan, meningkatkan sistem imunisasi tubuh badan dan menguatkan rambut.


SPECIAL OFFER!!! LIMITED EDITION!!


          The Science Behind IGF-LR3 Made Easy        
IGF-1 is a 70 amino acid sequence similar to the size and structure of Insulin. It belongs to the peptide family of substances identified as growth factors. It is a highly anabolic hormone released in the liver as well as in peripheral tissues such as skeletal muscle. In the body,...
           IT Cosmetics™IT’s Your 30 Seconds To Flawless-Looking Skin is QVC's Today's Special Value!        



IT Cosmetics™IT’s Your 30 Seconds To Flawless-Looking Skin 







IT Cosmetics™ IT’s Your 30 Seconds To Flawless-Looking Skin!
IT Cosmetics™ IT’s Your 30 Seconds To Flawless-Looking Skin


IT Cosmetics™ IT’s Your 30 Seconds To Flawless-Looking Skin!
IT Cosmetics™ IT’s Your 30 Seconds To Flawless-Looking Skin! 

IT's that time again!  IT Cosmetics is going to be live on QVC for our Today’s Special Value starting Friday at 12:01AM Eastern Daylight Time.  IT Cosmetics™ IT’s Your 30 Seconds To Flawless-Looking Skin! Supersize Celebration Foundation™ SPF 50+ with Heavenly Luxe™ Angled Buffing
Foundation Brush are packaged in one bundle to give you a really flawless complexion.  

This Today’s Special Value® is scheduled to debut on QVC® Friday, July 28, 2017 at midnight (ET) and will be offered for one day only! So yes, it is live right at this moment!

The kit includes:

- Two 0.30-oz Celebration Foundations SPF 50+
- Heavenly Luxe Angled Buffing Foundation Brush

Let's jump into the products and my thoughts on these.

IT Cosmetics Heavenly Luxe™ Angled Buffing Foundation Brush
IT Cosmetics Heavenly Luxe™ Angled Buffing Foundation Brush 

The IT Cosmetics Heavenly Luxe™ Angled Buffing Foundation Brush is one of my favorite brushes because of its angled, dense head.  It really picks up enough product with the lightest of dabs on the compact.  It effortlessly creates a seamless foundation look without looking cakey.  Best of all, IT Cosmetics brushes are known for their super soft hairs, and this is no exception!  The angled head is perfect for picking up product and buffing on the skin.




IT Cosmetics Supersize Celebration Foundation™ SPF 50+
IT Cosmetics Supersize Celebration Foundation™ SPF 50+

IT Cosmetics Supersize Celebration Foundation™ SPF 50+ in Light

IT Cosmetics Supersize Celebration Foundation™ SPF 50+
IT Cosmetics Supersize Celebration Foundation™ SPF 50+



IT Cosmetics Supersize Celebration Foundation™ SPF 50+ in Light swatched on back of hand



No edit/filter: Using IT Cosmetics Supersize Celebration Foundation™ SPF 50+ and taken under natural light.  I love how flawless it looks!

I have to say, I have used a lot of powder foundations, but the IT Cosmetics Supersize Celebration Foundation™ SPF 50+ is amazingly seamless and flawless.  It doesn't look cakey and yet it hides imperfections effortlessly.  I like to set it with my Skindinavia makeup setting spray, and it pretty much stays put the entire day, with very minimal touch-up.

The  Supersize Celebration Foundation™ SPF 50+  is formulated with SPF 50+ broad spectrum physical sunscreen, which is a definite plus for me, because I am very particular about my facial products - they have to contain sunscreen since my skin is very sensitive to sunlight.  It is also talc-free and contains peptides, hydrolyzed collagen, hyaluronic acid, grape seed oil, and other anti-aging ingredients.

The best part is that this kit is available for one day only, July 28th, Friday, on QVC.com, for the amazing price of $49.14 + S&H or 6 easy pays of only $8.19 (+ tax and S&H).  If you are a fan of IT Cosmetics, I am sure you will love this new Today's Special Value.  Head on over to QVC and check out Item # A293532.

(Media sample was provided by PR for consideration.  All opinions are mine.)


          Wasatch-Contract-Manufacturing Marketing Manager, Adam Green, Sanctions Utah Business Plan Focus for Equity Laboratory Production Expansion        

West Jordan, UT -- (SBWIRE) -- 10/02/2014 -- Wasatch Product Development is focused on providing the most responsive and flexible service in the industry and has a diverse clientele ranging from leading global companies to virtual and emerging entities. With unmatched technical expertise, innovative equipment and regulatory knowledge, Wasatch maintains a demonstrated record with the FDA as well as with its customers; many of whom have outsourced with the company for over ten years. The Wasatch Product Development's lab is compliant with Good Manufacturing Practices (cGMP) along with being registered and certified by the ATF, and FDA. Wasatch has been developing and manufacturing several unique products for many of the World's most successful consumer product companies since 1998.

The purpose of this press release is to announce that the G3 Development and Wasatch Contract Manufacturing Founder, Adam Paul Green, has just announced he will speak with Wasatch Liquid Contract Manufacturer. Wasatch Contract Manufacturing is a private label nutritional beverage co-packer providing the most responsive and flexible service in the industry and has a diverse clientele ranging from leading global companies to virtual and emerging entities.

Adam will speak with them on his weekly webinar, which is hosted from from his virtual office. Adam plans to address the Utah Business Plan Focus for Equity Laboratory Production Expansion.

The webinar will take place on October 22, 2014.

New call number: 1-888-998-7766
New virtual office login site: http://xocaimeeting.bojabie.com/

801-566-4449
Owner, Kevin Casey
http://wasatchcontractmanufacturing.com/contact/
kcasey@wasatchlabs.net

Mission Statement
To proactively serve our business community by providing solutions
in personal care, business development and liquid nutrition.

Vision Statement
To provide leadership in establishing our client's international businesses,
being built on a foundation of innovation, advocacy, technology and business integrity.

http://wasatchcontractmanufacturing.com/

~Wasatch Labs' Core Competencies are:

Anti-Aging
Gene Expression
Neuro-Peptides
Cosme-ceuticals (Skin Care)
Skin "Energy Systems"
OTC Products (Sanitizers, SunScreens, etc)
SPF: Sun Protection
Liquid Nutritionals and Juices
Unique Skin Treatments (Intimacy, Sanitation, and "plumping" products)
Think of Wasatch Labs when you are considering sourcing a secondary manufacturer for your existing products or perhaps a reliable, experienced laboratory for product development.
~Wasatch Lab's Competitive Advantages include:

In-House Capabilities (Packaging Engineering, Formula Development, Manufacturing)
International Capabilities
Total Customer Support
Complete Supply Chain Management
cGMP

Thanks for Stopping By – WPG – HOME Tab
https://vimeo.com/75658706
Inside Scoop on Wasatch – WPD - ABOUT Tab
https://vimeo.com/71997930

Whatever the size of the anti-aging product corporation, Wasatch Contract Manufacturing can take it to the next level. They provide packaging engineering, formula development, private labeling, and manufacturing of liquid products. Small Companies: They help small companies identify their industry niche, develop proprietary formulas, and make a strong debut on the market. Many of their current Salt Lake City start-ups are focused on emerging Utah and national markets: gene expression, skin energy systems, specialty sun care, and anti-aging.

Medium Size Companies: Wasatch helps medium companies refine their product lines, improve quality, and manage production growth.

Large Utah Companies: They help large companies diversify and respond to changes in the market. Many large companies are developing new product lines in high-demand mitochondrial anti-senescence, neuro peptides, and acne products. Wasatch Contract Manufacturing is a cGMP, FDA, EPA, and ATF compliant facility. Wasatch has been formulating liquid products for over twenty years without an FDA violation. Call their operations manager today to learn how Wasatch can help a company move forward.

About Wasatch Product Development
Wasatch Product Development is focused on providing the most responsive and flexible service in the industry and has a diverse clientele ranging from leading global companies to virtual and emerging entities. With unmatched technical expertise, innovative equipment and regulatory knowledge, Wasatch maintains a demonstrated record with the FDA as well as with its customers; many of whom have outsourced with the company for over ten years. The Wasatch Product Development's lab is compliant with Good Manufacturing Practices (cGMP) along with being registered and certified by the ATF, and FDA. Wasatch has been developing and manufacturing several unique products for many of the World's most successful consumer product companies since 1998.

http://wasatchcontractmanufacturing.com/

For more information on this press release visit: http://www.sbwire.com/press-releases/wasatch-contract-manufacturing-marketing-manager-adam-green-sanctions-utah-business-plan-focus-for-equity-laboratory-production-expansion-548677.htm

Media Relations Contact

Adam Green
Telephone: 801-566-4449
Email: Click to Email Adam Green
Web: http://wasatchcontractmanufacturing.com/


          Private-Label Skin Care Co-Packer News: Wasatch Contract Manufacturing Sales Manager, Adam Green, Ratifies Utah Business Plan Focus for Equity Laboratory Production Expansion        

Burbank, CA -- (SBWIRE) -- 10/01/2014 -- Wasatch Product Development is focused on providing the most responsive and flexible service in the industry and has a diverse clientele ranging from leading global companies to virtual and emerging entities. With unmatched technical expertise, innovative equipment and regulatory knowledge, Wasatch maintains a demonstrated record with the FDA as well as with its customers; many of whom have outsourced with the company for over ten years. The Wasatch Product Development's lab is compliant with Good Manufacturing Practices (cGMP) along with being registered and certified by the ATF, and FDA. Wasatch has been developing and manufacturing several unique products for many of the World's most successful consumer product companies since 1998.

The purpose of this press release is to announce that the G3 Development and Wasatch Contract Manufacturing Founder, Adam Paul Green, has just announced he will speak with Wasatch Liquid Contract Manufacturer. Wasatch Contract Manufacturing is a private label nutritional beverage co-packer providing the most responsive and flexible service in the industry and has a diverse clientele ranging from leading global companies to virtual and emerging entities.

Adam will speak with them on his weekly webinar, which is hosted from from his virtual office. Adam plans to address the Utah Business Plan Focus for Equity Laboratory Production Expansion.

The webinar will take place on October 22, 2014.

New call number: 1-888-998-7766
New virtual office login site: http://xocaimeeting.bojabie.com/

801-566-4449
Owner, Kevin Casey
http://wasatchcontractmanufacturing.com/contact/
kcasey@wasatchlabs.net

Mission Statement
To proactively serve our business community by providing solutions
in personal care, business development and liquid nutrition.

Vision Statement
To provide leadership in establishing our client's international businesses,
being built on a foundation of innovation, advocacy, technology and business integrity.

http://wasatchcontractmanufacturing.com/

~Wasatch Labs' Core Competencies are:

Anti-Aging
Gene Expression
Neuro-Peptides
Cosme-ceuticals (Skin Care)
Skin "Energy Systems"
OTC Products (Sanitizers, SunScreens, etc)
SPF: Sun Protection
Liquid Nutritionals and Juices
Unique Skin Treatments (Intimacy, Sanitation, and "plumping" products)
Think of Wasatch Labs when you are considering sourcing a secondary manufacturer for your existing products or perhaps a reliable, experienced laboratory for product development.
~Wasatch Lab's Competitive Advantages include:

In-House Capabilities (Packaging Engineering, Formula Development, Manufacturing)
International Capabilities
Total Customer Support
Complete Supply Chain Management
cGMP

Thanks for Stopping By – WPG – HOME Tab
https://vimeo.com/75658706
Inside Scoop on Wasatch – WPD - ABOUT Tab
https://vimeo.com/71997930

Whatever the size of the anti-aging product corporation, Wasatch Contract Manufacturing can take it to the next level. They provide packaging engineering, formula development, private labeling, and manufacturing of liquid products. Small Companies: They help small companies identify their industry niche, develop proprietary formulas, and make a strong debut on the market. Many of their current Salt Lake City start-ups are focused on emerging Utah and national markets: gene expression, skin energy systems, specialty sun care, and anti-aging.

Medium Size Companies: Wasatch helps medium companies refine their product lines, improve quality, and manage production growth.

Large Utah Companies: They help large companies diversify and respond to changes in the market. Many large companies are developing new product lines in high-demand mitochondrial anti-senescence, neuro peptides, and acne products. Wasatch Contract Manufacturing is a cGMP, FDA, EPA, and ATF compliant facility. Wasatch has been formulating liquid products for over twenty years without an FDA violation. Call their operations manager today to learn how Wasatch can help a company move forward.

About Wasatch Product Development
Wasatch Product Development is focused on providing the most responsive and flexible service in the industry and has a diverse clientele ranging from leading global companies to virtual and emerging entities. With unmatched technical expertise, innovative equipment and regulatory knowledge, Wasatch maintains a demonstrated record with the FDA as well as with its customers; many of whom have outsourced with the company for over ten years. The Wasatch Product Development's lab is compliant with Good Manufacturing Practices (cGMP) along with being registered and certified by the ATF, and FDA. Wasatch has been developing and manufacturing several unique products for many of the World's most successful consumer product companies since 1998.

http://wasatchcontractmanufacturing.com/

For more information on this press release visit: http://www.sbwire.com/press-releases/private-label-skin-care-co-packer-news-wasatch-contract-manufacturing-sales-manager-adam-green-ratifies-utah-business-plan-focus-for-equity-laboratory-production-expansion-548676.htm

Media Relations Contact

Adam Green
Telephone: 801-566-4449
Email: Click to Email Adam Green
Web: http://wasatchcontractmanufacturing.com/


          Contract-Manufacturer Adam Green and Steve ThomasNet Big Success: Adam Green, Backs the Draper Based Private Label Manufacturer Body Care Technology on Wednesday        

Glendale, AZ -- (SBWIRE) -- 10/01/2014 -- Wasatch Product Development is focused on providing the most responsive and flexible service in the industry and has a diverse clientele ranging from leading global companies to virtual and emerging entities. With unmatched technical expertise, innovative equipment and regulatory knowledge, Wasatch maintains a demonstrated record with the FDA as well as with its customers; many of whom have outsourced with the company for over ten years. The Wasatch Product Development's lab is compliant with Good Manufacturing Practices (cGMP) along with being registered and certified by the ATF, and FDA. Wasatch has been developing and manufacturing several unique products for many of the World's most successful consumer product companies since 1998.

801-566-4449
Owner, Kevin Casey
http://wasatchcontractmanufacturing.com/contact/
kcasey@wasatchlabs.net

Mission Statement
To proactively serve our business community by providing solutions
in personal care, business development and liquid nutrition.

Vision Statement
To provide leadership in establishing our client's international businesses,
being built on a foundation of innovation, advocacy, technology and business integrity.

http://wasatchcontractmanufacturing.com/

~Wasatch Labs' Core Competencies are:

Anti-Aging
Gene Expression
Neuro-Peptides
Cosme-ceuticals (Skin Care)
Skin "Energy Systems"
OTC Products (Sanitizers, SunScreens, etc)
SPF: Sun Protection
Liquid Nutritionals and Juices
Unique Skin Treatments (Intimacy, Sanitation, and "plumping" products)
Think of Wasatch Labs when you are considering sourcing a secondary manufacturer for your existing products or perhaps a reliable, experienced laboratory for product development.
~Wasatch Lab's Competitive Advantages include:

In-House Capabilities (Packaging Engineering, Formula Development, Manufacturing)
International Capabilities
Total Customer Support
Complete Supply Chain Management
cGMP

Thanks for Stopping By – WPG – HOME Tab
https://vimeo.com/75658706

Whatever the size of the anti-aging product corporation, Wasatch Contract Manufacturing can take it to the next level. They provide packaging engineering, formula development, private labeling, and manufacturing of liquid products. Small Companies: They help small companies identify their industry niche, develop proprietary formulas, and make a strong debut on the market. Many of their current Salt Lake City start-ups are focused on emerging Utah and national markets: gene expression, skin energy systems, specialty sun care, and anti-aging.

Medium Size Companies: Wasatch helps medium companies refine their product lines, improve quality, and manage production growth.

Large Utah Companies: They help large companies diversify and respond to changes in the market. Many large companies are developing new product lines in high-demand mitochondrial anti-senescence, neuro peptides, and acne products. Wasatch Contract Manufacturing is a cGMP, FDA, EPA, and ATF compliant facility. Wasatch has been formulating liquid products for over twenty years without an FDA violation. Call their operations manager today to learn how Wasatch can help a company move forward.

About Wasatch Product Development
Wasatch Product Development is focused on providing the most responsive and flexible service in the industry and has a diverse clientele ranging from leading global companies to virtual and emerging entities. With unmatched technical expertise, innovative equipment and regulatory knowledge, Wasatch maintains a demonstrated record with the FDA as well as with its customers; many of whom have outsourced with the company for over ten years. The Wasatch Product Development's lab is compliant with Good Manufacturing Practices (cGMP) along with being registered and certified by the ATF, and FDA. Wasatch has been developing and manufacturing several unique products for many of the World's most successful consumer product companies since 1998.

http://wasatchcontractmanufacturing.com/

For more information on this press release visit: http://www.sbwire.com/press-releases/contract-manufacturer-adam-green-and-steve-thomasnet-big-success-adam-green-backs-the-draper-based-private-label-manufacturer-body-care-technology-on-wednesday-548378.htm

Media Relations Contact

Adam Green
Telephone: 801-566-4449
Email: Click to Email Adam Green
Web: http://wasatchcontractmanufacturing.com/


          Private-Label-Manufacturer Adam Green and Steve ThomasNet Big Success: G3-Development Board Member, Approves the Draper Based Nutritional Toll Supplier Cosmetic Technology        

Surprise, AZ -- (SBWIRE) -- 10/01/2014 -- Wasatch Product Development is focused on providing the most responsive and flexible service in the industry and has a diverse clientele ranging from leading global companies to virtual and emerging entities. With unmatched technical expertise, innovative equipment and regulatory knowledge, Wasatch maintains a demonstrated record with the FDA as well as with its customers; many of whom have outsourced with the company for over ten years. The Wasatch Product Development's lab is compliant with Good Manufacturing Practices (cGMP) along with being registered and certified by the ATF, and FDA. Wasatch has been developing and manufacturing several unique products for many of the World's most successful consumer product companies since 1998.

801-566-4449
Owner, Kevin Casey
http://wasatchcontractmanufacturing.com/contact/
kcasey@wasatchlabs.net

Mission Statement
To proactively serve our business community by providing solutions
in personal care, business development and liquid nutrition.

Vision Statement
To provide leadership in establishing our client's international businesses,
being built on a foundation of innovation, advocacy, technology and business integrity.

http://wasatchcontractmanufacturing.com/

~Wasatch Labs' Core Competencies are:

Anti-Aging
Gene Expression
Neuro-Peptides
Cosme-ceuticals (Skin Care)
Skin "Energy Systems"
OTC Products (Sanitizers, SunScreens, etc)
SPF: Sun Protection
Liquid Nutritionals and Juices
Unique Skin Treatments (Intimacy, Sanitation, and "plumping" products)
Think of Wasatch Labs when you are considering sourcing a secondary manufacturer for your existing products or perhaps a reliable, experienced laboratory for product development.
~Wasatch Lab's Competitive Advantages include:

In-House Capabilities (Packaging Engineering, Formula Development, Manufacturing)
International Capabilities
Total Customer Support
Complete Supply Chain Management
cGMP

Thanks for Stopping By – WPG – HOME Tab
https://vimeo.com/75658706

Whatever the size of the anti-aging product corporation, Wasatch Contract Manufacturing can take it to the next level. They provide packaging engineering, formula development, private labeling, and manufacturing of liquid products. Small Companies: They help small companies identify their industry niche, develop proprietary formulas, and make a strong debut on the market. Many of their current Salt Lake City start-ups are focused on emerging Utah and national markets: gene expression, skin energy systems, specialty sun care, and anti-aging.

Medium Size Companies: Wasatch helps medium companies refine their product lines, improve quality, and manage production growth.

Large Utah Companies: They help large companies diversify and respond to changes in the market. Many large companies are developing new product lines in high-demand mitochondrial anti-senescence, neuro peptides, and acne products. Wasatch Contract Manufacturing is a cGMP, FDA, EPA, and ATF compliant facility. Wasatch has been formulating liquid products for over twenty years without an FDA violation. Call their operations manager today to learn how Wasatch can help a company move forward.

About Wasatch Product Development
Wasatch Product Development is focused on providing the most responsive and flexible service in the industry and has a diverse clientele ranging from leading global companies to virtual and emerging entities. With unmatched technical expertise, innovative equipment and regulatory knowledge, Wasatch maintains a demonstrated record with the FDA as well as with its customers; many of whom have outsourced with the company for over ten years. The Wasatch Product Development's lab is compliant with Good Manufacturing Practices (cGMP) along with being registered and certified by the ATF, and FDA. Wasatch has been developing and manufacturing several unique products for many of the World's most successful consumer product companies since 1998.

http://wasatchcontractmanufacturing.com/

For more information on this press release visit: http://www.sbwire.com/press-releases/private-label-manufacturer-adam-green-and-steve-thomasnet-big-success-g3-development-board-member-approves-the-draper-based-nutritional-toll-supplier-cosmetic-technology-548379.htm

Media Relations Contact

Adam Green
Telephone: 801-566-4449
Email: Click to Email Adam Green
Web: http://wasatchcontractmanufacturing.com/


          Private Label Pill Co-Packer News: G3-Development Adam Green, Recommends Utah Business Plan Focus for Equity Laboratory Production Expansion        

Pembroke Pines, FL -- (SBWIRE) -- 10/01/2014 -- Wasatch Product Development is focused on providing the most responsive and flexible service in the industry and has a diverse clientele ranging from leading global companies to virtual and emerging entities. With unmatched technical expertise, innovative equipment and regulatory knowledge, Wasatch maintains a demonstrated record with the FDA as well as with its customers; many of whom have outsourced with the company for over ten years. The Wasatch Product Development's lab is compliant with Good Manufacturing Practices (cGMP) along with being registered and certified by the ATF, and FDA. Wasatch has been developing and manufacturing several unique products for many of the World's most successful consumer product companies since 1998.

The purpose of this press release is to announce that the G3 Development and Wasatch Contract Manufacturing Founder, Adam Paul Green, has just announced he will speak with Wasatch Liquid Contract Manufacturer. Wasatch Contract Manufacturing is a private label nutritional beverage co-packer providing the most responsive and flexible service in the industry and has a diverse clientele ranging from leading global companies to virtual and emerging entities.

Adam will speak with them on his weekly webinar, which is hosted from from his virtual office. Adam plans to address the Utah Business Plan Focus for Equity Laboratory Production Expansion.

The webinar will take place on October 22, 2014.

New call number: 1-888-998-7766
New virtual office login site: http://xocaimeeting.bojabie.com/

801-566-4449
Owner, Kevin Casey
http://wasatchcontractmanufacturing.com/contact/
kcasey@wasatchlabs.net

Mission Statement
To proactively serve our business community by providing solutions
in personal care, business development and liquid nutrition.

Vision Statement
To provide leadership in establishing our client's international businesses,
being built on a foundation of innovation, advocacy, technology and business integrity.

http://wasatchcontractmanufacturing.com/

~Wasatch Labs' Core Competencies are:

Anti-Aging
Gene Expression
Neuro-Peptides
Cosme-ceuticals (Skin Care)
Skin "Energy Systems"
OTC Products (Sanitizers, SunScreens, etc)
SPF: Sun Protection
Liquid Nutritionals and Juices
Unique Skin Treatments (Intimacy, Sanitation, and "plumping" products)
Think of Wasatch Labs when you are considering sourcing a secondary manufacturer for your existing products or perhaps a reliable, experienced laboratory for product development.
~Wasatch Lab's Competitive Advantages include:

In-House Capabilities (Packaging Engineering, Formula Development, Manufacturing)
International Capabilities
Total Customer Support
Complete Supply Chain Management
cGMP

Thanks for Stopping By – WPG – HOME Tab
https://vimeo.com/75658706
Inside Scoop on Wasatch – WPD - ABOUT Tab
https://vimeo.com/71997930

Whatever the size of the anti-aging product corporation, Wasatch Contract Manufacturing can take it to the next level. They provide packaging engineering, formula development, private labeling, and manufacturing of liquid products. Small Companies: They help small companies identify their industry niche, develop proprietary formulas, and make a strong debut on the market. Many of their current Salt Lake City start-ups are focused on emerging Utah and national markets: gene expression, skin energy systems, specialty sun care, and anti-aging.

Medium Size Companies: Wasatch helps medium companies refine their product lines, improve quality, and manage production growth.

Large Utah Companies: They help large companies diversify and respond to changes in the market. Many large companies are developing new product lines in high-demand mitochondrial anti-senescence, neuro peptides, and acne products. Wasatch Contract Manufacturing is a cGMP, FDA, EPA, and ATF compliant facility. Wasatch has been formulating liquid products for over twenty years without an FDA violation. Call their operations manager today to learn how Wasatch can help a company move forward.

About Wasatch Product Development
Wasatch Product Development is focused on providing the most responsive and flexible service in the industry and has a diverse clientele ranging from leading global companies to virtual and emerging entities. With unmatched technical expertise, innovative equipment and regulatory knowledge, Wasatch maintains a demonstrated record with the FDA as well as with its customers; many of whom have outsourced with the company for over ten years. The Wasatch Product Development's lab is compliant with Good Manufacturing Practices (cGMP) along with being registered and certified by the ATF, and FDA. Wasatch has been developing and manufacturing several unique products for many of the World's most successful consumer product companies since 1998.

http://wasatchcontractmanufacturing.com/

For more information on this press release visit: http://www.sbwire.com/press-releases/private-label-pill-co-packer-news-g3-development-adam-green-recommends-utah-business-plan-focus-for-equity-laboratory-production-expansion-548664.htm

Media Relations Contact

Adam Green
Telephone: 801-566-4449
Email: Click to Email Adam Green
Web: http://wasatchcontractmanufacturing.com/


          Contract-Manufacturer Adam Green and Steve ThomasNet Big Success: G3 Development Chairman, Commends the Draper Based Custom Pharmaceutical Provider Anti-Aging Technology        

Ann Arbor, MI -- (SBWIRE) -- 10/01/2014 -- Wasatch Product Development is focused on providing the most responsive and flexible service in the industry and has a diverse clientele ranging from leading global companies to virtual and emerging entities. With unmatched technical expertise, innovative equipment and regulatory knowledge, Wasatch maintains a demonstrated record with the FDA as well as with its customers; many of whom have outsourced with the company for over ten years. The Wasatch Product Development's lab is compliant with Good Manufacturing Practices (cGMP) along with being registered and certified by the ATF, and FDA. Wasatch has been developing and manufacturing several unique products for many of the World's most successful consumer product companies since 1998.

801-566-4449
Owner, Kevin Casey
http://wasatchcontractmanufacturing.com/contact/
kcasey@wasatchlabs.net

Mission Statement
To proactively serve our business community by providing solutions
in personal care, business development and liquid nutrition.

Vision Statement
To provide leadership in establishing our client's international businesses,
being built on a foundation of innovation, advocacy, technology and business integrity.

http://wasatchcontractmanufacturing.com/

~Wasatch Labs' Core Competencies are:

Anti-Aging
Gene Expression
Neuro-Peptides
Cosme-ceuticals (Skin Care)
Skin "Energy Systems"
OTC Products (Sanitizers, SunScreens, etc)
SPF: Sun Protection
Liquid Nutritionals and Juices
Unique Skin Treatments (Intimacy, Sanitation, and "plumping" products)
Think of Wasatch Labs when you are considering sourcing a secondary manufacturer for your existing products or perhaps a reliable, experienced laboratory for product development.
~Wasatch Lab's Competitive Advantages include:

In-House Capabilities (Packaging Engineering, Formula Development, Manufacturing)
International Capabilities
Total Customer Support
Complete Supply Chain Management
cGMP

Thanks for Stopping By – WPG – HOME Tab
https://vimeo.com/75658706

Whatever the size of the anti-aging product corporation, Wasatch Contract Manufacturing can take it to the next level. They provide packaging engineering, formula development, private labeling, and manufacturing of liquid products. Small Companies: They help small companies identify their industry niche, develop proprietary formulas, and make a strong debut on the market. Many of their current Salt Lake City start-ups are focused on emerging Utah and national markets: gene expression, skin energy systems, specialty sun care, and anti-aging.

Medium Size Companies: Wasatch helps medium companies refine their product lines, improve quality, and manage production growth.

Large Utah Companies: They help large companies diversify and respond to changes in the market. Many large companies are developing new product lines in high-demand mitochondrial anti-senescence, neuro peptides, and acne products. Wasatch Contract Manufacturing is a cGMP, FDA, EPA, and ATF compliant facility. Wasatch has been formulating liquid products for over twenty years without an FDA violation. Call their operations manager today to learn how Wasatch can help a company move forward.

About Wasatch Product Development
Wasatch Product Development is focused on providing the most responsive and flexible service in the industry and has a diverse clientele ranging from leading global companies to virtual and emerging entities. With unmatched technical expertise, innovative equipment and regulatory knowledge, Wasatch maintains a demonstrated record with the FDA as well as with its customers; many of whom have outsourced with the company for over ten years. The Wasatch Product Development's lab is compliant with Good Manufacturing Practices (cGMP) along with being registered and certified by the ATF, and FDA. Wasatch has been developing and manufacturing several unique products for many of the World's most successful consumer product companies since 1998.

http://wasatchcontractmanufacturing.com/

For more information on this press release visit: http://www.sbwire.com/press-releases/contract-manufacturer-adam-green-and-steve-thomasnet-big-success-g3-development-chairman-commends-the-draper-based-custom-pharmaceutical-provider-anti-aging-technology-548662.htm

Media Relations Contact

Adam Green
Telephone: 801-566-4449
Email: Click to Email Adam Green
Web: http://wasatchcontractmanufacturing.com/


          Wasatch Liquid Contract-Manufacturer and Nutritional Supplement-Supplier Lab News: G3 Development Fund Raiser, Adam Green, Defends Wasatch New Personal Care Technology        

Tucson, AZ -- (SBWIRE) -- 09/30/2014 -- Wasatch Product Development is focused on providing the most responsive and flexible service in the industry and has a diverse clientele ranging from leading global companies to virtual and emerging entities. With unmatched technical expertise, innovative equipment and regulatory knowledge, Wasatch maintains a demonstrated record with the FDA as well as with its customers; many of whom have outsourced with the company for over ten years. The Wasatch Product Development's lab is compliant with Good Manufacturing Practices (cGMP) along with being registered and certified by the ATF, and FDA. Wasatch has been developing and manufacturing several unique products for many of the World's most successful consumer product companies since 1998.

Mr. Adam Paul Green, the G3-Development Founder, has just announced he will speak with Wasatch Liquid Contract Manufacturer and Nutritional Supplement Supplier Lab, concerning their "801- Personal Care Technology" on his weekly webinar, which is hosted from from his virtual office in Tucson, AZ.

The webinar for "801- Personal Care Technology" will take place on October 9, 2014.

New call number: 888-998-7766
New virtual office login site: http://xocaimeeting.bojabie.com/
http://wasatchcontractmanufacturing.com/ Webinar

801-566-4449
Owner, Kevin Casey
http://wasatchcontractmanufacturing.com/contact/
kcasey@wasatchlabs.net

Mission Statement
To proactively serve our business community by providing solutions
in personal care, business development and liquid nutrition.

Vision Statement
To provide leadership in establishing our client's international businesses,
being built on a foundation of innovation, advocacy, technology and business integrity.

http://wasatchcontractmanufacturing.com/

~Wasatch Labs' Core Competencies are:

Anti-Aging
Gene Expression
Neuro-Peptides
Cosme-ceuticals (Skin Care)
Skin "Energy Systems"
OTC Products (Sanitizers, SunScreens, etc)
SPF: Sun Protection
Liquid Nutritionals and Juices
Unique Skin Treatments (Intimacy, Sanitation, and "plumping" products)
Think of Wasatch Labs when you are considering sourcing a secondary manufacturer for your existing products or perhaps a reliable, experienced laboratory for product development.

~Wasatch Lab's Competitive Advantages include:

In-House Capabilities (Packaging Engineering, Formula Development, Manufacturing)
International Capabilities
Total Customer Support
Complete Supply Chain Management
cGMP

Thanks for Stopping By – WPG – HOME Tab
https://vimeo.com/75658706
Inside Scoop on Wasatch – WPD - ABOUT Tab
https://vimeo.com/71997930

Whatever the size of the anti-aging product corporation, Wasatch Contract Manufacturing can take it to the next level. They provide packaging engineering, formula development, private labeling, and manufacturing of liquid products. Small Companies: They help small companies identify their industry niche, develop proprietary formulas, and make a strong debut on the market. Many of their current Salt Lake City start-ups are focused on emerging Utah and national markets: gene expression, skin energy systems, specialty sun care, and anti-aging.

Medium Size Companies: Wasatch helps medium companies refine their product lines, improve quality, and manage production growth.

Large Utah Companies: They help large companies diversify and respond to changes in the market. Many large companies are developing new product lines in high-demand mitochondrial anti-senescence, neuro peptides, and acne products. Wasatch Contract Manufacturing is a cGMP, FDA, EPA, and ATF compliant facility. Wasatch has been formulating liquid products for over twenty years without an FDA violation. Call their operations manager today to learn how Wasatch can help a company move forward.

About Wasatch Product Development
Wasatch Product Development is focused on providing the most responsive and flexible service in the industry and has a diverse clientele ranging from leading global companies to virtual and emerging entities. With unmatched technical expertise, innovative equipment and regulatory knowledge, Wasatch maintains a demonstrated record with the FDA as well as with its customers; many of whom have outsourced with the company for over ten years. The Wasatch Product Development's lab is compliant with Good Manufacturing Practices (cGMP) along with being registered and certified by the ATF, and FDA. Wasatch has been developing and manufacturing several unique products for many of the World's most successful consumer product companies since 1998.
http://wasatchcontractmanufacturing.com/

For more information on this press release visit: http://www.sbwire.com/press-releases/wasatch-liquid-contract-manufacturer-and-nutritional-supplement-supplier-lab-news-g3-development-fund-raiser-adam-green-defends-wasatch-new-personal-care-technology-548374.htm

Media Relations Contact

Adam Green
Telephone: 801-566-4449
Email: Click to Email Adam Green
Web: http://wasatchcontractmanufacturing.com/


          G3-Development Sales Manager, Adam Green, Favors Wasatch New Hair Care Technology        

Honolulu, HI -- (SBWIRE) -- 09/30/2014 -- Wasatch Product Development is focused on providing the most responsive and flexible service in the industry and has a diverse clientele ranging from leading global companies to virtual and emerging entities. With unmatched technical expertise, innovative equipment and regulatory knowledge, Wasatch maintains a demonstrated record with the FDA as well as with its customers; many of whom have outsourced with the company for over ten years. The Wasatch Product Development's lab is compliant with Good Manufacturing Practices (cGMP) along with being registered and certified by the ATF, and FDA. Wasatch has been developing and manufacturing several unique products for many of the World's most successful consumer product companies since 1998.

Mr. Adam Paul Green, the G3-Development Founder, has just announced he will speak with Wasatch Liquid Contract Manufacturer and Nutritional Supplement Supplier Lab, concerning their "801- Hair Care Technology" on his weekly webinar, which is hosted from from his virtual office in Honolulu, HI.

The webinar for "801- Hair Care Technology" will take place on October 9, 2014.

New call number: 888-998-7766
New virtual office login site: http://xocaimeeting.bojabie.com/
http://wasatchcontractmanufacturing.com/about/ Webinar

801-566-4449
Owner, Kevin Casey
http://wasatchcontractmanufacturing.com/contact/
kcasey@wasatchlabs.net

Mission Statement
To proactively serve our business community by providing solutions
in personal care, business development and liquid nutrition.

Vision Statement
To provide leadership in establishing our client's international businesses,
being built on a foundation of innovation, advocacy, technology and business integrity.

http://wasatchcontractmanufacturing.com/

~Wasatch Labs' Core Competencies are:

Anti-Aging
Gene Expression
Neuro-Peptides
Cosme-ceuticals (Skin Care)
Skin "Energy Systems"
OTC Products (Sanitizers, SunScreens, etc)
SPF: Sun Protection
Liquid Nutritionals and Juices
Unique Skin Treatments (Intimacy, Sanitation, and "plumping" products)
Think of Wasatch Labs when you are considering sourcing a secondary manufacturer for your existing products or perhaps a reliable, experienced laboratory for product development.

~Wasatch Lab's Competitive Advantages include:

In-House Capabilities (Packaging Engineering, Formula Development, Manufacturing)
International Capabilities
Total Customer Support
Complete Supply Chain Management
cGMP

Thanks for Stopping By – WPG – HOME Tab
https://vimeo.com/75658706
Inside Scoop on Wasatch – WPD - ABOUT Tab
https://vimeo.com/71997930

Whatever the size of the anti-aging product corporation, Wasatch Contract Manufacturing can take it to the next level. They provide packaging engineering, formula development, private labeling, and manufacturing of liquid products. Small Companies: They help small companies identify their industry niche, develop proprietary formulas, and make a strong debut on the market. Many of their current Salt Lake City start-ups are focused on emerging Utah and national markets: gene expression, skin energy systems, specialty sun care, and anti-aging.

Medium Size Companies: Wasatch helps medium companies refine their product lines, improve quality, and manage production growth.

Large Utah Companies: They help large companies diversify and respond to changes in the market. Many large companies are developing new product lines in high-demand mitochondrial anti-senescence, neuro peptides, and acne products. Wasatch Contract Manufacturing is a cGMP, FDA, EPA, and ATF compliant facility. Wasatch has been formulating liquid products for over twenty years without an FDA violation. Call their operations manager today to learn how Wasatch can help a company move forward.

About Wasatch Product Development
Wasatch Product Development is focused on providing the most responsive and flexible service in the industry and has a diverse clientele ranging from leading global companies to virtual and emerging entities. With unmatched technical expertise, innovative equipment and regulatory knowledge, Wasatch maintains a demonstrated record with the FDA as well as with its customers; many of whom have outsourced with the company for over ten years. The Wasatch Product Development's lab is compliant with Good Manufacturing Practices (cGMP) along with being registered and certified by the ATF, and FDA. Wasatch has been developing and manufacturing several unique products for many of the World's most successful consumer product companies since 1998.
http://wasatchcontractmanufacturing.com/

For more information on this press release visit: http://www.sbwire.com/press-releases/g3-development-sales-manager-adam-green-favors-wasatch-new-hair-care-technology-548375.htm

Media Relations Contact

Adam Green
Telephone: 801-566-4449
Email: Click to Email Adam Green
Web: http://wasatchcontractmanufacturing.com/


          Adam Green and Steve ThomasNet Big Success: G3-Development Founder, Affirms the Draper Based Custom Pharmaceutical Provider Skin Care Technology        

Charleston, SC -- (SBWIRE) -- 09/30/2014 -- Wasatch Product Development is focused on providing the most responsive and flexible service in the industry and has a diverse clientele ranging from leading global companies to virtual and emerging entities. With unmatched technical expertise, innovative equipment and regulatory knowledge, Wasatch maintains a demonstrated record with the FDA as well as with its customers; many of whom have outsourced with the company for over ten years. The Wasatch Product Development's lab is compliant with Good Manufacturing Practices (cGMP) along with being registered and certified by the ATF, and FDA. Wasatch has been developing and manufacturing several unique products for many of the World's most successful consumer product companies since 1998.

801-566-4449
Owner, Kevin Casey
http://wasatchcontractmanufacturing.com/contact/
kcasey@wasatchlabs.net

Mission Statement
To proactively serve our business community by providing solutions
in personal care, business development and liquid nutrition.

Vision Statement
To provide leadership in establishing our client's international businesses,
being built on a foundation of innovation, advocacy, technology and business integrity.

http://wasatchcontractmanufacturing.com/

~Wasatch Labs' Core Competencies are:

Anti-Aging
Gene Expression
Neuro-Peptides
Cosme-ceuticals (Skin Care)
Skin "Energy Systems"
OTC Products (Sanitizers, SunScreens, etc)
SPF: Sun Protection
Liquid Nutritionals and Juices
Unique Skin Treatments (Intimacy, Sanitation, and "plumping" products)
Think of Wasatch Labs when you are considering sourcing a secondary manufacturer for your existing products or perhaps a reliable, experienced laboratory for product development.

~Wasatch Lab's Competitive Advantages include:

In-House Capabilities (Packaging Engineering, Formula Development, Manufacturing)
International Capabilities
Total Customer Support
Complete Supply Chain Management
cGMP

Thanks for Stopping By – WPG – HOME Tab
https://vimeo.com/75658706

Whatever the size of the anti-aging product corporation, Wasatch Contract Manufacturing can take it to the next level. They provide packaging engineering, formula development, private labeling, and manufacturing of liquid products. Small Companies: They help small companies identify their industry niche, develop proprietary formulas, and make a strong debut on the market. Many of their current Salt Lake City start-ups are focused on emerging Utah and national markets: gene expression, skin energy systems, specialty sun care, and anti-aging.

Medium Size Companies: Wasatch helps medium companies refine their product lines, improve quality, and manage production growth.

Large Utah Companies: They help large companies diversify and respond to changes in the market. Many large companies are developing new product lines in high-demand mitochondrial anti-senescence, neuro peptides, and acne products. Wasatch Contract Manufacturing is a cGMP, FDA, EPA, and ATF compliant facility. Wasatch has been formulating liquid products for over twenty years without an FDA violation. Call their operations manager today to learn how Wasatch can help a company move forward.

About Wasatch Product Development
Wasatch Product Development is focused on providing the most responsive and flexible service in the industry and has a diverse clientele ranging from leading global companies to virtual and emerging entities. With unmatched technical expertise, innovative equipment and regulatory knowledge, Wasatch maintains a demonstrated record with the FDA as well as with its customers; many of whom have outsourced with the company for over ten years. The Wasatch Product Development's lab is compliant with Good Manufacturing Practices (cGMP) along with being registered and certified by the ATF, and FDA. Wasatch has been developing and manufacturing several unique products for many of the World's most successful consumer product companies since 1998.
http://wasatchcontractmanufacturing.com/

For more information on this press release visit: http://www.sbwire.com/press-releases/adam-green-and-steve-thomasnet-big-success-g3-development-founder-affirms-the-draper-based-custom-pharmaceutical-provider-skin-care-technology-548376.htm

Media Relations Contact

Adam Green
Telephone: 801-566-4449
Email: Click to Email Adam Green
Web: http://wasatchcontractmanufacturing.com/


          Wasatch Liquid-Contract-Manufacturer and Nutritional-Supplement-Supplier Lab News: G3-Development Capitalist, Adam Green, Confirms Wasatch New 801- Cosmeceutical Technology        

Charlotte, NC -- (SBWIRE) -- 09/30/2014 -- Wasatch Product Development is focused on providing the most responsive and flexible service in the industry and has a diverse clientele ranging from leading global companies to virtual and emerging entities. With unmatched technical expertise, innovative equipment and regulatory knowledge, Wasatch maintains a demonstrated record with the FDA as well as with its customers; many of whom have outsourced with the company for over ten years. The Wasatch Product Development's lab is compliant with Good Manufacturing Practices (cGMP) along with being registered and certified by the ATF, and FDA. Wasatch has been developing and manufacturing several unique products for many of the World's most successful consumer product companies since 1998.

Mr. Adam Paul Green, the G3-Development Founder, has just announced he will speak with Wasatch Liquid Contract Manufacturer and Nutritional Supplement Supplier Lab, concerning their "801- Cosmeceutical Technology" on his weekly webinar, which is hosted from from his virtual office in Charlotte, NC

The webinar for "801- Cosmeceutical Technology" will take place on October 9, 2014.

New call number: 888-998-7766
New virtual office login site: http://xocaimeeting.bojabie.com/

Saturday http://wasatchcontractmanufacturing.com/contact/ Webinar

801-566-4449
Owner, Kevin Casey
http://wasatchcontractmanufacturing.com/contact/
kcasey@wasatchlabs.net

Mission Statement
To proactively serve our business community by providing solutions
in personal care, business development and liquid nutrition.

Vision Statement
To provide leadership in establishing our client's international businesses,
being built on a foundation of innovation, advocacy, technology and business integrity.

http://wasatchcontractmanufacturing.com/

~Wasatch Labs' Core Competencies are:

Anti-Aging
Gene Expression
Neuro-Peptides
Cosme-ceuticals (Skin Care)
Skin "Energy Systems"
OTC Products (Sanitizers, SunScreens, etc)
SPF: Sun Protection
Liquid Nutritionals and Juices
Unique Skin Treatments (Intimacy, Sanitation, and "plumping" products)
Think of Wasatch Labs when you are considering sourcing a secondary manufacturer for your existing products or perhaps a reliable, experienced laboratory for product development.

~Wasatch Lab's Competitive Advantages include:

In-House Capabilities (Packaging Engineering, Formula Development, Manufacturing)
International Capabilities
Total Customer Support
Complete Supply Chain Management
cGMP

Thanks for Stopping By – WPG – HOME Tab
https://vimeo.com/75658706
Inside Scoop on Wasatch – WPD - ABOUT Tab
https://vimeo.com/71997930

Whatever the size of the anti-aging product corporation, Wasatch Contract Manufacturing can take it to the next level. They provide packaging engineering, formula development, private labeling, and manufacturing of liquid products. Small Companies: They help small companies identify their industry niche, develop proprietary formulas, and make a strong debut on the market. Many of their current Salt Lake City start-ups are focused on emerging Utah and national markets: gene expression, skin energy systems, specialty sun care, and anti-aging.

Medium Size Companies: Wasatch helps medium companies refine their product lines, improve quality, and manage production growth.

Large Utah Companies: They help large companies diversify and respond to changes in the market. Many large companies are developing new product lines in high-demand mitochondrial anti-senescence, neuro peptides, and acne products. Wasatch Contract Manufacturing is a cGMP, FDA, EPA, and ATF compliant facility. Wasatch has been formulating liquid products for over twenty years without an FDA violation. Call their operations manager today to learn how Wasatch can help a company move forward.

About Wasatch Product Development
Wasatch Product Development is focused on providing the most responsive and flexible service in the industry and has a diverse clientele ranging from leading global companies to virtual and emerging entities. With unmatched technical expertise, innovative equipment and regulatory knowledge, Wasatch maintains a demonstrated record with the FDA as well as with its customers; many of whom have outsourced with the company for over ten years. The Wasatch Product Development's lab is compliant with Good Manufacturing Practices (cGMP) along with being registered and certified by the ATF, and FDA. Wasatch has been developing and manufacturing several unique products for many of the World's most successful consumer product companies since 1998.
http://wasatchcontractmanufacturing.com/

For more information on this press release visit: http://www.sbwire.com/press-releases/wasatch-liquid-contract-manufacturer-and-nutritional-supplement-supplier-lab-news-g3-development-capitalist-adam-green-confirms-wasatch-new-801-cosmeceutical-technology-548372.htm

Media Relations Contact

Adam Green
Telephone: 801-566-4449
Email: Click to Email Adam Green
Web: http://wasatchcontractmanufacturing.com/


          Custom Pharmaceutical and Nutritional Toll Supplier Update for Wasatch Labs: G3-Development Owner, Adam Green, Endorses the Draper Based Private Label Manufacturer        

Peoria, AZ -- (SBWIRE) -- 09/29/2014 -- To provide leadership in establishing our client's international businesses, being built on a foundation of innovation, advocacy, technology and business integrity.

http://wasatchcontractmanufacturing.com/

~Wasatch Labs' Core Competencies are:

Anti-Aging
Gene Expression
Neuro-Peptides
Cosme-ceuticals (Skin Care)
Skin "Energy Systems"
OTC Products (Sanitizers, SunScreens, etc)
SPF: Sun Protection
Liquid Nutritionals and Juices
Unique Skin Treatments (Intimacy, Sanitation, and "plumping" products)
Think of Wasatch Labs when you are considering sourcing a secondary manufacturer for your existing products or perhaps a reliable, experienced laboratory for product development.

~Wasatch Lab's Competitive Advantages include:

In-House Capabilities (Packaging Engineering, Formula Development, Manufacturing)
International Capabilities
Total Customer Support
Complete Supply Chain Management
cGMP

Thanks for Stopping By – WPG – HOME Tab
https://vimeo.com/75658706
Inside Scoop on Wasatch – WPD - ABOUT Tab
https://vimeo.com/71997930

Whatever the size of the anti-aging product corporation, Wasatch Contract Manufacturing can take it to the next level. They provide packaging engineering, formula development, private labeling, and manufacturing of liquid products. Small Companies: They help small companies identify their industry niche, develop proprietary formulas, and make a strong debut on the market. Many of their current Salt Lake City start-ups are focused on emerging Utah and national markets: gene expression, skin energy systems, specialty sun care, and anti-aging.

Medium Size Companies: Wasatch helps medium companies refine their product lines, improve quality, and manage production growth.

Large Utah Companies: They help large companies diversify and respond to changes in the market. Many large companies are developing new product lines in high-demand mitochondrial anti-senescence, neuro peptides, and acne products. Wasatch Contract Manufacturing is a cGMP, FDA, EPA, and ATF compliant facility. Wasatch has been formulating liquid products for over twenty years without an FDA violation. Call their operations manager today to learn how Wasatch can help a company move forward.

About Wasatch Product Development
Wasatch Product Development is focused on providing the most responsive and flexible service in the industry and has a diverse clientele ranging from leading global companies to virtual and emerging entities. With unmatched technical expertise, innovative equipment and regulatory knowledge, Wasatch maintains a demonstrated record with the FDA as well as with its customers; many of whom have outsourced with the company for over ten years. The Wasatch Product Development's lab is compliant with Good Manufacturing Practices (cGMP) along with being registered and certified by the ATF, and FDA. Wasatch has been developing and manufacturing several unique products for many of the World's most successful consumer product companies since 1998.
http://wasatchcontractmanufacturing.com/

For more information on this press release visit: http://www.sbwire.com/press-releases/custom-pharmaceutical-and-nutritional-toll-supplier-update-for-wasatch-labs-g3-development-owner-adam-green-endorses-the-draper-based-private-label-manufacturer-548368.htm

Media Relations Contact

Adam Green
Telephone: 801-566-4449
Email: Click to Email Adam Green
Web: http://wasatchcontractmanufacturing.com/


          Private-Label-Manufacturer and Custom-Pharmaceutical Update for Wasatch Labs: Adam Green, Advocates the Draper Based Nutritional Toll Supplier        

Santa Clarita, CA -- (SBWIRE) -- 09/29/2014 -- To provide leadership in establishing our client's international businesses, being built on a foundation of innovation, advocacy, technology and business integrity.

http://wasatchcontractmanufacturing.com/

~Wasatch Labs' Core Competencies are:

Anti-Aging
Gene Expression
Neuro-Peptides
Cosme-ceuticals (Skin Care)
Skin "Energy Systems"
OTC Products (Sanitizers, SunScreens, etc)
SPF: Sun Protection
Liquid Nutritionals and Juices
Unique Skin Treatments (Intimacy, Sanitation, and "plumping" products)
Think of Wasatch Labs when you are considering sourcing a secondary manufacturer for your existing products or perhaps a reliable, experienced laboratory for product development.
~Wasatch Lab's Competitive Advantages include:

In-House Capabilities (Packaging Engineering, Formula Development, Manufacturing)
International Capabilities
Total Customer Support
Complete Supply Chain Management
cGMP

Thanks for Stopping By – WPG – HOME Tab
https://vimeo.com/75658706
Inside Scoop on Wasatch – WPD - ABOUT Tab
https://vimeo.com/71997930

Whatever the size of the anti-aging product corporation, Wasatch Contract Manufacturing can take it to the next level. They provide packaging engineering, formula development, private labeling, and manufacturing of liquid products. Small Companies: They help small companies identify their industry niche, develop proprietary formulas, and make a strong debut on the market. Many of their current Salt Lake City start-ups are focused on emerging Utah and national markets: gene expression, skin energy systems, specialty sun care, and anti-aging.

Medium Size Companies: Wasatch helps medium companies refine their product lines, improve quality, and manage production growth.

Large Utah Companies: They help large companies diversify and respond to changes in the market. Many large companies are developing new product lines in high-demand mitochondrial anti-senescence, neuro peptides, and acne products. Wasatch Contract Manufacturing is a cGMP, FDA, EPA, and ATF compliant facility. Wasatch has been formulating liquid products for over twenty years without an FDA violation. Call their operations manager today to learn how Wasatch can help a company move forward.

ABOUT Wasatch Product Development
Wasatch Product Development is focused on providing the most responsive and flexible service in the industry and has a diverse clientele ranging from leading global companies to virtual and emerging entities. With unmatched technical expertise, innovative equipment and regulatory knowledge, Wasatch maintains a demonstrated record with the FDA as well as with its customers; many of whom have outsourced with the company for over ten years. The Wasatch Product Development's lab is compliant with Good Manufacturing Practices (cGMP) along with being registered and certified by the ATF, and FDA. Wasatch has been developing and manufacturing several unique products for many of the World's most successful consumer product companies since 1998.

http://wasatchcontractmanufacturing.com/

For more information on this press release visit: http://www.sbwire.com/press-releases/private-label-manufacturer-and-custom-pharmaceutical-update-for-wasatch-labs-adam-green-advocates-the-draper-based-nutritional-toll-supplier-548370.htm

Media Relations Contact

Adam Green
Telephone: 801-566-4449
Email: Click to Email Adam Green
Web: http://wasatchcontractmanufacturing.com/


          Private-Label Pill Co-Packer News: G3-Development Adam Green, Ratifies Utah Business Plan Focus for Equity Laboratory Production Expansion        

Seattle, WA -- (SBWIRE) -- 09/25/2014 -- Wasatch Product Development is focused on providing the most responsive and flexible service in the industry and has a diverse clientele ranging from leading global companies to virtual and emerging entities. With unmatched technical expertise, innovative equipment and regulatory knowledge, Wasatch maintains a demonstrated record with the FDA as well as with its customers; many of whom have outsourced with the company for over ten years. The Wasatch Product Development's lab is compliant with Good Manufacturing Practices (cGMP) along with being registered and certified by the ATF, and FDA. Wasatch has been developing and manufacturing several unique products for many of the World's most successful consumer product companies since 1998.

G3 Development and Wasatch Contract Manufacturing Founder, Adam Paul Green, has just announced he will speak with Wasatch Liquid Contract Manufacturer. Wasatch Contract Manufacturing is a private label nutritional beverage co-packer providing the most responsive and flexible service in the industry and has a diverse clientele ranging from leading global companies to virtual and emerging entities.

Adam will speak with them on his weekly webinar, which is hosted from from his virtual office in Port St. Lucie, FL. Adam plans to address the Utah Business Plan Focus for Equity Laboratory Production Expansion.

The webinar will take place on October 22, 2014.

New call number: 888-998-7766
New virtual office login site: http://xocaimeeting.bojabie.com/

801-566-4449
Owner, Kevin Casey
http://wasatchcontractmanufacturing.com/contact/
kcasey@wasatchlabs.net

Mission Statement
To proactively serve our business community by providing solutions
in personal care, business development and liquid nutrition.

Vision Statement
To provide leadership in establishing our client's international businesses,
being built on a foundation of innovation, advocacy, technology and business integrity.

http://wasatchcontractmanufacturing.com/

~Wasatch Labs' Core Competencies are:

Anti-Aging
Gene Expression
Neuro-Peptides
Cosme-ceuticals (Skin Care)
Skin "Energy Systems"
OTC Products (Sanitizers, SunScreens, etc)
SPF: Sun Protection
Liquid Nutritionals and Juices
Unique Skin Treatments (Intimacy, Sanitation, and "plumping" products)
Think of Wasatch Labs when you are considering sourcing a secondary manufacturer for your existing products or perhaps a reliable, experienced laboratory for product development.

~Wasatch Lab's Competitive Advantages include:

In-House Capabilities (Packaging Engineering, Formula Development, Manufacturing)
International Capabilities
Total Customer Support
Complete Supply Chain Management
cGMP

Thanks for Stopping By – WPG – HOME Tab
https://vimeo.com/75658706
Inside Scoop on Wasatch – WPD - ABOUT Tab
https://vimeo.com/71997930

Whatever the size of the anti-aging product corporation, Wasatch Contract Manufacturing can take it to the next level. They provide packaging engineering, formula development, private labeling, and manufacturing of liquid products. Small Companies: They help small companies identify their industry niche, develop proprietary formulas, and make a strong debut on the market. Many of their current Salt Lake City start-ups are focused on emerging Utah and national markets: gene expression, skin energy systems, specialty sun care, and anti-aging.

Medium Size Companies: Wasatch helps medium companies refine their product lines, improve quality, and manage production growth.

Large Utah Companies: They help large companies diversify and respond to changes in the market. Many large companies are developing new product lines in high-demand mitochondrial anti-senescence, neuro peptides, and acne products. Wasatch Contract Manufacturing is a cGMP, FDA, EPA, and ATF compliant facility. Wasatch has been formulating liquid products for over twenty years without an FDA violation. Call their operations manager today to learn how Wasatch can help a company move forward.

About Wasatch Product Development
Wasatch Product Development is focused on providing the most responsive and flexible service in the industry and has a diverse clientele ranging from leading global companies to virtual and emerging entities. With unmatched technical expertise, innovative equipment and regulatory knowledge, Wasatch maintains a demonstrated record with the FDA as well as with its customers; many of whom have outsourced with the company for over ten years. The Wasatch Product Development's lab is compliant with Good Manufacturing Practices (cGMP) along with being registered and certified by the ATF, and FDA. Wasatch has been developing and manufacturing several unique products for many of the World's most successful consumer product companies since 1998.
http://wasatchcontractmanufacturing.com/

For more information on this press release visit: http://www.sbwire.com/press-releases/private-label-pill-co-packer-news-g3-development-adam-green-ratifies-utah-business-plan-focus-for-equity-laboratory-production-expansion-547734.htm

Media Relations Contact

Adam Green
Telephone: 801-566-4449
Email: Click to Email Adam Green
Web: http://wasatchcontractmanufacturing.com/


          G3 Development and Wasatch Contract Manufacturing Chairman, Adam Green, Recommends Utah Business Plan Focus for Equity Laboratory Production Expansion on Monday        

Naperville, IL -- (SBWIRE) -- 09/25/2014 -- Wasatch Product Development is focused on providing the most responsive and flexible service in the industry and has a diverse clientele ranging from leading global companies to virtual and emerging entities. With unmatched technical expertise, innovative equipment and regulatory knowledge, Wasatch maintains a demonstrated record with the FDA as well as with its customers; many of whom have outsourced with the company for over ten years. The Wasatch Product Development's lab is compliant with Good Manufacturing Practices (cGMP) along with being registered and certified by the ATF, and FDA. Wasatch has been developing and manufacturing several unique products for many of the World's most successful consumer product companies since 1998.

G3 Development and Wasatch Contract Manufacturing Founder, Adam Paul Green, has just announced he will speak with Wasatch Liquid Contract Manufacturer. Wasatch Contract Manufacturing is a private label nutritional beverage co-packer providing the most responsive and flexible service in the industry and has a diverse clientele ranging from leading global companies to virtual and emerging entities.

Adam will speak with them on his weekly webinar, which is hosted from from his virtual office in Naperville, IL . Adam plans to address the Utah Business Plan Focus for Equity Laboratory Production Expansion.

The webinar will take place on October 22, 2014.

New call number: 888-998-7766
New virtual office login site: http://xocaimeeting.bojabie.com/

801-566-4449
Owner, Kevin Casey
http://wasatchcontractmanufacturing.com/contact/
kcasey@wasatchlabs.net

Mission Statement
To proactively serve our business community by providing solutions
in personal care, business development and liquid nutrition.

Vision Statement
To provide leadership in establishing our client's international businesses,
being built on a foundation of innovation, advocacy, technology and business integrity.

http://wasatchcontractmanufacturing.com/

~Wasatch Labs' Core Competencies are:

Anti-Aging
Gene Expression
Neuro-Peptides
Cosme-ceuticals (Skin Care)
Skin "Energy Systems"
OTC Products (Sanitizers, SunScreens, etc)
SPF: Sun Protection
Liquid Nutritionals and Juices
Unique Skin Treatments (Intimacy, Sanitation, and "plumping" products)
Think of Wasatch Labs when you are considering sourcing a secondary manufacturer for your existing products or perhaps a reliable, experienced laboratory for product development.

~Wasatch Lab's Competitive Advantages include:

In-House Capabilities (Packaging Engineering, Formula Development, Manufacturing)
International Capabilities
Total Customer Support
Complete Supply Chain Management
cGMP

Thanks for Stopping By – WPG – HOME Tab
https://vimeo.com/75658706
Inside Scoop on Wasatch – WPD - ABOUT Tab
https://vimeo.com/71997930

Whatever the size of the anti-aging product corporation, Wasatch Contract Manufacturing can take it to the next level. They provide packaging engineering, formula development, private labeling, and manufacturing of liquid products. Small Companies: They help small companies identify their industry niche, develop proprietary formulas, and make a strong debut on the market. Many of their current Salt Lake City start-ups are focused on emerging Utah and national markets: gene expression, skin energy systems, specialty sun care, and anti-aging.

Medium Size Companies: Wasatch helps medium companies refine their product lines, improve quality, and manage production growth.

Large Utah Companies: They help large companies diversify and respond to changes in the market. Many large companies are developing new product lines in high-demand mitochondrial anti-senescence, neuro peptides, and acne products. Wasatch Contract Manufacturing is a cGMP, FDA, EPA, and ATF compliant facility. Wasatch has been formulating liquid products for over twenty years without an FDA violation. Call their operations manager today to learn how Wasatch can help a company move forward.

About Wasatch Product Development
Wasatch Product Development is focused on providing the most responsive and flexible service in the industry and has a diverse clientele ranging from leading global companies to virtual and emerging entities. With unmatched technical expertise, innovative equipment and regulatory knowledge, Wasatch maintains a demonstrated record with the FDA as well as with its customers; many of whom have outsourced with the company for over ten years. The Wasatch Product Development's lab is compliant with Good Manufacturing Practices (cGMP) along with being registered and certified by the ATF, and FDA. Wasatch has been developing and manufacturing several unique products for many of the World's most successful consumer product companies since 1998.
http://wasatchcontractmanufacturing.com/

For more information on this press release visit: http://www.sbwire.com/press-releases/g3-development-and-wasatch-contract-manufacturing-chairman-adam-green-recommends-utah-business-plan-focus-for-equity-laboratory-production-expansion-on-monday-547730.htm

Media Relations Contact

Adam Green
Telephone: 801-566-4449
Email: Click to Email Adam Green
Web: http://wasatchcontractmanufacturing.com/


          Private-Label Weight Loss Co-Packer News: G3-Development Board Member, Adam Green, Favors Utah Business Plan Focus for Equity Laboratory Production Expansion        

Alexandria, VA -- (SBWIRE) -- 09/25/2014 -- Wasatch Product Development is focused on providing the most responsive and flexible service in the industry and has a diverse clientele ranging from leading global companies to virtual and emerging entities. With unmatched technical expertise, innovative equipment and regulatory knowledge, Wasatch maintains a demonstrated record with the FDA as well as with its customers; many of whom have outsourced with the company for over ten years. The Wasatch Product Development's lab is compliant with Good Manufacturing Practices (cGMP) along with being registered and certified by the ATF, and FDA. Wasatch has been developing and manufacturing several unique products for many of the World's most successful consumer product companies since 1998.

The purpose of this press release is to announce that the G3 Development and Wasatch Contract Manufacturing Founder, Adam Paul Green, has just announced he will speak with Wasatch Liquid Contract Manufacturer. Wasatch Contract Manufacturing is a private label nutritional beverage co-packer providing the most responsive and flexible service in the industry and has a diverse clientele ranging from leading global companies to virtual and emerging entities.

Adam will speak with them on his weekly webinar, which is hosted from from his virtual office in Alexandria, VA. Adam plans to address the Utah Business Plan Focus for Equity Laboratory Production Expansion.

The webinar will take place on October 22, 2014.

New call number: 1-888-998-7766
New virtual office login site: http://xocaimeeting.bojabie.com/

801-566-4449
Owner, Kevin Casey
http://wasatchcontractmanufacturing.com/contact/
kcasey@wasatchlabs.net

Mission Statement
To proactively serve our business community by providing solutions
in personal care, business development and liquid nutrition.

Vision Statement
To provide leadership in establishing our client's international businesses,
being built on a foundation of innovation, advocacy, technology and business integrity.

http://wasatchcontractmanufacturing.com/

~Wasatch Labs' Core Competencies are:

Anti-Aging
Gene Expression
Neuro-Peptides
Cosme-ceuticals (Skin Care)
Skin "Energy Systems"
OTC Products (Sanitizers, SunScreens, etc)
SPF: Sun Protection
Liquid Nutritionals and Juices
Unique Skin Treatments (Intimacy, Sanitation, and "plumping" products)
Think of Wasatch Labs when you are considering sourcing a secondary manufacturer for your existing products or perhaps a reliable, experienced laboratory for product development.
~Wasatch Lab's Competitive Advantages include:

In-House Capabilities (Packaging Engineering, Formula Development, Manufacturing)
International Capabilities
Total Customer Support
Complete Supply Chain Management
cGMP

Thanks for Stopping By – WPG – HOME Tab
https://vimeo.com/75658706
Inside Scoop on Wasatch – WPD - ABOUT Tab
https://vimeo.com/71997930

Whatever the size of the anti-aging product corporation, Wasatch Contract Manufacturing can take it to the next level. They provide packaging engineering, formula development, private labeling, and manufacturing of liquid products. Small Companies: They help small companies identify their industry niche, develop proprietary formulas, and make a strong debut on the market. Many of their current Salt Lake City start-ups are focused on emerging Utah and national markets: gene expression, skin energy systems, specialty sun care, and anti-aging.

Medium Size Companies: Wasatch helps medium companies refine their product lines, improve quality, and manage production growth.

Large Utah Companies: They help large companies diversify and respond to changes in the market. Many large companies are developing new product lines in high-demand mitochondrial anti-senescence, neuro peptides, and acne products. Wasatch Contract Manufacturing is a cGMP, FDA, EPA, and ATF compliant facility. Wasatch has been formulating liquid products for over twenty years without an FDA violation. Call their operations manager today to learn how Wasatch can help a company move forward.

About Wasatch Product Development
Wasatch Product Development is focused on providing the most responsive and flexible service in the industry and has a diverse clientele ranging from leading global companies to virtual and emerging entities. With unmatched technical expertise, innovative equipment and regulatory knowledge, Wasatch maintains a demonstrated record with the FDA as well as with its customers; many of whom have outsourced with the company for over ten years. The Wasatch Product Development's lab is compliant with Good Manufacturing Practices (cGMP) along with being registered and certified by the ATF, and FDA. Wasatch has been developing and manufacturing several unique products for many of the World's most successful consumer product companies since 1998.

http://wasatchcontractmanufacturing.com/

For more information on this press release visit: http://www.sbwire.com/press-releases/private-label-weight-loss-co-packer-news-g3-development-board-member-adam-green-favors-utah-business-plan-focus-for-equity-laboratory-production-expansion-547725.htm

Media Relations Contact

Adam Green
Telephone: 801-566-4449
Email: Click to Email Adam Green
Web: http://wasatchcontractmanufacturing.com/


          Nutritional Supplement-Supplier Lab News: G3 Development Capitalist, Adam Green, Favors Wasatch New Hair Care Technology        

Tempe, AZ -- (SBWIRE) -- 09/24/2014 -- Wasatch Product Development is focused on providing the most responsive and flexible service in the industry and has a diverse clientele ranging from leading global companies to virtual and emerging entities. With unmatched technical expertise, innovative equipment and regulatory knowledge, Wasatch maintains a demonstrated record with the FDA as well as with its customers; many of whom have outsourced with the company for over ten years. The Wasatch Product Development's lab is compliant with Good Manufacturing Practices (cGMP) along with being registered and certified by the ATF, and FDA. Wasatch has been developing and manufacturing several unique products for many of the World's most successful consumer product companies since 1998.

The purpose of this press release is to announce that Mr. Adam Paul Green, the G3-Development Founder, has just announced he will speak with Wasatch Liquid Contract Manufacturer and Nutritional Supplement Supplier Lab, concerning their "801- Hair Care Technology" on his weekly webinar, which is hosted from from his virtual office in Tempe, AZ.

The webinar for "801- Hair Care Technology" will take place on October 9, 2014.

New call number: 1-888-998-7766
New virtual office login site: http://xocaimeeting.bojabie.com/
http://wasatchcontractmanufacturing.com/ Webinar

801-566-4449
Owner, Kevin Casey
http://wasatchcontractmanufacturing.com/contact/
kcasey@wasatchlabs.net

Mission Statement
To proactively serve our business community by providing solutions
in personal care, business development and liquid nutrition.

Vision Statement
To provide leadership in establishing our client's international businesses,
being built on a foundation of innovation, advocacy, technology and business integrity.

http://wasatchcontractmanufacturing.com/

~Wasatch Labs' Core Competencies are:

Anti-Aging
Gene Expression
Neuro-Peptides
Cosme-ceuticals (Skin Care)
Skin "Energy Systems"
OTC Products (Sanitizers, SunScreens, etc)
SPF: Sun Protection
Liquid Nutritionals and Juices
Unique Skin Treatments (Intimacy, Sanitation, and "plumping" products)
Think of Wasatch Labs when you are considering sourcing a secondary manufacturer for your existing products or perhaps a reliable, experienced laboratory for product development.
~Wasatch Lab's Competitive Advantages include:

In-House Capabilities (Packaging Engineering, Formula Development, Manufacturing)
International Capabilities
Total Customer Support
Complete Supply Chain Management
cGMP

Thanks for Stopping By – WPG – HOME Tab
https://vimeo.com/75658706
Inside Scoop on Wasatch – WPD - ABOUT Tab
https://vimeo.com/71997930

Whatever the size of the anti-aging product corporation, Wasatch Contract Manufacturing can take it to the next level. They provide packaging engineering, formula development, private labeling, and manufacturing of liquid products. Small Companies: They help small companies identify their industry niche, develop proprietary formulas, and make a strong debut on the market. Many of their current Salt Lake City start-ups are focused on emerging Utah and national markets: gene expression, skin energy systems, specialty sun care, and anti-aging.

Medium Size Companies: Wasatch helps medium companies refine their product lines, improve quality, and manage production growth.

Large Utah Companies: They help large companies diversify and respond to changes in the market. Many large companies are developing new product lines in high-demand mitochondrial anti-senescence, neuro peptides, and acne products. Wasatch Contract Manufacturing is a cGMP, FDA, EPA, and ATF compliant facility. Wasatch has been formulating liquid products for over twenty years without an FDA violation. Call their operations manager today to learn how Wasatch can help a company move forward.

ABOUT Wasatch Product Development
Wasatch Product Development is focused on providing the most responsive and flexible service in the industry and has a diverse clientele ranging from leading global companies to virtual and emerging entities. With unmatched technical expertise, innovative equipment and regulatory knowledge, Wasatch maintains a demonstrated record with the FDA as well as with its customers; many of whom have outsourced with the company for over ten years. The Wasatch Product Development's lab is compliant with Good Manufacturing Practices (cGMP) along with being registered and certified by the ATF, and FDA. Wasatch has been developing and manufacturing several unique products for many of the World's most successful consumer product companies since 1998.

http://wasatchcontractmanufacturing.com/

For more information on this press release visit: http://www.sbwire.com/press-releases/nutritional-supplement-supplier-lab-news-g3-development-capitalist-adam-green-favors-wasatch-new-hair-care-technology-547719.htm

Media Relations Contact

Adam Green
Telephone: 801-566-4449
Email: Click to Email Adam Green
Web: http://wasatchcontractmanufacturing.com/


          Private-Label-Manufacturer Adam Green and Steve ThomasNet Big Success: Adam Green, Backs the Draper Based Custom Pharmaceutical Provider Body Care Technology        

Reno, NV -- (SBWIRE) -- 09/24/2014 -- Wasatch Product Development is focused on providing the most responsive and flexible service in the industry and has a diverse clientele ranging from leading global companies to virtual and emerging entities. With unmatched technical expertise, innovative equipment and regulatory knowledge, Wasatch maintains a demonstrated record with the FDA as well as with its customers; many of whom have outsourced with the company for over ten years. The Wasatch Product Development's lab is compliant with Good Manufacturing Practices (cGMP) along with being registered and certified by the ATF, and FDA. Wasatch has been developing and manufacturing several unique products for many of the World's most successful consumer product companies since 1998.

801-566-4449
Owner, Kevin Casey
http://wasatchcontractmanufacturing.com/contact/
kcasey@wasatchlabs.net

Mission Statement
To proactively serve our business community by providing solutions
in personal care, business development and liquid nutrition.

Vision Statement
To provide leadership in establishing our client's international businesses,
being built on a foundation of innovation, advocacy, technology and business integrity.

http://wasatchcontractmanufacturing.com/

~Wasatch Labs' Core Competencies are:

Anti-Aging
Gene Expression
Neuro-Peptides
Cosme-ceuticals (Skin Care)
Skin "Energy Systems"
OTC Products (Sanitizers, SunScreens, etc)
SPF: Sun Protection
Liquid Nutritionals and Juices
Unique Skin Treatments (Intimacy, Sanitation, and "plumping" products)
Think of Wasatch Labs when you are considering sourcing a secondary manufacturer for your existing products or perhaps a reliable, experienced laboratory for product development.

~Wasatch Lab's Competitive Advantages include:

In-House Capabilities (Packaging Engineering, Formula Development, Manufacturing)
International Capabilities
Total Customer Support
Complete Supply Chain Management
cGMP

Thanks for Stopping By – WPG – HOME Tab
https://vimeo.com/75658706

Whatever the size of the anti-aging product corporation, Wasatch Contract Manufacturing can take it to the next level. They provide packaging engineering, formula development, private labeling, and manufacturing of liquid products. Small Companies: They help small companies identify their industry niche, develop proprietary formulas, and make a strong debut on the market. Many of their current Salt Lake City start-ups are focused on emerging Utah and national markets: gene expression, skin energy systems, specialty sun care, and anti-aging.

Medium Size Companies: Wasatch helps medium companies refine their product lines, improve quality, and manage production growth.

Large Utah Companies: They help large companies diversify and respond to changes in the market. Many large companies are developing new product lines in high-demand mitochondrial anti-senescence, neuro peptides, and acne products. Wasatch Contract Manufacturing is a cGMP, FDA, EPA, and ATF compliant facility. Wasatch has been formulating liquid products for over twenty years without an FDA violation. Call their operations manager today to learn how Wasatch can help a company move forward.

About Wasatch Product Development
Wasatch Product Development is focused on providing the most responsive and flexible service in the industry and has a diverse clientele ranging from leading global companies to virtual and emerging entities. With unmatched technical expertise, innovative equipment and regulatory knowledge, Wasatch maintains a demonstrated record with the FDA as well as with its customers; many of whom have outsourced with the company for over ten years. The Wasatch Product Development's lab is compliant with Good Manufacturing Practices (cGMP) along with being registered and certified by the ATF, and FDA. Wasatch has been developing and manufacturing several unique products for many of the World's most successful consumer product companies since 1998.
http://wasatchcontractmanufacturing.com/

For more information on this press release visit: http://www.sbwire.com/press-releases/private-label-manufacturer-adam-green-and-steve-thomasnet-big-success-adam-green-backs-the-draper-based-custom-pharmaceutical-provider-body-care-technology-547724.htm

Media Relations Contact

Adam Green
Telephone: 801-566-4449
Email: Click to Email Adam Green
Web: http://wasatchcontractmanufacturing.com/


          Contract-Manufacturer Adam Green and Steve ThomasNet Big Success: Adam Green, Endorses the Draper Based Custom Pharmaceutical Provider Tube Technology        

Orange, CA -- (SBWIRE) -- 09/24/2014 -- Wasatch Product Development is focused on providing the most responsive and flexible service in the industry and has a diverse clientele ranging from leading global companies to virtual and emerging entities. With unmatched technical expertise, innovative equipment and regulatory knowledge, Wasatch maintains a demonstrated record with the FDA as well as with its customers; many of whom have outsourced with the company for over ten years. The Wasatch Product Development's lab is compliant with Good Manufacturing Practices (cGMP) along with being registered and certified by the ATF, and FDA. Wasatch has been developing and manufacturing several unique products for many of the World's most successful consumer product companies since 1998.

801-566-4449
Owner, Kevin Casey
http://wasatchcontractmanufacturing.com/contact/
kcasey@wasatchlabs.net

Mission Statement
To proactively serve our business community by providing solutions
in personal care, business development and liquid nutrition.

Vision Statement
To provide leadership in establishing our client's international businesses,
being built on a foundation of innovation, advocacy, technology and business integrity.

http://wasatchcontractmanufacturing.com/

~Wasatch Labs' Core Competencies are:

Anti-Aging
Gene Expression
Neuro-Peptides
Cosme-ceuticals (Skin Care)
Skin "Energy Systems"
OTC Products (Sanitizers, SunScreens, etc)
SPF: Sun Protection
Liquid Nutritionals and Juices
Unique Skin Treatments (Intimacy, Sanitation, and "plumping" products)
Think of Wasatch Labs when you are considering sourcing a secondary manufacturer for your existing products or perhaps a reliable, experienced laboratory for product development.
~Wasatch Lab's Competitive Advantages include:

In-House Capabilities (Packaging Engineering, Formula Development, Manufacturing)
International Capabilities
Total Customer Support
Complete Supply Chain Management
cGMP

Thanks for Stopping By – WPG – HOME Tab
https://vimeo.com/75658706

Whatever the size of the anti-aging product corporation, Wasatch Contract Manufacturing can take it to the next level. They provide packaging engineering, formula development, private labeling, and manufacturing of liquid products. Small Companies: They help small companies identify their industry niche, develop proprietary formulas, and make a strong debut on the market. Many of their current Salt Lake City start-ups are focused on emerging Utah and national markets: gene expression, skin energy systems, specialty sun care, and anti-aging.

Medium Size Companies: Wasatch helps medium companies refine their product lines, improve quality, and manage production growth.

Large Utah Companies: They help large companies diversify and respond to changes in the market. Many large companies are developing new product lines in high-demand mitochondrial anti-senescence, neuro peptides, and acne products. Wasatch Contract Manufacturing is a cGMP, FDA, EPA, and ATF compliant facility. Wasatch has been formulating liquid products for over twenty years without an FDA violation. Call their operations manager today to learn how Wasatch can help a company move forward.

About Wasatch Product Development
Wasatch Product Development is focused on providing the most responsive and flexible service in the industry and has a diverse clientele ranging from leading global companies to virtual and emerging entities. With unmatched technical expertise, innovative equipment and regulatory knowledge, Wasatch maintains a demonstrated record with the FDA as well as with its customers; many of whom have outsourced with the company for over ten years. The Wasatch Product Development's lab is compliant with Good Manufacturing Practices (cGMP) along with being registered and certified by the ATF, and FDA. Wasatch has been developing and manufacturing several unique products for many of the World's most successful consumer product companies since 1998.

http://wasatchcontractmanufacturing.com/

For more information on this press release visit: http://www.sbwire.com/press-releases/contract-manufacturer-adam-green-and-steve-thomasnet-big-success-adam-green-endorses-the-draper-based-custom-pharmaceutical-provider-tube-technology-547720.htm

Media Relations Contact

Adam Green
Telephone: 801-566-4449
Email: Click to Email Adam Green
Web: http://wasatchcontractmanufacturing.com/


          Private-Label-Manufacturer Adam Green and Steve ThomasNet Big Success: Manager, Adam Green, Advocates the Draper Based Private Label Manufacturer Airless Pump Technology        

Virginia Beach, VA -- (SBWIRE) -- 09/24/2014 -- Wasatch Product Development is focused on providing the most responsive and flexible service in the industry and has a diverse clientele ranging from leading global companies to virtual and emerging entities. With unmatched technical expertise, innovative equipment and regulatory knowledge, Wasatch maintains a demonstrated record with the FDA as well as with its customers; many of whom have outsourced with the company for over ten years. The Wasatch Product Development's lab is compliant with Good Manufacturing Practices (cGMP) along with being registered and certified by the ATF, and FDA. Wasatch has been developing and manufacturing several unique products for many of the World's most successful consumer product companies since 1998.

801-566-4449
Owner, Kevin Casey
http://wasatchcontractmanufacturing.com/contact/
kcasey@wasatchlabs.net

Mission Statement
To proactively serve our business community by providing solutions
in personal care, business development and liquid nutrition.

Vision Statement
To provide leadership in establishing our client's international businesses,
being built on a foundation of innovation, advocacy, technology and business integrity.

http://wasatchcontractmanufacturing.com/

~Wasatch Labs' Core Competencies are:

Anti-Aging
Gene Expression
Neuro-Peptides
Cosme-ceuticals (Skin Care)
Skin "Energy Systems"
OTC Products (Sanitizers, SunScreens, etc)
SPF: Sun Protection
Liquid Nutritionals and Juices
Unique Skin Treatments (Intimacy, Sanitation, and "plumping" products)
Think of Wasatch Labs when you are considering sourcing a secondary manufacturer for your existing products or perhaps a reliable, experienced laboratory for product development.
~Wasatch Lab's Competitive Advantages include:

In-House Capabilities (Packaging Engineering, Formula Development, Manufacturing)
International Capabilities
Total Customer Support
Complete Supply Chain Management
cGMP

Thanks for Stopping By – WPG – HOME Tab
https://vimeo.com/75658706

Whatever the size of the anti-aging product corporation, Wasatch Contract Manufacturing can take it to the next level. They provide packaging engineering, formula development, private labeling, and manufacturing of liquid products. Small Companies: They help small companies identify their industry niche, develop proprietary formulas, and make a strong debut on the market. Many of their current Salt Lake City start-ups are focused on emerging Utah and national markets: gene expression, skin energy systems, specialty sun care, and anti-aging.

Medium Size Companies: Wasatch helps medium companies refine their product lines, improve quality, and manage production growth.

Large Utah Companies: They help large companies diversify and respond to changes in the market. Many large companies are developing new product lines in high-demand mitochondrial anti-senescence, neuro peptides, and acne products. Wasatch Contract Manufacturing is a cGMP, FDA, EPA, and ATF compliant facility. Wasatch has been formulating liquid products for over twenty years without an FDA violation. Call their operations manager today to learn how Wasatch can help a company move forward.

About Wasatch Product Development
Wasatch Product Development is focused on providing the most responsive and flexible service in the industry and has a diverse clientele ranging from leading global companies to virtual and emerging entities. With unmatched technical expertise, innovative equipment and regulatory knowledge, Wasatch maintains a demonstrated record with the FDA as well as with its customers; many of whom have outsourced with the company for over ten years. The Wasatch Product Development's lab is compliant with Good Manufacturing Practices (cGMP) along with being registered and certified by the ATF, and FDA. Wasatch has been developing and manufacturing several unique products for many of the World's most successful consumer product companies since 1998.

http://wasatchcontractmanufacturing.com/

For more information on this press release visit: http://www.sbwire.com/press-releases/private-label-manufacturer-adam-green-and-steve-thomasnet-big-success-manager-adam-green-advocates-the-draper-based-private-label-manufacturer-airless-pump-technology-547721.htm

Media Relations Contact

Adam Green
Telephone: 801-566-4449
Email: Click to Email Adam Green
Web: http://wasatchcontractmanufacturing.com/


          Wasatch Liquid Contract Manufacturer Lab News: Adam Green, Confirms Wasatch New 801- Cosmeceutical Technology on wasatchcontractmanufacturing.com/resources/ Webinar        

Paradise, NV -- (SBWIRE) -- 09/23/2014 -- Wasatch Product Development is focused on providing the most responsive and flexible service in the industry and has a diverse clientele ranging from leading global companies to virtual and emerging entities. With unmatched technical expertise, innovative equipment and regulatory knowledge, Wasatch maintains a demonstrated record with the FDA as well as with its customers; many of whom have outsourced with the company for over ten years. The Wasatch Product Development's lab is compliant with Good Manufacturing Practices (cGMP) along with being registered and certified by the ATF, and FDA. Wasatch has been developing and manufacturing several unique products for many of the World's most successful consumer product companies since 1998.

Mr. Adam Paul Green, the G3-Development Founder, has just announced he will speak with Wasatch Liquid Contract Manufacturer and Nutritional Supplement Supplier Lab, concerning their "801- Cosmeceutical Technology" on his weekly webinar, which is hosted from from his virtual office in Paradise, NV.

The webinar for "801- Cosmeceutical Technology" will take place on October 9, 2014.

New call number: 888-998-7766
New virtual office login site: http://xocaimeeting.bojabie.com/
http://wasatchcontractmanufacturing.com/resources/ Webinar

801-566-4449
Owner, Kevin Casey
http://wasatchcontractmanufacturing.com/contact/
kcasey@wasatchlabs.net

Mission Statement
To proactively serve our business community by providing solutions
in personal care, business development and liquid nutrition.

Vision Statement
To provide leadership in establishing our client's international businesses,
being built on a foundation of innovation, advocacy, technology and business integrity.

http://wasatchcontractmanufacturing.com/

~Wasatch Labs' Core Competencies are:

Anti-Aging
Gene Expression
Neuro-Peptides
Cosme-ceuticals (Skin Care)
Skin "Energy Systems"
OTC Products (Sanitizers, SunScreens, etc)
SPF: Sun Protection
Liquid Nutritionals and Juices
Unique Skin Treatments (Intimacy, Sanitation, and "plumping" products)
Think of Wasatch Labs when you are considering sourcing a secondary manufacturer for your existing products or perhaps a reliable, experienced laboratory for product development.

~Wasatch Lab's Competitive Advantages include:

In-House Capabilities (Packaging Engineering, Formula Development, Manufacturing)
International Capabilities
Total Customer Support
Complete Supply Chain Management
cGMP

Thanks for Stopping By – WPG – HOME Tab
https://vimeo.com/75658706
Inside Scoop on Wasatch – WPD - ABOUT Tab
https://vimeo.com/71997930

Whatever the size of the anti-aging product corporation, Wasatch Contract Manufacturing can take it to the next level. They provide packaging engineering, formula development, private labeling, and manufacturing of liquid products. Small Companies: They help small companies identify their industry niche, develop proprietary formulas, and make a strong debut on the market. Many of their current Salt Lake City start-ups are focused on emerging Utah and national markets: gene expression, skin energy systems, specialty sun care, and anti-aging.

Medium Size Companies: Wasatch helps medium companies refine their product lines, improve quality, and manage production growth.

Large Utah Companies: They help large companies diversify and respond to changes in the market. Many large companies are developing new product lines in high-demand mitochondrial anti-senescence, neuro peptides, and acne products. Wasatch Contract Manufacturing is a cGMP, FDA, EPA, and ATF compliant facility. Wasatch has been formulating liquid products for over twenty years without an FDA violation. Call their operations manager today to learn how Wasatch can help a company move forward.

About Wasatch Product Development
Wasatch Product Development is focused on providing the most responsive and flexible service in the industry and has a diverse clientele ranging from leading global companies to virtual and emerging entities. With unmatched technical expertise, innovative equipment and regulatory knowledge, Wasatch maintains a demonstrated record with the FDA as well as with its customers; many of whom have outsourced with the company for over ten years. The Wasatch Product Development's lab is compliant with Good Manufacturing Practices (cGMP) along with being registered and certified by the ATF, and FDA. Wasatch has been developing and manufacturing several unique products for many of the World's most successful consumer product companies since 1998.
http://wasatchcontractmanufacturing.com/

For more information on this press release visit: http://www.sbwire.com/press-releases/wasatch-liquid-contract-manufacturer-lab-news-adam-green-confirms-wasatch-new-801-cosmeceutical-technology-on-wasatchcontractmanufacturingcomresources-webinar-547717.htm

Media Relations Contact

Adam Green
Telephone: 801-566-4449
Email: Click to Email Adam Green
Web: http://wasatchcontractmanufacturing.com/


          Private-Label-Manufacturer and Custom-Pharmaceutical Update for Wasatch Labs: G3-Development President, Adam Green, Commends the Draper Based Nutritional Toll Supplier        

Enterprise, NV -- (SBWIRE) -- 09/23/2014 -- Wasatch Product Development is focused on providing the most responsive and flexible service in the industry and has a diverse clientele ranging from leading global companies to virtual and emerging entities. With unmatched technical expertise, innovative equipment and regulatory knowledge, Wasatch maintains a demonstrated record with the FDA as well as with its customers; many of whom have outsourced with the company for over ten years. The Wasatch Product Development's lab is compliant with Good Manufacturing Practices (cGMP) along with being registered and certified by the ATF, and FDA. Wasatch has been developing and manufacturing several unique products for many of the World's most successful consumer product companies since 1998.

801-566-4449
Owner, Kevin Casey
http://wasatchcontractmanufacturing.com/contact/
kcasey@wasatchlabs.net

Mission Statement
To proactively serve our business community by providing solutions
in personal care, business development and liquid nutrition.

Vision Statement
To provide leadership in establishing our client's international businesses,
being built on a foundation of innovation, advocacy, technology and business integrity.

http://wasatchcontractmanufacturing.com/

~Wasatch Labs' Core Competencies are:

Anti-Aging
Gene Expression
Neuro-Peptides
Cosme-ceuticals (Skin Care)
Skin "Energy Systems"
OTC Products (Sanitizers, SunScreens, etc)
SPF: Sun Protection
Liquid Nutritionals and Juices
Unique Skin Treatments (Intimacy, Sanitation, and "plumping" products)
Think of Wasatch Labs when you are considering sourcing a secondary manufacturer for your existing products or perhaps a reliable, experienced laboratory for product development.
~Wasatch Lab's Competitive Advantages include:

In-House Capabilities (Packaging Engineering, Formula Development, Manufacturing)
International Capabilities
Total Customer Support
Complete Supply Chain Management
cGMP

Thanks for Stopping By – WPG – HOME Tab
https://vimeo.com/75658706
Inside Scoop on Wasatch – WPD - ABOUT Tab
https://vimeo.com/71997930

Whatever the size of the anti-aging product corporation, Wasatch Contract Manufacturing can take it to the next level. They provide packaging engineering, formula development, private labeling, and manufacturing of liquid products. Small Companies: They help small companies identify their industry niche, develop proprietary formulas, and make a strong debut on the market. Many of their current Salt Lake City start-ups are focused on emerging Utah and national markets: gene expression, skin energy systems, specialty sun care, and anti-aging.

Medium Size Companies: Wasatch helps medium companies refine their product lines, improve quality, and manage production growth.

Large Utah Companies: They help large companies diversify and respond to changes in the market. Many large companies are developing new product lines in high-demand mitochondrial anti-senescence, neuro peptides, and acne products. Wasatch Contract Manufacturing is a cGMP, FDA, EPA, and ATF compliant facility. Wasatch has been formulating liquid products for over twenty years without an FDA violation. Call their operations manager today to learn how Wasatch can help a company move forward.

ABOUT Wasatch Product Development
Wasatch Product Development is focused on providing the most responsive and flexible service in the industry and has a diverse clientele ranging from leading global companies to virtual and emerging entities. With unmatched technical expertise, innovative equipment and regulatory knowledge, Wasatch maintains a demonstrated record with the FDA as well as with its customers; many of whom have outsourced with the company for over ten years. The Wasatch Product Development's lab is compliant with Good Manufacturing Practices (cGMP) along with being registered and certified by the ATF, and FDA. Wasatch has been developing and manufacturing several unique products for many of the World's most successful consumer product companies since 1998.

http://wasatchcontractmanufacturing.com/

For more information on this press release visit: http://www.sbwire.com/press-releases/private-label-manufacturer-and-custom-pharmaceutical-update-for-wasatch-labs-g3-development-president-adam-green-commends-the-draper-based-nutritional-toll-supplier-547713.htm

Media Relations Contact

Adam Green
Telephone: 801-566-4449
Email: Click to Email Adam Green
Web: http://wasatchcontractmanufacturing.com/


          Custom Pharmaceutical and Nutritional Toll Supplier Update for Wasatch Labs: G3 Development Founder, Adam Green, Approves the Draper Based Private Label Manufacturer        

Daly City, CA -- (SBWIRE) -- 09/23/2014 -- Wasatch Product Development is focused on providing the most responsive and flexible service in the industry and has a diverse clientele ranging from leading global companies to virtual and emerging entities. With unmatched technical expertise, innovative equipment and regulatory knowledge, Wasatch maintains a demonstrated record with the FDA as well as with its customers; many of whom have outsourced with the company for over ten years. The Wasatch Product Development's lab is compliant with Good Manufacturing Practices (cGMP) along with being registered and certified by the ATF, and FDA. Wasatch has been developing and manufacturing several unique products for many of the World's most successful consumer product companies since 1998.

801-566-4449
Owner, Kevin Casey
http://wasatchcontractmanufacturing.com/contact/
kcasey@wasatchlabs.net

Mission Statement
To proactively serve our business community by providing solutions
in personal care, business development and liquid nutrition.

Vision Statement
To provide leadership in establishing our client's international businesses,
being built on a foundation of innovation, advocacy, technology and business integrity.

http://wasatchcontractmanufacturing.com/

~Wasatch Labs' Core Competencies are:

Anti-Aging
Gene Expression
Neuro-Peptides
Cosme-ceuticals (Skin Care)
Skin "Energy Systems"
OTC Products (Sanitizers, SunScreens, etc)
SPF: Sun Protection
Liquid Nutritionals and Juices
Unique Skin Treatments (Intimacy, Sanitation, and "plumping" products)
Think of Wasatch Labs when you are considering sourcing a secondary manufacturer for your existing products or perhaps a reliable, experienced laboratory for product development.

~Wasatch Lab's Competitive Advantages include:

In-House Capabilities (Packaging Engineering, Formula Development, Manufacturing)
International Capabilities
Total Customer Support
Complete Supply Chain Management
cGMP

Thanks for Stopping By – WPG – HOME Tab
https://vimeo.com/75658706
Inside Scoop on Wasatch – WPD - ABOUT Tab
https://vimeo.com/71997930

Whatever the size of the anti-aging product corporation, Wasatch Contract Manufacturing can take it to the next level. They provide packaging engineering, formula development, private labeling, and manufacturing of liquid products. Small Companies: They help small companies identify their industry niche, develop proprietary formulas, and make a strong debut on the market. Many of their current Salt Lake City start-ups are focused on emerging Utah and national markets: gene expression, skin energy systems, specialty sun care, and anti-aging.

Medium Size Companies: Wasatch helps medium companies refine their product lines, improve quality, and manage production growth.

Large Utah Companies: They help large companies diversify and respond to changes in the market. Many large companies are developing new product lines in high-demand mitochondrial anti-senescence, neuro peptides, and acne products. Wasatch Contract Manufacturing is a cGMP, FDA, EPA, and ATF compliant facility. Wasatch has been formulating liquid products for over twenty years without an FDA violation. Call their operations manager today to learn how Wasatch can help a company move forward.

About Wasatch Product Development
Wasatch Product Development is focused on providing the most responsive and flexible service in the industry and has a diverse clientele ranging from leading global companies to virtual and emerging entities. With unmatched technical expertise, innovative equipment and regulatory knowledge, Wasatch maintains a demonstrated record with the FDA as well as with its customers; many of whom have outsourced with the company for over ten years. The Wasatch Product Development's lab is compliant with Good Manufacturing Practices (cGMP) along with being registered and certified by the ATF, and FDA. Wasatch has been developing and manufacturing several unique products for many of the World's most successful consumer product companies since 1998.
http://wasatchcontractmanufacturing.com/

For more information on this press release visit: http://www.sbwire.com/press-releases/custom-pharmaceutical-and-nutritional-toll-supplier-update-for-wasatch-labs-g3-development-founder-adam-green-approves-the-draper-based-private-label-manufacturer-547712.htm

Media Relations Contact

Adam Green
Telephone: 801-566-4449
Email: Click to Email Adam Green
Web: http://wasatchcontractmanufacturing.com/


          Nutritional-Supplement-Supplier Lab News: Defends Wasatch New Personal Care Technology        

Austin, TX -- (SBWIRE) -- 09/23/2014 -- Wasatch Product Development is focused on providing the most responsive and flexible service in the industry and has a diverse clientele ranging from leading global companies to virtual and emerging entities. With unmatched technical expertise, innovative equipment and regulatory knowledge, Wasatch maintains a demonstrated record with the FDA as well as with its customers; many of whom have outsourced with the company for over ten years. The Wasatch Product Development's lab is compliant with Good Manufacturing Practices (cGMP) along with being registered and certified by the ATF, and FDA. Wasatch has been developing and manufacturing several unique products for many of the World's most successful consumer product companies since 1998.

Mr. Adam Paul Green, the G3-Development Founder, has just announced he will speak with Wasatch Liquid Contract Manufacturer and Nutritional Supplement Supplier Lab, concerning their "801- Personal Care Technology" on his weekly webinar, which is hosted from from his virtual office in Austin, TX.

The webinar for "801- Personal Care Technology" will take place on October 9, 2014.

New call number: 888-998-7766
New virtual office login site: http://xocaimeeting.bojabie.com/
http://wasatchcontractmanufacturing.com/contact/ Webinar

801-566-4449
Owner, Kevin Casey
http://wasatchcontractmanufacturing.com/contact/
kcasey@wasatchlabs.net

Mission Statement
To proactively serve our business community by providing solutions
in personal care, business development and liquid nutrition.

Vision Statement
To provide leadership in establishing our client's international businesses,
being built on a foundation of innovation, advocacy, technology and business integrity.

http://wasatchcontractmanufacturing.com/

~Wasatch Labs' Core Competencies are:

Anti-Aging
Gene Expression
Neuro-Peptides
Cosme-ceuticals (Skin Care)
Skin "Energy Systems"
OTC Products (Sanitizers, SunScreens, etc)
SPF: Sun Protection
Liquid Nutritionals and Juices
Unique Skin Treatments (Intimacy, Sanitation, and "plumping" products)
Think of Wasatch Labs when you are considering sourcing a secondary manufacturer for your existing products or perhaps a reliable, experienced laboratory for product development.

~Wasatch Lab's Competitive Advantages include:

In-House Capabilities (Packaging Engineering, Formula Development, Manufacturing)
International Capabilities
Total Customer Support
Complete Supply Chain Management
cGMP

Thanks for Stopping By – WPG – HOME Tab
https://vimeo.com/75658706
Inside Scoop on Wasatch – WPD - ABOUT Tab
https://vimeo.com/71997930

Whatever the size of the anti-aging product corporation, Wasatch Contract Manufacturing can take it to the next level. They provide packaging engineering, formula development, private labeling, and manufacturing of liquid products. Small Companies: They help small companies identify their industry niche, develop proprietary formulas, and make a strong debut on the market. Many of their current Salt Lake City start-ups are focused on emerging Utah and national markets: gene expression, skin energy systems, specialty sun care, and anti-aging.

Medium Size Companies: Wasatch helps medium companies refine their product lines, improve quality, and manage production growth.

Large Utah Companies: They help large companies diversify and respond to changes in the market. Many large companies are developing new product lines in high-demand mitochondrial anti-senescence, neuro peptides, and acne products. Wasatch Contract Manufacturing is a cGMP, FDA, EPA, and ATF compliant facility. Wasatch has been formulating liquid products for over twenty years without an FDA violation. Call their operations manager today to learn how Wasatch can help a company move forward.

About Wasatch Product Development
Wasatch Product Development is focused on providing the most responsive and flexible service in the industry and has a diverse clientele ranging from leading global companies to virtual and emerging entities. With unmatched technical expertise, innovative equipment and regulatory knowledge, Wasatch maintains a demonstrated record with the FDA as well as with its customers; many of whom have outsourced with the company for over ten years. The Wasatch Product Development's lab is compliant with Good Manufacturing Practices (cGMP) along with being registered and certified by the ATF, and FDA. Wasatch has been developing and manufacturing several unique products for many of the World's most successful consumer product companies since 1998.
http://wasatchcontractmanufacturing.com/

For more information on this press release visit: http://www.sbwire.com/press-releases/nutritional-supplement-supplier-lab-news-defends-wasatch-new-personal-care-technology-547718.htm

Media Relations Contact

Adam Green
Telephone: 801-566-4449
Email: Click to Email Adam Green
Web: http://wasatchcontractmanufacturing.com/


          Private Label Hair Care Co-Packer News: Adam Green, Upholds Utah Business Plan Focus for Equity Laboratory Production Expansion        

Cape Coral, FL -- (SBWIRE) -- 09/10/2014 -- Wasatch Product Development is focused on providing the most responsive and flexible service in the industry and has a diverse clientele ranging from leading global companies to virtual and emerging entities. With unmatched technical expertise, innovative equipment and regulatory knowledge, Wasatch maintains a demonstrated record with the FDA as well as with its customers; many of whom have outsourced with the company for over ten years. The Wasatch Product Development's lab is compliant with Good Manufacturing Practices (cGMP) along with being registered and certified by the ATF, and FDA. Wasatch has been developing and manufacturing several unique products for many of the World's most successful consumer product companies since 1998.

801-566-4449
Owner, Kevin Casey
http://wasatchcontractmanufacturing.com/contact/
kcasey@wasatchlabs.net

Mission Statement
To proactively serve our business community by providing solutions
in personal care, business development and liquid nutrition.

Vision Statement
To provide leadership in establishing our client's international businesses,
being built on a foundation of innovation, advocacy, technology and business integrity.

http://wasatchcontractmanufacturing.com/

~Wasatch Labs' Core Competencies are:

Anti-Aging
Gene Expression
Neuro-Peptides
Cosme-ceuticals (Skin Care)
Skin "Energy Systems"
OTC Products (Sanitizers, SunScreens, etc)
SPF: Sun Protection
Liquid Nutritionals and Juices
Unique Skin Treatments (Intimacy, Sanitation, and "plumping" products)
Think of Wasatch Labs when you are considering sourcing a secondary manufacturer for your existing products or perhaps a reliable, experienced laboratory for product development.
~Wasatch Lab's Competitive Advantages include:

In-House Capabilities (Packaging Engineering, Formula Development, Manufacturing)
International Capabilities
Total Customer Support
Complete Supply Chain Management
cGMP

Thanks for Stopping By – WPG – HOME Tab
https://vimeo.com/75658706
Inside Scoop on Wasatch – WPD - ABOUT Tab
https://vimeo.com/71997930

Whatever the size of the anti-aging product corporation, Wasatch Contract Manufacturing can take it to the next level. They provide packaging engineering, formula development, private labeling, and manufacturing of liquid products. Small Companies: They help small companies identify their industry niche, develop proprietary formulas, and make a strong debut on the market. Many of their current Salt Lake City start-ups are focused on emerging Utah and national markets: gene expression, skin energy systems, specialty sun care, and anti-aging.

Medium Size Companies: Wasatch helps medium companies refine their product lines, improve quality, and manage production growth.

Large Utah Companies: They help large companies diversify and respond to changes in the market. Many large companies are developing new product lines in high-demand mitochondrial anti-senescence, neuro peptides, and acne products. Wasatch Contract Manufacturing is a cGMP, FDA, EPA, and ATF compliant facility. Wasatch has been formulating liquid products for over twenty years without an FDA violation. Call their operations manager today to learn how Wasatch can help a company move forward.

ABOUT Wasatch Product Development
Wasatch Product Development is focused on providing the most responsive and flexible service in the industry and has a diverse clientele ranging from leading global companies to virtual and emerging entities. With unmatched technical expertise, innovative equipment and regulatory knowledge, Wasatch maintains a demonstrated record with the FDA as well as with its customers; many of whom have outsourced with the company for over ten years. The Wasatch Product Development's lab is compliant with Good Manufacturing Practices (cGMP) along with being registered and certified by the ATF, and FDA. Wasatch has been developing and manufacturing several unique products for many of the World's most successful consumer product companies since 1998.

http://wasatchcontractmanufacturing.com/

For more information on this press release visit: http://www.sbwire.com/press-releases/private-label-hair-care-co-packer-news-adam-green-upholds-utah-business-plan-focus-for-equity-laboratory-production-expansion-544611.htm

Media Relations Contact

Adam Green
Telephone: 801-566-4449
Email: Click to Email Adam Green
Web: http://wasatchcontractmanufacturing.com/


          Private-Label-Manufacturer Adam Green & Steve ThomasNet Big Success: G3-Development Marketing Managers Affirms the Draper Based Private Label Manufacturer Skin Care Technology        

Coral Springs, FL -- (SBWIRE) -- 09/08/2014 -- Wasatch Product Development is focused on providing the most responsive and flexible service in the industry and has a diverse clientele ranging from leading global companies to virtual and emerging entities. With unmatched technical expertise, innovative equipment and regulatory knowledge, Wasatch maintains a demonstrated record with the FDA as well as with its customers; many of whom have outsourced with the company for over ten years. The Wasatch Product Development's lab is compliant with Good Manufacturing Practices (cGMP) along with being registered and certified by the ATF, and FDA. Wasatch has been developing and manufacturing several unique products for many of the World's most successful consumer product companies since 1998.

801-566-4449
Owner, Kevin Casey
http://wasatchcontractmanufacturing.com/contact/
kcasey@wasatchlabs.net

Mission Statement
To proactively serve our business community by providing solutions
in personal care, business development and liquid nutrition.

Vision Statement
To provide leadership in establishing our client's international businesses,
being built on a foundation of innovation, advocacy, technology and business integrity.

http://wasatchcontractmanufacturing.com/

~Wasatch Labs' Core Competencies are:

Anti-Aging
Gene Expression
Neuro-Peptides
Cosme-ceuticals (Skin Care)
Skin "Energy Systems"
OTC Products (Sanitizers, SunScreens, etc)
SPF: Sun Protection
Liquid Nutritionals and Juices
Unique Skin Treatments (Intimacy, Sanitation, and "plumping" products)
Think of Wasatch Labs when you are considering sourcing a secondary manufacturer for your existing products or perhaps a reliable, experienced laboratory for product development.
~Wasatch Lab's Competitive Advantages include:

In-House Capabilities (Packaging Engineering, Formula Development, Manufacturing)
International Capabilities
Total Customer Support
Complete Supply Chain Management
cGMP

Thanks for Stopping By – WPG – HOME Tab
https://vimeo.com/75658706

Whatever the size of the anti-aging product corporation, Wasatch Contract Manufacturing can take it to the next level. They provide packaging engineering, formula development, private labeling, and manufacturing of liquid products. Small Companies: They help small companies identify their industry niche, develop proprietary formulas, and make a strong debut on the market. Many of their current Salt Lake City start-ups are focused on emerging Utah and national markets: gene expression, skin energy systems, specialty sun care, and anti-aging.

Medium Size Companies: Wasatch helps medium companies refine their product lines, improve quality, and manage production growth.

Large Utah Companies: They help large companies diversify and respond to changes in the market. Many large companies are developing new product lines in high-demand mitochondrial anti-senescence, neuro peptides, and acne products. Wasatch Contract Manufacturing is a cGMP, FDA, EPA, and ATF compliant facility. Wasatch has been formulating liquid products for over twenty years without an FDA violation. Call their operations manager today to learn how Wasatch can help a company move forward.

About Wasatch Product Development
Wasatch Product Development is focused on providing the most responsive and flexible service in the industry and has a diverse clientele ranging from leading global companies to virtual and emerging entities. With unmatched technical expertise, innovative equipment and regulatory knowledge, Wasatch maintains a demonstrated record with the FDA as well as with its customers; many of whom have outsourced with the company for over ten years. The Wasatch Product Development's lab is compliant with Good Manufacturing Practices (cGMP) along with being registered and certified by the ATF, and FDA. Wasatch has been developing and manufacturing several unique products for many of the World's most successful consumer product companies since 1998.

http://wasatchcontractmanufacturing.com/

For more information on this press release visit: http://www.sbwire.com/press-releases/private-label-manufacturer-adam-green-steve-thomasnet-big-success-g3-development-marketing-managers-affirms-the-draper-based-private-label-manufacturer-skin-care-technology-542859.htm

Media Relations Contact

Adam Green
Telephone: 801-566-4449
Email: Click to Email Adam Green
Web: http://wasatchcontractmanufacturing.com/


          For bacteria that cheat, food is at the forefront        
08/04/2017
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OSU News Release
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Microbes that produce important secretions for use in a community suffer a blow to their own fitness for supplying the non-producing “cheater” bacteria – but not always.

CORVALLIS, Ore. – If you’ve got plenty of burgers and beers on hand and your own stomach is full, an uninvited guest at your neighborhood barbecue won’t put much strain on you.

But if you’re hungry and food and drink supplies are running low when the moocher shows up, it’s a different story.

New research at Oregon State University indicates bacteria know just how you feel.

Microbes that produce important secretions for use in a community suffer a blow to their own fitness for supplying the non-producing “cheater” bacteria – but only when production requires the same nutrients that would otherwise go into growth and biomass.

Findings were published today in Nature Communications.

Bacteria are important organisms for evolutionary biology research because their fast growth allows scientists to study evolution in real time in the lab. The common, rod-shaped bacteria in the study, Pseudomonas aeruginosa, can lead to infections in humans, and cheater strains are often found among the infection-causing organisms.

“The big picture of this research is a better understanding of how cooperation works and how cooperation evolved,” said corresponding author Martin Schuster. “We can use microbes to study social evolution. Essentially every environment is nutrient limited in some way, and our study allows us to make predictions about what types of environments are conducive to cooperation or cheating.”

The study by Schuster and 2017 Ph.D. graduate Joe Sexton involved P. aeruginosa and a peptide siderophore it secretes, pyoverdine, or PVD.

P. aeruginosa uses PVD to scavenge iron, an essential and hard-to-get nutrient; the cheaters don’t produce PVD but have a receptor to collect the iron the siderophore binds with.

“The secretions benefit everyone, and cheating bacteria don’t participate in the production,” said Schuster, associate professor in OSU’s Department of Microbiology in the colleges of Science and Agricultural Sciences. “In general, cooperation is considered costly; therefore, cheaters can exploit the process by saving on the costs of cooperation.”

Building on earlier studies that showed cooperative behavior in P. aeruginosa can be exploited by mutant cheaters, this research demonstrates that the costs of bacterial cooperation are conditional.

“It’s all contextual and depends on the environment, the available nutrients, the bacterial diet,” Schuster said. “Sometimes cooperation is very costly, other times not at all. And if cooperation isn’t costly, it means that cheating doesn’t provide an advantage.”

In the case of PVD secretion, there’s a fitness cost involved for P. aeruginosa when carbon or nitrogen are in limited supply; those are building blocks for PVD and also necessary for producing cellular biomass.

But shortages of other nutrients – iron, phosphorus and sulfur – don’t result in a fitness cost; thus, the cheaters don’t gain an edge in those scenarios.

“Before, fitness cost was thought to be proportional to how much siderophore was being made,” Sexton said. “We showed that under different nutrient conditions the bacteria were still making the same amount, but the fitness costs varied dramatically.”

The researchers experimentally verified their modeling predictions with a chemostat format, an open system in which fresh nutrients flow in at the same rate spent growth medium flows out; cell density and growth rate are kept constant. In this system, the fitness costs of PVD production were apparent as growth differences between cooperators and cheaters in a mixed culture.

“In addition to fundamental questions about the evolution of cooperation, our work is also relevant to natural populations,” Sexton said. “There are siderophore-negative strains in the soil and the ocean and in human infections. Where did they come from? Did they evolve as cheaters, or for some other reason? Our work provides a new piece of the puzzle to consider in real-world contexts.”

The National Science Foundation and the Alexander von Humboldt Fellowship for Experienced Researchers supported this research.

Media Contact: 

Steve Lundeberg, 541-737-4039

Multimedia Downloads
Multimedia: 

Siderophore cross-feeding

Bacterial "cheating"

          Why Whey Protein is Considered Best for Weight Loss?        

Whey protein is the latest and the best dietary supplement that you can use to achieve that perfect figure. With a judicious combination of a healthy lifestyle, good diet and exercise, whey protein can aid in the removal of the extra stubborn fat that often refuses to shed easily.


What constitutes Whey Protein?

 

Whey protein is the liquid by-product that is formed in the production of cheese. There are three major forms in which Whey Protein can be found in supplements.

 

  • Whey Protein Concentrate- whey protein concentrate has fat and lactose in percentage varying from 29% and 89% depending on the product. Concentrates have more compounds that are bio-active.
  • Whey Protein Isolates- Isolates have lower fat content and cholesterol as well. The lactose content is also lower and more than 90% of the product is protein.
  • Whey Protein Hydrolysates- This is often used in many clinical nutrition applications since they are already pre-digested and broken down and thus easier to absorb in the human body.

 

Whey protein has a higher content of protein digestibility corrected amino acids (PDCAA) over any other form of protein supplements. This implies that Whey proteins are able to supply the amino acids required by humans more effectively as compared to other supplements. Whey has the highest amount of branched chain amino acids (BCAAs) and leucine as compared to other forms of proteins.


Why does Whey Protein aid in the removal of excess body fat?

 

Whey protein has been known to have beneficial advantages for people looking to shed the extra weight. There are a few basic reasons for this.

 

  • Rich in Leucine- Leucine has been clinically proved to serve a great role in protein synthesis which takes up a good amount of calories. Leucine has also been known to stimulate fatty acid oxidation that makes it a potent fat burner.
  • Satiates appetite- Whey protein has been known to satiate appetite better than a number of other proteins. Milk proteins have Glymacropeptide which stimulates the formation of cholecstokinin (CCK) which is an intestinal hormone that is generally released after eating a full meal and sends a signal of satiation to the brain.


Clinical studies to show the beneficial effects of Whey protein in losing body fat

 

  • In a research conducted by the University of Oklahoma, two groups of subjects were asked not to make a change in their diets. One group was given a nutrition supplement containing whey protein (300calories and 40grams of protein). After ten weeks, the groups were engaged in a supervised endurance and resistance training program. Results showed a 5.3% more decrease in fat mass in the group that had taken the supplements.
  • Another similar research, conducted in 2006 found that 60gms of whey protein daily led to a significant weight loss in 6 months as compared to 60gms of soy protein or carbohydrates.

 

Whey protein is one of the best supplements for people looking to shed stubborn excess body fat and lose weight.  However, it yields successful results only when combined with a balanced diet and exercise.


          The Quest for Aphrodisia: Pheromones        
For the human brain, all roads lead to aphrodisia. We can be sexually stimulated through any of our five senses — thanks to a bit of imagination, memory, and a really big brain. Although mankind continues to ransack the planet for anything that might raise his expectations, the most authentic aphrodisiac is a lot closer than we think.

In the morning of the world, when mortal man first encountered the original aphrodisiac, he got mixed results. Paris, a young prince of Troy, had to choose "The Fairest" of three goddesses. Hera offered him riches and dominion over all men. Athena promised him wisdom and renown as the bravest, most invincible of heroes.

Then the goddess of love and beauty spoke. In a sweet voice, teasing with laughter and understanding, Aphrodite said, "Choose me and I will give you love and the most beautiful woman in the world for your wife."

Without hesitation, Paris chose Aphrodite. True to her word, the enchanting goddess introduced him to the lovely Helen, whom Paris promptly proceeded to abduct from her husband, the King of Sparta, which didn't go down too well with him and his boys. (Did somebody say Trojan War?) The rest is mythstory. . . .

Casualties of Lore
Aphrodite herself had a somewhat violent origin. Known to the Romans as Venus, she was born of the sea, having emerged from the white foam (aphros) produced by the god Uranus's severed genitals. Today, mankind's eternal quest for an aphrodisiac — a food, drink, drug, or scent that can arouse or increase sexual desire — continues to bring its share of violence.

Many innocent creatures have suffered abuse from our insatiable appetite that continues to devour creatures large and small, from seahorse to rhinoceros. Animals aren't the only ones who suffer, though. A legendary aphrodisiac called Spanish fly is made from the dried bodies of blister beetles that contain cantharidine. This irritating chemical causes a rush of blood to the sex organs. Spanish fly is a poison that can lead to genitourinary infections, scarring of the urethra, and even death.

Stimulant vs. Tonic
Herbs can be used to stimulate the genitals, but in the long run it's safer and more effective to use tonics — botanicals that strengthen the sexual system — not ones that stimulate it. "If you take an aphrodisiac that creates the illusion of more energy, then you're ripping yourself off," cautions Felice Dumas, Ph.D., author of Passion Play: Ancient Secrets for a Lifetime of Health and Happiness Through Sensational Sex. "You will have used more of your life force. It's like emptying the cup very quickly to feel more in the short term."

Coffee is an empty stimulant; it doesn't strengthen anything. Alcohol is another example. "Venus drowned in Bacchus" was the proverbial Roman expression for the debilitating effects of alcoholic intoxication. Drinking, said Shakespeare in Macbeth "provokes the desire but takes away the performance."

Size Matters
Unlike other primates, who are sexually active only when females are in estrus, human beings have evolved the capacity to engage in year-round sexual activity. Perhaps our 24/7 sexuality is related to our relatively large brain. (Dolphins, too, have proportionately large brains and have been observed to be very sexual.)

Ultimately, the human brain is the greatest aphrodisiac of all. Like the legendary philosophers' stone that transforms whatever it touches into gold, our brains can imbue most anything with aphrodisiacal qualities.

Men and women have devised and believed in love charms since the beginning. Aphrodite herself possessed an enchanting girdle, called Cestus, which was embroidered with arousing amulets that made its wearer quite irresistible. One can only imagine. . . .

The Touch of Kindness
We get sex on the brain through imagination and memory, as well as through all our sensory portals: eyes, ears, nose, mouth, and of course touch. We are easily turned on by the caress of a lover, or even from casual contact with an attractive stranger. Massage relaxes and sets the mood for love, or arouses in the extreme.

Affectionate touching — especially the breasts, lips, and earlobes — can raise levels of oxytocin, a powerful neurohormone. Dubbed the "cuddling chemical," oxytocin is released during female orgasm and nursing. In men, moderate concentrations of oxytocin facilitate both erection and ejaculation.

Singing Me Softly
Sounds can certainly be an aphrodisiac. (It works for birds.) That special tone of a lover's sweet whisperings, even over the telephone, can stir the loins. For the Greek poet, Homer, Aphrodite was "a lover of laughter." Whether the flirtatious giggling and coy cooing of young maidens or the tender tenor of a Cyrano or a Bocelli — the human voice has arousing possibilities.

Charles Darwin suggested that early human females originally acquired musical powers and used their high voices as musical instruments in order to attract the opposite sex. Love songs are certainly a hallmark of our society. We will never know to what extent our population explosion was coaxed along by the seductive sound of Sinatra or Sade, the romantic resonance of Enya or Iglesias.

Who has not been swayed by the music of the world: caressed by jazz; rolled with rock; lifted by arias; transported by Caribbean rhythms. The primal beat of different drums — from Ravel's "Bolero" to Jagger's "Moonlight Mile" — has lit a fire under many a bedspread.

Another auditory aspect is story-telling and its stimulating effect upon the imagination. The word "romance" originated from the fanciful medieval love tales, often in verse, about a hero and his lady. Later written, they were the beginning of erotic literature (Eros is the son of Aphrodite). In ancient Greece, "pornographos" was one who wrote about prostitutes.

First Sight
Studies show that humans everywhere strongly respond to the same visual signals, such as smooth skin, dilated pupils, and a symmetrical face and body. Young women throughout the world have been observed to flirt in exactly the same manner: first she smiles at her admirer and lifts her eyebrows in a swift, jerky movement. This briefly displays more of her eyes until she turns her head sideways, looks back, and drops her eyelids. (Even King Solomon warned his son not to be "ensnared by her eyelids.")

More than skin deep, beauty is a certificate of health. Men are attracted to youthful fertility suggested by rounded buttocks and breasts, full lips, wide eyes, a heart-shaped face, and a particular figure. Whether Rubenesque or Twiggyesque, men unconsciously prefer women with about a 2 to 3 waist-hip ratio — one that suggests a high reproductive status. Although Miss America's weight has decreased over the past fifty years, her waist to hip ratio has been a consistent 7.2, according to David M. Buss, Ph.D., author of The Evolution of Desire: Strategies of Human Mating.

For women, power is an aphrodisiac. In a global survey of more than 10,000 people in 37 cultures, Dr. Buss found it universally true that women prefer confident, ambitious, and successful men with money, resources, power, and high social status — men who will invest in them and their children.

Visual stimuli such as tallness and broad shoulders are physical cues indicating the potential of a man to protect and provide. The reproductive success of taller men was recently demonstrated in a study of 3,200 Polish men, aged 25 to 60. Those who had fathered at least one child were on average 1.2 inches taller than the men without children. (Nature, Jan. 13, 2000)

Brain chemicals are also affected by visual stimuli. The sight of an infant's face can increase levels of oxytocin, which helps a mother to bond with her child, or a woman with her lover. The chemical basis of "love at first sight" might be phenylethylamine (PEA), a neurotransmitter that can surge at the sight of an attractive partner, or even in response to a romantic movie.

The Dance of Imagination
Thanks to imagination, the flash of a Victorian ankle was a turn-on. The allure of lingerie is a combination of what you see and what you imagine you will get.

Dance is a universal turn-on. From indigenous tribes to trendy clubs, women shake their booties and men strut their stuff in various versions of the human mating dance, from the Masai leap and the flamenco stomp, to the hula, belly dance, and now the lap dance.

The Shape of Things to Come
Sight plays another role in aphrodisia: the notion that animal organs or plants resembling genitalia may impart sexual powers. For example, because of their shape, the tuberous roots of orchids were used as an aphrodisiac. The plant is even named after the Greek word for testicle (orkhis). More well-known examples include rhinoceros horn, oysters, and ginseng.

Rhinoceros horn contains polypeptides, sugars, phosphorus, calcium, ethanolamine, and free amino acids. If one were seriously malnourished, this could possibly provide a boost, but a good multivitamin would do as well.

Based on their shape, foods such as bananas, carrots, and cucumbers were once considered aphrodisiacs. Perhaps the enzyme bromelain found in bananas and other tropical fruits may influence erectile function due to its positive effect on circulation.

Nineteenth-century French bridegrooms were advised to consume mass quantities of warm asparagus at their prenuptial dinner. In West Africa, the mucilage seeds of the okra pod are considered an aphrodisiac. They are rich in magnesium, iron, zinc, and B vitamins.

Venus on the Half-Shell
Cleopatra's favorite fruit was said to be figs, and the ancient Greeks celebrated the arrival of a new crop of figs by ritual copulation. Other foods that may suggest female genitalia include oysters, clams, and mussels. Many seafoods such as eels, octopus, conch, fugu, sashimi — as well as savory soups like bouillabaisse and chowder — have a reputation as an aphrodisiac, in part because of their association with Aphrodite's emergence from the sea.

In a sense, human beings also emerged from the sea. Recent archeological findings show that early humans thrived along seacoasts and lakeshores where foods high in omega-3 fatty acids were plentiful. The evolution of the large human brain depended on these rich sources of docosahexaenoic acid (DHA). (Click here for more information about essential fatty acids and brain structure.)

The omega-3 fatty acids obtained from seafood are also needed by the body to make anti-inflammatory PGE3 prostaglandins, which support proper blood circulation by preventing blood platelets from clumping.

Oysters and Pearls, Boys and Girls
Rich in zinc, selenium, and other minerals, oysters may have gained their reputation at a time when diets were more apt to be deficient. High concentrations of zinc are found in the testes and prostate, and zinc is essential for hormonal activity and reproductive health in both men and women. Zinc is vital to healthy immune and circulatory systems, and is depleted by stress.

Zinc deficiency in children has been linked to a failure of sex organs to properly mature. A deficit of this vital mineral substantially reduces testosterone levels, sperm production, and muscle endurance, as well as decreases the ability to taste and smell.

Raw oysters can be risky due to pollution. Other good sources of zinc include lean meats, fish, eggs, nuts, seeds, peas, lima beans, and wheat germ. Although whole grains contain zinc, they also contain phytates that inhibit the absorption of zinc and other vital minerals. By soaking grains overnight, phytates can be neutralized so the grains, in effect, are predigested and their nutrients more available. These alternatives, however, are no match for fresh fleshy oysters, even if you don't find the pearl.

Seeds of Construction
Eggs and seeds are strong fertility symbols. Chicken eggs are one of the most sexually nutritious foods available. Caviar and a number of plant seeds, especially pumpkin, were considered to be aphrodisiacs. We now know they are rich in vitamin E and fatty acids essential for reproduction. Pumpkin seeds are also high in zinc and selenium.

Then there's the truffle. Ever since the Romans raved about it, this musky mystery has been a perennial favorite in the realm of aphrodisia. A famous French epicurean claimed truffles were "not vegetables, but miracles." Their great rarity, cost, and indescribable aroma adds to their fame.

Ginseng — "the Man Root"
Ginseng's reputation as an aphrodisiac may have originated from its marked similarity to the male body. By far the most widely used herbal tonic, ginseng has been used for millennia because of its invigorating and rejuvenating effects.

Chemical evidence supports the stimulatory influence of ginseng; several steroids, peptides, sugars, and saponins have been isolated from root extracts. Animals treated with ginseng have demonstrated a sexual response, however no successful animal model for assessing aphrodisiacs has been developed that can be applied to humans. Our psychological and socioeconomic factors cannot be replicated.

Just Say NO — Nitric Oxide
A study at the Yale University School of Medicine found a link between Panax ginseng and nitric oxide (NO). Researchers concluded that the aphrodisiac action of the root could be due to enhanced NO synthesis that contributed to ginseng-associated vasodilation in the corpus cavernosum. (Biochem Pharmacol 1997 Jul 1;54.1:1-8) A later animal study showed that crude extracts of Panax ginseng acted as a nitric oxide donor and induced the relaxation of smooth muscle of rabbit penises through the L-arginine/nitric oxide pathway. (Br J Urol 1998 Nov;82.5:744-8)

The corpus cavernosum is a sponge-like structure that forms the erectile tissue which expands with blood in the penis and in the clitoris. Nitric oxide — not nitrous oxide, the "laughing gas" used by dentists — enables the corpus cavernosum (and the corpus spongiosum in the penis) to relax, fill with blood, and become erect.

For both men and women, healthy sexual arousal depends on a sufficient flow of blood to the genital area. Poor circulation can be a major cause of sexual dysfunction, which is perhaps why many hot foods gained their claim to aphrodisiac fame. Peppers, chilies, curries and other spices can raise heart rate and sometimes cause sweating: physiological effects similar to the physical reactions experienced during sex. Damiana, a Mexican herb, is reputed to stimulate blood flow to the genitals, (but it can interfere with iron absorption).

Arginine, Viagra, and Yohimbe
In the body, the amino acid arginine is the primary source of nitrogen for the production of nitric oxide. In turn, nitric oxide increases levels of a substance called cyclic GMP. A shortage of cyclic GMP interferes with the erectile tissue relaxation response that is necessary before blood can engorge the clitoris and penis. Foods high in arginine include chocolate, carob, and oats.

Viagra works by prolonging the effects of cyclic GMP, allowing the penis to engorge with so much blood that the outflow of blood is blocked. Because Viagra will not work without sexual stimulation, it is not considered an aphrodisiac. It is only promoted as an impotence drug, however Hugh Hefner regards Viagra as a good deal more than that: "It takes the uncertainty out of performance. . . It redefines the boundary between fantasy and reality."

NO may help account for the sexually stimulating effects of yohimbine, an alkaloid found in the bark of the West African yohimbe tree, which natives have long regarded as a tonic to enhance sexual power and virility. Yohimbine has been used in the West as a sexual stimulant for domestic animals and, more recently, to treat impotence in men. A 1999 study with humans found that certain compounds of yohimbine functioned as nitric oxide donors. (J Pharmacol Exp Ther 1999 Jul;290.1:121-8) The FDA considers yohimbine an unsafe herb, due to its potentially dangerous effects on the cardiovascular and nervous systems.

Padre, Is That a Rocket in Your Garden?
Arugula, also known as garden rocket, had a good reputation in Europe as an aphrodisiac, except for one 17th-century French monastery where arugula was grown and consumed regularly by the monks. An 1869 book on aphrodisiacs reported they "were so stimulated by its aphrodisiacal virtues that, transgressing alike their monastic walls and vows, they sought relief for their amorous desires in the fond embraces of the women residing in the neighborhood."

Europeans have long appreciated parsley and savory for their aphrodisiac properties. More recently, nettles, oats, and saw palmetto berries have been studied for their ability to maintain levels of free testosterone, which stimulates sexual activity in both men and women. Compounds in these plants seem to inhibit the breakdown of testosterone into di-hydrotestosterone (DHT), a metabolite that causes the prostate gland to enlarge and lose its vitality.

Montezuma's Romance
While many sweet herbs, such as skirret and licorice root, were at one time considered sexual stimulants, chocolate's designation as an aphrodisiac has remained undisputed for centuries. In the early 1500s, the Aztecs introduced the Spanish to the bitter seeds of the cacao tree, which was concocted into a sacred drink associated with Xochiquetzal, the goddess of fertility. (The Spanish reciprocated with small pox, the god of decimation.)

Besides added sugar, chocolate contains significant amounts of caffeine (5-10 mg per ounce), iron, plus an amphetamine-like substance called phenylethylamine (PEA). In the brain, PEA is a neurotransmitter involved in states of arousal and activation. It may be responsible for the excitement and euphoria of falling in love. It's not certain, however, that the PEA in chocolate actually reaches the brain. (The essential amino acid phenylalanine is known to raise PEA levels in the brain, and D-phenylalanine inhibits enzymes that break down endorphins.)

The psychological effect of indulging in chocolate, especially when received from a lover, certainly adds to its aphro-mystique. The power of mind to imbue food with passion is well-illustrated in Like Water for Chocolate, where cooking is used to enchant a lover.

Cornucopia and Coition
Many foods are exotic and sensual in their own right. From peaches and apricots to strawberries and grapes, the texture, color, taste, and aroma of these botanical delights can, in the right circumstances, jump-start amorous intentions. Aphrodite herself was associated with golden apples and red pomegranates.

Around the Mediterranean, pine nuts have a reputation as an aphrodisiac. Nineteen-hundred years ago, the Greek physician Galen recommended drinking a glassful of thick honey, and eat 20 almonds and 100 grains of the pine tree before going to bed. After three nights, a man will acquire "vigour for coition."

Honey Do
The Greeks frequently referred to Aphrodite's beauty as "golden," and golden honey is another classic food for lovers. Cavemen no doubt used sweet honey to win female favors (and vice versa). Since honey was obtainable only seasonally and at great personal risk, its annual collection and sharing may be echoed by our annual Valentine's Day, although rejection is now the primary risk.

The wedding ceremonies of many cultures include honey, and that month of tender pleasures is called the honeymoon — also named because love is as changeable as the moon.

Made from the nectar of flowers, honey is a natural candidate for aphrodisia. Bee pollen is the male sexual grains of seed-bearing plants, and royal jelly nurtures queen bees. The ultimate preservative, honey never spoils. A Haitian text describes honey on bananas as an "exquisite" aphrodisiac.

Aphrodite: A Memoir of the Senses is Isabel Allende's evocative personal odyssey to aphrodisia. In it, she tells how Cleopatra beautified her skin by applying honey and ground almonds, and how her lovers, Julius Caesar and Mark Antony, were "fond of licking dessert from the intimate goblet of that seductive queen."

Olfactory Alchemy
Aromas such as pumpkin pie and freshly baked cinnamon buns can be more sexually stimulating than fine perfume, according to research done by neurologist Alan R. Hirsch, M.D., author of Scentsational Sex: the Secret of Using Aroma for Arousal. He reports that the smell of certain foods, especially licorice and doughnuts, actually increased penile blood flow.

Older men experienced the greatest enhancement with vanilla. Those who felt sexually satisfied responded most to strawberry. Lavender was most stimulating for men whose sexual partners wore cologne.

Aphrodite's favorite flower was the rose, and for multitude of Valentines, roses will do the trick. Cleopatra supposedly perfumed the sails of her gilded yacht with the scent of Damascus rose, so the desert winds would announce her arrival.

"A rose is a rose is a rogue," novelist Tom Robbins reminds us in Jitterbug Perfume, his erotic ode to aroma. In his signature style, Robbins salutes the magnificent nose of a legendary perfume formulator: "It functioned as a catalytic laser, oxidizing the passion that slept unaware in a violet, releasing the trade winds bottled up in orange peel; identifying by name and number the butterflies dissolved in chips of sandalwood and marrying them off, one by one, to the wealthy sons of musk."

Reminiscents — Aroma and Memory
The sense of smell is closely connected with the sense of taste, and much of a food's emotional impact is due to its scent. The olfactory pathway is a direct route to the brain's limbic system, the cerebral crossroads of emotion and memory. That's why smell is the most nostalgic of all the senses. One whiff of eucalyptus can transport an octogenarian back to his kindergarten playground faster than you can say "sinful Caesar sipped his snifter, seized his knees and sneezed."

Probably the most renowned aphrodisiacs are essential oils, especially those derived from white, night-blooming flowers that are moth-pollinated, such as jasmine and narcissus.

The Oil of Olé
"Jasmine has the poise of a wild creature, some elusive self-sufficient thing that croons like an organic saxophone in the tropical night." (Robbins again, who also bemoans the modern trend of naming perfumes after "glorified tailors" — in contrast to the epic scents of yesteryear: Tabu, My Sin, Love Potion, and Sorcery.) Cleopatra used jasmine to distract Marc Antony during business meetings.

Essential oils used in aphrodisia start by promoting physical relaxation. Their fragrance can then trigger more subtle sensations of bodily pleasure. Neroli, named after an Italian princess, is distilled from the white blossoms of the evergreen orange tree. Patchouli is obtained from the fermented leaves of a perennial herb that grows in tropical Asia. Ylang-ylang is distilled from the freshly picked yellow flowers of a tree native to Southeast Asia. It's said that when a man is aroused, he releases an aroma similar to sandalwood (extracted from the roots and heartwood of a small Asian evergreen tree).

The Essence of Aphrodisia — Pheromones
Many romantic fragrances are essentially the sexual attractants of flowers that beckon insects to help with pollination. Humans also react to chemicals from animals, especially musk from the East Asian musk deer, castoreum from the scent glands of certain beavers, and civit, a honey-like secretion from the Ethiopian civit cat. No surprise then that we have our own natural scents, and ones that do a much better job at attracting a mate.

Hormones are potent "local" chemicals that travel throughout your body to help regulate metabolism and behavior. "Hormone" means to set in motion, excite, stimulate. You also produce similar "long distance" chemicals called pheromones, which work outside the body and can affect the hormones of others. "Pherein" means to bring, to bear along. Your pheromones literally entice and excite the opposite sex.

Numerous glands in the skin around your armpits and genitals produce these sexual scents, and the tufts of hair that begin sprouting at puberty collect and help broadcast your fragrant chemicals (some so subtle, they're considered odorless). Trapped beneath layers of clothing, however, these potentially erotic scents can become stale and deteriorate.

Fragrant Tokens
In her classic 1992 book, Anatomy of Love: A Natural History of Mating, Marriage, and Why We Stray, Helen Fisher, Ph.D., tells how a woman in Shakespeare's time would hold a peeled apple under her arm until it was ingrained with her scent. She would then offer this "love apple" to her lover to inhale. In parts of Greece and the Balkans today, some men successfully invite women to dance after offering them a handkerchief which had been carried in the armpit.

In Aromantics: Enhancing Romance, Love, and Sex with Nature's Essential Oils, Valerie Ann Worwood reports that men find a woman's odor most alluring during ovulation, when she is most likely to conceive. In response, men produce an odor of their own that has an aphrodisiac effect on women. Also, during ovulation women were found to be a thousand times more sensitive to a testosterone-like chemical.

A poor sense of smell will dull your love life. In tests with mice and monkeys, when the males' noses were plugged, they ignored females in heat. Good nutrition, especially enough zinc, is important to a healthy sense of smell. Sickness exudes an ill wind of its own that some people say they can sense — a good evolutionary adaptation that we probably all have to some degree. Unfortunately, though, the prefrontal cortex in the human brain can override an instinctual response to olfactory input.

Excessive bathing or use of deodorants and perfumes can overwhelm your sexual scents. Napoleon knew this. He asked his sweetheart Josephine to abstain from bathing several days before he returned to her.

Sweat T-Shirt Contest
In her 1998 book, Sex on the Brain: The Biological Differences Between Men and Women, Deborah Blum tells about a revealing Swiss experiment with a group of college students. Each woman was seated alone in a room at the time of ovulation, when her sense of smell was most acute. She then sniffed the T-shirts slept in by different men over the previous weekend. The women rated each shirt for sexiness, pleasantness, and intensity of smell.

What's remarkable was that the sexiness of the shirts correlated with the degree of difference in MHC genes. This is good, because these MHC (major histocompatibility complex) genes code for the disease detectors in the immune system — the more variety, the better. The women had a stinkual attraction to males whose MHC genes were least like their own.

Be the Aphrodisiac
Our natural scents and sensitivity thus play a vital role in identifying and attracting an ideal mate, one with whom we have the best chances of producing a healthy child capable of withstanding the onslaughts of life. And that's the name of the evolutionary game.

Our smell is as unique as our face. While it won't be alluring to everyone, we can count on having real chemistry with the ones we do attract. And the feeling will be mutual.

Not surprisingly, the quest for aphrodisia brings us full circle back to ourselves. This is good news for all Earth's creatures and gives new meaning to the words: "in the end, the love you take is equal to the love you make."
          Salivary proline rich peptide decreases cell growth in HCC38 triple negative breast cancer cell line        

Objective: The objective of this study is to determine the effects of p1978 on the growth rate of a triple receptor negative breast cancer cell line.

Methods: Three cell lines, 185B5 normal tissue, HCC38, and AU585, were seeded with peptide p1978. Corresponding plates were seeded with PBS to serve as controls. Baseline line cell counts were taken at 30% confluence prior to seeding. Counts were again made 48 hours later.

Results: The HCC38 cell line showed decreased growth when exposed to the low and high dose of p1978 peptide.

Conclusion: The results suggest that p1978 may have potential in treating triple receptor negative breast cancer.


          Peptide Immunotx Well Tolerated in New-Onset Type 1 Diabetes        
No decline in C-peptide with peptide immunotherapy; no change in insulin use over 12 months
          Eye Creams        
Women tend to lose fat under the eye area with age giving a hollow appearance to the eyes. Find out more about eye creams with peptide, eye creams with Vitamin K and eye creams with retinol. Learn how to apply eye cream.
          Best Eye Wrinkle Cream Delivers Results        
Every cosmetic line seems to have an eye cream these days and rightfully so. Who's to blame them for wanting a piece of the billion dollar a year cosmetics industry. Whether or not these eye cream products deliver on their promises is another story. When in search of the most effective skin care products, you need not look any further than Hollywood. In fact, entertainers are constantly being judged by their appearance. So, it only makes sense for Hollywood A-listers to use only the best products.




Some New Tricks




Anti aging eye creams are nothing new but what is new are the scientifically formulated ingredients being added to these miracle potions. One company has gone as far as to base their formula on Nobel Prize winning science. Actors, actresses, supermodels, and other entertainers depend on having access to cutting edge skin care treatments in order to look their best.




We're Not That Different




Celebrities really aren't that much different from you and I. As we age, we have the same skin aging concerns: fine lines and wrinkles, dark circles and bags under the eyes, age spots, sagging skin and those dreadful crow's feet. These aging signs are triggered by excessive sun exposure, our body's reduced production of collagen, and genetics.




Hollywood's Secret Weapon




Celebrities have been raving about an anti aging treatment so advanced it combats all of the most pressing signs of aging. This is made possible by incorporating 6 powerful but gentle ingredients into their breakthrough formula that works in tandem with your body's natural regenerative abilities. These fountains of youth have made believers out of Hollywood's top make-up gurus.







  1. Silicon Dioxide
  2. in the form of 3-D crystals that refract light minimizes the appearance of fine lines and wrinkles


  3. D3PA fights collagen-destroying free radicals in the body



  4. Idebenone reduce dryness and smoothes the skin's texture



  5. Ascorbyl Palmitate is an antioxidant that supercharges the effectiveness of vitamin C in the body



  6. Deanol helps improve blood circulation, tones the lip area, creating a fuller appearance



  7. Acetyl Hexapeptide-3 is the ultimate Botox alternative for erasing fine lines and wrinkles








Not Easy To Come By




The all-in-one anti aging treatment is called LifeCell by South Beach Skincare. Most people have never heard of it because they don't utilize mainstream advertising. LifeCell is so expensive to manufacture that there are limited quantities available at any given time. It's no wonder the word hasn't gotten out about this incredible treatment, the celebrities have been keeping it all to themselves for nearly two years. Remarkably, South Beach Skincare offers a FREE 30-day trial of LifeCell so you can prove to yourself that it really works.


Visit www.skincarecounsel.com for answers to all of your anti aging skin care questions and concerns. Discover for yourself which breakthrough skin care product blew away the competition in our best anti wrinkle cream review. Find out why anti aging cream for wrinkles is the latest trend.

lifecell review: wrinkle cream reviews

lifecell review: wrinkle cream reviews

Article Source: www.articlesnatch.com


          Best Eye Wrinkle Cream Delivers Results        
Every cosmetic line seems to have an eye cream these days and rightfully so. Who's to blame them for wanting a piece of the billion dollar a year cosmetics industry. Whether or not these eye cream products deliver on their promises is another story. When in search of the most effective skin care products, you need not look any further than Hollywood. In fact, entertainers are constantly being judged by their appearance. So, it only makes sense for Hollywood A-listers to use only the best products.




Some New Tricks




Anti aging eye creams are nothing new but what is new are the scientifically formulated ingredients being added to these miracle potions. One company has gone as far as to base their formula on Nobel Prize winning science. Actors, actresses, supermodels, and other entertainers depend on having access to cutting edge skin care treatments in order to look their best.




We're Not That Different




Celebrities really aren't that much different from you and I. As we age, we have the same skin aging concerns: fine lines and wrinkles, dark circles and bags under the eyes, age spots, sagging skin and those dreadful crow's feet. These aging signs are triggered by excessive sun exposure, our body's reduced production of collagen, and genetics.




Hollywood's Secret Weapon




Celebrities have been raving about an anti aging treatment so advanced it combats all of the most pressing signs of aging. This is made possible by incorporating 6 powerful but gentle ingredients into their breakthrough formula that works in tandem with your body's natural regenerative abilities. These fountains of youth have made believers out of Hollywood's top make-up gurus.







  1. Silicon Dioxide
  2. in the form of 3-D crystals that refract light minimizes the appearance of fine lines and wrinkles


  3. D3PA fights collagen-destroying free radicals in the body



  4. Idebenone reduce dryness and smoothes the skin's texture



  5. Ascorbyl Palmitate is an antioxidant that supercharges the effectiveness of vitamin C in the body



  6. Deanol helps improve blood circulation, tones the lip area, creating a fuller appearance



  7. Acetyl Hexapeptide-3 is the ultimate Botox alternative for erasing fine lines and wrinkles








Not Easy To Come By




The all-in-one anti aging treatment is called LifeCell by South Beach Skincare. Most people have never heard of it because they don't utilize mainstream advertising. LifeCell is so expensive to manufacture that there are limited quantities available at any given time. It's no wonder the word hasn't gotten out about this incredible treatment, the celebrities have been keeping it all to themselves for nearly two years. Remarkably, South Beach Skincare offers a FREE 30-day trial of LifeCell so you can prove to yourself that it really works.


Visit www.skincarecounsel.com for answers to all of your anti aging skin care questions and concerns. Discover for yourself which breakthrough skin care product blew away the competition in our best anti wrinkle cream review. Find out why anti aging cream for wrinkles is the latest trend.

lifecell review: wrinkle cream reviews

lifecell review: wrinkle cream reviews

Article Source: www.articlesnatch.com


          Eating Paleo        
Hello friends!  I hope you are well!  I'm sorry for the less frequent posts lately.  I am going to the gym after work a few times a week, and a lot of my time lately is also spent preparing food.  As I briefly touched on recently, I have joined CrossFit, and have adopted a paleo diet lifestyle for the past few weeks.  For those who aren't familiar with either of those things, I'll explain them both for you.  This post will deal with paleo.

Eating "paleo" refers to the diet of our Paleolithic ancestors who lived around 2.5 million years ago up until 10,000 years ago, with the development of agriculture.  Their diet would have consisted of only things they could hunt and gather.  The diet is also referred to as the caveman diet, or hunter-gatherer diet.  I would like to think it's not so much a diet as it is a lifestyle.  The paleolithic diet consists mainly of grass-fed pasture raised meats, fish, vegetables, fruit, nuts, and seeds, and excludes grains, legumes, dairy products, salt, refined sugar, and processed oils.

The premise behind this lifestyle involves the fact that modern humans are genetically adapted to the diet of their Paleolithic ancestors and that human genetics have barely changed since the dawn of agriculture, and therefore that an ideal diet for human health and well-being is one that resembles this ancestral diet.  The agricultural revolution lead to a dramatic change in human nutrition.  Cereal grains, legumes, dairy, vegetable oils, salt, alcohol, and refined sugars make up a huge portion of our Standard American Diet (how SAD).  These foods contain harmful substances associated to many "diseases of civilization", such as diabetes, celiac disease and other autoimmune diseases, obesity, hypertension, certain cancers, acne, poly cystic ovarian syndrome, myopia, dyslipidemia, cardiovascular disease, etc.

The human body is a fairly complicated machine.  I recently read The Paleo Solution by Robb Wolf, which fully explains the many biochemical processes in our bodies in relation to the food we eat.  I really encourage anyone to read this book - you will understand your body the way you really should.  Our body processes different kinds of foods in different ways.  The fact is, our bodies do not process grains, dairy, and legumes well.  We weren't built to process them.

Grains contain a protein that does us no good: gluten.  Gluten is a protein found in wheat, rye, oats, and barley.  I found an article by Rudy Silva (the "Natural Remedies that Work" guy), called Grains That Cause Illness, and I'm just going to quote this:
"As gluten moves into the intestine, it is digested and broken down into small protein molecules - peptides (which consist of 2-3 amino acids bound together) and free amino acids. Amino acids are the basic building blocks the make up protein. Once digestion is complete, peptides and free amino acids easily move into the intestinal wall cell structure and then into your blood stream. This is what happens in a healthy person.

Over many years of eating gluten, the intestinal cell structure deteriorates. Digested protein no longer passes through the cells walls but passes between cells and into the blood. These holes in the intestinal walls is what is know as "leaky gut syndrome" 

Because of the existence of these tiny holes in the intestinal wall, harmful substances can pass into the blood and settle into your organs and cells causing irritations and damage. Your intestinal wall is no longer a barrier keeping out unwanted substances from your blood and body.

Undigested foods can now enter your body creating food allergies. Toxins from various foods - dyes, preservatives, food additives, artificial flavors - can now enter you blood stream. Pathogens such as bacteria, worms, fungus and viruses can also enter your body and invade your organs. When this happens, you will slowly come down with a variety of symptoms and illnesses that you cannot attribute to anything specific.  Absorption of undigested proteins is a major threat to the health of your organs and to your immune system.

It is estimated that up to 40% of all people have some intestinal damage from eating gluten and are passing undigested proteins into their blood stream.

There are some of you that do not have the enzymes to digest gluten. Those of you have what is called "gluten sensitivity." Those of you that have the enzymes to digest gluten are not as prone to celiac disease and have less damage to your intestinal wall."
Lectin is a protein found in grains and legumes, dairy, and plants in the nightshade family.  Lectins are problematic because they are sticky molecules that can bind to the linings of human tissue, especially intestinal cells.   In so doing, they disable cells in the GI tract, keeping them from repairing and rebuilding. Therefore, lectins can contribute to eroding your intestinal barrier (leaky gut).

Because the lectins also circulate throughout the bloodstream they can bind to any tissue in the body ­— thyroid, pancreas, collagen in joints, etc. This binding can disrupt the function of that tissue and cause white blood cells to attack the lectin-bound tissue, destroying it. This is an autoimmune response.  The lectins in wheat for example, are specifically known to be involved in rheumatoid arthritis.

The behind the scenes of eating carbohydrates and sugars is quite interesting.  I will include information directly from here, as I think Jason Seib tells the story really well.
"Be forewarned, I’m going to get a little scientific, but I promise I will do my best to make it all make sense in the end.
Today I’m going to attempt to help you understand the basic biochemistry involved in fat storage and loss.  I said attempt because I am a geek and this stuff gets pretty geeky, and I said basic because nearly everything I type from here forward will be a huge oversimplification of the amazing biochemical symphony taking place in these processes.
Let’s pretend you have not heard of Everyday Paleo yet.  You are still “doing” diets instead of eating like a human.  Your head is still full of myth and fable grounded in anything but actual science.  Your typical day might have looked like this:
Oatmeal for breakfast.
Fat Free/Sugar Free Coffee-like Substance at your mid morning slump.
Subway sandwich for lunch because you want to be like Jared.
Bagel, granola, or other such processed carbs (or maybe another sugar-laden caffeinated beverage) to fight the afternoon slump.
Pasta or rice at dinner.
Something crunchy or sweet between 8 and 10 pm.
Carbohydrate is converted to glucose (blood sugar), so each one of these meals causes a nice bolus of glucose to enter your blood stream very quickly.  Your body closely regulates glucose to keep it within a safe range – not too high and not too low.  After you consume easily digestible carbohydrates like the ones on your daily menu above, your pancreas must secrete insulin to mitigate the resulting elevated glucose.  Insulin’s job is primarily to feed the glucose in your blood stream to hungry cells and then send the leftovers to the liver to be turned into triglycerides for storage in your fat cells.  Are you still with me?  Take a deep breath.  Maybe do a few squats.  Okay, let’s keep moving.  We need to dig deeper.
The story so far:  carbs are eaten and broken down to glucose, insulin sends glucose to your cells to be used as energy or to the liver for a quick composition change so it can be stored as fat.
Moving on.  Since your Standard American Diet (SAD) is nowhere near natural because of all those processed carbs, glucose and insulin remain high throughout your day.  This can eventually lead to insulin resistance in those cells that use glucose as energy.  Insulin resistance is when insulin is ever present and its “I come bearing food” signal to the cells is reduced to a whisper and then finally ignored.  This means your pancreas must produce more insulin to get the same job done, and this in turn means that insulin is ever present in greater quantities.  If you have managed to make sense of all this so far, you can see that you are amassing more and more insulin in your blood stream.  I’m about to explain why this is a problem, but you might want to do a few more squats first.
Hyperinsulinemia, this state of elevated insulin you have created by this point, is bad.  Very bad.  Robb Wolf once suggested that you can Google hyperinsulinemia and any noninfectious disease that comes to mind and you will at least find strong correlations in more links than you would ever take the time to read.  When insulin hangs around too often, it also means you store a lot of fat and have trouble using fat as energy.  This is because insulin is your body’s primary storage hormone.  Here’s how it works (take another deep breath):
High levels of glucose in the blood stream are toxic, just ask a type 1 diabetic.  As I said above, your body devotes a lot of energy to keeping glucose within a fairly tight range.  This means glucose is used for energy before fatty acids because it can’t be allowed to hang out and cause problems.  You can only store a small amount of glucose (as glycogen), but a nearly unlimited amount of fat can be stored, much to the dismay of your buns and thighs.  This is why the liver converts the extra glucose to triglycerides and ships it off to be stored in the fat cells.
Okay, we have finally come to the point of this whole sermon.  At the fat cell, an enzyme called lipoprotein lipase (LPL) acts as the doorman, ushering fatty acids into the fat cells.  Inside the fat cell, another enzyme, hormone sensitive lipase (HSL), has the job of cleaving the first sulfide bond on the triglycerides and releasing fatty acids to be used as energy.  So LPL is working when you are storing fat and HSL is working when you are “burning” fat.  Here’s the rub – both of these enzymes are sensitive to the presence of insulin.  When insulin  is present, LPL is on duty and you are storing fat.  When insulin is gone, HSL is on duty and you are using your stored fat as energy.  If you understand the story so far, this process makes perfect sense.  Since we know that glucose can’t be allowed to hang out and it must be used first, we also know that there is no reason to access stored fat in the presence of glucose and, therefore, insulin.  When insulin is in the blood stream, the message is clear – you have glucose to take care of before you use your stored fat.  Now it’s easy to see why hyperinsulinemia and insulin resistance are a problem.  They keep you in fat storage mode, without the ability to access your stored fat for energy, for plenty of time to make you plump and squishy.
Please don’t misunderstand, I am not trying to paint carbohydrates and insulin as villains.  They are a normal and natural part of human nutrition and biochemistry.  What is not normal is our mass consumption of processed carbohydrates, both in unnatural forms and in never ending supply regardless of season.  A solid paleo diet, along with proper exercise, will make you healthier and leaner by giving you back insulin sensitivity and helping you re-adapt to using your stored fat as energy so your fat cells can go back to being the batteries they are suppose to be instead of the warehouses they have become."
Soooooo, yeah.  This is why North Americans are so damn fat!  Our diets are laden with processed carbage and sugar galore, causing our bodies to use sugar for energy in an attempt to get rid of it, and store the rest as fat, as opposed to actually using stored fat for energy, which is actually the ideal and best energy source we have.  Humans were designed not to be fat, yet so many are.  They are not eating the optimal way to allow them to burn their fat and stay lean.  After reading the Paleo Solution, where I initially learned about this, there was no way I could keep eating the SAD way.  I decided that paleo was for me, and so I just started eating that way.  It's been 3 weeks now, and I feel really great.  It has enhanced my working out and allowed me to lose body fat, replacing it with lean muscle.  I'm on my way to being the fittest I've ever been.

I have always been on one "diet" after another.  I've even turned to anorexia habits to lose weight in the past.  With paleo, you can actually eat all the food you want, as long as your plate basically looks like this:


 It's actually a very simple way to eat.  My typical day now looks like this:
  • Breakfast: 2 eggs, sauteed rapini and onion - all cooked in coconut oil
  • Snack: fruit or veggies, olives
  • Lunch: 3 pieces turkey deli meat, a pile of greens (arugula, spinach), 1/2 avocado, a whole tomato cut up
  • Snack: hard boiled egg, veggies, olives
  • Dinner: meat, veggies

I'm still working my way into this -- and I'm actually not getting quite enough protein.  For the type of exercise I'm doing at CrossFit, I should be aiming for 1g of protein per pound of body weight.  I have to learn some tricks, like cooking up a whole bunch of meat on Sunday, to have as snacks during the week.

There is also the issue of fat.  North Americans with a SAD lifestyle have been told for decades to eat a low fat diet.  Fat is the bogey man, don't eat it.  You'll get fat.  Your arteries will get clogged.  And you'll die.  This simply isn't true.  There are good fats, and bad fats, and our bodies actually NEED fat to thrive.  I will do a post on fat soon, as it's a whole subject unto itself.  For now, just hear this: Fat does not make you fat.

I will be doing a paleo challenge starting on Thursday, through my gym.  This is going to be a very strict 30-day period which will hopefully put my body in ketosis, a state where the body uses nothing but stored fat for energy.  During this 30 days, I expect that I'll be able to drop a lot of fat and lean up.  I've been pretty good with my paleo lifestyle for the past few weeks, but I've still been eating fruit, and the occasional 90% dark chocolate as a treat.  I've also had a "cheat day" here and there.  There will be no more of that :\  Through the gym, there will be restaurant nights, where the participants will go out for paleo dinners, there will be seminars, and there will be a contest with great prizes!  Jeremy has just told me that he will be doing the challenge with me!  That should make things much easier.

Well, I hope you've learned a lot about this paleo stuff.  I know it's kind of complicated and sciency, but if you have any questions, please ask and I'll do my best to answer them, or refer you to good source.

I'm sitting here finishing up my post while Jeremy cooks me a paleo breakfast.  Then we're off to Kensington Market for some Halloween costume shopping.  I'll do my best to get another post up soon!

Have a great day!

~C.



          Oxytocin and Ontogeny: Interactions between Early life Experience, Development of Neural Nonapeptide Systems, and Social Behavior in the Prairie Vole (Microtus ochrogaster), Aug 16        
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          Macronutrients. Protein        

After water, the biggest component in the body is protein. Over 98% of the molecules in body are replaced every year. So we need protein as a building block. If we don't get enough protein, or if we are eating poor quality protein, our bodies will not grow strong muscles, bones, blood, teeth, etc.

There's no definitive answer how much protein do we really need. Every expert has a different opinion. Here are a few examples:

Let's start with sports nutrition expert Michael Colgan. His research suggests that the type of sport you do has an effect on the amount of protein you need. Strength sports people need approx 2.0 grams of protein per kg of bodyweight per day. Athletes who need speed first, then strength, then endurance need about 1.7 g/kg/day & endurance athletes need 1.4 g/kg/day.

This requirement is based on a high level of training, 3-4 hours a day. If you are only training 1-2 hours a day, your requirement will be less, by approx 0.3 g/kg/day. For an 80 kg man doing 1-2 hours riding a day, this would be 80 x 1.1g = 88 g per day. Doing 3-4 hours riding, he would need 80 x 1.4g = 112 g. These are his rough guidelines only, each person will have different individual needs.

The Zone's Barry Sears multiplies your lean body mass in lbs by a sliding scale ranging from 0.5 for couch potatoes, to 1.0 for very heavy training. Say our 80 kg cyclist has a fat % of 20%. That means his lean body mass is 64 kg (or approx 140 lbs). He would come into the 0.8 category, so would need 140 x 0.8 = 112 grams. However a very fit lean cyclist of the same weight with only 15% body fat, & a higher lean body mass, would need 120 grams.

The range we're talking about is slightly higher than Colgan, but depends on lean body mass, rather than weight. The other main difference is that the amount of protein, once calculated, must be strictly adhered to "to get into the Zone", and determines the amount of carbs &amp;amp; fat you can eat.

Eat Right 4 Your Blood Type diet's Peter D'adamo recommends different ratios for each blood type. His rough guidelines are 20% for A & AB, 34% for B, and 45% for O types. The metabolic diets don't specify protein requirements in grams, but Hunter-Gatherers need animal protein at every meal, whereas extreme Agriculturists thrive on a vegetarian diet.

Traditional nutritionists will probably recommend 10-15% of calories. A lot of naturopathic nutritionists are concerned that the level of protein consumption is too high. I have seen recommendations ranging from .6g/kg/day to 1g/kg/day.

So who's right? The best way to determine your need for protein is to determine your metabolic type first. That will give you a good idea of how high your protein levels need to be. If you are trying out a particular diet regime, start within those guidelines. Otherwise, start with Michael Colgan's recommendations and see how you feel. It's fairly easy to tell if you're not getting enough protein - you will lose (or at least not gain) muscle mass and strength. You may find that your muscles take a long time to recover after exercise, or your energy levels might be very low. Try adding a little more protein to your diet and see if you improve.

It's harder to tell if you're getting too much. If you are drinking lots of water and are feeling fine, you're probably doing OK. If you eat excess protein to a level that your kidneys can't handle, you will start to get kidney pain and feel generally unwell. It may take a bit of trial and error to get the balance right for you.

The best protein

The first factor here is bioavailability. Michael Colgan ranks protein sources in this order :

ProteProtein sourcein source

Bioavailablility

Whey peptide blends

110-159

Whey concentrate (lactalbumin)

104

Whole egg

100

Cow's milk

91

Egg White (albumin)

88

Fish

83

Beef

80

Chicken

79

Casein

77

Soy

74

Rice

59

Wheat

54

Beans

49

But you also need to take into account how your body responds to each of these protein sources. Some people don't digest whey products particularly well, even high quality ones. Your metabolic type will determine which proteins sources suit you best.

Some athletes following a whole food diet find they have excellent muscle growth and recovery eating raw egg yolks or raw liver after workouts, for example.

My take on this is : eat a variety of different foods - the ones that work for you - and get your protein from as many different sources as possible. If you find that you're not getting enough protein from your normal diet, you can add in a supplement. But if you're on a strict whole foods diet, you may find you can't have any of them.

If you are aiming to eat 120grams of protein a day, you might want 30 grams 4 times a day. 30 grams of complete protein would come from approx:

  • 110-120 grams of lean meat or poultry

  • 150 grams of fish
  • 6 eggs
  • 1 cup of cottage cheese
  • 2-3 cups yoghurt
  • 1 "shake" made from microfiltered whey protein powder, or whey protein concentrate
  • try not to use soy as a major protein source

Nuts and seeds have some protein, but have at least 75% fat in them, so should be considered a fat source. Legumes and grains also have some protein, but are primarily a carbohydrate source. If you are following a vegetarian diet, you need to combine 2-3 of these 4 food groups at a meal to make complete protein. Some examples :

  • Whole grains, with nut milk and some sunflower seeds or ground flaxseed

  • Beans and rice
  • Corn tortilla with mexican beans
  • Hummus (chick peas and sesame paste) with whole grain pita breads
  • Tempeh with stir fried with rice and veges, with a handful of pumpkin seeds

It's good to have a a dollop of protein at breakfast, 20-30 grams if possible. This helps keep your blood sugar steady throughout the day. If you are taking a supplementary "shake", take it when your body needs easily digested protein most, either an hour or two before hard training, or straight after. Other than that, spread your protein intake evenly throughout the day, and aim to have at least some protein and fat with every meal or snack.

More: Macronutrients. Carbohydrates, Macronutrients. Fat (We Like It, Don't We?)

Protein


          Elite Serum RX Review        
 
I have a new eye extra strength eye serum that I know you will want to know about called Skinpro's new and improved Elite Serum RX!


I know that you have seen me review this product before and some others that are in the same line but they have added 2 more ingredients to this Elite Serum RX to make it work even better for all of us.

Those two ingredients are:
Syn®-Coll is an aqueous based peptide considered ideal for activating Tissue Growth Factor (TGF), which is the key element in the synthesis of collagen, a crucial component of the extra cellular matrix (ECM) of the skin. Degenerative changes in the skin take place without this crucial piece of the cellular puzzle. Syn-Coll compensates for collagen deficits and makes the skin look more youthful.

Inyline is a peptide that works to help constrict muscle contraction, reducing the depth and appearance of expression lines, those pesky lines that we earn from smiling, laughing, frowning and crying.  Expression lines are the hardest to treat.
 
I grin every time I see this because it reminds me of a really big syringe or needle. I used to be terrified of them! I mean really bad that I sometimes would pass out so to now be able to look at something like this and not freak out is very comforting. But, seriously, the whole concept I think is to make it look like you might be getting something like Botox but far from it.

This awesome serum will help plump up the lines around your mouth and eyes and help your skin appear much more smoother and younger. The new reformulated version has the consistency more like a cream instead of a serum.  It is still considered an eye serum, but it’s thicker, much like a cream, but with the benefits of a serum in the way that its not oily; it won’t cause breakouts or greasy skin.


The advanced compound is intended to reduce the appearance of dark circles, puffiness, and the appearance of crow’s feet and fine lines around the eyes. With continued use as directed, Elite Serum can improve tone, skin elasticity, and firmness, which improves the youthful appearance of users of any age by restoring a more youthful eye contour.

I have to tell you that I really love this awesome serum! It has done more for my eyes and the tops of my forehead closest to my eyes than just about anything else that I have tried. I have always been a firm believer in serums and just feel like they soak in better for my skin type. This new and improved serum is lighter and almost looks like clear drops of water when it is dispensed thru the syringe.

You just pump it and at the tip where normally a needle would be if you were having Botox, instead you get the clear serum and it doesn't take much because it glides on so smooth and it will spread so start small and work your way up if you need to.

In addition to the two ingredients that I already told you about, here is another one that is important to this serum:

Eyeliss™is a proprietary combination of three active peptide molecules designed to rapidly, and effectively, reduce puffiness and bag volume under the eyes. This bio-molecular engineered solution was discovered as a result of sensory perception screening tests, which were specifically designed to treat puffiness under the eyes. Eyeliss is composed of three important ingredients:
1. Hesperidin Methyl Chalcone decreases the capillary permeability in the lower eyelid. This molecule primes the delicate skin of this area for lymphatic drainage and toning.
2. Dipeptide Valyl-Tryptophane is a peptide, which increases lymphatic circulation leading to drainage. This peptide is responsible for safely draining the fluid out of the puffy eye bags.
3. Lipopeptide Pal-GQPR improves skin firmness and elasticity, which helps to remove fine lines and wrinkles on the sensitive lower eyelid skin. In addition to aiding firmness and elasticity, this peptide decreases the inflammation commonly caused by other lymphatic drainage agents.
There are a lot more other ingredients that I don't have time to explain all of them so please go and check out the rest of them and what they help do to make this awesome serum work.  I wanted you to know about the ones above because of the puffy eyes and how this serum could help with those in addition to helping with the fine lines and wrinkles.

Here's a little bit about the people behind Skinpro:
We are a science inspired cosmeticeutical company that is focused on discovering, developing, and commercializing novel products and ingredients for skin care, anti-aging, weight management, and other cosmetic applications. 
Our flagship product is Elite Serum, an internally developed, anti-aging topical cosmeceutical. Our staff of specially trained cosmetic pharmacists and scientists developed Elite Serum using our proprietary anti-aging technology, which is based on a unique combination of patented DNA precursor pool peptides. 
In addition to Elite Serum, we have discovered and commercialized other scientific breakthroughs in skin care.  Our Delfogo line of products consist of some of the most advanced and award-winning cosmeceutical innovations in the anti-aging industry. Additionally, our in-house cosmetic engineers have recently designed the Bellapulse Advanced Pulsar Technology device specifically to work in conjunction with our scientifically developed line of skin care treatments. 
Our specially trained cosmetic pharmacists are currently testing two new products that represent breakthroughs in the biopharmaceutical industry.  Tepamine, a dietary supplement for weight loss and anti-aging, is the first of these new products.  This potent formulation is currently in Phase I of development, where it will be extensively evaluated prior to submitting the product for consumer testing.   
Our team has also developed DNA Serum, which breaks new ground using patented peptides derived from Borneo’s Temple Viper snake venom in a powerful topical anti-aging eye treatment.  DNA Serum is currently in the Preliminary Phase of our developmental process.
Connect with Skinpro:

Mailing Address
SkinPro International
1602 Alton Road, 597
Miami Beach, FL 33139
Email:  info@skinpro.com
Phone:  1-800-575-2065

Disclosure: Mary Bearden personally reviewed these products. I did not receive any monetary compensation for my review, just a sample product. All opinions are mine and belong to me solely. My thoughts and opinions may differ from yours.

          Low Risk of Side-effects and Non-toxic Nature to Drive Global Market for Peptide Drugs        
Peptides are biomolecules that have unique pharmacological properties compared to large proteins and small molecule drugs. Peptides play an important role in synchronizing intercellular communications and modulating a number of cellular functions. Scientists say that the medical world can significantly benefit from peptides and the more they are utilized in the production of medicines, the more safe and specific drugs can be manufactured. The several benefits of peptides have been realized by the pharmaceutical industry in the past few years and several peptide drugs are entering the market at a steady pace. The market has witnessed significant traction in the past few years, however, only a few peptide drugs entered clinical trials. Currently, several hundreds of peptide drugs enter clinical trials and are released in the market for treating a variety of ailments. The global peptide market has started attaining maturity and the global population is becoming more receptive of the several potential benefits of peptides against a number of medical challenges. The major demand for peptide drugs is found in specialty medical areas such as oncology, cardiovascular conditions, metabolic diseases, and infectious diseases. Nevertheless, the demand for peptide drugs has also substantially increased on the fronts such as hematology and endocrinology.  The major benefits of peptide drugs are a much reduced risk of side-effects and their non-toxic nature. As peptide drug molecules and the parent molecules they are derived from are closely related, peptide drugs are known to pose little or no harm to the patients by virtue of undesired side effects. Side-effects caused by peptide drugs, if any, are mostly caused due to dosage-related or some kind of local reactions. So in general, no serious immune responses are known to result from peptide drugs. Also, as peptide drugs are manufactured from substances that are naturally occurring and are metabolically tolerable amino acids, they are usually non-toxic. All these factors are resulting in the introduction of a relatively larger number of peptide drugs as compared to the past in the market.

Original Post Low Risk of Side-effects and Non-toxic Nature to Drive Global Market for Peptide Drugs source Twease
          Nutricosmetics Taking the Beauty World by Storm         
The concept of nutricosmetics was developed by Swedish biochemist Ake Dahlgren in the late 1980s, along with the catchphrase “Beautiful skin comes from within”. Imedeen was one of the very first nutricosmetics brand developed by Dahlgren and was based on the idea that skin cells can absorb nutrients and improve the external appearance of the skin. Just like any other novel idea, Dahlgren’s claims and theory was faced with skepticism, if not disbelief. At that time, his concept was believed to be just a marketing trick. Little did people in the beauty industry know that one day the idea of nutricosmetics would take the world of beauty and cosmetics by storm.  The growth in the nutricosmetics market is presently attributed to rising clinical data, increased research and development activities, and modern manufacturing technologies.  When it comes to the idea of ‘beauty comes from within’, Asia is a strong supporter and promoter. A trend that has been inspired from the food and beverages sector and moved on to the constantly evolving beauty industry is the idea of adding collagen to a number of products. In the food industry, collagen is added to yogurt drinks, dried fruits and other foods so improve their nutrition value.  For instance, the Asian market saw the introduction of Nestle’s instant coffee containing collagen – Nescafe Collagen. Malaysia was introduced to the concept of nutricosmetics with a milk drink called Vitagen Collagen, which was low in sugar and contained 500mg of marine collagen peptides. The Collaskin formula was brought into being in Thailand with the Sappe Beauti Drink. Nutricosmetics in the East is fueled by growing awareness among consumers about beauty, health, and overall wellbeing, a large consumer base, and surge in disposable income and expenditure on beauty and health products. A key trend that has significantly propelled the nutricosmetics market in this region is the shift from synthetic to “green” and natural beauty products.

Original Post Nutricosmetics Taking the Beauty World by Storm source Twease
          Essential Reasons Why Your Body's Cells Must Have Sufficient Glutathione        
Glutathione (sometimes abbreviated as GSH)is a tripetide that functions as the body's most important antioxidant. Because all other antioxidants depend upon the presence of glutathione to function properly, scientists call it the "Master Antioxidant".




Glutathione (pronounced 'gloota-thigh-own') is the body's essential health ABC's - Antioxidant, Blood Booster and Cell Detoxifer.




As a tripeptide composed of glutamic, cysteine and glycine,this substance is found in all cells in the body, including the bile, the epithelial lining fluid of the lungs, and - at much smaller concentrations - in the blood.




Glutathione is the smallest intracellular non-protein thiol (molecule containing an S_H or sulfhydryl group) molecule in the cells. This characteristic emphasizes its potent antioxidant action and supports a multifaceted thiol exchange system, which regulates cell activity.




This small protein, produced naturally in the body, maintains these three crucial protective functions. In fact, your life depends on this amazing substance. Without it, your cells would disintegrate from unrestrained oxidation, your body would have little resistance to metabolic acids, and your liver would shrivel up from the eventual accumulation of acidic toxins.




Glutathione is not yet a household word. Even some medical and holistic doctors who have heard the term may still have only a vague idea of what it is. However, everyone will soon be talking about this critical non-nutritive substance.




There was a time when only scientists had heard of cholesterol and vitamins, but today, everyone knows about them. Now the magnificence of glutathione is becoming known.




In the last five years, over 25,000 medical articles about this substance have been published, and the scientific understanding of glutathione is gradually becoming common knowledge.




Each and every cell in the body is responsible for its own supply of GSH and must have the necessary raw materials in order to produce it. GSH is always in great demand and is rapidly consumed when we experience any sort of emotional or physical stress, fatigue and even moderate exercise.




Some well-known causes of glutathione depletion are as follows:




Hectic lifestyle and diet, air and water pollution, prescription and recreational drugs, ultraviolet light and radiation from mobile phones, computers, electrical cars, power lines, hair dryers, etc. Emotional and physical stress, injury, trauma or burns cigarette smoke, household chemicals, acetaminophen poisoning not to forget exhaust from motor vehicles.




The Master Antioxidant




Over the past thirty years, researchers have explored the role of antioxidants in good health as well as the treatment and prevention of diseases involving oxidation or fermentation by metabolic acids.




Well known and widely used antioxidants such as vitamin A, vitamin E and selenium neutralize acid. They occur naturally in nature, but not in the body. They must be introduced as part of a balanced diet.




Given the critical role of antioxidants in good health, it is not surprising that the body itself manufactures its own natural antioxidants. The most important of these is glutathione. Because all other antioxidants depend upon the presence of GSH to function properly, scientists call it 'the master antioxidant.'




Glutathione binds to toxins, forming a water-soluble complex - which is ultimately excreted in the urine or bile as waste.




Food for the Blood




Elevated GSH levels enable the body to produce more white blood cells. White blood cells are the body's garbage collectors and are the most important cells for maintaining sterility of the body fluids.




Glutathione plays a central role in the proper function of the white blood cells. Dr. Bustavo Bounous, a leading glutathione expert, says, 'The limiting factor in the proper activity of our lymphocytes (the white blood cells) is the availability of glutathione.' In other words, healthy growth and activity of the white blood cells depends upon glutathione's availability. Put simply, GSH is 'food' for the white blood cells.




Cellular Detoxifier




Whether we know it or not, we are continually inhaling and ingesting natural and synthetic acidic toxins. They are unavoidable in these modern times both in our polluted cities and our poorly engineered food supplies. When the body has the health and the nourishment it needs, it works tirelessly to eliminate acidic toxins and to protect itself.




But, increasing levels of environmental pollution are depleting the body's store of glutathione more and more rapidly.




Our main organ of detoxification of acidic waste products is the lymphatic system and the liver. This is the body's most concentrated source of glutathione.




Studies show that low GSH levels lead to poor lymphatic and liver function, causing more and more acidic toxins to circulate through the body and resulting in damage to individual cells and organs.




One of the obvious responses many people have to reading an article like this, is to start taking supplements which contain glutathione or indeed eat foods which are known to have a high level of antioxidants such as dark chocolate or red berries.However the problem with this is that the body's digestive system tends to break down and destroy these glutathione supplements and or antioxidants before they have any chance of being fully absorbed into the body's cells.




So what is the solution? Well, you should consider taking a type of supplement known as a " glutathione accelerator" - this type of supplement is not glutathione itself but contains a formula which allows every cell in the body to increase and speed up its own supply of GSH.


Paul Mitchell is an independent consultant with a keen interest in health care and anti-ageing products.
He is a distributor for one of the most effective brands of "glutathione accelerator" products,known as MaxGxl.
Please go to his website to find out more and order the product.
http://www.malthouse.mymaxsystem.com/products.php

maxgxlvip1: Pain Relief MaxGXL.com MAXGXL Glutathione Free Radicals Best Antioxidant

maxgxlvip1: Pain Relief MaxGXL.com MAXGXL Glutathione Free Radicals Best Antioxidant

Article Source: www.articlesnatch.com


          Novartis’ New Drug for Heart Comes with a Risk of Alzheimer’s Disease        
A drug by Novartis LCZ696, developed for heart failure is all set to gain its FDA approval by the end of this year. Though researchers predict this drug to be a soaring hit, the speculations that it could be a precursor to Alzheimer’s disease hang heavy in the air. This controversy might just be the new obstacle in the way of that approval. Meanwhile, an article in a leading cardiology journal states the intricacies of this growing concern with regards to the drug. While the authors concur on the fact that the drug could lead to Alzheimer’s disease, they do not believe that it will ruin the chances of this drug to hit the market. However, they do emphasize that the consequence of the drug will have to be monitored carefully. Milton Packer, main investigator of PARADIGM-HF, the trial for the drug in question offers a persuasive argument defending that LCZ696 and asserting that Alzheimer’s disease won’t be the Achilles’ heel for LCZ696. A paper published in European Heart Journal by French researchers talk about the impact of sacubitril, an important ingredient in LCZ696. The other important ingredient in the drug is neprilysin. However, the researchers argue that sacubitril acts as an inhibitor to the neprilysin. The paper further focuses on the contradictory actions of neprilysin.  Neprilysin benefits the cardiovascular its inhibition in the heart causes improved levels of vasodilators and neuropeptides bring down rates of hypertension and heart failure. On the other hand, neprilysin shows as a key cause of lowering beta amyloid plaque in the brain which is the mainly seen signal for Alzheimer’s disease. While the French authors have concerns about LCZ696 accelerating the progression of Alzheimer’s disease, they also contest whether the drug can seep through blood brain barrier for the dreaded effect.

Original Post Novartis’ New Drug for Heart Comes with a Risk of Alzheimer’s Disease source Twease
          Anti-Migraine Drugs Market Research Reports and Industry Analysis        
In the coming years, the market for anti-migraine drugs [ http://www.marketresearchreports.biz/analysis/207524 ] is anticipated to witness several launches of new generic migraine drugs that will steadily increase the drug-treatment levels and rate of diagnosis paving a sustainable path to an annual global growth of the overall anti-migraine drugs market.  Migraines are frequent attacks of moderate to severe headaches and anti-migraine drugs are its therapeutic curing agents. In the next five years, the cost of migraine drugs is expected to reduce due to the growing awareness of migraine and its treatment via specific anti-migraine drugs amongst individuals in the emerging countries.  The market for anti-migraine drugs is projected for an upward growth curve mainly due to the development of new generic entrants and treatment therapies such as BOTOX and calcitonin gene-related peptides (CGRP) receptor antagonist. The market is also poised for a significant growth due to increasing incidences of migraine sufferers, increased acceptance levels, and technological advances in the development of anti-migraine drugs, thus boosting the demand for anti-migraine drugs market to grow further on a global level. Some of the major anti-migraine drugs used to cure migraine problems include, Triptans like Sumatriptan, Zolmitriptan, and others.  The United States is accounted to be the largest market for anti-migraine drugs as stated by a Medline article earlier. Around 12% of the U.S. population suffers from migraine headaches, which precisely pushes a number of drug companies to manufacture specific preventive medications and anti-migraine drugs that help patients relieve their intense and periodic headaches with the right treatment.   The key market players majorly contributing to the anti-migraine drugs market include GlaxoSmithKline plc, Abbott Laboratories, Inc., Pfizer Inc., Impax, Endo Pharmaceuticals, Eli Lilly and Company, Eisai, Inc., Nautilus and Allergan, and AstraZeneca plc.  The market research reports provided by Marketresearchreports.biz based on the anti-migraine drugs market also include a comprehensive review of micro and macro factors necessary for the existing players and new entrants, as well as covers a complete market study of recent developments in the anti-migraine drugs market. 

Original Post Anti-Migraine Drugs Market Research Reports and Industry Analysis source Twease
          Bioxcin Quantum Bio Activ Serum 15x6ml - 80.10 TL         
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Bioxcin Quantum Bio Activ Serum 15x6ml, Bio activ peptides ile saçların daha kalın ve gür görünmesini sağlar.İçeriğindeki saç dökülmesine karşı ekstre ile de saç tellerini besleyerek saç dökülmesini gidermeye yardımcı olur.


          The Effect of Phosphorylation on the Electron Capture Dissociation of Peptide Ions        
Creese, Andrew J. and Cooper, Helen J. (2008) The Effect of Phosphorylation on the Electron Capture Dissociation of Peptide Ions. Journal of the American Society for Mass Spectrometry, 19 (9). pp. 1263-1274. ISSN 1044-0305
          Dear Mark: Collagen Peptides, Fasting vs Sleeping, Dog Bone Broth, and Pork Broth        

For today’s edition of Dear Mark, I’m answering four question. First, are collagen peptides just as effective as bone broth or other collagen sources? Second, how should I choose between IFing or sleeping like a baby using pre-bedtime nutrients that may impede autophagy? Next, I explore whether you should be making dog bone broth (it’s not what you think, so don’t worry about that). And finally, what are some of my favorite pork bone broth recipes?

Let’s go:

Nicole asks:

Hello – I am wondering if anybody has any opinions on the Pacific Organic Bone Broth one can get at Costco. I’m skeptical it is the “good stuff.” Also, do collagen peptide powders offer the same benefits?

I haven’t tried the Pacific broth, but a good rule of thumb is to look at the protein content on the label. If it’s high, you can assume it’s high in collagen.

Collagen peptides appear to have many of the same effects as broth or straight collagen or gelatin powder. They should. They’re made of the same stuff, only more digestible.

Collagen peptides improved body composition , increased fat free mass, and boosted strength in sarcopenic (muscle-wasting) older men. No, collagen amino acids don’t directly contribute to muscle protein synthesis, but they are protein-sparing—when you eat collagen/gelatin/collagen peptides, you need fewer amino acids from more androgenic sources to get the same effect.

Collagen peptides derived from beef bone and pork skin improved quality of life and subjective pain levels compared to placebo in osteoarthritis patients. Just like gelatin/collagen does .

Drinking fermented milk with added collagen peptides  increased collagenous amino acid levels in plasma .

Peptides certainly work. But so does straight-up collagen or gelatin (or bone broth, for that matter).

Stefan M. wonders:

Hello, Mark! I have a question. I’m a fan of the IF protocol, but I like to eat a tablespoon of honey, of coconut oil, and drink a big mug of bone broth 30 m – 1 hr before sleep.

It knocks me out good. I’m following your suggestions for sleep!!

The problem is that my schedule is most compatible with a eating window from 8 AM to 12 PM, so say I drink the bone broth at 9 PM; I fear it could affect the autophagy effects of fasting.

Are the quantities mentioned going to break fasting-induced autophagy? If so, how could I make it up, if I still drink before bed because it’s so helpful?

Should I try to make a compromise or, say, add 2 daily-long fasts a week; or one 5 day-long fast a month, or whatever, for enhanced autophagy? What would be most effective?

If I cyclically switch between a carb-loaded crossfit training period (high stress and high energy requirements) and a more relaxed ketogenic weightlifting training period (maintenance rather than constant pushing), what’s the best course of action for each scenario?

On the hierarchy of health decisions, sleep trumps almost everything else. If a spoonful of honey, a mouthful of coconut oil, and a big mug of bone broth are the key to getting you 8 hours of solid sleep a night, it’s worth giving up a

The post Dear Mark: Collagen Peptides, Fasting vs Sleeping, Dog Bone Broth, and Pork Broth appeared first on Mark's Daily Apple.


          Cerebrolysin to Help Treat Alzheimer’s Disease and Mental Decline        

Normal Brain vs. Alzheimer's Brain
Mental decline is one of the major causes of debilitating condition of an individual during old age. Today, Alzheimer’s disease falls under top five reasons of deaths in America and other parts of the world as well. So far no plausible cure has been found for this fatal disease. This is worst form of mental decline which finally costs not only the life of the victim but his/her family as a whole as the person tends to forget everything including himself and his family.

The condition renders him absolutely helpless and debilitated to perform his/her daily activities. However, if you happen to diagnose Azheimer’s disease at its early stages, the speed and intensity of mental decline can be easily controlled and even reversed in certain lucky cases using the new age mind power drugs and medicines known as smart drugs or nootropics. Of all the mind boosting medicines available in the market, cerebrolysin happens to be the strongest of them all.

What makes cerebrolysin different and potent as compoared to other mind power drugs, is its role in alzheimer’s disease treatment. Instead of trying to inhibit an enzyme that destroys neurotransmitters in the brain when alzheimer disease is contracted, cerebrolysin targets the causes. Working to improve the function and the quantity of neurons and brain transmitters, cerebrolysin not only decreases the rate at which brain cells die, it’s known to block exitocins – now believed to be one of the main causes of alzheimer disease.

Cerebrolysin thus is a peptide-based drug product supporting the survival, stability, and function of neurons. As Alzheimer’s disease results in the rapid decline and death of brain cells or neurons, cerebrolysin by decreasing free radical damage and promoting synaptic repair helps in improving cognitive, memory and behavioral performance in alzeimer’s disease patients as well as those with other types of mental decline.

Moreover, as cerebrolysin improves behavioral performance by affecting synaptic transmission in the hippocampus, it has also been proven to be effective in the treatment of parkinson’s disease, which is another form of mental and physical decline resulting in death of the individual. In over 80 clinical trials with over 5000 patients with mild to moderate cases of the condition, using cerbrolysin was found to significantly improve cognitive powers. Cerebrlysin fluid is generally believed to be most effective when injected intravenously.

As cerebrolysin is well tolerated by the body, cerebrolysin side effects are very few and mild. These include chills, headaches, or slight increases in body temperature of the patient.

          L'Oreal Age Perfect Re-Hydrating Night Cream 50ml        
L'Oreal Age Perfect Re-Hydrating Night Cream 50ml

L'Oreal Age Perfect Re-Hydrating Night Cream 50ml

Anti-Sagging: Enriched with Soya Peptides, Age Perfect Re-Hydrating Night Cream helps stimulate and natural production and maintenance of skin's fibres Anti-Age Spots: Enriched with Melanin-Block, it helps reduced the appearance of age spots and helps prevent the appearance of new ones Lipid-Replenishing Night Action: It helps restore the hydro-lipid barrier for re-hydrated skin when you wake-up In the morning, your skin feels hydrated, smoother and more comfortable. In 1 month, skin feels reinforced. Skin surface contours appear refined. The appearance of dark pigmentation looks reduced. Directions: Apply every night on a thoroughly cleansed face and neck. Massage into the skin with circular motions for a better absorption.


          TiZO AM Rejuvenation Skincare        
Firms and Brightens with Multi Peptide Complex

Size: 1 fl. oz./29 ml airless pump bottle

TiZO® AM Rejuvenation is formulated with Peptides, Niacinamide, Tea Tr..

Price: $51.95


          (USA-CA-FREMONT) SR Scientist, Analytical Science        
Boehringer Ingelheim is an equal opportunity global employer who takes pride in maintaining a diverse and inclusive culture. We embrace diversity of perspectives and strive for an inclusive environment which benefits our employees, patients and communities. **Description:** As an Analytical Development Scientist in the Process Science organization, your responsibilities will primarily include analytical development and characterization activities in support of innovative biopharmaceuticals development. The successful candidate will carry out detailed characterization of proteins using LCMS, including charge/size variant isolation / enrichment/identification, sequence variants and host cell protein analyses. The successful candidate will perform method development and qualifications, and support method validations in accordance with ICH guidelines. Trouble shooting for methods based on HPLC, CE and other analytical techniques is required. In addition, the successful candidate may represent Analytical Science on CMC teams and provide leadership for development programs. As an employee of Boehringer Ingelheim, you will actively contribute to the discovery, development and delivery of our products to our patients and customers. Our global presence provides opportunity for all employees to collaborate internationally, offering visibility and opportunity to directly contribute to the companies' success. We realize that our strength and competitive advantage lie with our people. We support our employees in a number of ways to foster a healthy working environment, meaningful work, diversity and inclusion, mobility, networking and work-life balance. Our competitive compensation and benefit programs reflect Boehringer Ingelheim's high regard for our employees. **Duties & Responsibilities:** + This position develops standards around which lab staff members operate, and is accountable for administration and results in his/her functional areas. + This position is responsible for applying state of the art technologies to enable reliable clinical supplies that are consistent in quality and are manufactured according to cGMP, including continuous assessment of new development, analytical and manufacturing technologies to reduce development timelines and to increase productivity and product quality to ensure competitive position. In addition, the position is responsible for generating innovative, business driven ideas to improve processes and technologies for the corresponding functional areas including writing proposals, supporting, and/or managing external collaborations. + This position is responsible for the development of analytical methods for therapeutic biologics by applying state of the art technologies for analyzing bulk product. This position is also responsible for assisting in acquisition and efficient transfer of analytical methods from third parties and if required, implementation of method adaptations. + (For the formulation function): Design and execute the formulation development experiments independently. + This position is responsible for leading the development and optimization of and scientific troubleshooting for analytical methodologies required to ensure, high quality and safe product to support pre-clinical and clinical studies and commercial manufacturing. In addition, this position is responsible for planning and executing experiments in support of analytical method qualification and product characterization. + This position is responsible for effective development of biopharmaceuticals by implementing decisions with internal and international partners as well as with regulatory agencies. + Builds, develops and maintains a lab with cutting edge expertise and capabilities. + Mentors, coaches and develops staff and supports capability and skill level improvement. + Provides effective management of the Analytical Science group within a project matrix concept. Manages interfaces, maintains flexibility, and prioritizes workload in order to complete complex and variable projects tasks. + Permanent development of a technically & scientifically oriented team to ensure personal development, increase flexibility and improve processes. + Collaborates closely with other Lab Heads, Principle Scientists, Senior Scientists and partners. + Fosters a flexible true team culture (One PS team) and support others as needed to allow organization to rapidly adapt to the dynamic business environment and changing project portfolios. + Possession of ability to motivate and develop employees. + Identify and establish state-of-the-art technologies for analysis (including asset management and strategic investments). + Foster an innovative environment/culture in alignment with the line management and Director of BioProcess Engineering. + Ensure continuous improvement and technology leadership and build a stronger IP position for BI. + Keep up to date with external patents and literature; pursue active presentation/publishing and patenting strategies. + Present technology and scientific results at international symposia / congresses. + Ensure development & transfer of analytical methods for therapeutic biologics to manufacturing or QC, including CMO and NBE/Biosimilar projects. + Ensure timely supply of analytical methodologies required to ensure, high quality and safe product to support pre-clinical and clinical studies and commercial manufacturing (including CMO and NBE/Biosimilar projects). + Knowledge of SixSigma and LEAN are helpful. + Compliance with regulatory authorities, e.g. virus clearance, method qualification, assistance with regulatory dossiers and GMP requirements, safety at work (EHS) and customer relations/visits (internal/clients) + Ensure worker safety including training, supervision and control of safety guidelines. + Understand current regulatory guidelines for production of human recombinant products, including process or method validation. **Requirements:** + Doctoral degree in Chemistry plus up to four (4) years’ relevant experience and/or Masters’ degree in Biopharmaceuticals plus three (3) to six (6) years’ relevant experience and/or Bachelors’ degree in Biochemistry plus five (5) to eight (8) years’ relevant experience. + Expertise incharacterization of protein primary structure, post-translationalmodifications, degradations, identification of process and/or product relatedvariants and impurities with LC-MS such as peptidemapping, intact mass analysis. + Must possess broadprotein analytical chemistry knowledge and/or broad knowledge of analyticaltechnologies supporting analysis and characterization of protein basedtherapeutics. + Experience in HPLC methoddevelopment (RPLC, IEC, SEC, Affinity, HILIC, glycan analysis). Hands-onexperience with Waters HPLC and UPLC instruments is desired. + Familiar with electrophoresismethods such as cIEF, CGE, and instrument operation. + Understandingof method development and validation per ICH regulations. + Knowledge andbroad understanding of the cGMP requirements as they apply to theBiopharmaceutical industry. Good understanding of relevant USP methodologiesand ICH guidelines. + Experienceparticipating in and leading CMC teams is highly desirable. + Good multi-tasking, timemanagement and organizational skills are essential + Possess excellent verbal andwritten skills + Effective and collaborative cross **Eligibility Requirements:** + Must be legally authorized to work in the United States without restriction. + Must be willing to take a drug test and post-offer physical (if required) + Must be 18 years of age or older **Our Culture:** Boehringer Ingelheim is one of the world’s top 20 pharmaceutical companies and operates globally with approximately 50,000 employees. Since our founding in 1885, the company has remained family-owned and today we are committed to creating value through innovation in three business areas including human pharmaceuticals, animal health and biopharmaceutical contract manufacturing. Since we are privately held, we have the ability to take an innovative, long-term view. Our focus is on scientific discoveries and the introduction of truly novel medicines that improve lives and provide valuable services and support to patients and their families. Employees are challenged to take initiative and achieve outstanding results. Ultimately, our culture and drive allows us to maintain one of the highest levels of excellence in our industry. We are also deeply committed to our communities and our employees create and engage in programs that strengthen the neighborhoods where we live and work. Boehringer Ingelheim, including Boehringer Ingelheim Pharmaceuticals, Inc., Boehringer Ingelheim USA, Boehringer Ingelheim Animal Health USA, Inc., Merial Barceloneta, LLC and Boehringer Ingelheim Fremont, Inc. is an equal opportunity and affirmative action employer committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender identity or expression; affectional or sexual orientation; disability; veteran or military status, including protected veteran status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law. Boehringer Ingelheim is firmly committed to ensuring a safe, healthy, productive and efficient work environment for our employees, partners and customers. As part of that commitment, Boehringer Ingelheim conducts pre-employment verifications and drug screenings. *LI-SF1 **Organization:** _US-BI Fremont_ **Title:** _SR Scientist, Analytical Science_ **Location:** _Americas-United States-CA-Fremont_ **Requisition ID:** _178944_
          (USA-CT-RIDGEFIELD) Scientist II, Biotherapeutics Mass Spectrometry        
Boehringer Ingelheim is an equal opportunity global employer who takes pride in maintaining a diverse and inclusive culture. We embrace diversity of perspectives and strive for an inclusive environment which benefits our employees, patients and communities. **Description:** Boehringer Ingelheim is currently seeking a talented and innovative Scientist III to join the Mass Spectrometry Lab within the Biotherapeutics Department located at our US headquarters in Ridgefield, CT. This position will provide analytical data to support our drug discovery efforts for biologics. This will require experience in protein mass spectrometry, HPLC, and the drug discovery process. This individual will be expected to make major contributions to the generation of best-in-class and first-in-class therapeutics to address major unmet medical needs. Contributes to R&D discovery research by performing scientific research. Implements protocols as required. Provides expertise within a technical specialty required for skill center productivity. As an employee of Boehringer Ingelheim, you will actively contribute to the discovery, development and delivery of our products to our patients and customers. Our global presence provides opportunity for all employees to collaborate internationally, offering visibility and opportunity to directly contribute to the companies' success. We realize that our strength and competitive advantage lie with our people. We support our employees in a number of ways to foster a healthy working environment, meaningful work, diversity and inclusion, mobility, networking and work-life balance. Our competitive compensation and benefit programs reflect Boehringer Ingelheim's high regard for our employees. **Duties & Responsibilities:** + Responsiblefor characterization of proteins and antibodies by mass spectrometry, includingintact MW analysis, enzymatic digestion/peptide mapping, post-translationalmodification characterization, protein quantitation, and Hydrogen/DeuteriumExchange Mass Spectrometry methods + Initiatesand completes routine procedures in an independent and efficient manner;Troubleshoots effectively and solves scientific problems; Operates labequipment and is independently responsible for maintenance; Interprets andanalyzes technical data accurately and independently + Independentlyapplies basic scientific principles, performs literature searches, attendsscientific meetings, and keeps abreast of literature in own field + Proposesand implements new technologies based on science as well as overallunderstanding of drug discovery process + Effectivelycommunicates orally and in writing; Discusses own work in the context of teamand department goals in a concise and accurate manner both orally and inwriting; Drafts and audits technical reports and contributes to writing ofpublications + Reportsand treats data with a high level of integrity and ethics + Complieswith applicable regulations, performing all work in a safe manner; Maintainsproper records in accordance with SOPs and policies **Requirements:** + Bachelor’s Degree with 3+ years’ experiencein Biochemistry or related scientific discipline or Master’s Degree with 0+years’ experience in Biochemistry or related scientific discipline + Experience with protein and antibodycharacterization + Familiar with the operation of massspectrometry and HPLC instruments. + Experience with using mass spectrometrysoftware + Ability to implement, adapt and modifyliterature protocols to help solve problems concerning the characterization ofproteins + Ability to draft technical documents + Ability to troubleshoot + Ability to multi-task + Written and verbal communication skills **Desired Experience, Skills andAbilities:** + Needsexperience or education in one or more of the skills listed above, and theability to apply those skills to the drug discovery process. **Eligibility Requirements:** + Must be legally authorized to work in the United Stateswithout restriction. + Must be willing to submit to a background investigation,including verification of your past employment, criminal history, andeducational background + Must be willing to take a drug test and post-offer physical(if required) + Must be 18 years of age or older **Our Culture:** Boehringer Ingelheim is one of the world’s top 20 pharmaceutical companies and operates globally with approximately 50,000 employees. Since our founding in 1885, the company has remained family-owned and today we are committed to creating value through innovation in three business areas including human pharmaceuticals, animal health and biopharmaceutical contract manufacturing. Since we are privately held, we have the ability to take an innovative, long-term view. Our focus is on scientific discoveries and the introduction of truly novel medicines that improve lives and provide valuable services and support to patients and their families. Employees are challenged to take initiative and achieve outstanding results. Ultimately, our culture and drive allows us to maintain one of the highest levels of excellence in our industry. We are also deeply committed to our communities and our employees create and engage in programs that strengthen the neighborhoods where we live and work. Boehringer Ingelheim, including Boehringer Ingelheim Pharmaceuticals, Inc., Boehringer Ingelheim USA, Boehringer Ingelheim Animal Health USA, Inc., Merial Barceloneta, LLC and Boehringer Ingelheim Fremont, Inc. is an equal opportunity and affirmative action employer committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender identity or expression; affectional or sexual orientation; disability; veteran or military status, including protected veteran status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law. Boehringer Ingelheim is firmly committed to ensuring a safe, healthy, productive and efficient work environment for our employees, partners and customers. As part of that commitment, Boehringer Ingelheim conducts pre-employment verifications and drug screenings. **Organization:** _US-BI Pharma/BI USA_ **Title:** _Scientist II, Biotherapeutics Mass Spectrometry_ **Location:** _Americas-United States-CT-Ridgefield_ **Requisition ID:** _178023_
          Cosmetics Smoothing Face Prep - Silk 30ml (01)        
Cosmetics Smoothing Face Prep - Silk 30ml (01)

Cosmetics Smoothing Face Prep - Silk 30ml (01)

Our luxuriously soft serum glides effortlessly over skin, smoothing over pores and fine lines. This velvety veil is the perfect base for evem longer lasting foundation and a flawless finish. Packed with potent peptides, daily wear will visibly help to plump and firm skin.


          Eye Loving BB Cream        
Eye Loving BB Cream

Eye Loving BB Cream

Gentle yet deeply hydrating, our Beauty Balm Eye Cream works to revitalise, repair and add radiance to the delicate eye area leaving you looking refreshed and wonderfully rested. Raspberry stem cells restore skin, SPF protects, hyaluronic acid helps to plump fine lines, peptides help puffiness while light diffusing particles disguise imperfections.


          Champagne for your skin:        


All of you know that wine is ideal for health and beauty, for both skin and hair, so there are several products containing traces of the drink, well, in addition to wine, champagne is also ideal for beauty treatments.

Champagne, sparkling power to be further properties of the grapes because they increase the levels of amino acids, peptides and nitrogen, together with calcium and potassium, help significantly to human body.

The combination of these components makes the antioxidant is activated, hydrating the skin in an ideal way, avoiding likewise the expansion of free radicals because it stimulates the body to produce collagen and elastin.

Similarly, note that beauty treatments based on champagne leave your face smoother and illuminated. It is desirable that after each treatment session, whether carried out in a special center or at home, which let stand a few minutes, then remove the remains not absorbed by the skin. 

Most interesting, and you will feel rejuvenated for these summer days, which normally suffers more sunlight is the skin, so they should moisturize the fullest and take good care, because as you all know, the skin has memory.



Todas sabéis que el vino es ideal para la salud, tanto para la piel como para el cabello, por eso hay varios productos que contienen trazas de esta bebida, pues bien, además del vino, el champagne también es ideal para tratamientos de belleza.

El champagne, al ser espumoso potencia aun más las propiedades de la uva, ya que aumentan los niveles de aminoácidos, péptidos y nitrogenados, que junto con el calcio y el potasio, ayudan notablemente al organismo humano.

La combinación de todos estos componentes hace que se active la acción antioxidante, hidratando la piel de una forma ideal, evitando del mismo modo la expansión de los radicales libres, ya que estimula al organismo para la producción de colágeno y elastina.

Del mismo modo, destacar que los tratamientos de belleza a base de champagne dejaran  vuestro rostro más terso e iluminado. Es conveniente que después de cada tratamiento o sesión, ya sea realizada en un centro especial o en casa, que se deje reposar unos minutos, para después retirar los restos no absorbidos por la piel.

Os sentiréis más guapas y rejuvenecidas para estos días de verano, que normalmente lo que más sufre con los rayos solares es la piel, por eso se debe hidratar al máximo y cuidarla bien, porque como todas sabéis, la piel tiene memoria.



          Anti Aging Skin and the 3 Most Popular Ingredients on Today's Market        
New advances are constantly being made for anti-aging in the skin care industry. The masses are interested in combating aging and the cosmetic industry is up for the challenge. An example of one of the new creams to be released is Dermajuv.

We're always finding new components which can be used with great results. Effective components that aid in minimizing lines, tighten up and tone up the skin. The outcome of using these anti wrinkle creams with these effective components may frequently begin to become evident as early on as 2-4 weeks.

Well known department store lines of anti aging skin care products contain 3 ingredients that have become the latest rage.

DMAE

DMAE or dimethylaminoethanol is a key component, keeping healthy cell membranes which naturally encourages the substance in the human body titled phosphatidylcholine. DMAE is found in anti aging and wrinkle products to combat signs of age by making the skin taught, sometimes giving it another name, "facelift in a jar".

Coenzyme Q10

Ubiquinone is a necessary nutrient which cells must have in order to function well. CoQ 10 is an active component in many anti wrinkle creams. This is a mighty antioxidant that is a major player in energy production. This means it is good at preventing harm to collagen and elastin production and assisting you combat wrinkles and lines. Conezyme Q10 is utilized in a popular department store cream for the skin called Prevage.

Matrixyl

Matrixyl contains palmitoyl pentapeptide-3 which is a very common substance which heals and repairs skin. An example of the type of product that contains this is Dermajuv. Matrixyl is the primary active component in Strivectin, which was at first commercialized as a stretch mark reducing agent, but afterwards, was identified as an efficient way to eliminate wrinkles and lines.

Astonishingly these components can be found being sold by companies who don't have a small order quantity and will trade with the public. These components are also cheap, in the region of $10-$14 for an adequate amount to add to 4-8 oz of your own cream or product.

Additional resources:

Wrinkle Creams
Skin Care - A Short Guide About What To Look Out For
A Short Guide To Skin Care

          Placental peptide reverses symptoms of preeclampsia        
  Preeclampsia is a serious complication that develops in about 5-8% of pregnant women. It is characterized by elevated blood pressure and is typically accompanied by excess protein in the urine (a sign of kidney problems). Symptoms often (but not always) return to normal after delivery of the baby. Elabela is a recently discovered micropeptide secreted by the placenta in…
          September Mishibox Unboxing        
Note:  This month's Mishibox was provided to me for review, so that makes this a sponsored post.  Being sponsored does not buy a positive review, and this post is my honest opinion and impression of this month's box and Mishibox as a whole.

This post is giving me such mixed emotions, as it's my first ever sponsored post.  I wanted to procrastinate for a couple more days even, but it's been over a month(?!) since I even posted anything.  I've got stuff coming, I swear!  I'm just trying to get used to my work schedule and it's just...it's been crazy.


About Mishibox


Mishibox is a new US-based Korean Beauty subscription box that debuted back in June.  It costs $19.95 with free shipping in the US and $5.95 to ship to Canada.  For that price, you get 4-6 deluxe samples and full sized items of the following categories:  Skincare, Makeup, Beauty tools/accessories, Haircare, Bath & Body, Nailcare, Fragrances.

The Box



I Snapchatted the live opening of this box.  It didn't impress me, and I was feeling all annoyed at having to review it, because this company is seriously so awesome.  But I'll get to that later.


Magis Lene Cell Precieux Toner

WHAT:  This luxurious and highly concentrated toner made with caramel and colloidal gold provides both whitening and wrinkle care functions.  The Cell Precieux line helps your skin maintain its balance to preserve your natural beauty.
HOW:  After cleansing, use a cotton ball (for exfoliating) or fingertips (for moisturizing) to apply the toner to your face.  Gently wipe with the cotton ball, or pat and tap your face with your fingertips to help with absorption.
Retail Price:  $65 | 120 ml/4.05 fl oz

Ingredients:
Glycerin, Water, Alcohol, Betaine, Viola Tricolor Extract, Eclipta Prostrata Extract, Dimethicone, Niacinamide, Phellodendron Amurense Bark Extract, Pseudoalteromonas Ferment Extract, Palmitoyl Oligopeptide, Palmitoyl Tetrapeptide-7, Acetyl Hexapeptide-8, Acetyl Heptapeptide-9, Piper Methysticum Leaf/Root/Stem Extract, Phellinus Linteus Extract, Arctium Lappa Root Extract, Citrus Limon (Lemon) Fruit Extract, Euterpe Oleracea Fruit Extract, Panax Ginseng Root Extract, Pearl Extract, Carica Papaya (Papaya) Fruit Extract, Propolis Extract, Portulaca Oleracea Extract, Pueraria Thunbergiana Root Extract, Glycyrrhiza Glabra (Licorice) Root Extract, Paeonia Lactiflora Bark/Sap Extract, Cnidium Officinale Root Extract, Panax Ginseng Callus Culture Extract, Salix Nigra (Willow) Bark Extract, Avena Sativa (Oat) Meal Extract, Panicum Miliaceum (Millet) Seed Extract, Hordeum Vulgare Extract, Oryza Sativa (Rice) Extract, Secale Cereale (Rye) Seed Extract, Usnea Barbata (Lichen) Extract, Zanthoxylum Piperitum Fruit Extract, Pulsatilla Koreana Extract, Soluble Collagen, Aloe Barbadensis Leaf Juice, Sodium Hyaluronate, Hydrogenated Lecithin, 1,2-Hexanediol, PEG-10 Dimethicone, PEG-60 Hydrogenated Castor Oil, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Ethylhexylglycerin, Polyquaternium-51, Tromethamine, Xanthan Gum, Adenosine, Steareth-20, N-Hydroxysuccinimide, Caramel, Chrysin, Propylene Glycol, Acacia Senegal Gum, Lecithin, Colloidal Gold, Fragrance, Phenoxyethanol


Magis Lene Cell Precieux Emulsion

WHAT:  The luxurious and highly concentrated emulsion from the same Cell Precieux line also provides both whitening and wrinkle care functions.  Use together with the bonus serum and cream samples for the best results.
HOW:  After toner and serum, take an adequate amount of the emulsion and gently massage onto your face with fingertips.  Follow with the cream.  Order recommended by Magis Lene is Toner, Serum, Emulsion, and then Cream.
Retail Price:  $69 | 120 ml/4.05 fl oz (emulsion), $135 | 45ml/1.52 fl oz (serum), $170 | 50 ml/1.69 fl oz (cream)

Ingredients:  (Emulsion)
Water, Glycerin, Viola Tricolor Extract, Eclipta Prostrata Extract, Dimethicone, Cyclopentasiloxane, Butylene Glycol, Niacinamide, Euterpe Oleracea Fruit Extract, Hydrogenated Poly(C6-14 Olefin), Pseudoalteromonas Ferment Extract, Palmitoyl Oligopeptide, Palmitoyl Tetrapeptide-7, Acetyl Hexapeptide-8, Palmitoyl Pentapeptide-4, Acetyl Heptapeptide-9, Phellinus Linteus Extract, Arctium Lappa Root Extract, Phellodendron Amurense Bark Extract, Piper Methysticum Leaf/Root/Stem Extract, Portulaca Oleracea Extract, Pueraria Thunbergiana Root Extract, Glycyrrhiza Glabra (Licorice) Root Extract, Paeonia Lactiflora Bark/Sap Extract, Cnidium Officinale Root Extract, Himanthalia Elongata (Brown Algae) Extract, Hamamelis Virginiana (Witch Hazel) Extract, Panax Ginseng Root Extract, Pearl Extract, Propolis Extract, Panax Ginseng Callus Culture Extract, Avena Sativa (Oat) Meal Extract, Panicum Miliaceum (Millet) Seed Extract, Hordeum Vulgare Extract, Oryza Sativa (Rice) Extract, Secale Cereale (Rye) Seed Extract, Usnea Barbata (Lichen) Extract, Zanthoxylum Piperitum Fruit Extract, Pulsatilla Koreana Extract, Soluble Collagen, Rosa Centifolia Flower Water, Aloe Barbadensis Leaf Juice, Hydrogenated Lecithin, Argania Spinosa Kernel Oil, Sodium Hyaluronate, 1,2-Hexanediol, Betaine, Sodium Polyacrylate, Trideceth-6, PEG/PPG-18/18 Dimethicone, Glyceryl Stearate, Cetyl Alcohol, Bisabolol, Ethylhexylglycerin, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Squalane, PEG-75 Stearate, Steareth-20, Adenosine, Ceteth-20, Polysorbate 60, Dicaprylyl Carbonate, N-Hydroxysuccinimide, Sucrose Distearate, Chrysin, Polyquaternium-51, Panthenol, Ceramide 3, Xanthan Gum, Folic Acid, Caramel, Cholesterol, Raffinose, Propylene Glycol, Tromethamine, Lecithin, Acacia Senegal Gum, Colloidal Gold, Fragrance, Phenoxyethanol

Ingredients:  (Serum)
Water, Glycerin, Dipropylene Glycol, Viola Tricolor Extract, Eclipta Prostrata Extract, Cyclopentasiloxane, Caprylic/Capric Triglyceride, Glycereth-26, Niacinamide, Dimethicone, Butyrospermum Parkii (Shea) Butter, Polyglyceryl-10 Stearate, Polyglyceryl-3 Methylglucose Distearate, Methyl Gluceth-20, Pentaerythrityl Distearate, Hydrogenated Poly(C6-14 Olefin), Pseudoalteromonas Ferment Extract, Palmitoyl Oligopeptide, Palmitoyl Tetrapeptide-7, Acetyl Hexapeptide-8, Palmitoyl Pentapeptide-4, Acetyl Heptapeptide-9, Phellodendron Amurense Bark Extract, Phellinus Linteus Extract, Arctium Lappa Root Extract, Piper Methysticum Leaf/Root/Stem Extract, Portulaca Oleracea Extract, Pueraria Thunbergiana Root Extract, Glycyrrhiza Glabra (Licorice) Root Extract, Paeonia Lactiflora Bark/Sap Extract, Cnidium Officinale Root Extract, Euterpe Oleracea Fruit Extract, Panax Ginseng Root Extract, Pearl Extract, Propolis Extract, Centella Asiatica Extract, Houttuynia Cordata Extract, Panax Ginseng Callus Culture Extract, Avena Sativa (Oat) Meal Extract, Panicum Miliaceum (Millet) Seed Extract, Hordeum Vulgare Extract, Oryza Sativa (Rice) Extract, Secale Cereale (Rye) Seed Extract, Prunus Mume Flower Extract, Thymus Quinquecostatus Extract, Prunus Serrulata Flower Extract, Prunus Persica (Peach) Flower Extract, Acacia Farnesiana Flower Extract, Magnolia Liliflora Flower Extract, Lilium Tigrinum Extract, Usnea Barbata (Lichen) Extract, Zanthoxylum Piperitum Fruit Extract, Pulsatilla Koreana Extract, Soluble Collagen, Aloe Barbadensis Leaf Juice, Hydrogenated Lecithin, Argania Spinosa Kernel Oil, Sodium Hyaluronate, 1,2-Hexanediol, Polysorbate 20, Ammonium Acryloyldimethyltaurate/VP Copolymer, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Tromethamine, Xanthan Gum, Allantoin, Ethylhexylglycerin, Polyquaternium-51, Glyceryl Polymethacrylate, Adenosine, Disodium EDTA, Bisabolol, Steareth-20, N-Hydroxysuccinimide, Butylene Glycol, Chrysin, Panthenol, Caramel, Dicaprylyl Carbonate, Propylene Glycol, Sucrose Distearate, Ceramide 3, Folic Acid, Cholesterol, Raffinose, Acacia Senegal Gum, Lecithin, Colloidal Gold, Fragrance, Phenoxyethanol

Ingredients:  (Cream)
Water, Dipropylene Glycol, Glycerin, Glycereth-26, Viola Tricolor Extract, Eclipta Prostrata Extract, Cyclopentasiloxane, Polyquaternium-51, Phytosteryl/Behenyl/Octyldodecyl Lauroyl Glutamate, Hydrogenated Poly(C6-14 Olefin), Dimethicone, Hydrogenated Polydecene, Glycosyl Trehalose, Butylene Glycol, Niacinamide, Butyrospermum Parkii (Shea) Butter, Behenyl Alcohol, Hydrogenated Starch Hydrolysate, Glyceryl Stearate, PEG-100 Stearate, 1,2-Hexanediol, Betaine, Vegetable Oil, Euterpe Oleracea Fruit Extract, Polysorbate 20, Pseudoalteromonas Ferment Extract, Palmitoyl Oligopeptide, Palmitoyl Tetrapeptide-7, Acetyl Hexapeptide-8, Palmitoyl Pentapeptide-4, Acetyl Heptapeptide-9, Phellinus Linteus Extract, Arctium Lappa Root Extract, Phellodendron Amurense Bark Extract, Piper Methysticum Leaf/Root/Stem Extract, Portulaca Oleracea Extract, Pueraria Thunbergiana Root Extract, Glycyrrhiza Glabra (Licorice) Root Extract, Paeonia Lactiflora Bark/Sap Extract, Cnidium Officinale Root Extract, Hippophae Rhamnoides Fruit Extract, Panax Ginseng Root Extract, Pearl Extract, Propolis Extract, Panax Ginseng Callus Culture Extract, Avena Sativa (Oat) Meal Extract, Panicum Miliaceum (Millet) Seed Extract, Hordeum Vulgare Extract, Oryza Sativa (Rice) Extract, Secale Cereale (Rye) Seed Extract, Usnea Barbata (Lichen) Extract, Zanthoxylum Piperitum Fruit Extract, Pulsatilla Koreana Extract, Soluble Collagen, Aloe Barbadensis Leaf Juice, Hydrogenated Lecithin, Argania Spinosa Kernel Oil, Sodium Hyaluronate, C12-13 Pareth-23, Divinyldimethicone/Dimethicone Copolymer, Dimethicone/Vinyl Dimethicone Crosspolymer, Sodium Polyacrylate, Trideceth-6, PEG/PPG-18/18 Dimethicone, C12-13 Pareth-3, Bisabolol, Ethylhyxylglycerin, Tocopheryl Acetate, Adenosine, Magnesium Aspartate, Sarcosine, Sodium Cocoyl Amino Acids, Potassium Aspartate, Steareth-20, Dicaprylyl Carbonate, N-Hydroxysuccinimide, Sucrose Distearate, Chrysin, Panthenol, Ceramide 3, Xanthan Gum, Folic Acid, Caramel, Cholesterol, Raffinose, Propylene Glycol, Tromethamine, Lecithin, Acacia Senegal Gum, Colloidal Gum, Fragrance, Phenoxyethanol


Skylake Silk Cocoon Hair Conditioner

WHAT:  This rich hair conditioner made with real silk cocoon extracts and hydrolyzed silk cocoon extracts that contain natural proteins and other natural nutrients will keep your hair healthy, soft, and energized.  Highly recommended for those with weak, damaged, and/or dry hair.  Use with your Skylake shampoo from your June MISHIBOX!
HOW:  After washing your hair with your shampoo, apply the conditioner onto your hair and massage with extra care to your roots.  Wash off with warm water.
Retail Price:  $5 | 25 ml/0.84 fl oz, $36 | 500 ml/16.9 fl oz

Ingredients:
Skylake Oriental Herb Water (Water, Morus Bombycis Leaf Extract, Angelica Gigas Extract, Mentha Arvensis Leaf Extract, Morus Alba Bark Extract, Cnidium Officinale Root Extract, Glycyrrhiza Glabra (Licorice) Root Extract, Artemisia Absinthium Extract, Angelica Dahurica Root Extract, Scutellaria Baicalensis Root Extract, Pueraria Lobata Root Extract, Inula Helenium Extract, Laminaria Japonica Extract, Phellodendron Amurense Bark Extract, Eugenia Caryophyllus (Clove) Flower Extrac), Cetearyl Alcoho, Glycerin, Methylpropanediol, Stearamidopropyl Dimethylamine, Cetyl Alcohol, Stearamidopropyl Dimethylamine, Cetyl Alcohol, Cyclopentasiloxane, Pentylene Glycol, Silkworm Cocoon Extract, Poria Cocos Extract, Panax Ginseng Root Extract, Paeonia Albiflora Root Extract, Biota Orientalis Leaf Extract, Polygonum Multiflorum Root Extract, Eclipta Prostrata Extract, Hydrolyzed Silk, Butylene Glycol, Hydrolyzed Keratin, Argania Spinsoa Kernel Oil, Tocopheryl Acetate, Dimethiconol, Dicaprylyl Carbonate Polysorbate 80, Lactic Acid, Dimethicone, C12-15 Pareth-3, Amodimethicone, Cetrimonium Chloride, Trideceth-12, Panthenol, Ceteareth-20, Cacao Color, Disodium EDTA, Benzophenone-9, Cananga Odorata Flower Oil, Fragrance


Holika Holika Basic Nails (2015 SS Collection) (Sunshine)

WHAT:  Finish off the summer with these bright and long-lasting nail colors from the Holika Holika 2015 Spring/Summer Collection.
HOW:  After preparing your nails by applying one base coat onto your clean fingernails, apply your nail polish.  Use two coats for best results.  When dry, finish off with a top coat.
Retail Price:  $5 | 10 ml/0.33 fl oz

Ingredients:
Butyl Acetate, Ethyl Acetate, Nitrocellulose, Acetyl Tributyl Citrate, Adipic Acid/Neopentyl Glycol/Trimetllitic Anhydride Copolymer, Isopropyl Alcohol, Acrylates Copolymer, Stearalkonium Bentonite, n-Butyl Alcohol, Styrene/Acrylates Copolymer, Octocrylene, Trimethylpentanediyl Dibenzoate, Polyvinyl Butyral, CI 11680, Titanium Dioxide (CI 77891)


Cleomee Snowy Pore Balm

WHAT:  Say good-bye to oily skin with this soft white pore balm made with donkey milk and oil that minimizes the appearance of your pores and fine lines, brightens skin, neutralizes redness, and evens out uneven skin tone.  Great for sebum control.  Spatula and sponge included.
HOW:  Take an adequate amount of the balm using the spatula and then apply onto your face with the sponge.  Use this lightweight pore balm on your clean skin either alone on your T-Zone or your entire face as a makeup primer.
Retail Price:  $25 | 25g

Ingredients:
Dimethicone, Cyclopentasiloxane, Silica, Polymethyl Methacrylate, C12-15 Alkyl Benzoate, Cyclopentasiloxane, Microcrystalline Wax, Beeswax, Dimethicone/Vinyl Dimethicone Crosspolymer, Butyrospermum Parkii (Shea) Butter, Macadamia Integrifolia Seed Oil, Propyl Paraben, Bixa Orellana Seed Oil, Tocopherol, Donkey Milk 0.04 mg, Donkey Oil 1,225 mg, Argania Spinosa Kernal Oil, Illicium Verum (Anise) Fruit Extract, Butylene Glycol, Caprylyl Glycol, Butyl Paraben, 1,2-Hexanediol, Sorbitan Olivate, Fragrance


Cleomee Donkey Real Milk Oil Mask

WHAT;  Treat yourself to a mini facial at home with this highly moisturizing sheet mask.  The donkey milk and oil blend works to provide whitening and wrinkle care while also providing soothing and nourishing effects.
HOW;  After cleanser and toner, place sheet mask onto your face for 15-25 minutes.  Gently pat remaining essence to help absorption.  We recommend using this sheet mask at night so you can wake up to soft and moisturized skin in the morning.  Store in fridge before use for a refreshing feel.
Retail Price:  $3.50 | 25g

Ingredients:
Purified Water, Butylene Glycol, Glycerin, Centella Asiatica Extract, Niacinamide, Donkey Milk, Sodium Hyaluronate, Carbomer, Triethanolamine, Sodium PCA, Witch Hazel Extract, PEG-60 Hydrogenated Castor Oil, Dipotassium Glycyrrizate, Hydroxyethylcellulose, Polysorbate 80, Tocopherol Acetate, Disodium EDTA, Adenosine, Sodium Ascorbyl Phosphate, Calcium Pantothenate, Pyridoxine HCl, Maltodextrin, Sodium Starch Octenylsuccinate, Silica, Caprylhydroxamic Acid, 1,2-Hexanediol, Caprylyl Glycol, Boswellia Serrata Resin Extract, Fragrance

My Impressions

When I first opened this, I wasn't impressed.  To be honest, I'm still not impressed.  There's nothing in here that makes me go, "Ye gods!  Let me take this box straight to the bathroom and slather everything on right now!"  There's not even anything that made me immediately go, "Ooooh...."  And the nail polish...  I just don't care for nail polish.  I don't care for anything really, aside from skincare products.  I know they kind of have to be in there, but nail polish would've come dead last on any list of what I would want in a subscription box.  Especially yellow nail polish.

But.


They include an extra one in every box since people thought the sticker was so adorable.
I sat there and stared at the little chubby bunny sticker, trying to figure out how to review it.  Honestly, what are my expectations?  That every $20 box comes with full size Sulwhasoo, History of Whoo, su:m37, and OHUI skincare?  That it be loaded with amazing things no one's seen before?  Why did I subscribe in the first place?  Well, I subscribed...firstly, because I love the company.  Their social media presence is amazing.  They're real, they're adorable, they're funny, they're helpful, and they listen.  When their first box came out, it had a high pH cleanser.  A few people spoke out, and they immediately sent out a survey asking if people would prefer only low pH cleansers.  People thought the sticker holding the tissue paper together was so cute, so they threw an extra one in.  It doesn't seem like it would take much effort to do that, but how many companies can you name that would do that?

But cute don't pay the bills, which brings me to my second reason...  I subscribed because I wanted an affordable way to find new skincare products.  Because I can't just go through Avecko and haul dozens of random products from unknown brands, crossing my fingers that they're not duds.  I lose sight of that sometimes, when I open a new box and there's nothing there that I immediately recognize or blows my mind with how gorgeous the packaging is.  And you know what?  Mishibox does an excellent job, especially considering this is their 4th box.  Ever.  Every box includes a couple of items from a new brand or two, and usually an item from an established brand.  They're at minimum deluxe samples, which allows you to at least feel out a brand and decide if that's something you're interested in, and ultimately, isn't that the whole point of a subscription box?

This box introduces (to me, anyway) Cleomee in the form of a full size Pore Balm (what?) and a sheet mask.  They both have donkey oil, and actually look pretty interesting - especially once I actually opened up the Pore Balm and saw that it had a couple of accessories.  Holika Holika is a pretty recognizable brand, and I'm sure there are people out there who would love to try things outside of their skincare lines, even though I don't care for it.  I was pretty excited to see the Skylake conditioner, as the shampoo rocked my socks off back in June.  I still have a tiny bit of the shampoo that I've been saving actually, so I get to try them as a set (also adorable that they left that in the description, "Use with your Skylake shampoo from your June Mishibox!").  Magis Lene is new (to me) too, and sounds like a super luxe brand, possibly to compete with Sulwhasoo from the sound of some of the ingredients, so having basically a whole skincare line in samples to try out is quite thoughtful.

So out of the 6 items, I'm willing to try 5.  I consider that a win even though it doesn't look crazy impressive.  And that right there is why I will keep supporting Mishibox.  Even when the boxes are underwhelming, you can see that they put thought into it - and who knows?  Maybe there is a new favorite in there.  It's not a bunch of random things they slap together.  And when they get feedback, they work on it, and they improve.  They provide full, English ingredients of all the products on their site.  They advise you to patch test on the info card, and they show you manufacturer date vs. expiration date. They don't artificially mark up the worth of their items 10x...

Would I recommend someone drop $20 a month on Mishibox?  If you're like me, and are willing to spend that much to explore new brands without having to do the research and pay for Avecko fees and shipping, I totally think it's worth it.  But if you want to get more familiar brands or a more themed box, you're probably better off using Memebox when they have something closer to what suits your fancy, or saving up your monthly budget to make a proper haul instead.
          Scinic Honey All In One Ampoule        
Y'all, I'm trying to finish the Vitamin C post, I swear.  I just get so drained working on it, I burn out and pretend I don't have a blog for a couple of days before repeating.  It's actually ~80% done, if that's any consolation.  Also, I got SnapChat now, and I post some DIY stuff on there.  My handle on there is "theonetruesnail" if anyone wants to follow along.  I've been posting on Instagram a lot, if anyone wants to follow me on there too.  I'm also revising how I review products, and am in the process of going back and standardizing my old reviews.  Today though, I'll be reviewing something I'm pretty excited about, the Scinic Honey All-In-One Ampoule that I got from my first Avecko order.




Hangul:  
싸이닉 허니올인원앰플

Weight:
321 g
 
Description:
Contains 90% Honey Extract!  Scinic Honey All in One Ampoule makes your skin moist and soft with honey extract.

Scinic has been around for a while, but doesn't get as much buzz as say, the typical roadhouse brands like Missha, Etude House, or Innisfree.  This is my first product from them, and I can't wait to try more.

Price: ($$)








This seriously cannot be beat.  250 ml of product, and it goes for around $10-12.  I've seen it sold on eBay for anywhere from $18-24, which isn't too bad if you're just looking to buy 1-2 items.  I paid a total of around $18 for it, after Avecko's handling fee and shipping, which makes it about $0.07/ml.  Soooo affordable, so much lovely, yummy product.  [5/5]

Ingredients:






Honey Extract, Glycerin, Water, Niacinamide, Royal Jelly Extract, Propolis Extract, Centella Asiatica Extract, Polygonum Cuspidatum Root Extract, Scutellaria Baicalensis Root Extract, Camellia Sinensis Leaf Extract, Glycyrrhiza Glabra (Licorice) Root Extract, Chamomilla Recutita (Matricaria) Flower Extract, Rosmarinus Officinalis (Rosemary) Leaf Extract, Hydrolyzed Silk, Aloe Barbadensis Leaf Extract, Lactobacillus/Soybean Ferment Extract, Salix Alba (Willow) Bark Extract, Cinnamomum Cassia Bark Extract, Origanum Vulgare Leaf Extract, Chamaecyparis Obtusa Leaf Extract, Portulaca Oleracea Extract, Dipotassium Glycyrrhizate, Hydroxyethylcellulose, Carbomer(1), PEG-60 Hydrogenated Castor Oil, Triethanolamine(2)(4), Caramel, Adenosine, Xanthan Gum, Disodium EDTA, 1,2-Hexanediol, Caprylyl Glycol, Illicium Verum (Anise) Fruit Extract, Fragrance, Phenoxyethanol

  • Potential acne triggers are listed in red.
  • Potential irritation triggers are listed in orange.
  • Potentially hazardous ingredients are listed in purple.  (Note:  this is according to the rating system on CosDNA, which rates them according to reports from CIR, RTECS, and the FDA on if these ingredients could be harmful with long term usage to the skin, cells, or human body.)
A general rule I read about when I got into DIY (particularly, DIYing dupes) and skincare ingredients was to assume that after the first 5 ingredients, everything else listed is 1% or less.  This isn't a hard rule, but it's a pretty good starting point.  This makes this ampoule even more attractive, as its first 5 ingredients are 90% Honey Extract (moisturizing), Glycerin (humectant), Water (solvent), Niacinamide (brightening, moisture barrier, ceramides, acne, collagen, and so much more), and Royal Jelly Extract (high in Vit B, anti-inflammatory).  It has some popular hanbang extracts like Licorice Root (11th, brightening) and Scutellaria Baicalensis (9th, antioxidant, anti-irritant).  There are more lower down on the list, which also contribute some antioxidant and anti-inflammatory properties.

Other notable, although probably in too low of concentration to matter, ingredients are Fermented Soybean (antioxidant), Green Tea Leaf Extract (anti-inflammatory, antioxidant), Centella Asiatica Extract (anti-inflammatory), Hydrolyzed Silk (moisturizing), and Adenosine.  If you're a Bio kid, Adenosine is the A in ATP, and something you really only hear about during photosynthesis/cellular respiration week.  As a drug, it is used as a cardiac depressant and vasodilator.  For cosmetic purposes though, Paula's Choice, known for being quite conservative in ingredient claims, considers it a cell-communicating ingredient with anti-inflammatory properties.  Some other sites claim it's an anti-wrinkle superstar, and there are some studies indicating its potential as an effective anti-aging ingredient.  From what I've found, it's effective at 0.1%, so that's great news even when it's low in an ingredients list.

This does not contain alcohol, and seems pretty clean from the CosDNA sweep.  Carbomer (thickener) and Triethanolamine (pH adjuster) are very commonly used in skincare products, and have studies backing their safety at the typical concentrations used.  It does contain fragrance, although I definitely don't find it overwhelming.  It smells like real honey, straight from the jar.



Let's face it:  this is a dupe of Shara Shara's Honey Bomb All In One Ampoule.  After shipping and everything, it's still less than half the price of it, but how does it compare?  Well, I sent 50 Shades of Snail a decant of this to try, and hopefully she'll do a post on its performance vs. the Shara Shara, but let's look at the difference in ingredients. 


Scinic Honey All-In-One Ampoule Shara Shara Honey Bomb All-In-One Ampoule
Honey Extract (90%) Water
Glycerin Glycerin
Water Butylene Glycol
Niacinamide Niacinamide
Royal Jelly Extract Diglycerin
Propolis Extract Betaine
Centella Asiatica Extract Pentylene Glycol
Polygonum Cuspidatum Root Extract Polyquaternium-51
Scutellaria Baicalensis Root Extract Piper Methylsticum Leaf/Root/Stem Extract
Camellia Sinensis Leaf Extract Phellinus Linteus Extract
Glycyrrhiza Glabra (Licorice) Root Extract Arctium Lappa Root Extract
Chamomilla Recutita (Matricaria) Flower Extract Honey Extract
Rosmarinus Officinalis (Rosemary) Leaf Extract Royal Jelly Extract
Hydrolyzed Silk Hippophae Rhamnoides Fruit Extract
Aloe Barbadensis Leaf Extract Citrus Grandis (Grapefruit) Fruit Extract
Lactobacillus/Soybean Ferment Extract Propolis Extract
Salix Alba (Willow) Bark Extract Centella Asiatica Extract
Cinnamomum Cassia Bark Extract Houttuynia Cordata Extract
Origanum Vulgare Leaf Extract Portulaca Oleracea Extract
Chamaecyparis Obtusa Leaf Extract Pueraria Thunbergiana Root Extract
Portulaca Oleracea Extract Glycyrrhiza Glabra (Licorice) Root Extract
Dipotassium Glycyrrhizate Paeonia Lactiflora Root Extract
Hydroxyethylcellulose Cnidium Officinale Root Extract
Carbomer PEG-40 Hydrogenated Castor Oil
PEG-60 Hydrogenated Castor Oil Bambusa Vulgaris Water
Triethanolamine Hamamelis Virginiana Flower Water
Caramel Soluble Collagen
Adenosine Aloe Barbadensis Leaf Juice
Xanthan Gum Hydrogenated Lecithin
Disodium EDTA Sodium Hyaluronate
1,2-Hexanediol Glycosyl Trehalose
Caprylyl Glycol Hydrogenated Starch
Illicium Verum (Anise) Fruit Extract Hydrolysate
Fragrance Carbomer
Phenoxyethanol Triethanolamine
Xanthan Gum
Glyceryl Polymethacrylate
Ethylhexylglycerin
Adenosine
Disodium EDTA
Caramel
Sodium Polyacrylate
PVM/MA Copolymer
Propylene Glycol
Panthenol
Acacia Senegal Gum
Folic Acid
Ceramide 3
Cholesterol
Raffinose
Tromethamine
Palmitoyl Pentapeptide-4
Fragrance
Phenoxyethanol

The Shara Shara has a much longer ingredients list, with some pretty snazzy ingredients in there (Ceramide 3, Cholesterol, Hyaluronic Acid, etc).  However, you have to keep in mind that with such a long list, many of the ingredients in there are so miniscule, it hardly matters how impressive they sound, they're just padding at a certain point.  I can say the same for Scinic actually, but I know it contains 90% Honey extract as the first ingredient (vs 12th on Shara Shara!), and its top ingredients are much more impressive.  [5/5]


Performance:





How Long Have I Been Using This?
Every night for just over a month now.

Product Claims:
Moistens and softens skin.



Such modest claims.  It definitely satisfies them though.  This is my Tretinoin warrior.  My allergies have returned after a decade long break, and they've returned with a vengeance.  Combine that with Tretinoin, and I'm a flaky mess all over againIn comes this amazing ampoule that's been keeping my flakes at bay, regardless of which other products I use with it.  I notice when I swap out a different ampoule (which only happened once, to test), I was flaky all over my chin area within a couple of hours.  This is also pretty soothing and calming in general.  If I get a little stressed and start picking at my skin, some of this dabbed on helps so much with healing.

Snapchat Ponderings...


I've only used this product as an ampoule so far, so I can't speak for its multitasking abilities.  I've heard people layering it over their creams as a sleeping pack, or slathering it on as a hydrating, wash off pack.  Labelled as an "All-In-One," it is suppose to be used in place of your Toner, Serum, and Moisturizer, reducing quite a few steps.  To that I say:  HA!  Good luck taking my steps away from me.  My preciousesssssss...  I recently snagged some LJH Vita Propolis Ampoules off of BonjourHK, and have been mixing a drop of that into my Scinic every night.  It doesn't affect consistency, and it's too early to tell if it's actually doing anything new.

Yikes, over contrasted.  But some products that you might have already for scale.  Especially the Banana Sleeping Pack.


This comes packaged in a jar with a screw on lid, much like a jar of jelly.  It has a large spatula that's perfect for scooping skincare - I use it for everything in my routine.  I think I have to actually take points off on the packaging though, because it's seriously scary sometimes when handling it.  50 Shades of Snail has the Shara Shara AIO, which is the same type of packaging, and she recently dumped like half of it on accident.  I almost did the same the other day, but caught it in time.  The ampoule is a good consistency:  a watery gel that dries quickly and isn't sticky.  It is amber colored, which I'm guessing is actually where the "caramel" in the ingredients list comes in.  I have its Snail AIO brother, and that sucker is clear.  The smell is actually like real honey.  I feel like I should be drizzling it on my toast, and my hubby almost had a mishap in the kitchen when I brought it down to decant for some friends.



This is ALL that is needed.

Quite a lot.



I know it says 250 ml, but you really don't appreciate how much is there though until you use it.  I dip the spatula in about an inch, lift it straight up, and that's all I use.  It doesn't look like much, but it would probably be more than a dropper full, compared to other serums.  And it just does. Not. Make. A. Dent. In this stuff.  Goodness, I love a good bargain, but this?  It works well, it's in a cute packaging, it has great ingredients, it's cheap, and there's so much of it.  So perfect.  [4.5/5]


Personal View:





I want to say I would repurchase it, but I'd have to run out of it first.  That won't happen anytime soon, even with the rate that I'm decanting it to entice everyone I know.  I definitely recommend this to everyone.  It would work for everyone - dry skin, oily skin, every skin in between.  What a great product.  [5/5]


TL;DR:


The Good: A LOT of product, inexpensive, great ingredients list, works as advertised

The Bad:  Packaging can spill easily
  • Price:  5/5
  • Ingredients:  5/5
  • Performance:  4.5/5
  • Personal View:  5/5
  • Average:  4.88/5

Where to Buy:

 Want some for yourself?  You can get this through Avecko, Gmarket, 11st, or eBay.  If you want to try the Shara Shara Honey Bomb to compare, you can snag that from GlowRecipe (US Shipping!), where you can get $5 off your first order.

DIY Week is next!

              Haul Day! June Mishibox, June Birchbox, and Jolse order!        

    Haul day!  There are few things better than waking up to a bunch of Korean beauty packages.   You should've seen the goofy grin on my face as I tore into these.  I've been super excited for Mishibox's introductory subscription box, having waited for months with some hints and teases on social media, and it's finally here!





     June 2015 Mishibox

    I've heard a couple of people expressing their disappointment with the inaugural box, but honestly, I am quite happy with it.  First, what I got:

    • Banila Co Clean It Zero (Deluxe Sample):  Try this award-winning and bestselling cleansing oil balm to easily remove makeup and other pore-clogging impurities without stripping your skin of its beneficial oils.
    • Benton Honest Cleansing Foam (Deluxe Sample):  After the Clean It Zero, try out this hypoallergenic facial cleanser that uses many natural ingredients to gently cleanse your skin, provide moisture, and minimize skin tightening.
    • Benton Snail Bee High Content Mask Pack (Single Mask/Full Size):  Pamper your face with this popular 100% cotton sheet mask that uses natural ingredients such as snail secretion filtrate, EGF, and bee venom for anti-aging, whitening, and skin-soothing effects.
    • Holika Holika Aloe 99% Soothing Gel (Full Size):  Kick off the summer with this versatile soothing gel that contains over 99% fermented aloe vera leaf juice.  Use it on your hair, face, or body for moisturizing, soothing, cooling, and rejuvenating effects without stickiness.
    • Holika Holika Jewel Light Waterproof Eyeliner (Full Size):  Use this long-lasting waterproof eyeliner that won't smudge through sweat or sebum.  It is blendable, creamy, and highly pigmented with shimmer & glitter to highlight and define your eyes.
    • Skylake Oriental Herb Cool Shampoo (Deluxe Sample);  Cool down with this natural shampoo formulated with the patented SKYLAKE oriental herbal extract to clean your hair.  This product also claims to prevent dandruff, itching, and hair loss.


     6 products!  I've always wanted one of those little deluxe samples of the Banila Clean It Zeroes actually, so I could give it away when someone wants to try a balm cleanser.  The Benton Cleansing Foam is high pH, and I definitely won't be using it.  Benton seems to be on their way out, with all their preservative and quality control drama, but I've yet to actually hear anyone complain about their sheet masks.  I've tried one a while back, and liked it quite a bit, so I don't mind at all getting another one.

    I've wanted one of those giant aloe vera bottles since I've started my AB journey, but never made it a priority to get, because shipping.  The eyeliner, I couldn't really care about, as I wear makeup maybe twice a year, but I suppose I could use it when the time comes.  The shampoo?  The shampoo is too cool.



    It's surprisingly minty smelling.  I posted this to my Instagram, thinking it had a piece of mushroom, but Mishibox themselves actually jumped in and corrected.  It is actually Cynanchum wilfordii root, which is used in Chinese herbal medicine (HANBAAAAAANG).  They announced a few months back that Skylake was going to be one of their partner brands, so I was kind of expecting it.



    A photo posted by MISHIBOX (@mishibox) on


    Another pretty amazing thing they did was after these boxes were sent out, they posted this:




    How awesome is that?  I just really like this company.  They have great social media presence, they listen to customers, and they do little things like this.  I don't think their first box had shockingly good value or anything, but you can see they actually put thought into their selection.  I got a couple of products I've been wanting, but didn't bother getting because of shipping, some I don't mind having, and a new product I'm pretty excited to try out (Tracy from Fanserviced-B said some good things about Skylake on her Insta).  I am definitely interested in seeing what new boxes they put together.

    Unsolicited Suggestions for Mishibox:

    1. More hanbang products, please.  I don't know a lot of brands other than Sulwhasoo, which is ultra high-end, and Evercos, which I've mentioned.  I would love to see what else is out there.
    2. Please, no more high pH cleansers.  I won't use them.  A lot of informed consumers aren't going to use them.  If you don't know which cleansers are high pH, the /r/AsianBeauty sub has a list.  I'd rather have a toner.  I mean, I'd rather have serums and creams, but I'm assuming toners are in the same price range.
    3. I would not mind sunscreens.  Not one bit.  I'm always wanting to try new sunscreens, but am afraid of committing to full sizes without knowing if they'll break me out.
    4. I don't care for body products unless it's like a foot peeling mask or an adorable hand lotion.  I don't want body gels or soaps or anything.
    5. I know sometimes you just gotta throw a sheet mask in there to fill a box.  I'm ok with that.  Please, no Missha Pure Source masks.  And definitely not the 3D Red Ginseng mask.  They're just awful.  Hydrogels would make me (and quite a few others, I imagine) swoon. :)
    Psst, I wouldn't mind this in a box.



    June 2015 Birchbox

    I got this for $1, actually.  I think the code was TATIOFFER for new members, but I don't know if it's expired or not.  Very pleasantly surprised!  Unfortunately, I don't think I will keep the subscription, as I already have my Mishibox subscription, and that's $10 more per month on top of it.  I just don't need more deluxe samples...  I saw some people post theirs on Instagram, and I'm assuming they actually do some level of customization, as some people got more makeup stuff and body care products.   Here's what I got:

    • Beauty Protector Protect & Detangle:  Best-selling leave-in that locks in color, protects from heat damage, and adds silkiness.
    • Coola Classic SPF 30 Cucumber Moisturizer for Face:  Hydrator that blocks UV rays, protects against future signs of aging, and has a fresh cucumber scent.
    • Marcelle BB Cream Golden Glow:  This multitasker, rich in antioxidants and aloe, covers imperfections, evens tone, and calms skin.
    • Marcelle Waterproof Eyeliner:  This blendable waterproof eyeliner goes on smoothly and stays put all day.
    • Skynn Iceland Hydro Cool Firming Eye Gels:  Peptide-packed cooling treatment to hydrate and refresh stressed skin under the eyes.
    • Emi Jay Hair Tie (Lifestyle Extra):  We've added in this chic hair tie from Emi Jay for all your summer 'dos.


    I actually don't think this would be a bad subscription at all for $10, considering I got a bunch of deluxe samples.  I don't particularly care for any of these brands, but I'll definitely get some use out of those eye gels and the eyeliner.  By the way, if anyone actually uses these types of hair ties, go save yourself a bunch of money - find a fabric shop and ask for fold-over elastic.  They're less than $1 a yard.  I have a couple dozen yards collecting dust in my crafts room from my old cloth diaper sewing days.


    Jolse Cosrx Haul

    I placed my order 5/25 and received it 6/18.  24 days from start to finish.  Also, I was a cheapass and didn't pay the $2.50 for the tracking number, but went on their site to look, and it had tracking!

    This is mostly a 50 Shades of Snail inspired haul, as she is basically a spokeswoman for the miracles of Cosrx, and we bond on Twitter over late night cravings for sugary sweets, so I'm weak to her enabling.  I got the following:

    • Cosrx Galactomyces 95 White Power Essence (aka the Racism essence)
    • Cosrx Natural BHA Skin Returning A-Sol
    • Cosrx BHA Blackhead Power Liquid
    • Cosrx Honey Ceramide Full Moisture Cream
    • Innisfree No Sebum Mineral Powder


    I'm trying out the Cosrx Natural BHA Skin Returning A-Sol tonight, and will report back after a couple of weeks to see how it goes.  Speaking of, I need to share these magnificent exchanges with everyone:




    [Ay-sol] 😄👍🏻

    Too cute.  Also, apparently Jolse is gaining legendary status for their samples.  I expected the free gift to brag about.  I got this instead:




    That's 14 sample packets, an Etude House Tea Tree Sheet Mask, and my free gift, the Skin Watchers Green Snail Healing Gel Cream, because I totally need another cream, right?  But seriously, damn, Bae.  I like to imagine whoever is in charge of packing the boxes and selecting samples must step back every time a box is taped up, and go "BAM, bitches!"

              Heart Failure        
    Epidemiology
    Heart failure, defined as an impairment that prevents the heart from adequately perfusing body tissues to meet metabolic demands, is a major health problem that affects between 2 and 3 million Americans. With 400,000 new cases of HF diagnosed annually, the cost to the U.S. health care system is considerable, since HF is the primary reason for an estimated 1 million hospitalizations per year. In 1990, HF was responsible for approximately $10 billion in direct (e.g., hospitalization) and indirect (e.g., prolonged nursing home stays) costs.
    HF has a poor prognosis. After the onset of symptoms, the five-year mortality rate in patients with HF-based on data from the Framingham Heart Study-is 62 percent in men and 42 percent in women, with 200,000 deaths attributable to HF each year in the United States alone.

    Pathophysiology
    Traditionally, HF has been thought to be a result of an impairment of systolic (inotropic) function, which is a reflection of decreased contractility of myocardial cells, most common in the left ventricle. More recently, impaired left ventricular (LV) filling, or diastolic dysfunction, has also been recognized as a significant contributor to the development of HF and is a reflection of reduced ventricular compliance related to scar tissue, ischemia, or hypertrophy of normal myocardial cells. Many cases of HF have components of both systolic and diastolic dysfunction.
    hypertrophic responseshypertrophic responseshypertrophic responses 
    Figure 1 Schematic illustration of selected types of hypertrophic responses. In A, the left ventricular dimensions are normal. With end-stage systolic dysfunction (B), cardiac chamber wall thickness remains the same or decreases in association with generalized dilatation of several cardiac chambers. Contractile activity is globally reduced. In lesser degrees of  systolic dysfunction, contractility is reduced, but cardiac chambers do not necessarily demonstrate marked dilatation. In pure diastolic dysfunction (C), symmetric thickening of the IVS and LVFW occurs at the expense of left ventricular  cavitary volume. Cardiac contractility is typically preserved, if not increased, resulting in corresponding preservation (or increase) in ejection fraction. However, overall cardiac output is reduced because the ventricle never completely  fills.
    IVS = interventricular septum;
    LA = left atrium; LV = left ventricle;
    LVFW = left ventricular free wall;
    RA = right atrium; RV = right ventricle.

    In HF due to systolic dysfunction, the left ventricle is enlarged and overstretched (i.e., thinned) (Figure 1B; Figure 1A corresponds to a normal heart). Systolic dysfunction is the result of decreased cardiac contractility, which causes low cardiac output. Common causes of systolic dysfunction include scarring due to mycardial infarction and viral cardiomyopathy. The heart in end-stage HF due to systolic dysfunction is easily recognized on echocardiography as a Òbig, baggy heart.
    In HF due to diastolic dysfunction, cardiac contractility is preserved or even increased (Figure 1C). The thickened and stiffened ventricle limits the amount of blood that can enter the heart, resulting in decreased ventricular filling during diastole. Ventricular dysfunction is often mixed, however, and has elements of both systolic and diastolic dysfunction.
    Unfortunately, the physical examination will usually not allow the physician to reliably distinguish between systolic and diastolic dysfunction. Sometimes, a laterally displaced, dilated point of maximum impulse (PMI) may suggest that HF has a component of systolic dysfunction. On the other hand, in pure diastolic dysfunction, the PMI is not typically displaced or dilated, albeit the impulse may be abnormally sustained in duration.
    It is important to recognize that diastolic and systolic dysfunction often overlap and may occur in the same patient. As an example, hypertensive patients commonly develop concentric hypertrophy with diastolic dysfunction as a result of the increase in afterload associated with persistent hypertension. If the hypertension is not controlled, LV function eventually deteriorates, and systolic dysfunction becomes superimposed on the initially hypertrophied left ventricle. Eventually, the left ventricle dilates and the diastolic dysfunction present in the early HF of hypertension evolves to dilated cardiomyopathy, so that the component of diastolic dysfunction may no longer be recognized.
    Myocardial function is controlled by preload, afterload, ventricular contractility, heart rate, and heart rhythm. In HF, impaired heart function results in hemodynamic stress in the form of falling cardiac output. This stress unleashes a series of interdependent acute and chronic compensatory events, all of which are intended to maintain perfusion to vital organs.
    Myocardial cell hypertrophy and increased LV wall thickness resulting from HF are accompanied by decreased ventricular compliance (increased ventricular stiffness), and, in the elderly, increased vascular resistance. The ensuing structural deterioration transforms the left ventricle from its normal elliptical shape to a rounded shape-a process known as remodeling. The rounded, or globoid, heart of late-stage HF may be accompanied by functional mitral regurgitation, ventricular dilatation, and thinning of the ventricular wall.
    Neurohormonal Activation
    The functional decrease in cardiac output and atrial hypertension results in arterial hypovolemia that characterizes HF. HF activates the adrenergic (sympathetic) nervous system and the renin-angiotensin-aldosterone (RAA) system, increases release of atrial natriuretic peptide (ANP), may increase the secretion of antidiuretic hormone (ADH) and renal
    prostaglandins, and has long-term pathologic consequences.
    Early in the course of HF, neurohormonal responses to hypovolemia lead to plasma expansion and selective vasoconstriction. The cardiovascular system compensates for the functional decrease in circulatory volume by shunting blood away from nonvital organ systems (e.g., kidneys, gastrointestinal tract), and by increasing cardiac contractility. Long-term neurohormonal adaptation to decreased perfusion results in desensitization of the heart to sympathetic stimulation, increased impedence to LV outflow, dysfunctional vascular endothelium, impaired glycolysis in fasttwitch muscles, physical deconditioning, and muscle deterioration.
    In HF, norepinephrine is chronically elevated due to an increase in release and spillover from the adrenal gland, decreased plasma clearance, and decreased neuronal and non-neuronal reuptake. Norepinephrine increases afterload, causes cardiac arrhythmias, and has a direct toxic effect on the myocardium. There is a direct correlation between norepinephrine levels and both the hemodynamic severity and the poor prognosis of HF.
    Decreased cardiac output, characteristic of HF, results in constriction of the kidney's efferent arterioles, which maintain the glomerular filtration rate (GFR). As HF progresses, a point is reached at which further constriction is impossible, and the GFR becomes flowdependent and decreases in tandem with additional decreases in cardiac output.
    When the GFR falls, sodium is reabsorbed by the renal tubules, which activates the RAA system. The RAA system plays a key role in regulating blood pressure and vascular tone, and maintaining salt and water homeostasis. Renin, a proteolytic enzyme stored in the juxtaglomerular complex, cleaves angiotensinogen (a glycoprotein formed in the liver) to form angiotensin I. Angiotensin I is split by angiotensin-converting enzyme into angiotensin II, a potent vasoconstrictor that also stimulates the synthesis and secretion of aldosterone, which leads to sodium retention. Activation of the RAA system in HF is thought to occur in steps, as it normalizes in early-stage, compensated HF. As HF worsens, the RAA system is reactivated, and is a major contributor to the relatively intense edema and vasoconstriction typical of decompensated HF.
    ADH is produced in the posterior pituitary and promotes renal tubular reabsorption of water by the kidneys in response to decreased plasma volume, as occurs in HF. Although ADH is often increased in HF, its contribution to the vascular dynamics of HF is unclear.
    ANP is produced in atrial tissue of the heart in response to atrial stretch from increased blood volume. This causes natriuresis and vasodilation, and counteracts the waterretaining effect of the adrenergic and RAA systems. In early-stage HF, the vasodilatory response of peripheral arteries to ANP is preserved, but it becomes blunted as the HF enters a decompensation phase, an effect attributed to the down-regulation of ANP receptors.
    One of the compensatory responses to the chronic overstimulation of the sympathetic nervous system (SNS) and the RAA system is an increased release of prostaglandins, resulting in peripheral vasodilation.

    Clinical Findings
    It is essential to keep in mind that mild HF is not necessarily the same as early-stage HF. Mild HF suggests that the patient's ability to function is only "mildly" affected. Earlystage HF, on the other hand, refers to the duration of pathogenic events that occur in the compensated phase of HF.
    It is also important to emphasize that LV dysfunction does not always progress in a predictable fashion, nor is the degree of LV dysfunction necessarily paralleled by the clinical severity of symptoms. Some patients may present with significant symptoms of HF, yet only have minimal alteration of LV function. Other patients with only mild symptoms may come to medical attention in later stages of HF, which reflects the efficacy of the body's compensatory mechanisms.
    For practical purposes, HF may be divided into high-output failure, which is usually secondary to other, noncardiac conditions, and low-output failure, which is primarily due to cardiac pump failure. High-output HF is very unusual in clinical practice and may be due to a marked hyperdynamic circulation with minimal functional myocardial abnormalities, in which the demand outstrips the capacity, resulting in a hyperkinetic state.
    In low-output HF, the cardiac output falls below the tissue requirements for oxygen. It is associated with increased vascular resistance and oxygen consumption, decreased cardiac index and oxygen saturation, and lactic acidosis. Low-output HF may be "forward,"  in which oxygenated blood does not reach peripheral tissues, or "backward," in which blood backs up in the lungs.
    The symptoms of low-output forward HF include weakness, fatigue, lethargy, lightheadedness, and confusion. In decompensated HF, cardiac cachexia, which is characterized by generalized exhaustion and loss of lean muscle mass, ensues. The symptoms of lowoutput backward, or congestive, HF reflect pulmonary edema, in which fluids accumulate in the lungs and result in dyspnea, initially only on exertion. Decompensated low-output backward failure is characterized by orthopnea and paroxysmal nocturnal dyspnea.
    The clinical findings in HF include peripheral edema, rales, S3 gallop, sinus tachycardia, hypotension, increased jugular venous pressure, and hepatojugular reflux. Despite the presence of one or more of these signs, HF may be misdiagnosed in up to 40 percent of patients. The severity of HF can also be evaluated with chest radiography. Chest films may demonstrate cardiac enlargement, interstitial and alveolar edema, and pulmonary vascular redistribution in HF. However, HF may also be misdiagnosed using x-ray studies. Therefore, all patients suspected of having HF should be evaluated by two-dimensional echocardiography and Doppler studies to determine LV contractility, ventricular compliance, hypertrophy, and the presence or absence of other underlying conditions, such as valve pathology.

    Management Strategies
    HF is a syndrome that consists of a constellation of symptoms evoked by a wide range of conditions and precipitating factors (Table 1). Its management hinges on correction (when possible) of precipitating factors, treatment of acute symptoms, and compliance with long-term strategies that are intended to prolong survival.

    Expunerea prelungită la factorii externi poate cauza ruperea lanțurilor de keratină, care la rându-i duce la solubilitatea acesteia și îndepărtarea keratinei din firul de păr.

     

    Cum ajută părul?

     

    Produsele de îngrijire ce au la bază keratină completează proteina pierdută de firul de păr de-a lungul timpului din cauza procedeelor de styling la care este supus.

    Părul devine treptat fragil, casant, se subțiază, iar vârfurile se degradează și se rup.

     

                                               

     

    Keratina pătrunde în interiorul firului de păr, reparând zonele afecctate, îmbracă firul de păr într-un strat protector și nivelează cuticulele care se află în exteriorul firului de păr, astfel lumina reflectându-se dând părului un apect strălucitor.

     

    Cum se folosește?

     

    Keratina se impregnează în interiorul firului de păr, revitalizându-l atât din interior, cât și din exterior. Pentru a se fixa pe suprafața firului de păr, keratina are nevoie de  căldură, iar majoritatea produselor care o conțin au ca specificație folosirea uscătorului de păr după aplicare.

    Astfel, substanța pătrunde în interiorul firului de păr și aderă pe suprafața acestuia, făcându-l mai rezistent, reparând zonele afectate.

     

                                                

     

    În ce tipuri de produse o poți regăsi?

     

    Saloanele oferă pachete de îngrijire a părului, dar aceleași rezultate poți obține și acasă. Există o gamă variată de tratamente regeneratoare și cosmentice pentru îngrijirea părului pe bază de keratină, de la șampon, mască, ser protector, balsm leave-in, keratină lichidă până la soluție bifazică.

                                                

    Alege intotdeauna produsele care se potrivesc tipului tău de păr și respectă cu strictețe indicațiile inscripționate pe ambalaj.

     

    Diferența folosirii produselor cu keratină acasă față de cele folosite la salon

     

    În saloanele de înfrumusețare tratamentul cu keratină  este folosit în alt scop față de produsele de larg consum unde este folosită pentru refacerea părului degradat  și tern.

    Este folosită în cadrul unui procedeu complex alături de alte substanțe, pentru a obține un păr drept pentru mai mult timp. Se adresează persoanelor cu părul creț sau ondulat, cu o textură rebelă, care folosesc des placa de întins părul.

                                             

    Această procedură are efectul de a îndrepta părul și de a reface structura părului deteriorat și de a-i oferi strălucire și rezistență.

     

    Cât timp durează efectele tratamentului cu keratină?

     

    După tratament nu este indicat să folosiți șampoane ce conțin sulfați sau fosfați (SLS- Sodium Laureth/Lauryl Sulfate)

     

    Sulful din componența șampoanelor este un element care curăța excesiv firul de păr, astfel efectul keratinei fiind îndepărtat repede de pe suprafața firului de păr.

     

    În urma tratamentului folosiți produse care conțin keratină, collagen, polypeptide, care hrănesc firul de păr, cât și seruri sau uleiuri protectoare pentru vârfuri, înaintea uscării cu uscătorul de păr.

     

                                            

    Pentru un efect mai bun, se recomandă repetarea tratamentului după 3 luni, deoarece efectul acestuia este progresiv, obținându-se de fiecare data efecte din ce în ce mai bune.

     

    Întrebări frecvente despre keratină

     

    Estă anumite mituri care spun despre keratină că are efectul de a grăbi procesul creșterii părului și că are efect benefic asupra scalpului afectat de mătreță. În realitate, keratina nu are aceste efecte, iar pentru a rezolva problemele menționate trebuie să folosiți produse specifice acestor nevoi.

    Este indicat să oprești tratamentul cu keratină dacă observi că acesta nu îmbunătățește calitatea firului de păr și dacă acesta se rupe. De asemenea, persoanele care suferă de anumite afecțiuni inflamatorii ale scalpului, precum psoriazis sau dermatită seboreica trebuie să discute înainte cu un dermatolog.

    În afară de aceste categorii de persoane, oricine poate folosi în siguranță produsele pe bază de keratină, atata timp cât concentrația de formaldehidă este echilibrată sau lipsește. Este indicat să eviți produsele care conțin formaldehidă în concentrație mai mare de 7%.

                                                   

    Produsele cosmetice cu keratină pot fi folosite și de persoanele care nu au mari probleme cu firul de păr. După un astfel de tratament, părul devine mai puternic, mai mătăsos și se reduce riscul de electrizare.

     

    Sfaturi după tratament

     

    După tratamentul cu keratină:

    • părul nu trebuie spălat timp de 72 de ore
    • nu este indicat să strângeți părul în coadă,
    • nu folosiți clame, agrafe sau bentițe de păr
    • nu aplicați alte substanțe pe păr
    • evitați activitățile fizice, înotul, pentru a nu transpira și pentru a evita umezirea părului
    • nu utilizați șampoane cu sulfați sau fosfați, deoarece curață părul excesiv
    • după tratament folosiți șampoane care conțin keratină, collagen polypeptide, care hrănesc firul de păr
    • după spălare părul trebuie uscat complet cu foehn-ul, pentru a rămâne neted și drept. În caz contrar, părul va lua forma natural.
    • inaintea uscării cu foehn-ul este indicate folosirea unui ser sau ulei protector pentru vârfuri, înaintea uscării părului.

     


              New Eczema Cure Doors Open with Yeast Studies        
    Latest studies have found that common skin conditions such as eczema can be cured with the help of a yeast strain. This is found to be useful in all skin conditions characterized by inflammation. Peptides, which are present in the yeast, are useful in combating such conditions. In the United Kingdom, eczema affects a surprising […]
              Daf-2 A Peptide To Treat Ovarian Cancer In Advance Stage        
    The researchers from the University of Guelph claims that they have successfully found out a peptide that by decreasing the advancement of tumors leads to uplifted survival chances in ovarian cancer. A professor in U of G`s Department of Biomedical Sciences Jim Petrik who was also the lead researcher of the study has expressed his […]
              Review: Conture Face + Neck Kinetic Skin Toning System #Conture #KineticSkinToningSystem #AntiAging        
    (product photos courtesy of www.conture.com)

    Introducing the Conture Kinetic Skin Toning System, a safe, painless and non-invasive way to quickly and easily improve the appearance of aging skin. The Conture Kinetic Skin Toning System utilizes Isometric Compression combined with Low Frequency Vibrations to gently stimulate and tone skin for a more youthful looking appearance. This technology is similar to those used, and was once only available by professionals in medi-spas and skincare centers. If used daily, the Conture Kinetic Skin Toning System has been clinically shown to enhance the appearance and absorption of skincare products. The result? Overall signs of aging, dull and tired looking skin are improved and skin is left feeling and looking more radiant and more youthful.

    Inspired by cavitation devices and treatments available in medi-spas and professional offices, the device utilizes Isometric Compression in the form of a gentle vacuum that lifts and releases the skin zone within the Treatment Head. This action stimulates skin, similar to the positive effects seen in skin massaging. In a clinical study designed to measure the effect of hemoglobin, a protein responsible for carrying oxygen in the blood, the Conture Kinetic Skin Toning System was shown to have a positive effect on the epidermis compared to skin that had not been treated with the Conture System.*

    It utilizes Low Frequency Vibrations that radiate outward from the Treatment Head. The effects of Low Frequency Vibrations are a consistent focus area of new research designed to find increasing ways to stimulate skin, particularly aging skin. In a clinical study designed to measure the effect of skin absorption of topicals such as lotions and crèmes, the Conture Kinetic Skin Toning System was shown to improve the skin’s natural ability to absorb topicals by 300% compared to a skin area which just had topicals applied manually.*

    The Conture Kinetic Skin Toning System was subjected to a rigorous collection of clinical studies; safety, efficacy and usability assessments and numerous large-scale consumer in-use groups. Together, these studies add up to more than 250,000 hours of intensive observation and have independently shown that the system is safe, easy to use and far more effective than skincare alone at reducing the appearance of aging. In one principal study, the device delivered measurable results within the first application and increasing results with continued use including:
    • 90% Radiance & Luminosity
    • 84% Smoothness & Evenness
    • 81% Lift in Facial Skin
    • 78% Decrease in Fine Lines & Wrinkles
    • 78% Increase in Facial Firmness
    (*Percentage of Subjects With Clinical Improvement. 8 Week Clinical Study Using Conture System Twice Daily.)

    Why use the system at all? Well, you exercise the rest of your body; why aren’t you exercising your skin? The Conture Skin Toning Device is an anti-aging beauty device that tones skin to restore radiance and firmness to the three main areas: décolleté, eye area, forehead and everything in between.
    The original Conture Skin Toning Device features three treatment programs, each uniquely designed for the face, neck or delicate areas. Use this device in conjunction with Kinetic Treatment Serum to restore radiance and firmness to your décolleté, eye area, forehead and everything in between.     
    The Conture 3-Speed is a painless and non-invasive anti-aging device, to be used twice daily to help restore radiance and firmness to tired and aging skin.
    Key Benefits:
    • Quickly and easily improves the appearance of aging skin 
    • Gently stimulates and tones skin
    • Painless and non-invasive, can be done in the comfort of your own home
    How To Use: After priming cleansed skin with the Kinetic Treatment Serum, turn on Conture device and place on skin, ensuring connection is secure. After device pulses 3-5 times, gently slide it to the next section to be treated, slightly overlapping with previous section. Moving in an upward motion towards the top of the face, repeat until entire section has been treated. Treat one area at a time, working device over cheeks, jawline, forehead, neck, etc. independent of each other. Use once or twice daily for best results along with Kinetic Treatment Serum morning and night.
    Before and After:
    before using Conture Face + Neck Kinetic Skin Toning Device

    after using Conture Face + Neck Kinetic Skin Toning Device
    Can you see that in the before photo I have a lot of hyperpigmentation? There are also some spots of the beginning of fine lines. In the after photo everything looks clear and much firmer. The fine lines have disappeared. I had great results with the Conture Face + Neck Kinetic Skin Toning Device. I am going to keep using it. Out of all the skincare devices I have tried, and they are many, this is one that has really worked the best. It is a mixture of the serums and the way the device works that makes it do so well. It brings blood to the surface of the skin, allowing for oxygen to help work with the skincare and also to create collagen. Skin ends up looking radiant and younger when this device is used at least once a day. I tried to use it twice a day, but sometimes I was only able to use it once a day. It only takes 10 minutes to accomplish the toning.

    The device itself is $299. There is a new device that only has one single speed instead of three, like mine and it is $199. There are three serums that I was able to try with this device. They are as follows:
    Kinetic Treatment Serum $56.00: this serum is the superstar backbone of the Conture Kinetic Skin Toning System, a complete anti-wrinkle serum formulated with the revolutionary peptide SNAP-8, which has been clinically shown to reduce crow’s feet alone by up to 63%. This powerhouse anti-aging serum includes: Encapsulated Retinol, a highly effective anti-wrinkle ingredient shown to effectively build collagen and reduce wrinkle depth by 15%. It also includes Inyline, a peptide which has been clinically shown to reduce wrinkles by 14.9% in 28 days and Antarcticine, an ingredient derived from the Antarctic Sea, which has restructuring and anti-wrinkle properties, and has been shown to reduce the depth of wrinkles by 50% in 30 days. 



















    Kinetic AM Ignition Lotion $50.00: Kickstart your morning with this serum. It is a daily-use moisturizing, anti-aging facial lotion is designed for all skin types. This lightweight yet intensive moisturizer hydrates skin while helping it retain essential moisture so your skin remains looking luminous and radiant all day long. It doesn't matter what side of the bed you wake up on; you'll have beautiful skin with this must-have beauty product. The lotion was formulated specifically to be used as part of your morning beauty routine and regular toning sessions with your Conture Skin Toning Device. This serum moisturizes, plumps and lessens the appearance of fine lines and wrinkles. It has an anti-aging formula, perfect for all skin types. It is dermatologist tested and recommended. 

    Kinetic PM Recovery Crème $50.00: Take your beauty sleep to new levels with an intensive night cream that helps the skin recover while you sleep. Featuring a unique blend of encapsulated Retinol, Longevicell and Adaptonyl, it dramatically improves skin barrier function and the skin’s own ability to remain healthy and at peak performance, giving you beautiful, healthy skin that looks and feels younger. Generously apply as part of your nighttime beauty routine, and let the innovative formula do all the work for you, while you're busy counting sheep and recharging your batteries. It was formulated specifically to be used as part of your nighttime beauty routine and regular toning sessions with your Conture Skin Toning Device. It reduces wrinkle depth by up to 17% after 12 weeks (independent clinical study), helps restore sun-damaged skin and the appearance of fine lines and wrinkles and is dermatologist tested and recommended.
    Currently the Conture Face + Neck Kinetic Skin Toning System is available online at www.conture.com. Like Conture on Facebook: https://www.facebook.com/ContureSkin; Follow Conture on Twitter:@contureskincare; Follow Conture on Pinterest:https://www.pinterest.com/conture0365/; Follow Conture on Instagram:https://www.instagram.com/contureskincare/; Follow Conture on YouTube:https://www.youtube.com/channel/UCCQctj2ZpTBOF8wnpTgQ6Ng.

    Until Next Time~

    Marie PapachatzisI Am THE Makeup Junkie

    (This was sent for consideration)








              Review: Dr. John Zannis Rinnova Renaissance Day/Night Moisturizer #Rinnova #RenaissanceMoisturizer        
    (product photo courtesy of www.zannisplasticsurgery.com)


    1.7 fl.oz./50mL 
    $58.95 (one time purchase)/ $56.00 (subscription)

    Dr. John Zannis, a renowned plastic surgeon, began his quest for the ultimate face cream several years ago. After trial and error, intense research, and working with the best skincare chemists in the world, Rinnova Skincare was born. He worked on the line and came up with the formula for the Renaissance Day/Night Cream. The Renaissance Day/Night Cream is a proprietary formula of all-natural botanicals and hydropeptides that are designed to instantly erase wrinkles (through hydration) and restore your skin’s lifecycle to a younger state. The anti-oxidant properties protect your skin from further damage due to the aging process and sun exposure. Wrinkles caused by chronically dehydrated and sun-damaged skin are instantly improved (within 1 hr) by at least 7% according to clinical studies.
    skin before and after Renaissance Day/Night Cream
    Never before has a simple face cream revolutionized the science and practice of anti-aging skin care like Rinnova has. Celebrities are amazed at the efficacy of the ingredients used in their Renaissance Day/Night Moisturizer and Dr. Oz featured the key ingredient (proprietary biosphere) as a miracle cure for wrinkles. It has a clinically-proven anti-aging formula of all-natural botanicals that is soft and non-greasy.  This cream is suitable for men and women of all skin types.  Its benefits are:  immediate hydration that will instantly reduce wrinkles while other active ingredients like hydropeptides and antioxidants rejuvenate and protect your skin from further photodamage. 
    Dr. Zannis attributes much of his success to what they call their "Dynamic Duo", which is the Renaissance Day/Night Moisturizer and the Limu Foaming Cleansing Gel (sold together for $84.50). The Limu Foaming Cleansing Gel was made as a supplement to the face cream. Like all of Rinnova Skincare's products, the foundation is a natural botanical extract, in this case algae from seaweed, augmented by science. Rinnova is considered one of the most rapidly growing physician-created skincare lines.
    I was very happy with the sample of the Renaissance Day/Night Cream I received. The cream is very light, it would be great for oily skin too. I think it is better as a night cream since it does not contain a SPF, and I always wear a SPF during the day. It is light enough that you could use this and apply a light SPF on top if you wanted to do so. I do not have any wrinkles, so I cannot report on its ability to reduce wrinkles, but I do like how well it moisturizes and hydrates the skin. My skin has started to get drier over the years, even in summer. I do not produce as much sebum as I used to and therefore I need a stronger moisturizer. This one is quite good and it sinks into the skin, leaving it feeling as soft as silk. The line does have a SPF30 available separately that can be applied over the cream, it retails for $28.95.
    Rinnova Skincare is sold online at www.rinnovaskincare.com. It has been featured on television shows such as "Dr. Oz" and "The Doctors". It has also been featured in People magazine and USA Today
    Until Next Time~

    Marie PapachatzisI Am THE Makeup Junkie

    (This was sent for consideration)










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              Review: STARSKIN After Party Brightening, Close Up Firming BioCellulose Masks and The Gold Mask #STARSKIN #Masks #AfterParty #CloseUp #TheGoldMask        
    (product photos courtesy of www.starskinbeauty.com)

    1.4 oz./40 g/ 1 mask $10
    This leave-on coconut bio-cellulose mask is delivers a powerful serum complex to leave skin luminous, brightened and camera-ready. The Starskin After Party Bio-Cellulose Brightening Face Mask intensely energizes skin for a visibly brighter, radiant looking complexion. It is formulated with naturally fermented, vitamin-rich coconut juice and it revives and conditions the skin without any irritation. Energizes and recharges visibly dull, tired and lackluster skin. The translucent, cooling sheet contours closely to the face to deliver a powerful complex of Vitamin C and a proprietary herbal medley, all working together to reduce the aging signs of visible dark spots and uneven skin tone. Every brightening face mask is soaked in a full bottle of skin revitalizing organic skincare serum which transforms skin that has been up all night into starlet worthy luminous skin in just 20 minutes. Minimizes dark spots and evens skin tone. This is organic and innovative skincare at its finest. Easy to use, next generation bio-cellulose delivers results in 20 minutes. Cooling second skin brightening face mask. 

    Do you want bright skin immediately? Then this is the way to do it. I know you may not believe it, but my skin brightened up immediately when I wore this. I had been having hyperpigmentation problems for a while now and really wanted something that helped out with that. This was it. This lightens up skin and dark spots/freckles in 20-30 minutes. It is a minor miracle. After I saw the results I was about to say, "Hallelujah!"

    Here is a photo of me wearing the After Party mask:



    1.4 oz./40g/1 mask $10
    One of the other masks I tried was the Close-Up Firming Bio-Cellulose Second Skin Face Mask. This mask is also made from a coconut Bio-Cellulose, and is a Second Skin Firming face mask that delivers a powerful serum complex to leave skin looking youthfully lifted, smoothed and close-up ready. This mask firms, lifts and sculpts skin for a supple, youthful appearance. The premium Bio-Cellulose is formulated with a naturally fermented, vitamin-rich coconut juice, and firms and nourishes the skin without irritation. This translucent sheet mask contours closely to the face to deliver a powerful complex of Glacier extract and Tripeptide-1, which improves the appearance of saggy, drawn skin. Each and every face mask is soaked in 1 oz./30mL of serum that leaves skin looking flawlessly beautiful and ready for even the most high definition close-up. Ace the A-List way to restore firmer and smoother skin in just 20 minutes. This mask is easy to use, is a next generation bio-cellulose that delivers results in 20-30 minutes and is a cooling second skin firming face mask. 

    If your skin is pulling more these days, feels thinner and is sagging some, then this is the mask for you. Elasticity and collagen both wear away as we age and only collagen can be produced again. Once the elastin is gone, it is gone. That is why you stay out of the sun, as it is one of the things that promotes free radicals, which basically knocks away the elastin. So, use masks like this to firm up the skin, then sunscreen and keep it firm for as long as possible.

    1.4 oz./40g/1 mask $15
    THE GOLD MASK Luxury Bio-Cellulose Second Skin Revitalizing Face Mask instantly plumps, replenishes and pampers for a rejuvenated looking skin. Lavish your skin in pure luxury with this mask, a decadent treat for dull, dry or lackluster complexions. Formulated from naturally fermented coconut water, the premiu, Bio-Cellulose sheet mask is infused with a rich creamy serum made from the finest ingredients. A base of very deeply nourishing Evening Primrose extract (68%) leaves skin dramatically softer while pure colloidal gold diminishes the appearance of fine lines, wrinkles and sun damage. The mask's miraculous skin-rejuvenating effects are enhanced by collagen-boosting Ginkgo Biloba leaf extract, wrinkle smoothing Adenosine and brightening Kudzu root extract. When using the mask, in just 15-20 minutes The Gold Mask will leave your skin replenished, rehydrated and visibly plumper with and opulent, star like glow. 

    This mask is meant for those who have very dry, dehydrated and mature skins. It is for those who need a really good moisturizing pick me up. The mask is so rich and so creamy that it left my skin feeling so soft and supple. I didn't mind it at all. My skin is usually dry, except during the summer when it becomes normal. I think anyone with the skins mentioned above would adore this mask. Those with combination, oily and acneic skins should avoid it. 

    Here is a photograph of my skin in excellent condition after using all three masks:



    STARSKIN is sold in various outlets throughout the country: Barney's New York, www.cloud10beauty.com, www.beautymart.com, www.beautybay.com, Harvey Nichols, Anthropologie and Planet Parfum. The website says SEPHORA sells STARSKIN, but I checked and could not find them on the website. Maybe they only have them in store. Like STARSKIN on Facebook: https://www.facebook.com/starskinbeauty and Follow STARSKIN on Instagram: http://www.instagram.com/starskinbeauty.  

    Until Next Time~

    Marie Papachatzis

    (These were sent by consideration)










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              Review: Olay Skincare #Olay #Skincare #Retinol #TotalEffects #MicroSculptingCream        
    (product photos courtesy of www.olay.com)

    Olay has been around for many, many years. They were one of the first skincare companies around. Even though their skincare is sold in mass market retailers, it works extremely well, as well as skincare that costs 400% more than the price of the brand. I received a few items to try out and I was very happy with all of them. My skin has not looked this nice in a while. Sit back, relax and read on for the reviews...

    1.7 fl.oz./50mL
    Olay Total Effects is the main cream behind Olay's skincare success. When it was introduced, women went nuts over it. Why? Because it works so well. It treats 7 signs of aging. This cream does the following:
    • visibly smooths fine lines and wrinkles 
    • evens skin tone
    • enhances brightness
    • minimizes the look of pores
    • visibly reduces age spots
    • restores firmness
    • replenishes moisture
    Total Effects also has a variety of moisturizers with SolaSheer Technology and Broad Spectrum SPF 30. SolaSheer Technology and the Broad Spectrum SPF 30 helps protect against UVA/UVB rays from the sun, thus preventing sun damage and reducing the chance that your skin will have fine lines, wrinkles, age spots and hyperpigmentation in the future. The various moisturizers in the cream nourish with a moisturizing skin-enriching vitamin complex that helps keep skin looking healthy and rejuvenated. A few of the key ingredients in Total Effects are: Niacinamide (Vitamin B3), Panthenol, Vitamin E and Glycerin. 

    I have used Total Effects in the now and in the past. I have always liked this cream. It is an all around great anti-aging moisturizer that really works. For me, I noticed how well it helps with evening out my skin tone and making my skin look bright and minimizing its pores. If you are looking for a moisturizer for day, this is a good one. This is a good product for normal, dry, sensitive and combination skins. I would also say that this is for women who are in their 20's, 30's and 40's. 

    1.7 fl.oz./50mL $26.99
    Olay Regenerist Micro-Sculpting Cream SPF30 is a powerful daytime anti-aging moisturizer with sunscreen. It is formulated with Amino-Peptides and Niacinamide (Vitamin B3) to hydrate, plump and firm the skin. The lightweight moisturizer leaves skin feeling soft and immediately reduces the look of fine lines and wrinkles, all while protecting the skin from UVA/UVB rays. The sun's rays are the #1 cause of premature skin aging. The cream is fast absorbing and non-greasy. 

    As skin ages, it loses its ability to become responsive to anti-aging ingredients. This results in dryness, wrinkles and sagging skin. Regenerist Micro-Sculpting Cream reveals younger-looking skin with its unique formula. It has an advanced Amino-Peptide Complex and also hyaluronic acid that penetrates deep into the skin's surface to visibly reduce the appearance of wrinkles. The formula is designed to deliver moisturizing ingredients 10 layers deep into the skin's surface to reveal younger-looking skin. As soon as day 1, visible wrinkle results start. It improves the skin's texture in 4 weeks. 

    My skin was dry when I started to use this product and it really did help to moisturize and hydrate my skin. It is not a heavy product and works great under makeup. I don't have any wrinkles, so I cannot report on that, but from what I have heard it does work well on fine lines and wrinkles. This cream is recommended for dry and normal skins. Personally, I think this is something that would work well for women in their 40's, 50's and 60's. 

    1.7 oz./50mL $26.99
    Regenerist is Olay's Advanced Anti-Aging Skin Care Collection. Olay Regenerist Micro-Sculpting Cream is one of Olay's top selling creams, and with good reason. It hydrates skin better than ten of the top creams, even better than a cream that retails for $440 (proven by Good Housekeeping)! This formula is designed with advanced anti-aging ingredients for visible wrinkle results starting the first day you use it. Infused with Hyaluronic Acid, Amino-Peptides and Niacinamide (Vitamin B3), this moisture-binding formula instantly plumps and lifts surface cells away from the skin, leaving skin looking more radiant than before. The luxurious-feeling moisturizer immediately leaves skin hydrated, softens the look of fine lines and wrinkles and firms the look of skin with plumping hydration, to help take years off your "skin age". The anti-aging moisturizing formula penetrates deep into the skin's surface to improve the skin's texture and elasticity. As mentioned previously, the older we get, the harder it is for our skin to react to skincare ingredients. That is why Olay designed Regenerist to go up to 10 layers deep into the skin's surface.

    This cream was designed more for nighttime use, since the others have sunscreeen now. I like how this cream moisturizes my skin and makes it feel so soft and smooth. It really makes the texture of the skin change. This is a heavier cream than the daytime cream. I would recommend it for those with dry and normal skins. This is perfect for those in their 40's, 50's and 60's. 

    0.5 fl.oz./15mL $26.99
    Olay Pro Retinol Treatment for Eyes is a wonderful wrinkle-fighting cream. Using Retinyl Propionate, one of the best ways to fight wrinkles, it starts to immediately go to work on fine lines, deep wrinkles and crow's feet. You will find that it smooths skin in as little as 4 weeks. The potent formula helps increase the rate of cell turnover, which slows down as we age, to smooth the look of wrinkles. It also has strong hydrating ingredients to fortify the skin's natural moisture barrier, allowing skin to better retain moisture. This cream renews skin's surface over time for brighter skin too. 

    For best results, use the targeted applicator tip to apply along wrinkles. Lightly tap product with ring finger around the whole eye area to minimize pulling or rubbing on the delicate eye area. This product has been dermatologically tested. Use morning and evening. Retinol can be strong, if irritation develops, hold back and use only once a day. 

    I have just the very beginnings of fine lines under my eyes. I found that this product works extremely well, getting rid of my lines in as little as 2 weeks (like I said, they are very small). Personally, I think Retinol is one of the best anti-aging ingredients on the market. It really does work. Make sure to use an SPF when using this product, so irritation does not develop. 

    Olay products are available at mass market retailers nationwide, such as Walgreens, Rite-Aid, CVS, WalMart and Target. Like Olay on Facebook: https://www.facebook.com/OlayUS?brand_redir=1; Follow Olay on Twitter:@OlaySkin; Follow Olay on Pinterest:https://www.pinterest.com/OlayUS/; Follow Olay on Instagram:https://www.instagram.com/olay/ and Subscribe to Olay on YouTube:https://www.youtube.com/user/olay/Custom.

    Until Next Time~

    Marie Papachatzis

    (These items were sent for consideration)










               Quantitative and qualitative aspects of nitrogen supply in enteral nutrition in relation to free amino acids and peptides         
    Grimble, GK; (1995) Quantitative and qualitative aspects of nitrogen supply in enteral nutrition in relation to free amino acids and peptides. In: Cynober, L, (ed.) Amino acid metabolism in health and nutritional diseases. (pp. 319-336). CRC Press: Boca Raton, USA.
               A theoretical study of the active site complexes formed between endothiapepsin and three potent inhibitors: Pepstatin A, and peptide analogues containing difluorostatone and phosphostatine. Implications for inhibitor design.         
    Beveridge, AJ; Dealwis, C; Cooper, JB; (1995) A theoretical study of the active site complexes formed between endothiapepsin and three potent inhibitors: Pepstatin A, and peptide analogues containing difluorostatone and phosphostatine. Implications for inhibitor design. Journal of Molecular Structure: THEOCHEM , 333 pp. 87-97.
              Medical News Today: Immunotherapy found safe for type 1 diabetes in landmark trial        
    A new trial investigates the safety profile of proinsulin peptide immunotherapy for treating type 1 diabetes, and the results are encouraging.
               Inhibition of DNA synthesis in mitogen stimulated rat hepatocytes by the peptide acetyl-ser-asp-lys-pro         
    Calnan, D; Selden, C; Boulton, RA; Hodgson, HJF; (1995) Inhibition of DNA synthesis in mitogen stimulated rat hepatocytes by the peptide acetyl-ser-asp-lys-pro. In: (pp. A20-A20).
               Effects of papaverine and vasointestinal polypeptide on penile and vascular cAMP and cGMP in control and diabetic animals: an in vitro study         
    Miller, MA; Morgan, RJ; Thompson, CS; Mikhailidis, DP; Jeremy, JY; (1995) Effects of papaverine and vasointestinal polypeptide on penile and vascular cAMP and cGMP in control and diabetic animals: an in vitro study. Int.J.Impot.Res. , 7 (2) pp. 91-100.
               EFFECT OF PEPTIDE YY ON HUMAN RENAL-FUNCTION         
    PLAYFORD, RJ; MEHTA, S; UPTON, P; RENTCH, R; MOSS, S; CALAM, J; BLOOM, S; ... UNWIN, R; + view all <#> PLAYFORD, RJ; MEHTA, S; UPTON, P; RENTCH, R; MOSS, S; CALAM, J; BLOOM, S; PAYNE, N; GHATEI, M; EDWARDS, R; UNWIN, R; - view fewer <#> (1995) EFFECT OF PEPTIDE YY ON HUMAN RENAL-FUNCTION. AM J PHYSIOL-RENAL , 37 (4) F754 - F759.
               EFFECTS OF PEPTIDE TYROSINE TYROSINE (PYY) ON RENAL-FUNCTION - A POTENTIAL MEDIATOR OF POSTPRANDIAL NATRIURESIS         
    CALAM, J; CAPASSO, G; MEHTA, S; PLAYFORD, R; UNWIN, R; (1995) EFFECTS OF PEPTIDE TYROSINE TYROSINE (PYY) ON RENAL-FUNCTION - A POTENTIAL MEDIATOR OF POSTPRANDIAL NATRIURESIS. KIDNEY INT , 47 (2) 682 - 683.
              STARBUCKS/FIRST AID STATION        
    My subway ride down to Farmer's Market this afternoon recorded a bs reading of 170mg/dl.
    I figured that that number would provide safety while in the Market since it was also post lunch.
    At the Market I began to feel those familar symptoms of just before unconsciousness begins with the 1-2 second intervals of blackout while still upright.
    Immediately I rushed across the street not cognizant of green yellow or red light. My main goal was to reach the Starbucks on the near corner where I knew SUGAR would be available.
    The canisters of white granulated sugar were no-where to be found. I saw an employee and told her that I have Diabetes and am on the verge of losing consciousness in their store and was unable to find any sugar to treat my Hypoglycemia. She told me that they were "out of sugar" and asked if I would like sugar syrup instead. I said yes, and the manager asked me how many pumps of the syrup would I like?
    I said, "5 pumps."
    He quickly brought over a container of hot water which was filled with the 5 pumps of the sweet syrup.
    After I quickly drank the sweet mixture, I checked my bs and got a reading of 40mg/dl.
    Waiting 20 minutes for the effects to work, I rechecked and got a 77mg/dl.
    Another day in the adventures of having T1DM and being on Insulin Analogues that are missing C-peptide(found in Porcine and Bovine Derived Insulin) which always gave me much earlier warnings of impending Hypoglycemia.
               MUTANT RAS PROTEINS AND PEPTIDES - BAD-NEWS FOR TUMORS         
    STAUSS, HJ; (1995) MUTANT RAS PROTEINS AND PEPTIDES - BAD-NEWS FOR TUMORS. J NATL CANCER I , 87 (24) 1820 - 1822.
               Mechanical load and polypeptide growth factors stimulate cardiac fibroblast activity.         
    Butt, RP; Laurent, GJ; Bishop, JE; (1995) Mechanical load and polypeptide growth factors stimulate cardiac fibroblast activity. Ann N Y Acad Sci , 752 pp. 387-393.
               RIGOROUS PHYSICAL-TRAINING ALTERS BRAIN NATRIURETIC PEPTIDE LEVELS IN HEALTHY-YOUNG MALES         
    PRASAD, K; MONTGOMERY, H; FREDERICKS, S; MOULT, J; CLARKSON, P; DOLLERY, C; WORLD, M; ... MCKENNA, WJ; + view all <#> PRASAD, K; MONTGOMERY, H; FREDERICKS, S; MOULT, J; CLARKSON, P; DOLLERY, C; WORLD, M; STATTERS, D; HOLT, D; MCKENNA, WJ; - view fewer <#> (1995) RIGOROUS PHYSICAL-TRAINING ALTERS BRAIN NATRIURETIC PEPTIDE LEVELS IN HEALTHY-YOUNG MALES. CIRCULATION , 92 (8) 2239 - 2239.
               THE EFFECT OF RGD AND CS-1 PEPTIDES ON INTEGRIN INDUCED HISTAMINE RELEASE(HR) FROM HUMAN BASOPHILS         
    GOLDRING, K; LAVENS, SE; WARNER, JA; (1995) THE EFFECT OF RGD AND CS-1 PEPTIDES ON INTEGRIN INDUCED HISTAMINE RELEASE(HR) FROM HUMAN BASOPHILS. FASEB J , 9 (3) A224 - A224.
              NRS Announces 2016 Research Grant Award Recipients        

    The National Rosacea Society has awarded funding for three new studies, in addition to continuing support for two ongoing studies, as part of its research grants program. The purpose of the grant program is to increase knowledge and understanding of the causes and other key aspects of rosacea that may lead to improvements in its management, prevention or potential cure.

    “Research supported by the NRS has led to important insights into the physiology of the disorder, providing an essential foundation for developing new and better treatments,” said Dr. Martin Steinhoff, chairman of dermatology and director of the Charles Institute of Dermatology, University College, Dublin, and a member of the NRS Medical Advisory Board, which selects research proposals for funding. “In addition, our growing knowledge is now pointing toward potentially meaningful connections between rosacea and other systemic illnesses.”

    The NRS research grants program is funded by thousands of individuals who suffer from rosacea, and readers are encouraged to donate by renewing their memberships today.

    Dr. Luis Garza, associate professor of dermatology at Johns Hopkins University, and colleagues were awarded $15,000 to study epigenetic lesions in rosacea. Epigenetics is the study of how the essential DNA – the molecule that contains the genetic instructions –  might be modified to behave in certain ways. They noted that this process may be responsible for why rosacea persists even though keratinocytes, the predominant cell type in the outermost layer of skin, slough off and are replaced approximately every two months.

    Dr. Wenqing Li, assistant professor of dermatology at Brown University, was awarded $25,000 to clarify how hormone use and hormone levels associated with menopause and during pregnancy may affect the risk of developing rosacea. The study will use data from the well-known Nurses’ Health Study II, an ongoing prospective study updated biennially with questionnaires on the medical history of 116,000 nurses since 1989, including more than 6,000 women diagnosed with rosacea.

    Dr. Anna Di Nardo, associate professor of dermatology at the University of California-San Diego, and colleagues were awarded $25,000 to continue their quest to determine whether the release of cathelicidin antimicrobial peptides, key players in the body’s normal innate immune system, is central to the connection between the nervous system and skin inflammation through the activation of mast cells in rosacea. In previous research, Dr. Di Nardo showed that mast cells were highly significant in the overproduction of cathelicidins.

    The NRS has also continued to fund studies in 2016 by Dr. Gideon Smith, assistant physician in dermatology at Massachusetts General Hospital and instructor at Harvard University, and colleagues, who are investigating whether individuals with rosacea may be at higher risk for other disorders involving the vascular system, such as heart disease and high cholesterol; and Dr. Lori Lee Stohl, research associate in dermatology at Weill Cornell Medical School, who is examining how biochemicals released during stress may increase the number of mast cells, which have been linked to rosacea.

    These studies join more than 60 research projects that have received funding from the NRS research grants program since 2000.

    Issue:


              Molecular Insight May Lead to New Advances in Rosacea Treatment        

    Kallikrein-related peptidases (KLKs), a family of proteases recently identified as having a possible role in the development of rosacea, may help provide a pathway to controlling rosacea’s signs and symptoms, according to an article by Drs. Jan Fischer and Ulf Meyer-Hoffert of the University Hospital Schleswig-Holstein in Germany in the journal Thrombosis and Haemostasis.

    Proteases are enzymes that occur in all life forms, from single-celled organisms to plants and animals, for various metabolic processes. For example, acid proteases secreted into the stomach enable the digestion of protein in food, and other proteases present in blood play a role in clotting.

    Kallikrein-related peptidases have many biochemical activities. Already recognized as biomarkers for cancer, certain types of KLKs in the surface of the body have been found to be involved in the normal shedding of the outermost layer of skin, the authors noted. Moreover, KLKs have been described as processing cathelicidins, protective antimicrobial peptides that can speed physical repair but have been found to worsen rosacea symptoms.

    The authors noted that interference in KLK activity may have therapeutic potential. For example, an antibiotic with anti-inflammatory properties was shown to inhibit KLKs and the subsequent activation of cathelicidin, which may be why it is effective in rosacea, they said.

    They noted that further study of regulation of KLK activity may yield insights into therapeutic intervention.

    Dr. Meyer-Hoffert and Dr. Thomas Schwartz were awarded a National Rosacea Society research grant of $20,000 to study whether and how kallikreins, enzymes that contribute to inflammation in rosacea, can activate cytokines, which might contribute to the disease activity. They succeeded in cloning specific proteins from the interleukin family to identify whether the microbes they affect may contribute to rosacea inflammation in a variety of ways.

    Reference:
    Fischer J, Meyer-Hoffert U. Regulation of kallikrein-related peptidases in the skin – from physiology to diseases to therapeutic options. Thrombosis and Haemostasis. 2013;110:442–449.


              NRS Awards New Research Grants        

    The National Rosacea Society (NRS) announced it has awarded funding for three new studies, in addition to continuing support for two ongoing studies, as part of its research grants program to increase knowledge and understanding of the potential causes and other key aspects of rosacea that may lead to improvements in its treatment, prevention or potential cure.

    “Since the grants program began in 2000, research supported by donations from many thousands of rosacea patients has dramatically increased understanding of rosacea’s pathophysiology and potential causes,” said Dr. Mark Dahl, professor emeritus at the Mayo Clinic College of Medicine and chairman of the NRS Medical Advisory Board. “In addition, important studies are now beginning to uncover possible links between rosacea and increased risk of other serious disorders.”

    Dr. Gideon Smith, assistant physician in the department of dermatology at Mass General Hospital and instructor at Harvard University, and colleagues were awarded $25,000 to investigate whether individuals with rosacea may be at higher risk for other disorders involving the vascular system. The researchers will use a large clinical database to identify cases of rosacea and to examine the prevalence of markers of cardiovascular inflammation.

    Dr. Lori Lee Stohl, research associate in the department of dermatology at Weill Cornell Medical School, was awarded $25,000 to examine how norepinephrine and adenosine triphosphate (ATP), biochemicals released by sympathetic nerves during stress, may increase the number of mast cells, which have been linked to dysfunction of the innate immune system and the appearance of the signs and symptoms of rosacea. She will also study whether these chemicals induce cathelicidins, a peptide involved in the body’s innate immune system that is also linked to rosacea, to determine whether there is a potentially significant link between the two pathways.

    Earlier in 2015, Dr. Daniel Popkin, assistant professor of dermatology at Case Western Reserve University, and colleagues were awarded $25,000 to study the facial microbiomes – the unique community of microorganisms that resides in all individuals – of identical twins in whom only one has rosacea. In previous NRS- funded work, the researchers studied the contribution of genetics versus the environment to rosacea in identical and fraternal twins. They noted that studying rosacea in identical twins makes it easier to discover how specific factors affect its development without being potentially misled by the many genetic elements.The NRS also continues to fund studies by Dr. Anne Chang, assistant professor of dermatology at Stanford University, on identifying rosacea genes using a methodology called a genome-wide association study, and Dr. Anna Di Nardo, associate professor of dermatology at the University of California-San Diego, on mast cells and redness.

    Issue:


              NRS Announces New Research Grants        

    The National Rosacea Society (NRS) has awarded funding for two new studies in addition to continuing support for two ongoing studies during the year as part of its research grants program to increase knowledge and understanding of the potential causes and other key aspects of rosacea.

    “We are grateful for the thousands of donations from individuals with rosacea that allow us to fund important new studies and continue to support ongoing research that builds upon earlier findings,” said Dr. Mark Dahl, chairman of the NRS Medical Advisory Board, which selects grant applications for funding. “Ongoing research is now advancing a significantly better understanding of the disease process and potential new targets for medical therapy.”

    Dr. Anne Chang, assistant professor of dermatology at Stanford University School of Medicine, and colleagues were awarded $17,554 to begin to identify rosacea genes using a methodology called a genome-wide association study. A genome is an organism’s complete set of DNA, including all of its genes. Each genome contains all of the information needed to build and maintain that organism. In humans, a copy of the entire genome – more than 3 billion base pairs – is contained in all cells that have a nucleus. If genetic coding specific to rosacea is found, individuals at risk may be identified through a blood test so that early intervention and avoidance of triggers may be possible. This finding may also provide a better basis for further study and future therapy or potential prevention.

    Dr. Chang noted that five possible gene locations are linked to genes associated with human inflammatory conditions, including diabetes, inflammatory bowel disease, multiple sclerosis and sarcoidosis. Researchers will evaluate whether there is increased prevalence of these conditions in individuals with rosacea.

    Dr. Anna Di Nardo, associate professor of medicine at the University of California-San Diego, and colleagues were awarded $25,000 to study whether there are further indicators that mast cells (MCs) are a dermal translator of inflammatory signals from the epidermis. In this study, Dr. Di Nardo will note whether injection of a nerve blocker into both mice and humans will block the activity of a neuropeptide that activates inflammation in mice, and whether it may reduce redness in people. Results will be assessed by digital photography, clinical grading scales and colorimetry, a device that quantifies and describes color. In addition, they will evaluate whether enzyme levels that are altered in individuals with the inflammation of rosacea are normalized.

    The NRS has also continued to fund studies in 2014 by Dr. Di Nardo on an MC stabilizer and by Drs. Yoshikazu Uchida and Peter Elias at the University of California – San Francisco on a biochemical pathway that may lead to inflammation. A third study is under consideration for possible funding in early 2015.

    Issue:


              NRS Funds Five New Rosacea Studies        

    The National Rosacea Society (NRS) has awarded funding for five new studies as part of its research grants program to increase knowledge and understanding of the potential causes and other key aspects of rosacea.

    "We are very gratified to fund these new studies, which will both build on recent results of rosacea research and forge new paths toward improvements in its treatment, prevention and potential cure," said Dr. Mark Dahl, chairman of the NRS Medical Advisory Board, which selects grant applications for funding. "As always, we are indebted to the many thousands of patients whose donations make these important advances possible."

    Dr. Anna Di Nardo, associate professor of medicine at the University of California-San Diego, was awarded $25,000 to study the role of mast cells as a possible link between an overabundance of the antimicrobial peptides called cathelicidins in individuals with rosacea and the inflammation that appears on rosacea skin. Dr. Di Nardo will endeavor to identify inflammation-causing enzymes that are produced by mast cells as well as the influence of neuropeptides on the formation of these key enzymes.

    Drs. Meg Gerstenblith and Daniel Popkin, assistant professors of dermatology at Case Western Reserve University, were awarded $10,000 to study the incidence of rosacea in fraternal and identical twins, recruited at the annual Twins Day festival in Ohio. The study aims to document potential genetic factors by determining if there is a statistically significant difference in the correlation of rosacea between identical and fraternal twins.

    Drs. Ulf Meyer-Hoffert and Thomas Schwartz of the Department of Dermatology, University Clinic Schleswig-Holstein, were awarded $20,000 to study whether and how kallikreins, enzymes that contribute to inflammation in rosacea, can activate cytokines, which might contribute to the disease activity. The investigators will also research inhibitors of this substance that could have the potential to treat the disease.

    Dr. Barbara Summerer, postdoctoral research fellow in dermatology at Johns Hopkins University School of Medicine, was awarded $25,000 to use sophisticated analytical technology to evaluate specific microbes in rosacea patients. She will further use epifluorescence microscopy to identify possible biofilms — communities of bacteria that adhere to surfaces — that may exist in rosacea patients, as well as the differences in types of bacteria present in subtype 1 (erythematotelangiectatic) rosacea and subtype 2 (papulopustular) rosacea, so that therapy can target these bacteria.

    Dr. Yoshikazu Uchida, associate research dermatologist, and Dr. Peter Elias, professor of dermatology, at the University of California-San Francisco, were awarded $20,000 to study whether and how enhancing the production of human beta-defensin 2 and conversely suppressing the production of cathelicidin antimicrobial peptide, part of the body's innate immune system, may help suppress the excess of inflammation-causing peptides found in rosacea skin.

    The NRS is also continuing to fund studies by Dr. Richard Granstein at Cornell University on the potential role of Th17 cells in rosacea and Dr. Edward Wladis at Albany Medical College on identifying cytokines involved in ocular rosacea.

    Issue:


              NRS Research Grants Announced by NRS Medical Advisory Board        

    The National Rosacea Society (NRS) has awarded funding for three new studies in addition to continuing support for five ongoing studies as part of its research grants program to increase knowledge and understanding of the potential causes and other key aspects of rosacea.

    "We are pleased to award new grants for these additional avenues of rosacea research that may lead to important advances in its treatment and potential prevention or cure," said Dr. Jonathan Wilkin, chairman of the NRS Medical Advisory Board, which selects grant applications for funding. "Studies to date have made significant progress toward the more effective control of this disorder, and we are grateful for the support of the many thousands of patients whose donations make these studies possible."

    Dr. Ferda Cevikbas, postdoctoral fellow at the University of California-San Francisco, and colleagues were awarded $25,000 to assess the role of PACAP, a neuropeptide that may affect rosacea. They plan to define the distribution of PACAP in skin samples from rosacea patients, determine whether PACAP induces inflammation and test whether cathelicidin — a known factor in rosacea's pathophysiology — modulates the release of PACAP. The researchers also plan to test whether countering the effects of PACAP is beneficial and may thus be used as a rosacea therapy.

    Dr. Edward Wladis, assistant professor of ophthalmology at Albany Medical College, was awarded $12,100 to identify specific cytokines — molecules that regulate the immune system — that are involved in ocular rosacea by studying eyelid tissue from individuals with and without the disorder. Dr. Wladis noted that while inflammation is normally a healthy part of the immune response, aberrations in the cytokines' concentrations and functioning in rosacea may result in unhealthy and prolonged inflammation.

    This knowledge may have significant therapeutic implications for ocular rosacea, as medications have been designed to suppress specific cytokines.

    Dr. Richard Granstein, chairman of dermatology at Cornell University, and colleagues were awarded $25,000 to study the potential role of Th17 cells, a newly discovered class of cells that appear to be involved in a number of inflammatory and autoimmune disorders. Earlier study results strongly indicated that release of ATP — a neurotransmitter and carrier of chemical energy throughout the body — from nerves under stressful situations may initiate a sequence of events leading to or exacerbating inflammation in the skin. This study will investigate whether this inflammation results because Th17 cells are produced during this process in rosacea.

    The NRS is also continuing to fund studies by Dr. Richard Gallo and colleagues at the University of California-San Diego on the potential role of cathelicidins in rosacea1; Dr. Joseph Rothnagel and colleagues at the University of Queensland, Australia, on kallikreins and rosacea; Dr. Thad Wilson and colleagues at Ohio University on nerve activity in rosacea; Dr. Aki Ikoma and colleagues at the University of California-San Francisco on the neurovascular system and rosacea; and Dr. Noreen Lacey and colleagues at the University College in Ireland on the effect of antibiotics on sebocyte cells in rosacea.

    Reference

     

    1. Yamasaki K, DiNardo A, Bardan A, et al. Increased serine protease activity and cathelicidin promotes skin inflammation in rosacea. Nature Medicine 2007;13:975-980.

     

     


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    A  Q10-koenzim  és az  E-vitamin  segítik a regenerációs folyamatokat és csökkentik a ráncokat                
    A regeneráló  biopeptidek  kipótolják a rugalmasságot vesztett rostokat így megerősítve a bőr védőhálóját                 
    A kollagén csökkenti a ráncokat és megvédi a bőrt a rugalmasság elvesztésétől   
    A lifting hatású mikroalga  azonnal javítja a bőr tömörségét, simaságát és az arckontúrt              
    A  glicerin  és a  repceolaj  optimális hidratálást biztosít, így a bőr sima és puha lesz 
                  
    Mentes:   allergének, parabenek, színezékek
    Fő hatás: Lifting
    Kiszerelés: 50 ml
    Javaslat: Lifting hatású, feszesítő, ránctalanító termékcsalád.
    Használati javaslat: A szem környékét elkerülve minden este vigye fel a megtisztított arc, nyak és dekoltázs bőrére.

    AA AT Active Lifting 50+ nappali arckrém
    Jelenlegi ára: 4 159 Ft
    Az aukció vége: 2017-08-23 18:46
               Characterisation of Conus venom using polypeptide separation methods and mass spectrometric analysis.         
    Gerrits, A.J.; (2005) Characterisation of Conus venom using polypeptide separation methods and mass spectrometric analysis. Doctoral thesis, University of London. Green open access
               Versatile peptide dendrimers for nucleic acid delivery         
    Bayele, HK; Sakthivel, T; O'Donell, M; Pasi, KJ; Wilderspin, AF; Lee, CA; Toth, I; Bayele, HK; Sakthivel, T; O'Donell, M; Pasi, KJ; Wilderspin, AF; Lee, CA; Toth, I; Florence, AT; - view fewer <#> (2005) Versatile peptide dendrimers for nucleic acid delivery. JOURNAL OF PHARMACEUTICAL SCIENCES , 94 (2) pp. 446-457. 10.1002/jps.20230 .
               NMR assignment of the apo and peptide-bound SH2 domain from the Rous sarcoma viral protein Src         
    Taylor, JD; Fawaz, RR; Ababou, A; Williams, MA; Ladbury, JE; (2005) NMR assignment of the apo and peptide-bound SH2 domain from the Rous sarcoma viral protein Src. JOURNAL OF BIOMOLECULAR NMR , 32 (4) p. 339. 10.1007/s10858-005-0471-7 .
               A strong neuroprotective effect of the autonomous C-terminal peptide of IGF-1 Ec (MGF) in brain ischemia         
    Dluzniewska, J; Sarnowska, A; Beresewicz, M; Johnson, I; Srai, SKS; Ramesh, B; Goldspink, G; ... Zablocka, B; + view all <#> Dluzniewska, J; Sarnowska, A; Beresewicz, M; Johnson, I; Srai, SKS; Ramesh, B; Goldspink, G; Gorecki, DC; Zablocka, B; - view fewer <#> (2005) A strong neuroprotective effect of the autonomous C-terminal peptide of IGF-1 Ec (MGF) in brain ischemia. FASEB J , 19 (11) 1896 - +. 10.1096/fj.05-3786fje .
              Sieri Supreme e Sensitive per ciglia e sopracciglia di Develle cosmetics        
    Ciao ragazze,
    oggi vorrei parlarvi di Develle Premium Cosmetics, azienda tedesca i cui prodotti di punta sono senz'altro gli interessanti sieri per allungare, volumizzare/inspessire riempire e rinforzare ciglia e sopracciglia. I sieri presenti nella gamma sono 8 e io ne ho ricevuti da provare qualche mese fa 2:
    Supreme eye lash serum
    Sensitive eye lash serum, specifico per occhi delicati



    Il packaging è identico per entrambi i sieri, li differenzia esclusivamente il colore della fascia verticale centrale e delle scritte sulla confezione di cartone e sul tubetto al suo interno: Dorato per il Supreme e Argentato per il Sensitive, che come accennato già è specifico per occhi delicati, quindi ha una formulazione più leggera. Per il resto abbiamo in entrambi i casi un tubetto della stessa lunghezza di quelli standard per mascara che presenta al suo interno 7 ml di prodotto di colore trasparente e sul tappo un applicatore con pennellino come quelli standard per eyeliner.


    Le altre caratteristiche che accomunano i due sieri sono:
    - La possibilità di usarli sia per ciglia sia per sopracciglia
    - Assenza di effetti collaterali
    - Assenza di parabeni
    - Allungamento del 70%
    - Inspessimento del 60%
    - Produzione e sviluppo senza test sugli animali
    Istruzioni (clic per ingrandire)
    - Presenza del principio attivo SymPeptide Xlash

    L'utilizzo è davvero semplice, basta passare una o due volte al giorno il pennellino sulle sopracciglia dall'interno all'esterno seguendone la forma e sulle ciglia seguendone l'attaccatura, proprio come se fosse un eyeliner, sia sulle ciglia superiori che su quelle inferiori. Il siero non è appiccicoso, non cola, non brucia e asciuga rapidamente, quindi si può usare la mattina, prima di truccarsi ovviamente, e/o la sera dopo essersi struccate. Già dopo 2 settimane dovrebbero iniziare a vedersi i primi risultati, ma per avere risultati ottimali si dovrebbe procedere a un'applicazione costante per 6-8 settimane.



    Pennellino

    ESPERIENZA PERSONALE
    Se mi seguite/conoscete probabilmente sapete che se c'è una cosa di cui non posso lamentarmi è la carenza di peli/capelli, ho sopracciglia molto folte e piene e ciglia non proprio sfigatelle a livello di quantità e lunghezza, quindi in tutta sincerità non sono di partenza la persona più adatta a testare l'efficacia di questo prodotto, nonostante ciò sono stata felice di "raccogliere la sfida", francamente parlando chi non vorrebbe ciglia alla Marylin Monroe senza ricorrere alle ciglia finte?!?
    Ho cominciato l'applicazione il 22 agosto, con il siero per occhi sensibili che a livello di composizione dovrebbe essere più leggero, per abituarmi gradualmente al prodotto, e da circa una settimana sono passata al siero Supreme, l'ho applicato ad entrambe le sopracciglia, ma solo all'occhio destro per quanto riguarda le ciglia affinché fosse possibile vedere la differenza rispetto all'occhio non "trattato".
    Teoricamente il periodo di utilizzo rientrerebbe in quello dei risultati ottimali, in tutta sincerità devo però ammettere che non sono stata ehm per niente assidua, soprattutto il primo periodo, dal venerdì alla domenica tornavo dai miei per andare al mare e ho spesso dimenticato di portare con me il siero, e qualche altra sera è capitato che fossi così cotta da andare a letto senza applicarlo. Ciononostante qualche risultato l'ho notato, certo non sono diventata Elio o Blanca (per chi segue Orange is the new black) a livello di sopracciglia né la Marylin di cui sopra riguardo le ciglia, però ho dovuto ritoccare le sopracciglia ogni giorno (in genere lo faccio ogni 2 massimo 3 giorni) e mi sembra di notare che le ciglia dell'occhio destro siano leggermente più folte e più lunghe, soprattutto le ciglia inferiori. Insomma nulla di miracoloso, ma vedo un leggero miglioramento.



    Una fondamentale differenza che ho notato è che, mentre prima nel momento dello sfregamento per rimuovere il mascara sul dischetto restavano almeno 4-5 ciglia, ora non ne resta nessuna (sempre in relazione all'occhio dx), quindi effettivamente un rinforzamento avviene!
    
    Inci di Supreme eye lash serum

    Inci di Sensitive eye lash serum
    Certo è che per chi ha ciglia e sopracciglia più sfigatelle il risultato è sicuramente più evidente perché riempie e volumizza mentre qui su di me lo "spazio" è già abbastanza saturo :), però comunque in base alla mia esperienza non me la sento affatto di considerare il siero inutile o inefficace, piuttosto se non siete già abbastanza pelo-dotate come me ve lo consiglio.
    E voi cosa mi dite di questi sieri? Conoscete Develle Cosmetics? Avete provato i suoi sieri o sieri di altri brand con lo stesso scopo?
    Fatemi sapere, intanto vi lascio tutti i link così se siete curiose potete farvi un giro
    Sito Web:  https://develle-cosmetics.com   https://wimpernserum-24.de
    Pagina Facebook: https://www.facebook.com/develle.cosmetics/?fref=ts
    Instagram: https://www.instagram.com/devellepremiumcosmetics/






              Top 10 Foods Highest in Vitamin C        
    Vitamin C is an essential nutrient required by the body for the development and maintenance of scar tissue, blood vessels, and cartilage. Vitamin C is also necessary for creating ATP, dopamine, peptide hormones, and tyrosine. As a powerful antioxidant, vitamin C helps lessen oxidative stress to the body and is thought to lower cancer risk.
              Amino Acids and Peptides. XIV, Synthesis of a Tetrapeptide Sequence (A5-A8) of Glucagon        
    Amino Acids and Peptides. XIV, Synthesis of a Tetrapeptide Sequence (A5-A8) of Glucagon Handford, Brian O.; Hylton, Thomas A.; Weinstein, Boris A synthesis of the tetrapeptide sequence A5-A8 of glucagon is described that employs various blocking groups, coupling procedures, and routes. Author Institution: Department of Chemistry, Stanford University, Stanford, California 94305
              Surprising Health Benefits of Mung Beans        
    Surprising Health Benefits of Mung Beans, Myanmar Beans, Myanmar Green Mung Beans, Myanmar Mung Bean, Myanmar pulses
    Surprising Health Benefits of Mung Beans

    Mung Bean, also known as Green Gram, Golden Gram and Chinese Mung Bean, are varieties of legumes, which are widely consumed in the world. Because they are easy to handle, it is very useful for health. They are produced in the largest amount in Myanmar, China, India and Southeast Asia, but they are actually from South America. Its scientific name Vigna radiate, and are classified as legumes.

    It was domesticated before 1500 BC in India. Mung beans grow on sandy soils and prefer temperate tropical, subtropical and warm climate. Although most Mung beans are green, some rare varieties of yellow, greenish yellow, brown and black. Mung beans have become very popular in recent decades because of their high protein content. It is an excellent source of protein for vegetarians.

    How to Eat


    Mung beans can be eaten or germinated. It also serves as a main dish, soup, stew or dessert. They can be consumed in whole or in the form of flour, snacks, cereals, breads, soups, noodles and ice cream. Split seeds can be prepared as well as dhal, lentils or black gram. Mung beans can be processed in the form of starch noodles. The extract Mung bean starch used for the manufacture of jellies.


    Excessive consumption of Mung beans leads to cold extremities, abdominal pain, fatigue, diarrhea, cold leg pain, lower back, digestive disorders, and chronic gastritis. Excessive consumption of mung bean in patients with yin deficiency will lead to inflammation of the gums, and thus boqueras, etc. Children, pregnant women, the elderly, and people with weakened immune systems should avoid raw outbreaks.

    Health Benefits


    Mung beans possess enzymes, antioxidants and nutrients that are necessary to maintain good health. The availability of the medicinal properties of Mung Bean improves health. This is useful for healthy eyes, hair, nails and liver. It also improves blood circulation. It is loaded with high fiber and low in calories. Mung beans are used in traditional Chinese medicine for therapeutic use, for example, for detoxification and heat removal.

    1. Prevents heart ailments

    The study, which was published in the journal Human and Experimental Toxicology, shows that mung beans have the ability to reduce bad cholesterol levels. It helps to regulate cholesterol levels, since antioxidants eliminate free radicals, reduced damage to blood vessels and reduces inflammation. Strokes and heart attacks are responsible for the oxidation of LDL cholesterol. Mung bean helps clear arteries and increase blood circulation.

    2. Reduce blood pressure

    The food contained in Mung beans, has the ability to counteract cardiovascular disease and high blood pressure. Study, which was published in the Central Chemistry Journal, shows that Mung bean extracts decreased systolic blood pressure in rats. Researchers reported that the antihypertensive effects of Mung beans reduce the constriction of blood vessels, which leads to an increase in blood pressure.

    3. Prevents cancer

    Mung beans have a high content of polyphenols and oligosaccharides, which help to eliminate cancer. Clinical studies have shown that it has anti-tumor properties, which prevent DNA damage and dangerous mutation cells. A study from the University of Food Science and Engineering at the University of Agricultural Nutrients of China reported that the antioxidants found in mung beans have the ability to absorb free radicals. Flavonoids such as vitexin and izoviteksin, reduce oxidative stress, leading to the formation of cancer.

    Read Also: Health and Nutrition Tips: Benefits Of Urad Dal

    4. Prevents Type 2 diabetes

    Evidence suggests that the potency contained in the Mung bean has anti-diabetic effect, which helps treat Type 2 diabetes. A study by the Institute of Agricultural Sciences showed that the addition of Mung bean additive rats their blood glucose levels , Glucagon, C-peptide in plasma triglycerides and total cholesterol decreased, but at the same time, improve their glucose tolerance increased insulin sensitivity.

    5. Rich in protein

    Mung bean seeds contain nutrients such as isoleucine, leucine and valine, which make it an effective option for vegetarians. According to the Harbin Institute of Technology's Faculty of Chemistry, Mung beans contain 20 to 24 percent of the amino acids. Albumin and globulin are about 85 percent of the total number of amino acids, which are contained in Mung's grains.

    6. Enhance immunity

    Phytonutrients found in Mung beans, act as anti-inflammatory and antimicrobial agent that improves immunity and prevents harmful bacteria, colds, viruses, irritation, rashes, and so on. Mung beans improve nutrient absorption, and immune defense.

    7. Adequate Vitamins and Minerals

    Folate is necessary for DNA synthesis, tissue and cell growth, cognitive functions, balance and reproduction hormones. The required folate intake is vital during pregnancy to help prevent neural tube defects, prevention of early delivery and termination of pregnancy.

    Mung beans contain enough magnesium, which is necessary for the proper functioning of the heart, digestion, release of neurotransmitters and recovery of muscle tissue.

    8. Helps to lose weight

    Mung beans have a high content of protein and fiber. The researcher says that the grains are high in fiber increasing cholecystokinin, a hormone that is saturated. Other studies suggest that grain consumption increases saturation. Daily consumption of Mung beans reduces food intake, which increases weight loss.

    9. Reduce PMS

    Mung beans are loaded with vitamin B6, vitamin B and folic acid, which helps control the hormonal fluctuations that lead to the symptoms of premenstrual syndrome. They help reduce the severity of pain associated with premenstrual syndrome spasm, mood swings, headaches, muscle aches and fatigue.

    10. Assist digestion

    Mung beans are easily digested and help remove toxins from the body. Since they are rich in fiber, it helps in digestion and prevent the symptoms of IBS, such as constipation. India, Mung bean cooked with turmeric, cilantro, cumin and ginger, which help to add flavor and to eliminate the pain in the stomach.

    If you want to buy Green Mung Bean in Myanmar, you can visit at bagantrade.com, which is Myanmar’s first and the only B2B international trading platform that engage local and global market.

    Read Also: Top 10 Amazing Benefits of Onions for Hair

              Wyatt Technology Corporation Launches the ViscoStar III Online Vi        
    1888 PressRelease - The Next Generation of Viscometers is launched with ViscoStar III by Wyatt Technology for unmatched sensitivity, stability, and broadest range of solvents for macromolecular characterization. Houston, TX - Wyatt Technology, the world leader in instrumentation for absolute macromolecular characterization, announces the launch of the third generation of intrinsic viscosity detectors: the ViscoStar III. Used in conjunction with gel permeation chromatography (GPC) systems and multi-angle light scattering (MALS) detectors, such as the company's DAWN and miniDAWN, the ViscoStar III can determine the molar mass, size and conformation of all types of macromolecules, including polymers and proteins. The ViscoStar III's sensitivity, dynamic range, resolution and stability surpass other GPC viscometers by at least an order of magnitude-all while retaining robustness, ease-of-use and serviceability. Advanced Technology All contemporary online viscometers utilize a capillary bridge for highly sensitive measurement of differential pressures arising from the differences in viscosity of solutions passing through the capillaries. The four arms of the bridge must be perfectly balanced in order to make the most sensitive measurements; however, even a well-balanced bridge is inherently susceptible to systematic noise due to dynamic pressure pulses generated by the chromatography pump. At the heart of the ViscoStar III are two key advances for overcoming these issues: thermal bridge tuning and complete impedance matching. Thermal bridge tuning performs rapid, non-mechanical balancing of the capillary resistances to ensure perfect bridge balance on every GPC run, even after material has accumulated on the capillary walls and skewed the original bridge symmetry. Complete impedance matching goes beyond simple resistive bridge balancing. It symmetrizes the dynamic properties of the capillary bridge and suppresses pump pulses by 100x. And the ViscoStar III does it without introducing the artificial band broadening that is used by other online viscometers to smear out pump pulses at the cost of reduced chromatographic resolution. An additional, proprietary software filter eliminates residual pump pulse levels without any loss of resolution. The bridge-balancing, impedance matching and software filtering features were developed entirely in-house by Wyatt's outstanding R&D staff. "The ViscoStar III is a welcome addition to my macromolecular characterization lab" says Stepan Podzimek of the University of Pardubice in the Czech Republic. Prof. Podzimek, one of the premier authorities on polymer characterization, added "It far exceeds the sensitivity, resolution and chemical compatibility of all other GPC viscometers I have tried, and sets a new standard for such instruments. It even works well with older GPC systems that I would normally consider incompatible with online viscometry due to their excessive pump pulsations. In combination with a HELEOS or TREOS, the ViscoStar III represents a powerful tool for the thorough investigation of polymer conformation and branching and brings new capabilities to all laboratories involved in the characterization of synthetic and natural polymers." More innovation from Wyatt Technology Yet other "firsts" in the ViscoStar III include • The only viscometer with a "dual" Peltier thermal control, which reduces signal drift by 50x relative to competing instruments while allowing for both heating and cooling • pressure transducers with all-316L stainless steel wetted surfaces for reduced corrosion and highest compatibility with the widest range of chromatographic solvents • a system pressure sensor to detect capillary clogs and prevent transducer damage; • a replaceable solvent filter that protects sensitive downstream components • ready access to service all fluidic components. Protein applications "The ViscoStar III is a sensitive, stable and robust instrument. When combined with a DAWN or miniDAWN MALS detector and size exclusion chromatography (SEC), we find it provides a more precise measurement of the hydrodynamic radius of proteins especially at low concentrations, than the more commonly used online dynamic light scattering (DLS)" stated Dr. Michelle Chen, Head of Analytical Services at Wyatt Technology. "With sensitivity down to as little as 0.1 µg of 100 kDa polystyrene, or approximately 1 µg of BSA, and a dynamic range of over 135,000:1, the ViscoStar III will add to our protein and peptide characterization capabilities-in addition to enhancing our polymer analysis." A webinar describing the technological innovations, capabilities and applications of the ViscoStar III will be broadcast on October 19, 2016. Visit http://www.wyatt.com/events/live-webinars.html for details and to register, or view on-demand at http://www.wyatt.com/webinars/polymers beginning October 28, 2016. Additional information on the ViscoStar III may be found at www.wyatt.com/ViscoStar.
              How scientists are hunting for a safer opioid painkiller        

    Researchers are raiding libraries, tweaking known drugs and taking innovative approaches

    Scicurious
    colorful selection of pills

    People will always need pills of some kind to kill pain. Scientists are using different approaches to find new opioid painkillers that aren’t addictive and have fewer side effects.

    An opioid epidemic is upon us. Prescription painkillers such as fentanyl and morphine can ease terrible pain, but they can also cause addiction and death. The Centers for Disease Control and Prevention estimates that nearly 2 million Americans are abusing or addicted to prescription opiates. Politicians are attempting to stem the tide at state and national levels, with bills to change and monitor how physicians prescribe painkillers and to increase access to addiction treatment programs.

    Those efforts may make access to painkillers more difficult for some. But pain comes to everyone eventually, and opioids are one of the best ways to make it go away.  

    Morphine is the king of pain treatment. “For hundreds of years people have used morphine,” says Lakshmi Devi, a pharmacologist at the Ichan School of Medicine Mount Sinai in New York City.  “It works, it’s a good drug, that’s why we want it. The problem is the bad stuff.”

    The “bad stuff” includes tolerance — patients have to take higher and higher doses to relieve their pain. Drugs such as morphine depress breathing, an effect that can prove deadly. They also cause constipation, drowsiness and vomiting. But “for certain types of pain, there are no medications that are as effective,” says Bryan Roth, a pharmacologist and physician at the University of North Carolina at Chapel Hill.  The trick is constructing a drug with all the benefits of an opioid painkiller, and few to none of the side effects. Here are three ways that scientists are searching for the next big pain buster, and three of the chemicals they’ve turned up.

    Raid the chemical library

    To find new options for promising drugs, scientists often look to chemical libraries of known molecules. “A pharmaceutical company will have libraries of a few million compounds,” Roth explains. Researchers comb through these libraries trying to find those compounds that connect to specific molecules in the body and brain.

    When drugs such as morphine enter the brain, they bind to receptors on the outside of cells and cause cascades of chemical activity inside. Opiate drugs bind to three types of opiate receptors: mu, kappa and delta. The mu receptor type is the one associated with the pain-killing — and pleasure-causing — activities of opiates. Activation of this receptor type spawns two cascades of chemical activity. One,  the Gi pathway, is associated with pain relief. The other — known as the beta-arrestin pathway — is associated with slowed breathing rate and constipation. So a winning candidate molecule would be one that triggered only the Gi pathway, without triggering beta-arrestin.

    Roth and colleagues set out to find a molecule that fit those specifications. But instead of the intense, months-long process of experimentally screening molecules in a chemical library, Roth’s group chose a computational approach, screening more than 3 million compounds in a matter of days. The screen narrowed the candidates down to 23 molecules to test the old fashioned way — both chemically and in mice. Each of these potential painkillers went through even more tests to find those with the strongest bond to the receptor and the highest potency.

    In the end, the team focused on a chemical called PMZ21. It activates only the pathway associated with pain relief, and is an effective painkiller in mice. It does not depress breathing rate, and it might even avoid some of the addictive potential of other opiates, though Roth notes that further studies need to be done. He and his colleagues published their findings September 8 in Nature.

    Letting the computer handle the initial screen is “a smart way of going about it,” notes Nathanial Jeske, a neuropharmacologist at the University of Texas Health Science Center in San Antonio. But mice are only the first step. “I’m interested to see if the efficacy applies to different animals.”

    Making an opiate 2.0

    Screening millions of compounds is one way to find a new drug. But why buy new when you can give a chemical makeover to something you already have? This is a “standard medicinal chemistry approach,” Roth says: “Pick a known drug and make analogs [slightly tweaked structures], and that can work.”

    That was the approach that Mei-Chuan Ko and his group at Wake Forest University School of Medicine in Winston-Salem, N.C., decided to take with the common opioid painkiller buprenorphine. “Compared to morphine or fentanyl, buprenorphine is safer,” Ko explains, “but it has abuse liability. Physicians still have concerns about the abuse and won’t prescribe it.” Buprenorphine is what’s called a partial agonist at the mu receptor — it can’t fully activate the receptor, even at the highest doses. So it’s an effective painkiller that is harder to overdose on —  so much so that it’s used to treat addiction to other opiates. But it can still cause a high, so doctors still worry about people abusing the drug.

    So to make a version of buprenorphine with lower addictive potential, Ko and his colleagues focused on a chemical known as BU08028. It’s structurally similar to buprenorphine, but it also hits another type of opioid receptor called the nociceptin-orphanin FQ peptide (or NOP) receptor.

    The NOP receptor is not a traditional target. This is partially because its effect in rodents — usually the first recipients of a new drug — is “complicated,” says Ko. “It does kill pain at high doses but not at low doses.” In primates, however, it’s another matter. In tests in four monkeys, BU08028 killed pain effectively at low doses and didn’t suppress breathing. The monkeys also showed little interest in taking the drug voluntarily, which suggests it might not be as addictive as classic opioid drugs. Ko and his colleagues published their results in the Sept. 13 Proceedings of the National Academy of Sciences.*

    Off the beaten path

    Combing through chemical libraries or tweaking drugs that are already on the market takes advantage of systems that are already well-established. But sometimes, a tough question requires an entirely new approach. “You can either target the receptors you know and love … or you can do the complete opposite and see if there’s a new receptor system,” Devi says.

    Jeske and his group chose the latter option. Of the three opiate receptor types — mu, kappa and delta — most drugs (and drug studies) focus on the mu receptor. Jeske’s group chose to investigate delta instead. They were especially interested in targeting delta receptors in the body — far away from the brain and its side effects.

    The delta receptor has an unfortunate quirk. When activated by a drug, it can help kill pain. But most of the time, it can’t be activated at all. The receptor is protected — bound up tight by another molecule — and only released when an area is injured. So Jeske’s goal was to find out what was binding up the delta receptor, and figure out how to get rid of it.

    Working in rat neurons, Jeske and his group found that when a molecule called GRK2 was around, the delta receptor was inactive. “Knock down GRK2 and the receptor works just fine,” Jeske says. By genetically knocking out GRK2 in rats, Jeske and his group left the delta receptor free to respond to a drug — and to prevent pain. The group published their results September 6 in Cell Reports. 

    It’s “a completely new target and that’s great,” says Devi. “But that new target with a drug is a tall order.” A single drug is unlikely to be able to both push away GRK2 and then activate the delta receptor to stop pain.

    Jeske agrees that a single molecule probably couldn’t take on both roles. Instead, one drug to get rid of GRK2 would be given first, followed by another to activate the delta receptors.

    Each drug development method has unearthed drug candidates with early promise. “We’ve solved these problems in mice and rats many times,” Devi notes. But whether sifting through libraries, tweaking older drugs or coming up with entirely new ones, the journey to the clinic has only just begun.


    *Paul Czoty and Michael Nader, two authors on the PNAS paper, were on my Ph.D. dissertation committee. I have had neither direct nor indirect involvement with this research. 

    Follow me on Twitter: @scicurious


              Aneka Herbal Penurun Gula Darah        
    Sejumlah tanaman obat memiliki efek seperti insulin dalam tubuh manusia. Tanaman tersebut menurunkan gula darah yang berlebihan pada penyandang diabetes. Dipadu pola makan dan olahraga, herbal dikonsumsi sesudah makan untuk mengendalikan kadar gala darah.
    Jumlah penyandang diabetes melitus belakangan ini di Tanah Air terus meningkat. "Salah satu sebabnya adalah konsumsi terlalu banyak karbohidrat. Berapa banyak pun beras diproduksi di Indonesia, pasti habis. Seharusnya kita mengurangi asupan karbohidrat," ujar Prof. Dr. Sumali Wiryowidagdo, Apt, Kepala Pusat Studi Obat Bahan Alami, Departermen Farmasi Fakultas MIPA Universitas Indonesia.
    Terlalu banyak karbohidrat akan menyebabkan produksi gula berlebihan di dalam darah. Gula darah yang berlebihan itu menyebabkan terjadinya penyakit diabetes. Kabar buruknya, bila sudah terkena, diabetes hanya bisa dikendalikan dengan pengendalian gula darah.
    "Pengendalian gula darah itu tidak bisa dilakukan dengan pengaturan pola makan semata. Perlu olahraga," kata Prof. Sumali.
    Tanaman obat pun bisa dikonsumsi untuk membantu mengendalikan gula darah. "Obat herbal bekerja seperti insulin. Tanaman herbal ini bisa digunakan dalam jangka panjang tanpa efek samping berarti," imbuhnya.
    Diungkapkan Dr. Prapti Utami, dokter yang mendalami tanaman obat, tanaman obat berfungsi konstruktif, yaitu membangun kembali jaringan yang rusak serta menyembuhkan komplikasi. Obat herbal bekerja menurunkan gula darah dengan mekanisme menghambat penyerapan gula berkat kadar seratnya yang tinggi.
    Tanaman seperti pare bekerja memperbaiki sel beta pankreas. "Ada juga yang merangsang sel beta pankreas gula darah," ujar Dr Prapti.
    Untuk diabetesi yang harus mengongurns obat dari dokter agar gula darahnya terkendali, perlu konsultasi dengan dokter terlebih dahulu sebelum mengonsumsi tanaman obat. "Perlu jarak waktu antara minum obat clan minum tanaman obat," kata Prof. Sumali. Berikut adalah beberapa herbal penurun gula darah :
    1. Mahkota Dewa
    Efek farmakologi: antiradang, obat disentri, sakit kulit, dan eksim.
    Cara penggunaan : lima hingga tujuh iris buah mahkota dewa diseduh dengan satu gelas air panas (200 cc). Tutup dan biarkan sebentar agar melarut dulu. Setelah itu minum secukupnya.
    2. Brotowali
    Efek farmakologi : analgesik (menghilangkan rasa sakit), anti piretik  (menurunkan panas)
    Cara penggunaan :  siapkan 6 cm batang brotowali, cuci bersih, lalu potong-potong. Tambahkan sepertiga genggam daun sambiloto dlan sepertiga daun kumis kucing. Rebus dengan tiga gelas sampai menjadi dua gelas. Diminum setelah makan.
    3. Mengkudu
    Efek farmakologi : memperbaiki sel beta pankreas dan reseptor insulin yang tidak berfungsi dengan baik.
    Cara penggunaan : dua buah mengkudu masak diparut, tambahkan sedikit air kapur. Aduk sampai merata. Peras dengan sepotong kain lalu diminum.
    4. Lidah buaya
    Efek farmakologi : antiradang, pencahar
    Cara penggunaan : 1 lembar lidah buaya dicuci bersih, buang durinya, kemudian dipotong-potong, Rebus lidah buaya dengan tiga gelas air sampai menjadi satu setengah gelas. Minum 3 x1,5 gelas setiap habis makan.

    5. Pare
    Efek farmakologi : antiradang, sifatnya dingin. Charantin dan polypeptide-P di dalam pare merangsang sel beta pankreas mengeluarkan insulin.
    Cara penggunaan : 200 gram buah pare segar dipotong-potong, lalu dijus atau direbus. Kemudian airnya diminum. 6. Teh Hijau
    Efek farmakologi : polifenol di dalam teh meningkatkan sensitivitas sel terhadap insulin. Efek teh hijau terhadap insulin ini pernah diteliti oleh Hiroshi Tsuneki dkk dan diterbitkan dalam jumal BMC Pharmacology edisi 2004.
    Cara penggunaan : satu sendok tek daun teh hijau diseduh dengan air panas. Minum setelah makan.
    (Dian Savitri)


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